Helminth parasites alter protection against Plasmodium infection.

Abstract:

:More than one-third of the world's population is infected with one or more helminthic parasites. Helminth infections are prevalent throughout tropical and subtropical regions where malaria pathogens are transmitted. Malaria is the most widespread and deadliest parasitic disease. The severity of the disease is strongly related to parasite density and the host's immune responses. Furthermore, coinfections between both parasites occur frequently. However, little is known regarding how concomitant infection with helminths and Plasmodium affects the host's immune response. Helminthic infections are frequently massive, chronic, and strong inductors of a Th2-type response. This implies that infection by such parasites could alter the host's susceptibility to subsequent infections by Plasmodium. There are a number of reports on the interactions between helminths and Plasmodium; in some, the burden of Plasmodium parasites increased, but others reported a reduction in the parasite. This review focuses on explaining many of these discrepancies regarding helminth-Plasmodium coinfections in terms of the effects that helminths have on the immune system. In particular, it focuses on helminth-induced immunosuppression and the effects of cytokines controlling polarization toward the Th1 or Th2 arms of the immune response.

journal_name

Biomed Res Int

authors

Salazar-Castañon VH,Legorreta-Herrera M,Rodriguez-Sosa M

doi

10.1155/2014/913696

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

913696

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

杂志文章,评审
  • Effect of Different Body Postures on the Severity of Stuttering in Young Adults with Developmental Stuttering.

    abstract:Objective:The current study aimed to investigate the effects of body position on the level and severity of stuttering in young adults with developmental stuttering. Methods:A total of 24 subjects (male: 17; female: 7; mean age: 24.9 ± 6.2 years) with developmental stuttering participated. The participants were asked t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1817906

    authors: Almudhi A,Zafar H,Anwer S,Alghadir A

    更新日期:2019-08-05 00:00:00

  • Gene Expression Profile of Colon Mucosa after Cytotoxic Insult in wt and Apc-Mutated Pirc Rats: Possible Relation to Resistance to Apoptosis during Carcinogenesis.

    abstract::Apc-mutated Pirc rats, spontaneously developing intestinal tumours, are resistant to 1,2-dimethylhydrazine- (DMH-) induced colon apoptosis. To understand this phenomenon, we analyzed the expression of genotoxic stress-related genes Mgmt, Gsta1, and Gstp1 in the colon of wt and Pirc rats in basal conditions and 24 h af...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1310342

    authors: Femia AP,Luceri C,Lodovici M,Crucitta S,Caderni G

    更新日期:2016-01-01 00:00:00

  • Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.

    abstract::It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium deriva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/182846

    authors: Chen MF,Tsai JT,Chen LJ,Wu TP,Yang JJ,Yin LT,Yang YL,Chiang TA,Lu HL,Wu MC

    更新日期:2014-01-01 00:00:00

  • Multiblock discriminant analysis for integrative genomic study.

    abstract::Human diseases are abnormal medical conditions in which multiple biological components are complicatedly involved. Nevertheless, most contributions of research have been made with a single type of genetic data such as Single Nucleotide Polymorphism (SNP) or Copy Number Variation (CNV). Furthermore, epigenetic modifica...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/783592

    authors: Kang M,Kim DC,Liu C,Gao J

    更新日期:2015-01-01 00:00:00

  • Adverse Pregnancy Outcomes of Patients with History of First-Trimester Recurrent Spontaneous Abortion.

    abstract::Although a history of first-trimester recurrent spontaneous abortion (FRSA) is regarded as a risk factor in antenatal care, the characteristic of subsequent pregnancy outcome is not clearly elucidated. Here, a retrospective analysis was performed on the clinical data of 492 singleton pregnant women. 164 of them with t...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2017/4359424

    authors: Yang J,Wang Y,Wang XY,Zhao YY,Wang J,Zhao YY

    更新日期:2017-01-01 00:00:00

  • Somatostatin receptor-based molecular imaging and therapy for neuroendocrine tumors.

