Tumor Take Rate Optimization for Colorectal Carcinoma Patient-Derived Xenograft Models.

abstract：Background:Adenosine, derived from the degradation of ATP via ectonucleotidases CD39 and CD73, is a critical immunosuppressive metabolite in the hypoxic microenvironment of tumor tissue. Adenosine signaling via A2aR can inhibit the antitumor immune response of CD8+ T cells. CD39 and CD73 high-expressing Tregs play a cr...

journal_title：BioMed research international

authors： Shi L,Feng M,Du S,Wei X,Song H,Yixin X,Song J,Wenxian G

更新日期：2019-12-14 00:00:00

abstract：:Apc-mutated Pirc rats, spontaneously developing intestinal tumours, are resistant to 1,2-dimethylhydrazine- (DMH-) induced colon apoptosis. To understand this phenomenon, we analyzed the expression of genotoxic stress-related genes Mgmt, Gsta1, and Gstp1 in the colon of wt and Pirc rats in basal conditions and 24 h af...

journal_title：BioMed research international

authors： Femia AP,Luceri C,Lodovici M,Crucitta S,Caderni G

更新日期：2016-01-01 00:00:00

abstract：:The nonnucleoside reverse transcriptase inhibitors, used for the treatment of HIV infections, are reported to have low bioavailability pertaining to high first-pass metabolism, high protein binding, and enzymatic metabolism. They also show low permeability across blood brain barrier. The CNS is reported to be the most...

journal_title：BioMed research international

authors： Gupta S,Kesarla R,Chotai N,Misra A,Omri A

更新日期：2017-01-01 00:00:00

abstract：:Protein structure prediction (PSP) is computationally a very challenging problem. The challenge largely comes from the fact that the energy function that needs to be minimised in order to obtain the native structure of a given protein is not clearly known. A high resolution 20 × 20 energy model could better capture th...

journal_title：BioMed research international

authors： Rashid MA,Newton MA,Hoque MT,Sattar A

更新日期：2013-01-01 00:00:00

abstract：:The regulation of transcriptome expression level is a complex process involving multiple-level interactions among molecules such as protein coding RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA), which are essential for the transcriptome stability and maintenance and regulation of body homeostasis. The a...

journal_title：BioMed research international

authors： Liu C,Zhang YH,Deng Q,Li Y,Huang T,Zhou S,Cai YD

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to investigate the potential of microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol- (PEG-) 4000 to improve intravaginal delivery of miconazole nitrate (MN) for effective treatment of vulvova...

journal_title：BioMed research international

authors： Kenechukwu FC,Attama AA,Ibezim EC,Nnamani PO,Umeyor CE,Uronnachi EM,Momoh MA,Akpa PA,Ozioko AC

更新日期：2018-06-06 00:00:00

abstract：:The energy generated by an extremely low frequency electromagnetic field (ELF-EMF) is too weak to directly induce genotoxicity. However, it is reported that an extremely low frequency magnetic field (ELF-MF) is related to DNA strand breakage and apoptosis. The testes that conduct spermatogenesis through a dynamic cell...

journal_title：BioMed research international

authors： Lee SK,Park S,Gimm YM,Kim YW

更新日期：2014-01-01 00:00:00

abstract：:Chagas disease is caused by Trypanosoma cruzi infection. Besides the host-related factors, such as immune response and genetic background, the parasite, strain, and occurrences of reinfection episodes, may influence disease outcome. Our results demonstrate that both the primary infection and the reinfection with the C...

journal_title：BioMed research international

authors： Reis Machado J,Silva MV,Borges DC,da Silva CA,Ramirez LE,dos Reis MA,Castellano LR,Rodrigues V,Rodrigues DB

更新日期：2014-01-01 00:00:00

abstract：Introduction:The aim of the study was to analyze which variables influenced the completion of a cold loop hysteroscopic myomectomy in a one-step procedure in a large cohort of patients. Materials and Methods:A retrospective cohort study of 1434 cold loop resectoscopic myomectomies consecutively performed. The study po...

journal_title：BioMed research international

authors： Mazzon I,Favilli A,Grasso M,Horvath S,Bini V,Di Renzo GC,Gerli S

更新日期：2018-05-20 00:00:00

abstract：:Arrhythmia is a disease that is caused by abnormal electrical activity in the heart rate or rhythm. It is the major cause of cardiovascular morbidity and mortality. Although several antiarrhythmic drugs have been used in clinic for decades, their application is often limited by their adverse effects. As a result, natu...

