Genome-Wide Identification of Putative MicroRNAs in Cassava (Manihot esculenta Crantz) and Their Functional Landscape in Cellular Regulation.

Abstract:

:MicroRNAs are small noncoding RNAs, involved in the regulation of many cellular processes in plants. Hundreds of miRNAs have been identified in cassava by various techniques, yet these identifications were constrained by a lack of miRNA templates and the narrow range of conditions in transcriptome study. In this research, we conducted genome-wide analysis identification, whereby miRNAs from cassava genome were thoroughly screened using bioinformatics approach independent of predefined templates and studied conditions. Our work provided a catalog of putative mature miRNAs and explored the landscape of miRNAome in cassava. These putative miRNAs were validated using statistical analysis as well as available cassava expression data. We showed that the crowded locations of cassava miRNAs are consistent with other plants and animals and hypothesized to have the same evolutionary origin. At least 10 conserved miRNAs were identified in cassava based on the comparative study of miRNA conservation. Finally, investigation of miRNAs and target gene relationships enabled us to envisage the complexities of cellular regulatory systems modulated at posttranscriptional level.

journal_name

Biomed Res Int

authors

Yawichai A,Kalapanulak S,Thammarongtham C,Saithong T

doi

10.1155/2019/2019846

subject

Has Abstract

pub_date

2019-06-19 00:00:00

pages

2019846

eissn

2314-6133

issn

2314-6141

journal_volume

2019

pub_type

杂志文章
  • Screening and Molecular Identification of Pectinase Producing Microbes from Coffee Pulp.

    abstract::Application of enzymes in biotechnological process has expanded considerably in recent years. In food and related industry, major importance was being attached to the use of enzymes in upgrading quality, increasing yields of extractive processes, product stabilization, and improvement of flavor and byproduct utilizati...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2961767

    authors: Oumer OJ,Abate D

    更新日期:2018-04-03 00:00:00

  • Removal of Cu, Zn, Pb, and Cr from Yangtze Estuary Using the Phragmites australis Artificial Floating Wetlands.

    abstract::Contamination of heavy metals would threaten the water and soil resources; phytoremediation can be potentially used to remediate metal contaminated sites. We constructed the Phragmites australis artificial floating wetlands outside the Qingcaosha Reservoir in the Yangtze Estuary. Water characteristic variables were me...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/6201048

    authors: Huang X,Zhao F,Yu G,Song C,Geng Z,Zhuang P

    更新日期:2017-01-01 00:00:00

  • High-level antimicrobial efficacy of representative Mediterranean natural plant extracts against oral microorganisms.

    abstract::Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediter...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/839019

    authors: Karygianni L,Cecere M,Skaltsounis AL,Argyropoulou A,Hellwig E,Aligiannis N,Wittmer A,Al-Ahmad A

    更新日期:2014-01-01 00:00:00

  • Exploring the Association of Surface Plasmon Resonance with Recombinant MHC:Ig Hybrid Protein as a Tool for Detecting T Lymphocytes in Mice Infected with Leishmania (Leishmania) amazonensis.

    abstract::A surface plasmon resonance- (SPR-) based recognition method applying H-2 Ld:Ig/peptides complexes for ex vivo monitoring cellular immune responses during murine infection with Leishmania (Leishmania) amazonensis is described. Lymphocytes from lesion-draining popliteal lymph nodes were captured on a carboxylated senso...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/9089748

    authors: da Silveira-Júnior LS,Souza-Silva F,Pereira BA,Cysne-Finkelstein L,Cavalcanti Júnior GB,Alves CR

    更新日期:2017-01-01 00:00:00

  • Circadian Variation of Migraine Attack Onset: A Review of Clinical Studies.

    abstract::Several studies suggested that migraine attack onset shows a circadian variation; however, there has not been an overview and synthesis of these findings. A PubMed search with keywords "migraine" AND "circadian" resulted in ten studies directly investigating this topic. Results of these studies mostly show that migrai...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/4616417

    authors: Baksa D,Gecse K,Kumar S,Toth Z,Gal Z,Gonda X,Juhasz G

    更新日期:2019-08-25 00:00:00

  • Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze Dried Syzygium jambolanum (Lam.) DC Fruit Juice.

