UnderstAID, an ICT Platform to Help Informal Caregivers of People with Dementia: A Pilot Randomized Controlled Study.

abstract：Objective:To explore the ability of asiatic acid to interfere with the invasion and proliferation of breast cancer cells by inhibiting WAVE3 expression and activation through the PI3K/AKT signaling pathway. Methods:The MDA-MB-231 cells with strong invasiveness were screened by transwell assay, and plasmids with high e...

journal_title：BioMed research international

authors： Gou XJ,Bai HH,Liu LW,Chen HY,Shi Q,Chang LS,Ding MM,Shi Q,Zhou MX,Chen WL,Zhang LM

更新日期：2020-02-10 00:00:00

abstract：:Fermenticin HV6b is a class IIa antimicrobial peptide produced by Lactobacillus fermentum HV6b MTCC 10770 isolated from human vaginal ecosystem. It shows growth inhibition of a wide range of opportunistic pathogens of humans, for example, Bacteroides, Gardnerella vaginalis, Mobiluncus, Staphylococci, and Streptococci,...

journal_title：BioMed research international

authors： Kaur B,Balgir PP,Mittu B,Kumar B,Garg N

更新日期：2013-01-01 00:00:00

abstract：:Tumourigenesis is a mutation accumulation process, which is likely to start with a mutated founder cell. The evolutionary nature of tumor development makes phylogenetic models suitable for inferring tumor evolution through genetic variation data. Copy number variation (CNV) is the major genetic marker of the genome wi...

journal_title：BioMed research international

authors： Liang Y,Liao B,Zhu W

更新日期：2017-01-01 00:00:00

abstract：:Slaughterhouse work involves a high degree of repetitive and forceful upper limb movements and thus implies an elevated risk of work-related musculoskeletal disorders. High intensity strength training effectively rehabilitates musculoskeletal disorders among sedentary employees, but less is known about the effect amon...

journal_title：BioMed research international

authors： Sundstrup E,Jakobsen MD,Jay K,Brandt M,Andersen LL

更新日期：2014-01-01 00:00:00

abstract：:In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staph...

journal_title：BioMed research international

authors： Zatorska B,Arciola CR,Haffner N,Segagni Lusignani L,Presterl E,Diab-Elschahawi M

更新日期：2018-10-22 00:00:00

abstract：:Antipsychotic drugs (APDs) used to treat clinical psychotic syndromes cause a variety of blood dyscrasias. APDs suppress the aggregation of platelets; however, the underlying mechanism remains unknown. We first analyzed platelet aggregation and clot formation in platelets treated with APDs, risperidone, clozapine, or ...

journal_title：BioMed research international

authors： Wu CC,Tsai FM,Chen ML,Wu S,Lee MC,Tsai TC,Wang LK,Wang CH

更新日期：2016-01-01 00:00:00

abstract：:L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases ex...

journal_title：BioMed research international

authors： Izidoro LF,Sobrinho JC,Mendes MM,Costa TR,Grabner AN,Rodrigues VM,da Silva SL,Zanchi FB,Zuliani JP,Fernandes CF,Calderon LA,Stábeli RG,Soares AM

更新日期：2014-01-01 00:00:00

abstract：:The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited by its side effects like high toxicity and insolubility. Nanomedicine offers new hope for overcoming the shortcomings. But how to increase in vivo stability and to control intracellular drug release is a key issue for nano-based for...

journal_title：BioMed research international

authors： Chen L,Chen F,Zhao M,Zhu X,Ke C,Yu J,Yan Z,Zhang F,Sun Y,Chen D,Jiang C,Zhao X,Gao Y,Guo S,Li W

更新日期：2015-01-01 00:00:00

abstract：Background:Splenectomy can improve liver function and survival in patients with autoimmune hepatitis (AIH) and liver cirrhosis. We investigated the underlying mechanism in a mouse model of concanavalin A- (ConA-) induced liver fibrosis. Methods:We used ConA to induce immune liver fibrosis in BALB/c mice. Splenectomy w...