journal_title：BioMed research international

authors： Li J,Hu D,Song X,Han T,Gao Y,Xing Y

更新日期：2017-01-01 00:00:00

abstract：:Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts. Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin. ECMs are complicated structures that s...

journal_title：BioMed research international

authors： Nikitovic D,Kouvidi K,Karamanos NK,Tzanakakis GN

更新日期：2013-01-01 00:00:00

abstract：:WHO reported that adherence among patients with chronic diseases averages only 50% in developed countries. This is recognized as a significant public health issue, since medication nonadherence leads to poor health outcomes and increased healthcare costs. Improving medication adherence is, therefore, crucial and revea...

journal_title：BioMed research international

authors： Lam WY,Fresco P

更新日期：2015-01-01 00:00:00

abstract：:Postprandial metabolic response depends on the meals' components and can be different in normal weight and obese people. However, there are some discrepancies between various reports. The aim of this study was to determine the metabolic response after intake of standardised meals with various fat and carbohydrate cont...

journal_title：BioMed research international

authors： Adamska E,Ostrowska L,Gościk J,Waszczeniuk M,Krętowski A,Górska M

更新日期：2015-01-01 00:00:00

abstract：Purpose:β-Defensin 118 (DEFB118) is a novel host defense peptide (HDP) identified in humans. To evaluate its potentials for future utilization, the DEFB118 gene was expressed in Escherichia coli (E. coli) and the recombinant protein was fully characterized. Methods:The DEFB118 protein was obtained by heterologous expr...

journal_title：BioMed research international

authors： Lin Q,Xie K,Chen D,Yu B,Mao X,Yu J,Luo J,Zheng P,Luo Y,Yan H,He J

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Long-term survival of total knee arthroplasty (TKA) is mainly determined by optimal positioning of the components and prosthesis alignment. Implant positioning can be optimized by computer assisted surgery (CAS). Patient specific cutting blocks (PSCB) seem to have the potential to improve component alignment...

journal_title：BioMed research international

authors： Helmy N,Dao Trong ML,Kühnel SP

更新日期：2014-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2020/4671349.]. ...

journal_title：BioMed research international

authors： Dhahri H,Rahmany I,Mahmood A,Al Maghayreh E,Elkilani W

更新日期：2020-06-30 00:00:00

abstract：:A wide range of molecular techniques have been developed for genotyping Candida species. Among them, multilocus sequence typing (MLST) and microsatellite length polymorphisms (MLP) analysis have recently emerged. MLST relies on DNA sequences of internal regions of various independent housekeeping genes, while MLP iden...

journal_title：BioMed research international

authors： Spampinato C,Leonardi D

更新日期：2013-01-01 00:00:00

abstract：:In preclinical treatment of polytraumatized patients crystalloids are preferentially used. To avoid metabolic acidosis, metabolizable anions like lactate or acetate are used to replace chloride in these solutions. We here studied the effects of malated Ringer's in resuscitation of both shock severities in comparison t...

journal_title：BioMed research international

authors： Keitel J,Hussmann B,Lendemans S,de Groot H,Rohrig R

更新日期：2015-01-01 00:00:00

abstract：:Long noncoding RNAs play an essential role in bladder cancer progression. The role of long noncoding RNA EGFR-AS1 in bladder cancer needs further study. We used clinical specimens to analyze the relationship between EGFR-AS1 and bladder cancer patients' characteristics. The functional experiments and mechanism studies...

journal_title：BioMed research international

authors： Wang A,Jiang A,Gan X,Wang Z,Huang J,Dong K,Liu B,Wang L,Chen M

更新日期：2020-12-22 00:00:00

abstract：:COVID-19 is a pandemic which has spread to more than 200 countries. Its high transmission rate makes it difficult to control. To date, no specific treatment has been found as a cure for the disease. Therefore, prediction of COVID-19 cases provides a useful insight to mitigate the disease. This study aims to model and ...

