Abstract:
:Rheumatoid arthritis (RA) is a systemic multifactorial autoimmune disorder. The interactions between diverse environmental and genetic factors lead to the onset of this complex autoimmune disorder. Serum levels of vitamin D (VD) are involved in the regulation of various immune responses. Vitamin D is a key signaling molecule in the human body that maintains calcium as well as phosphate homeostasis. It also regulates the functions of the immune system and, thus, can play a substantial role in the etiology of various autoimmune disorders, including RA. Low serum VD levels have been found to be associated with a higher risk of RA, although this finding has not been replicated consistently. The molecular mechanisms by which VD influences autoimmunity need to be further explored to understand how variation in plasma VD levels could affect the pathogenesis of RA. This mini-review focuses on the influence of VD and its serum levels on RA susceptibility, RA-associated complexities, treatment, and transcriptome products of key proinflammatory cytokines, along with other cytokines that are key regulators of inflammation in rheumatoid joints.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Aslam MM,John P,Bhatti A,Jahangir S,Kamboh MIdoi
10.1155/2019/3494937subject
Has Abstractpub_date
2019-05-07 00:00:00pages
3494937eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1155/2014/292471
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2014/942148
更新日期:2014-01-01 00:00:00
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doi:10.1155/2014/482093
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:2019-11-20 00:00:00
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doi:10.1155/2014/576528
更新日期:2014-01-01 00:00:00
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