journal_title：BioMed research international

authors： Wang Y,Guo X,Jiao G,Luo L,Zhou L,Zhang J,Wang B

更新日期：2019-01-06 00:00:00

abstract：:The use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry criteria of probe dr...

journal_title：BioMed research international

authors： Wang L,Chiang C,Liang H,Wu H,Feng W,Quinney SK,Li J,Li L

更新日期：2015-01-01 00:00:00

abstract：:We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions. Male Wistar rats were divided into four groups: control (CON), diabetic (DM; streptozotocin (STZ), i.v. 55 mg/kg BW), control-treated with cu...

journal_title：BioMed research international

authors： Wongeakin N,Bhattarakosol P,Patumraj S

更新日期：2014-01-01 00:00:00

abstract：:The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects o...

journal_title：BioMed research international

authors： Pei K,Gui T,Kan D,Feng H,Jin Y,Yang Y,Zhang Q,Du Z,Gai Z,Wu J,Li Y

更新日期：2020-07-18 00:00:00

abstract：:Sun Island Bund Wetland (SIBW) is a river floodplain wetland located at the south part of Heilongjiang Province in Northeast China. An investigation of the influence of habitat type on macroinvertebrates assemblages structure was conducted in July 2016. Nine (9) sampling sites were selected based on sediment type, wat...

journal_title：BioMed research international

authors： Khudhair N,Yan C,Liu M,Yu H

更新日期：2019-02-13 00:00:00

abstract：:Atypical chemokine receptors (ACKRs) are a subclass of G protein-coupled receptors characterized by promiscuity of ligand binding and an obvious inability to signal after ligand binding. Although some discoveries regarding this family in Homo sapiens and other species have been reported in some studies, the evolution ...

journal_title：BioMed research international

authors： Pan L,Lv J,Zhang Z,Zhang Y

更新日期：2018-09-24 00:00:00

abstract：:Deep venous thrombosis (DVT) constitutes a great threat to health worldwide. Endothelial cell injury and dysfunction comprise the critical contributor for the development of DVT. However, the mechanism behind it remains poorly elucidated. The study is aimed at investigating the role of microRNA-122 (miR-122) and oxida...

journal_title：BioMed research international

authors： Li HQ,Pan ZY,Yang Z,Zhang DB,Chen Q

更新日期：2020-10-27 00:00:00

abstract：:Escherichia coli O157:H7 is the main causative agent of haemolytic uremic syndrome. Cattle are the main reservoir of these bacteria, and have been shown to develop immune response to colonization. Our aim was to investigate the faecal shedding pattern of E. coli O157:H7 in calves challenged intragastrically with eithe...

journal_title：BioMed research international

authors： Martorelli L,Hovde CJ,Vilte DA,Albanese A,Zotta E,Ibarra C,Cantet RJ,Mercado EC,Cataldi A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer's disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). METHODS:The baseline sample of 18...

journal_title：BioMed research international

authors： Laske C,Sohrabi HR,Jasielec MS,Müller S,Koehler NK,Gräber S,Förster S,Drzezga A,Mueller-Sarnowski F,Danek A,Jucker M,Bateman RJ,Buckles V,Saykin AJ,Martins RN,Morris JC,Dominantly Inherited Alzheimer Network Dian

更新日期：2015-01-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are considered to be the predominant cause of death in the world. Chinese herb medicines (CHMs) have been widely used for the treatment of CVDs in Asian countries for thousands of years. One reason of high efficacy of CHMs in treating CVDs is attributed to their inhibition in atheroscler...

journal_title：BioMed research international

authors： Lu L,Sun X,Qin Y,Guo X

更新日期：2018-06-13 00:00:00

abstract：:A metabolic disorder is considered one of the hallmarks of cancer. Multiple differentially expressed metabolic genes have been identified in colon cancer (CC), and their biological functions and prognostic values have been well explored. The purpose of the present study was to establish a metabolic signature to optimi...

journal_title：BioMed research international

authors： Luo D,Shan Z,Liu Q,Cai S,Li Q,Li X

更新日期：2020-11-17 00:00:00

abstract：:This study aimed to evaluate the genes that were expressed in the healing bones around SLA-treated titanium orthodontic mini-implants in a beagle at early (1-week) and late (4-week) stages with RNA-sequencing (RNA-Seq). Samples from sites of surgical defects were used as controls. Total RNA was extracted from the tiss...