    abstract::Neuroendocrine tumors (NETs) are tumors originated from neuroendocrine cells in the body. The localization and the detection of the extent of NETs are important for diagnosis and treatment, which should be individualized according to the tumor type, burden, and symptoms. Molecular imaging of NETs with high sensitivity...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/102819

    authors: Wang L,Tang K,Zhang Q,Li H,Wen Z,Zhang H,Zhang H

    更新日期:2013-01-01 00:00:00

  • Correlation of N-acetyltransferase 2 genotype with isoniazid acetylation in Polish tuberculosis patients.

    abstract:UNLABELLED:Isoniazid (INH), a key agent in the treatment of tuberculosis (TB), is metabolized primarily by the genetically polymorphic N-acetyltransferase 2 (NAT2) enzyme. Patients treated with INH can be classified as fast, intermediate, and slow acetylators. The objective of this study was to explore the relationship...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/853602

    authors: Zabost A,Brzezińska S,Kozińska M,Błachnio M,Jagodziński J,Zwolska Z,Augustynowicz-Kopeć E

    更新日期:2013-01-01 00:00:00

  • Corrigendum to "Safety and Efficacy of Small Bowel Examination by Capsule Endoscopy for Patients before Liver Transplantation".

    abstract::[This corrects the article DOI: 10.1155/2017/8193821.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2017/6418529

    authors: Kawano S,Takaki A,Iwamuro M,Yasunaka T,Kono Y,Miura K,Inokuchi T,Kawahara Y,Umeda Y,Yagi T,Okada H

    更新日期:2017-01-01 00:00:00

  • UnderstAID, an ICT Platform to Help Informal Caregivers of People with Dementia: A Pilot Randomized Controlled Study.

    abstract::Information and communications technology (ICT) could support ambient assisted living (AAL) based interventions to provide support to informal caregivers of people with dementia, especially when they need to cope with their feelings of overburden or isolation. An e-learning platform (understAID application) was tested...

    journal_title:BioMed research international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1155/2016/5726465

    authors: Núñez-Naveira L,Alonso-Búa B,de Labra C,Gregersen R,Maibom K,Mojs E,Krawczyk-Wasielewska A,Millán-Calenti JC

    更新日期:2016-01-01 00:00:00

  • Awareness of Pleiotropic and Cardioprotective Effect of Statins in Patients with Coronary Artery Disease.

    abstract:Background:Statins are commonly used in the secondary prevention of coronary artery disease. Studies have shown that the rate of statin use is low among patients with coronary artery disease. In this study, we aimed to investigate the reasons for poor patient compliance with statin treatment. Methods:A total of 504 pa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8961690

    authors: Ozkan B,Örsçelik Ö,Uyar H,Ballı M,Güçer E,Aslan O,Temel G,Çelik A,Türkay Özcan İ

    更新日期:2018-06-07 00:00:00

  • miR-20b Inhibits T Cell Proliferation and Activation via NFAT Signaling Pathway in Thymoma-Associated Myasthenia Gravis.

    abstract::Purpose. We examined the role of miR-20b in development of thymoma-associated myasthenia gravis, especially in T cell proliferation and activation. Materials and Methods. Using qRT-PCR, we assessed expression levels of miR-20b and its target genes in cultured cells and patient samples and examined the proliferation of...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/9595718

    authors: Xin Y,Cai H,Lu T,Zhang Y,Yang Y,Cui Y

    更新日期:2016-01-01 00:00:00

  • Effect of supracervical apposition and spontaneous labour on apoptosis and matrix metalloproteinases in human fetal membranes.

    abstract:BACKGROUND:Apoptosis and matrix metalloproteinase (MMP-9) are capable of hydrolysing components of the extracellular matrix and weakening the fetal membranes which leads to eventual rupture, a key process of human parturition. The aim of this study was to determine the effect of supracervical apposition and spontaneous...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/316146

    authors: Chai M,Walker SP,Riley C,Rice GE,Permezel M,Lappas M

    更新日期:2013-01-01 00:00:00

  • Bioactive surface modification of hydroxyapatite.

    abstract::The purpose of this study was to establish an acid-etching procedure for altering the Ca/P ratio of the nanostructured surface of hydroxyapatite (HAP) by using surface chemical and morphological analyses (XPS, XRD, SEM, surface roughness, and wettability) and to evaluate the in vitro response of osteoblast-like cells ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/626452

    authors: Abe Y,Okazaki Y,Hiasa K,Yasuda K,Nogami K,Mizumachi W,Hirata I

    更新日期:2013-01-01 00:00:00

  • Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

    abstract::Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/179568

    authors: Landová H,Vetchý D,Gajdziok J,Doležel P,Muselík J,Dvořáčková K,Jekl V,Hauptman K,Knotek Z