    abstract::This work aimed to explore the cardiovascular effects induced by freeze-dried juice from Syzygium jambolanum (Lam.) DC fruits (JSJ). JSJ presented high polyphenol content and steroids. HPLC analysis revealed that 2,5-dihydroxybenzoic and caffeic acid were present in higher amounts in the JSJ extract. In rat, JSJ induc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4827461

    authors: Assis KS,Araújo IGA,de Azevedo FLAA,Maciel PMP,Machado Calzerra NT,da Silva TAF,Assis VL,de Vasconcelos AP,Santos CAG,Meireles BRLA,Cordeiro AMTM,Araújo DAM,Ribeiro TP,Medeiros IA

    更新日期:2018-10-08 00:00:00

  • The association between autoantibodies and peripheral neuropathy in lupus nephritis.

    abstract:BACKGROUND AND AIM:The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. METHODS:Dat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/524940

    authors: Su YJ,Huang CR,Chang WN,Tsai NW,Kung CT,Lin WC,Huang CC,Su CM,Cheng BC,Chang YT,Lu CH

    更新日期:2014-01-01 00:00:00

  • Weaker Self-Esteem in Adolescence Predicts Smoking.

    abstract:BACKGROUND:To study whether weaker self-esteem in adolescence is connected with smoking behavior in adulthood. METHODS:An age cohort born in 1979 responded to the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the age of 16 (n = 1,072). Respondents' smoking behavior was monitored annually during adolescence and 75.3% ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/687541

    authors: Saari AJ,Kentala J,Mattila KJ

    更新日期:2015-01-01 00:00:00

  • MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39.

    abstract::Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2381482

    authors: Guo R,Gu J,Zhang Z,Wang Y,Gu C

    更新日期:2017-01-01 00:00:00

  • Circulating Tumour Cells, Circulating Tumour DNA and Circulating Tumour miRNA in Blood Assays in the Different Steps of Colorectal Cancer Management, a Review of the Evidence in 2019.

    abstract::Despite many advances in the diagnosis and treatment of colorectal cancer (CRC), its incidence and mortality rates continue to make an impact worldwide and in some countries rates are mounting. Over the past decade, liquid biopsies have been the object of fundamental and clinical research with regard to the different ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/5953036

    authors: Christou N,Meyer J,Popeskou S,David V,Toso C,Buchs N,Liot E,Robert J,Ris F,Mathonnet M

    更新日期:2019-12-04 00:00:00

  • Incidence of alpha-globin gene defect in the Lebanese population: a pilot study.

    abstract:BACKGROUND:It is well established that the Mediterranean and Arab populations are at high risk for thalassemias in general and for alpha-thalassemia in particular. Yet, reports on alpha-thalassemia in Lebanon are still lacking. In this study, we aim at assessing the incidence of alpha-thalassemia in the Lebanese popula...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/517679

    authors: Farra C,Daher R,Badra R,el Rafei R,Bejjany R,Charafeddine L,Yunis K

    更新日期:2015-01-01 00:00:00

  • Measurement Invariance and Psychometric Analysis of Oxford Happiness Inventory Scale across Gender and Marital Status.

    abstract:Background:The Oxford Happiness Inventory (OHI) is a self-report tool to measure happiness. A brief review of previous studies on OHI showed the lack of evaluation of OHI fairness/equivalence in measuring happiness among identified groups. Methods:To examine the psychometric properties and measurement invariance of th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8906209

    authors: Mousavi A,Sharafi Z,Mahmoudi A,Shahraki HR

    更新日期:2020-06-21 00:00:00

  • Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury.

    abstract::Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be especially detriment...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/864946

    authors: Zhou T,Chuang CC,Zuo L

    更新日期:2015-01-01 00:00:00

  • The Effect of Teriparatide on Fracture Healing of Osteoporotic Patients: A Meta-Analysis of Randomized Controlled Trials.

    abstract::Purpose. This meta-analysis is to assess the effectiveness of teriparatide in fracture healing and clinical function improvement of the osteoporotic patients. Methods. We searched PubMed, Embase, Web of Science, and the Cochrane databases for randomized and quasi-randomized controlled trials comparing teriparatide to ...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2016/6040379

    authors: Lou S,Lv H,Wang G,Zhang L,Li M,Li Z,Zhang L,Tang P

    更新日期:2016-01-01 00:00:00

  • In Silico Integration Approach Reveals Key MicroRNAs and Their Target Genes in Follicular Thyroid Carcinoma.

