Abstract:
:Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Landová H,Vetchý D,Gajdziok J,Doležel P,Muselík J,Dvořáčková K,Jekl V,Hauptman K,Knotek Zdoi
10.1155/2014/179568subject
Has Abstractpub_date
2014-01-01 00:00:00pages
179568eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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