journal_title：BioMed research international

authors： Attanayake AMCH,Perera SSN

更新日期：2020-12-03 00:00:00

abstract：:We compared the efficacy of intravitreal aflibercept (IVA) to intravitreal ranibizumab (IVR) injections in eyes with diabetic macular edema (DME). The medical records of 49 eyes of 36 patients who were diagnosed with DME and had received IVR and 46 eyes of 40 patients who had received IVA treatment were reviewed. The ...

journal_title：BioMed research international

authors： Shimizu N,Oshitari T,Tatsumi T,Takatsuna Y,Arai M,Sato E,Baba T,Yamamoto S

更新日期：2017-01-01 00:00:00

abstract：:Vitamin D is important for normal development and maintenance of the skeleton. Hypovitaminosis D adversely affects calcium metabolism, osteoblastic activity, matrix ossification, bone remodeling and bone density. It is well known that Vit. D deficiency in the developing skeleton is related to rickets, while in adults ...

journal_title：BioMed research international

authors： Christodoulou S,Goula T,Ververidis A,Drosos G

更新日期：2013-01-01 00:00:00

abstract：:Polyetheretherketone (PEEK), which has biomechanical performance similar to that of human cancellous bone, is used widely as a spinal implant material. However, its bioinertness and hydrophobic surface properties result in poor osseointegration. This study applies a novel modification method, arc ion plating (AIP), th...

journal_title：BioMed research international

authors： Tsou HK,Chi MH,Hung YW,Chung CJ,He JL

更新日期：2015-01-01 00:00:00

abstract：Objectives:Magnetic resonance imaging (MRI) and in particular diffusion-weighted imaging (DWI) have been broadly proven to be the reference imaging method to discriminate between cholesteatoma and noncholesteatomatous middle ear lesions, especially when high tissue specificity is required. The aim of this study is to d...

journal_title：BioMed research international

authors： Russo C,Elefante A,Di Lullo AM,Carotenuto B,D'Amico A,Cavaliere M,Iengo M,Brunetti A

更新日期：2018-04-24 00:00:00

abstract：:MicroRNAs are small noncoding RNAs, involved in the regulation of many cellular processes in plants. Hundreds of miRNAs have been identified in cassava by various techniques, yet these identifications were constrained by a lack of miRNA templates and the narrow range of conditions in transcriptome study. In this resea...

journal_title：BioMed research international

authors： Yawichai A,Kalapanulak S,Thammarongtham C,Saithong T

更新日期：2019-06-19 00:00:00

abstract：:Schistosomiasis, caused by infection with Schistosoma species, remains an important parasitic zoonosis. Thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR) plays an important role in the development of the parasite and for its survival. Here we present a recombinant plasmid DNA vaccine, pVAX1/SjTGR, to ...

journal_title：BioMed research international

authors： Cao Y,Zhao B,Han Y,Zhang J,Li X,Qiu C,Wu X,Hong Y,Ai D,Lin J,Fu Z

更新日期：2013-01-01 00:00:00

abstract：:This work evaluated the physicochemical properties and antioxidant activity of spray dried extracts (SDE) from Psidium guajava L. leaves. Different drying carriers, namely, maltodextrin, colloidal silicon dioxide, Arabic gum, and β -cyclodextrin at concentrations of 40 and 80% relative to solids content, were added to...

journal_title：BioMed research international

authors： Fernandes MR,Azzolini AE,Martinez ML,Souza CR,Lucisano-Valim YM,Oliveira WP

更新日期：2014-01-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States Food and Drug Admini...

journal_title：BioMed research international

authors： Murata S,Zhang C,Finch N,Zhang K,Campo L,Breuer EK

更新日期：2016-01-01 00:00:00

abstract：:The history of polyglutamine diseases dates back approximately 20 years to the discovery of a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of similar expansion mutations in Huntington's disease, SCA1, DRPLA, and the other spinocerebellar ataxias. This common molecular feature of...

journal_title：BioMed research international

authors： Weber JJ,Sowa AS,Binder T,Hübener J

更新日期：2014-01-01 00:00:00

abstract：:More than one-third of the world's population is infected with one or more helminthic parasites. Helminth infections are prevalent throughout tropical and subtropical regions where malaria pathogens are transmitted. Malaria is the most widespread and deadliest parasitic disease. The severity of the disease is strongly...

journal_title：BioMed research international

authors： Salazar-Castañon VH,Legorreta-Herrera M,Rodriguez-Sosa M

更新日期：2014-01-01 00:00:00