当前位置： SCI文献检索 > Biomed Research International期刊下所有文献 > Antioxidant and cytotoxic effects of crude extract, fractions and 4-nerolidylcathecol from aerial parts of Pothomorphe umbellata L. (Piperaceae).

Antioxidant and cytotoxic effects of crude extract, fractions and 4-nerolidylcathecol from aerial parts of Pothomorphe umbellata L. (Piperaceae).

Abstract：

:The crude ethanolic extract from aerial parts of Pothomorphe umbellata L. (Piperaceae) and fractions obtained by partitions sequentially among water-methanol, methylene chloride, and ethyl acetate, as well as the major constituent, 4-nerolidylcatechol, were, respectively, evaluated and evidenced for antioxidant and cytotoxic effects through fluorometric microplate and microculture tetrazolium assays in HL-60 cells. The crude ethanolic extract demonstrated the preeminent antioxidant activity (IC50 = 1.2  μg/mL) against exogenous cytoplasmic reactive oxygen species, followed by the water-methanolic (IC50 = 4.5  μg/mL), methylene chloride (IC50 = 5.9  μg/mL), ethyl acetate (IC50 = 8.0  μg/mL), 4-nerolidylcatechol (IC50 = 8.6  μg/mL), and the sterol fractions (IC50 > 12.5  μg/mL). Vitamin C, the positive control used in this assay, presented IC50 value equivalent to 1.7  μg/mL. 4-Nerolidylcatechol (IC50 = 0.4  μg/mL) and methylene chloride fraction (IC50 = 2.3  μg/mL) presented considerable cytotoxicity probably because of the presence of an o-quinone, an auto-oxidation by product of the catechol. Polar compounds, present in the ethanol extract, appear to increase the solubility and stability of the major active constituent, acting synergistically with 4-nerolidylcatechol, improving its pharmacokinetic parameters and increasing significantly its antioxidant activity which, in turn, suggests that the aqueous-ethanolic extract, used in folklore medicine, is safe and effective.

journal_name

Biomed Res Int

journal_title

BioMed research international

authors

Lopes AP,Bagatela BS,Rosa PC,Nanayakkara DN,Tavares Carvalho JC,Maistro EL,Bastos JK,Perazzo FF

doi

10.1155/2013/206581

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

206581

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

杂志文章

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