    更新日期:2014-01-01 00:00:00

  • Sensitivity of rabbit ventricular action potential and Ca²⁺ dynamics to small variations in membrane currents and ion diffusion coefficients.

    abstract::Little is known about how small variations in ionic currents and Ca²⁺ and Na⁺ diffusion coefficients impact action potential and Ca²⁺ dynamics in rabbit ventricular myocytes. We applied sensitivity analysis to quantify the sensitivity of Shannon et al. model (Biophys. J., 2004) to 5%-10% changes in currents conductanc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/565431

    authors: Lo YH,Peachey T,Abramson D,McCulloch A,Michailova A

    更新日期:2013-01-01 00:00:00

  • Corrigendum to "Calcium Channel Expression and Applicability as Targeted Therapies in Melanoma".

    abstract::[This corrects the article DOI: 10.1155/2015/587135.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2016/3017536

    authors: Macià A,Herreros J,Martí RM,Cantí C

    更新日期:2016-01-01 00:00:00

  • Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer.

    abstract:Background:Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectab...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6278403

    authors: D'Ascanio M,Pezzuto A,Fiorentino C,Sposato B,Bruno P,Grieco A,Mancini R,Ricci A

    更新日期:2018-08-27 00:00:00

  • Mystery of Retinal Vein Occlusion: Vasoactivity of the Vein and Possible Involvement of Endothelin-1.

    abstract::Retinal vein occlusion (RVO) is a common vascular disease of retina; however, the pathomechanism leading to RVO is not yet clear. In general, increasing age, hypertension, arteriosclerosis, diabetes mellitus, dyslipidemia, cardiovascular disorder, and cerebral stroke are systemic risk factors of RVO. However, RVO ofte...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4816527

    authors: Kida T

    更新日期:2017-01-01 00:00:00

  • GAS1 Deficient Enhances UPR Activity in Saccharomyces cerevisiae.

    abstract::Beta-1,3-glucanosyltransferase (Gas1p) plays important roles in cell wall biosynthesis and morphogenesis and has been implicated in DNA damage responses and cell cycle regulation in fungi. Yeast Gas1p has also been reported to participate in endoplasmic reticulum (ER) stress responses. However, the precise roles and m...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1238581

    authors: Cui HJ,Cui XG,Jing X,Yuan Y,Chen YQ,Sun YX,Zhao W,Liu XG

    更新日期:2019-06-02 00:00:00

  • Microscopic evaluation, molecular identification, antifungal susceptibility, and clinical outcomes in fusarium, Aspergillus and, dematiaceous keratitis.

    abstract:PURPOSE:Fusarium, Aspergillus, and Dematiaceous are the most common fungal species causing keratitis in tropical countries. Herein we report a prospective study on fungal keratitis caused by these three fungal species. METHODOLOGY:A prospective investigation was undertaken to evaluate eyes with presumed fungal keratit...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/605308

    authors: Gajjar DU,Pal AK,Ghodadra BK,Vasavada AR

    更新日期:2013-01-01 00:00:00

  • Class III Treatment with Skeletal and Dental Anchorage: A Review of Comparative Effects.

    abstract:Objectives:This review addresses the comparative effects of skeletal anchored maxillary protraction (MP) versus dental anchored MP. Materials and Methods:The studies retrieved had to have both test and control groups treated by the use of a facemask with or without the use of skeletal anchorage though either (palatal/...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/7946019

    authors: Clemente R,Contardo L,Greco C,Di Lenarda R,Perinetti G

    更新日期:2018-07-02 00:00:00

  • Morphometric Evaluation of Korean Femurs by Geometric Computation: Comparisons of the Sex and the Population.

