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Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency.

Abstract：

:We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures. The resulting average accuracy of classification has been proven to be above 95%, which overcomes the earlier achievements. We propose a constructive and transparent method of feature selection based on classifier accuracy. Enrichment analysis reveals statistically meaningful presence of stemness group and cancer discriminating genes among the selected best classifying features. These findings stimulate the further research on the functional consequences of these differences in methylation patterns. The presented approach can be broadly used to discriminate the cells of different phenotype or in different state by their methylation profiles, identify groups of genes constituting multifeature classifiers, and assess enrichment of these groups by the sets of genes with a functionality of interest.

journal_name

Biomed Res Int

journal_title

BioMed research international

authors

Druzhkov P,Zolotykh N,Meyerov I,Alsaedi A,Shutova M,Ivanchenko M,Zaikin A

doi

10.1155/2015/976362

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

976362

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章

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