    abstract::To better understand the molecular mechanism for the pathogenesis of follicular thyroid carcinoma (FTC), this study aimed at identifying key miRNAs and their target genes associated with FTC, as well as analyzing their interactions. Based on the gene microarray data GSE82208 and microRNA dataset GSE62054, the differen...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2725192

    authors: Hu S,Liao Y,Zheng J,Gou L,Regmi A,Zafar MI,Chen L

    更新日期:2019-03-28 00:00:00

  • Preoperative Chemotherapy for Gastric Cancer: Personal Interventions and Precision Medicine.

    abstract::In spite of the declining incidence of gastric cancer (GC) in recent years, the mortality rate is still high. The asymptomatic nature and nonspecific clinical manifestations combined with the lack of efficient screening programs delay the diagnosis of GC. Therefore, the prevalence of advanced gastric cancer (AGC) has ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3923585

    authors: Xu W,Beeharry MK,Liu W,Yan M,Zhu Z

    更新日期:2016-01-01 00:00:00

  • IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients.

    abstract::Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall surviva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/654727

    authors: Stancheva G,Goranova T,Laleva M,Kamenova M,Mitkova A,Velinov N,Poptodorov G,Mitev V,Kaneva R,Gabrovsky N

    更新日期:2014-01-01 00:00:00

  • The effect of nicotine dependence on psychopathology in patients with schizophrenia.

    abstract:INTRODUCTION:Our study aims to determine the prevalence of nicotine dependence and investigate the effect of nicotine dependence on psychopathology among schizophrenia patients. METHODS:A cross-sectional study was carried out in an outpatient psychiatric clinic at a general hospital in Malaysia. 180 recruited subjects...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2015/730291

    authors: Yee A,Bt Nek Mohamed NN,Binti Hashim AH,Loh HS,Harbajan Singh MK,Ng CG,Jambunathan ST

    更新日期:2015-01-01 00:00:00

  • Vulnerability assessment and application of bacterial technology on urban rivers for pollution eradication.

    abstract::To protect against the environmental pollution, the present research was undertaken to enumerate the Bacterial Technologies (BTs) on the restoration of polluted urban rivers, that is, Fenghu-Song Yang River (FSR) and Xuxi River (XXR). Experimental research accounted for the physiochemical parameters (pH; temperature; ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/241769

    authors: Hashim S,Yuebo X,Ahmad F,Arslan C,Saifullah M

    更新日期:2015-01-01 00:00:00

  • Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone.

    abstract::Our aim was to verify the effects of prednisone related to gastrointestinal motility, intestinal histology, and mucosal mast cells in rats. Two-month-old male Wistar rats were randomly assigned to control group (vehicle) animals receiving saline 0.9% (n = 7) or treated orally with 0.625 mg/kg/day of prednisone (n = 7)...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/4637621

    authors: de Lima MB,Gama LA,Hauschildt AT,Dall'Agnol DJR,Corá LA,Americo MF

    更新日期:2017-01-01 00:00:00

  • Galangin Suppresses Renal Inflammation via the Inhibition of NF-κB, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells.

    abstract::Renal inflammation can result in renal injury. Uric acid (UA) is the final product of purine metabolism in humans and because of the lack of urate oxidase, UA may accumulate in tissues, including kidney, causing inflammation. Galangin was isolated from a traditional Chinese medicine plant and possesses several benefic...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3018357

    authors: Lu H,Yao H,Zou R,Chen X,Xu H

    更新日期:2019-05-26 00:00:00

  • Evaluation of the presence of endocrine-disrupting compounds in dissolved and solid wastewater treatment plant samples of Gran Canaria Island (Spain).