journal_title：BioMed research international

authors： Nahm KY,Heo JS,Lee JH,Lee DY,Chung KR,Ahn HW,Kim SH

更新日期：2015-01-01 00:00:00

abstract：:Background. The epidemiology of atopic dermatitis (AD) in Chinese outpatients is yet to be clarified. Objectives. To investigate population-based prevalence and clinical features of AD in Chinese outpatients. Methods. A multicenter cross-sectional study was conducted in outpatients with eczema or dermatitis from 39 te...

journal_title：BioMed research international

authors： Wang X,Li LF,Zhao DY,Shen YW

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:(1) To evaluate a new acquisition protocol of (18)F-choline (FCH) PET/CT for prostate cancer patients (PC), (2) to review acquisition (18)F-choline PET/CT methodology, and (3) to propose a standardized acquisition protocol on FCH PET/CT in PC patients. MATERIALS:100 consecutive PC patients (mean age 70.5 years...

journal_title：BioMed research international

authors： Chondrogiannis S,Marzola MC,Grassetto G,Maffione AM,Rampin L,Veronese E,Massaro A,Rubello D

更新日期：2014-01-01 00:00:00

abstract：:Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricul...

journal_title：BioMed research international

authors： Liu T,Liu T,Liu H,Fan H,Chen B,Wang D,Zhang Y,Sun F

更新日期：2019-06-11 00:00:00

abstract：:Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL...

journal_title：BioMed research international

authors： Li XJ,Mishra SK,Wu M,Zhang F,Zheng J

更新日期：2014-01-01 00:00:00

abstract：:Pregnancy is associated with various physiological changes which may lead to significant alterations in the pharmacokinetics of many drugs. The present study was aimed to investigate the potential effects of pregnancy on the pharmacokinetic profile of zonisamide (ZNM) in the rabbit. Seven female rabbits were used in t...

journal_title：BioMed research international

authors： Matar KM

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Electrical Bioimpedance Cerebral Monitoring is assessment in real time of health of brain tissue through study of passive dielectric properties of brain. During the last two decades theory and technology have been developed in parallel with animal experiments aiming to confirm feasibility of using bioimpedance-...

journal_title：BioMed research international

authors： Seoane F,Reza Atefi S,Tomner J,Kostulas K,Lindecrantz K

更新日期：2015-01-01 00:00:00

abstract：:The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of AKNA in gastric cancer (GC). By using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, AKNA was found deregulat...

journal_title：BioMed research international

authors： Wang G,Sun D,Li W,Xin Y

更新日期：2020-05-13 00:00:00

abstract：Background:Preeclampsia (PE) is a pregnancy-specific hypertension syndrome and is one of the leading causes of maternal and perinatal morbidity and mortality. Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in many diseases, including preeclampsia. The present study is aimed at identifying t...

journal_title：BioMed research international

authors： Zhang Z,Wang P,Zhang L,Huang C,Gao J,Li Y,Yang B

更新日期：2020-06-05 00:00:00

abstract：Objectives:Despite the fact that it is widely acknowledged that immune checkpoint inhibitors (ICIs) rely on the presence of immune response to take their antitumor effect, little is known whether there is an influence exerted on the efficacy of ICIs based on patients' age. We performed a systematic review and meta-anal...

journal_title：BioMed research international

authors： Zhang L,Sun L,Yu J,Shan F,Zhang K,Pang X,Ma C,Zhang Y,Shen M,Ma S,Ruan S

更新日期：2019-05-13 00:00:00

abstract：:Early recovery from muscular injury is crucial for elite athletes. Hyperbaric oxygen therapy (HBOT) has been reported to be beneficial in terms of accelerating cell recovery and tissue repair, which are considered to be helpful for eliminating fatigue and recovering stamina. This study was performed to evaluate the ef...

journal_title：BioMed research international

authors： Chen CY,Chou WY,Ko JY,Lee MS,Wu RW

更新日期：2019-05-29 00:00:00