    abstract::We measured 28 parameters of 202 femurs from Koreans by an automated geometric computation program using 3D models generated from computed tomography images. The measurement parameters were selected with reference to physical and forensic anthropology studies as well as orthopedic implant design studies. All measureme...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/730538

    authors: Cho HJ,Kwak DS,Kim IB

    更新日期:2015-01-01 00:00:00

  • Short-Term Results Suggest That Sleeved Stomach without Resection Is as Effective as Sleeve Gastrectomy in Improving Glucose Control in Type 2 Diabetes Mellitus Sprague-Dawley Rat Model.

    abstract:Background:Although sleeve gastrectomy results in good weight loss and metabolic improvements, it is an irreversible procedure. Therefore, we attempted to assess the possibility of creating a sleeved stomach without resection. Material and Methods. A total of 22 male Sprague-Dawley rats with type 2 diabetes were random...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9024923

    authors: Zhang W,Widjaja J,Yao L,Shao Y,Zhu X,Li C

    更新日期:2020-05-01 00:00:00

  • Extracorporeal Membrane Oxygenation as a Bridge for Heart Failure and Cardiogenic Shock.

    abstract::Heart failure (HF) can be defined as cardiac structural or functional abnormality leading to a series of symptoms due to deficiency of oxygen delivery. In the clinical practice, acute heart failure (AHF) is usually performed as cardiogenic shock (CS), pulmonary edema, and single or double ventricle congestive heart fa...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/7263187

    authors: Zhong ZP,Wang H,Hou XT

    更新日期:2016-01-01 00:00:00

  • Weaker Self-Esteem in Adolescence Predicts Smoking.

    abstract:BACKGROUND:To study whether weaker self-esteem in adolescence is connected with smoking behavior in adulthood. METHODS:An age cohort born in 1979 responded to the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the age of 16 (n = 1,072). Respondents' smoking behavior was monitored annually during adolescence and 75.3% ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/687541

    authors: Saari AJ,Kentala J,Mattila KJ

    更新日期:2015-01-01 00:00:00

  • Incidence of alpha-globin gene defect in the Lebanese population: a pilot study.

    abstract:BACKGROUND:It is well established that the Mediterranean and Arab populations are at high risk for thalassemias in general and for alpha-thalassemia in particular. Yet, reports on alpha-thalassemia in Lebanon are still lacking. In this study, we aim at assessing the incidence of alpha-thalassemia in the Lebanese popula...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/517679

    authors: Farra C,Daher R,Badra R,el Rafei R,Bejjany R,Charafeddine L,Yunis K

    更新日期:2015-01-01 00:00:00

  • Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement.

    abstract::Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6416941

    authors: Liu T,Liu T,Liu H,Fan H,Chen B,Wang D,Zhang Y,Sun F

    更新日期:2019-06-11 00:00:00

  • Biomarkers as predictors of recurrence following curative resection for pancreatic ductal adenocarcinoma: a review.

    abstract::Pancreatic ductal adenocarcinoma (PDA) is the fourth most common cancer causing death in the United States. Early tumor recurrence is an important contributor to the dismal prognosis. The availability of an accurate prognostic biomarker for predicting disease recurrence following curative resection will be beneficial ...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2014/468959

    authors: Osayi SN,Bloomston M,Schmidt CM,Ellison EC,Muscarella P

    更新日期:2014-01-01 00:00:00

  • Aesthetic evaluation of the nasolabial region in children with unilateral cleft lip and palate comparing expert versus nonexperience health professionals.

    abstract::Esthetic evaluation of cleft lip and palate rehabilitation outcomes may assist in the determination of new surgical interventions and aid in reevaluation of treatment protocols. Our objective was to compare esthetics assessments of the nasolabial region in children with a unilateral cleft lip and palate between health...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/460106

    authors: Paiva TS,Andre M,Paiva WS,Mattos BS

    更新日期:2014-01-01 00:00:00

  • Automatic Segmentation of Ultrasound Tomography Image.

    abstract::Ultrasound tomography (UST) image segmentation is fundamental in breast density estimation, medicine response analysis, and anatomical change quantification. Existing methods are time consuming and require massive manual interaction. To address these issues, an automatic algorithm based on GrabCut (AUGC) is proposed i...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2059036

    authors: Wu S,Yu S,Zhuang L,Wei X,Sak M,Duric N,Hu J,Xie Y

    更新日期:2017-01-01 00:00:00