Abstract:
:Chromosome/DNA instability could be one of the primary causes of malignant cell transformation. The objective of the present study was to evaluate the spontaneous genetic damages in exfoliated cells of buccal mucosa of head and neck cancer (HNC) by counting micronucleus (MN) and binucleated (BN) cells frequencies. MN and BN frequencies were significantly increased in HNC patients compared with controls (5.53 ± 3.09/1000 cells, 5.63 ± 2.99/1000 cells versus 2.36 ± 2.11/1000 cells, 3.09 ± 1.82/1000 cells, P < 0.001). Regarding the gender and the age, the frequencies of the MN and BN were significantly higher than those of controls (P < 0.01). The evaluation of the MN and BN frequencies revealed a significant increase (P < 0.001) in the cases in relation to the control group after controlling the risk factors (tobacco smoking and chewing and occupational exposure) of HNC. Moreover, MN and BN frequencies were significantly increased in smokers and chewers compared with nonsmokers and nonchewers among patients (P < 0.05). MN frequency was significantly (P = 0.014) different between patients occupationally exposed (6.99 ± 3.40/1000 cells) and nonexposed (4.70 ± 2.48/1000 cells) among HNC group. The logistic regression model illustrated that HNC was significantly associated with frequencies of MN (OR = 8.63, P < 0.0001) and BN (OR = 5.62, P = 0.001). Our results suggest that increased chromosome/DNA instabilities may be associated with HNC.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Khlifi R,Trabelsi-Ksibi F,Chakroun A,Rebai A,Hamza-Chaffai Adoi
10.1155/2013/905252subject
Has Abstractpub_date
2013-01-01 00:00:00pages
905252eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::This study compared the coadministration among the three nematode predatory fungi, Duddingtonia flagrans, Monacrosporium thaumasium, and Arthrobotrys robusta, in the biological control of cattle gastrointestinal nematodiasis in comparison with the use of the fungus D. flagrans alone. Five groups consisting of eight Gi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2934674
更新日期:2018-03-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2854736
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9573248
更新日期:2019-08-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/820813
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/204532
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2020-05-22 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1980763
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/405794
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2394734
更新日期:2020-05-02 00:00:00
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pub_type: 杂志文章
doi:10.1155/2015/730538
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/356427
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9024923
更新日期:2020-05-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/532792
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/916352
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4250329
更新日期:2020-07-22 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9065181
更新日期:2018-09-24 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/1275491
更新日期:2019-04-02 00:00:00
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pub_type: 杂志文章
doi:10.1155/2019/9742765
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/348659
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3870508
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/958465
更新日期:2013-01-01 00:00:00
abstract::Tsetse flies (Glossina spp.) are the primary vectors of trypanosomes, which can cause human and animal African trypanosomiasis in Sub-Saharan African countries. The objective of this study was to explore the genome of Glossina morsitans morsitans for evidence of horizontal gene transfer (HGT) from microorganisms. We e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3164624
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/739010
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2019/1238581
更新日期:2019-06-02 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/208017
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/372045
更新日期:2014-01-01 00:00:00