    abstract::Liquid and solid samples from two wastewater treatment plants (WWTPs) on Gran Canaria Island (Spain) have been tested for the presence of compounds with endocrine-disrupting properties. The selected degradation stages were sampled bimonthly from each WWTP over the 12-month period from July 2010 to July 2011. The analy...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/790570

    authors: Vega-Morales T,Sosa-Ferrera Z,Santana-Rodríguez JJ

    更新日期:2013-01-01 00:00:00

  • Investigation of the interaction between patulin and human serum albumin by a spectroscopic method, atomic force microscopy, and molecular modeling.

    abstract::The interaction of patulin with human serum albumin (HSA) was studied in vitro under normal physiological conditions. The study was performed using fluorescence, ultraviolet-visible spectroscopy (UV-Vis), circular dichroism (CD), atomic force microscopy (AFM), and molecular modeling techniques. The quenching mechanism...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/734850

    authors: Yuqin L,Guirong Y,Zhen Y,Caihong L,Baoxiu J,Jiao C,Yurong G

    更新日期:2014-01-01 00:00:00

  • The role of 18F-FDG PET/CT in large-vessel vasculitis: appropriateness of current classification criteria?

    abstract::Patients with clinical suspicion of large-vessel vasculitis (LVV) may present with nonspecific signs and symptoms and increased inflammatory parameters and may remain without diagnosis after routine diagnostic procedures. Both the nonspecificity of the radiopharmaceutical (18)F-FDG and the synergy of integrating funct...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/687608

    authors: Balink H,Bennink RJ,van Eck-Smit BL,Verberne HJ

    更新日期:2014-01-01 00:00:00

  • Early second-trimester serum microRNAs as potential biomarker for nondiabetic macrosomia.

    abstract:BACKGROUND:Macrosomia has become a worldwide problem with the rapid economic growth in the past few years. However, the detailed mechanism of how the macrosomia happened remains unknown. Growing evidence indicates that miRNAs are involved in maintaining metabolic homeostasis. We hypothesized that serum miRNAs are poten...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/394125

    authors: Hu L,Han J,Zheng F,Ma H,Chen J,Jiang Y,Jiang H

    更新日期:2014-01-01 00:00:00

  • Degradation of diuron by Phanerochaete chrysosporium: role of ligninolytic enzymes and cytochrome P450.

    abstract::The white-rot fungus Phanerochaete chrysosporium was investigated for its capacity to degrade the herbicide diuron in liquid stationary cultures. The presence of diuron increased the production of lignin peroxidase in relation to control cultures but only barely affected the production of manganese peroxidase. The her...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/251354

    authors: Coelho-Moreira Jda S,Bracht A,de Souza AC,Oliveira RF,de Sá-Nakanishi AB,de Souza CG,Peralta RM

    更新日期:2013-01-01 00:00:00

  • Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma.

    abstract::This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM). Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study. The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-14...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1575468

    authors: Zhang ZY,Li YC,Geng CY,Wang HJ,Chen WM

    更新日期:2019-12-14 00:00:00

  • A Prospective Noninterventional, Observational Study to Describe the Effectiveness and Safety of Trandolapril and Verapamil Single-Pill Combination in the Management of Patients with Hypertension and Type 2 Diabetes Mellitus: A Harvest TR Study.

    abstract::Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2123601

    authors: Atalar E,Eskin F,Tugtekin HB,Karabulut A,Kanyilmaz S,Kirbiyik H,Ozyildiz AG

    更新日期:2020-09-05 00:00:00

  • Psoriasis: female skin changes in various hormonal stages throughout life--puberty, pregnancy, and menopause.

    abstract::Psoriasis is one of the most prevalent immune mediated skin diseases worldwide. Despite the large prevalence in both men and women, the pathogenesis of this disease has not yet been fully clarified. Nowadays, it is believed that psoriasis is most likely a T helper Th1/Th17 induced inflammatory disease. Stressful life ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/571912

    authors: Ceovic R,Mance M,Bukvic Mokos Z,Svetec M,Kostovic K,Stulhofer Buzina D

    更新日期:2013-01-01 00:00:00

  • The domain landscape of virus-host interactomes.

    abstract::Viral infections result in millions of deaths in the world today. A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies. In this study, we presented a landscape of virus-host interactomes based on protein domain interaction. Compared to the analysis at protei...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/867235

    authors: Zheng LL,Li C,Ping J,Zhou Y,Li Y,Hao P

    更新日期:2014-01-01 00:00:00