Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine.

abstract：:Aim. In periodontology lasers have been suggested for the photodynamic therapy (PDT): such therapy can be defined as the inactivation of cells, microorganisms, or molecules induced by light and not by heat. The aim of this study was to evaluate results of PDT using a 980 nm diode laser (Wiser Doctor Smile, Lambda SPA,...

journal_title：BioMed research international

authors： Caccianiga G,Baldoni M,Ghisalberti CA,Paiusco A

更新日期：2016-01-01 00:00:00

abstract：:Background. Whether additional benefit can be achieved with the use of L-carnitine (L-C) in patients with chronic heart failure (CHF) remains controversial. We therefore performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of L-C treatment in CHF patients. Methods. Pubmed, Ovid Emba...

journal_title：BioMed research international

authors： Song X,Qu H,Yang Z,Rong J,Cai W,Zhou H

更新日期：2017-01-01 00:00:00

abstract：:It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in a...

journal_title：BioMed research international

authors： Hazelhoff MH,Bulacio RP,Torres AM

更新日期：2013-01-01 00:00:00

abstract：:The increasing insect resistance against Bacillus thuringiensis delta-endotoxins is a serious problem which makes it urgent to look for new eco-friendly strategies. Combining these toxins with other biomolecules is one of the promising strategies against insect pests. In this work, we evaluated the bioinsecticidal pot...

journal_title：BioMed research international

authors： Mhalla D,Ben Farhat-Touzri D,Tounsi S,Trigui M

更新日期：2018-08-08 00:00:00

abstract：:This study aimed to evaluate the genes that were expressed in the healing bones around SLA-treated titanium orthodontic mini-implants in a beagle at early (1-week) and late (4-week) stages with RNA-sequencing (RNA-Seq). Samples from sites of surgical defects were used as controls. Total RNA was extracted from the tiss...

journal_title：BioMed research international

authors： Nahm KY,Heo JS,Lee JH,Lee DY,Chung KR,Ahn HW,Kim SH

更新日期：2015-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease and its targeting of the joints indicates the presence of a candidate autoantigen(s) in synovial joints. Patients with RA show immune responses in their peripheral blood to proteoglycan (PG) aggrecan. One of the most relevant animal models of RA appears to be ...

journal_title：BioMed research international

authors： Hanyecz A,Olasz K,Tarjanyi O,Nemeth P,Mikecz K,Glant TT,Boldizsar F

更新日期：2014-01-01 00:00:00

abstract：:The intra- and extracellular accumulation of misfolded and aggregated amyloid proteins is a common feature in several neurodegenerative diseases, which is thought to play a major role in disease severity and progression. The principal machineries maintaining proteostasis are the ubiquitin proteasomal and lysosomal aut...

journal_title：BioMed research international

authors： Maiti P,Manna J,Veleri S,Frautschy S

更新日期：2014-01-01 00:00:00

abstract：:Healthcare professionals undergo high levels of occupational stress as a result of their working conditions. Thus, the aim of this study is to develop a model that focuses on healthcare professionals so as to analyze the influence that job demands, control, social support, and recognition have on the likelihood that a...

journal_title：BioMed research international

authors： García-Herrero S,Lopez-Garcia JR,Herrera S,Fontaneda I,Báscones SM,Mariscal MA

更新日期：2017-01-01 00:00:00

abstract：:Objectives. The aim of the study is to detect the prevalence and the characteristics of infraorbital canal and Haller's cells on panoramic radiography of edentulous patients. Methods. The study group comprised 291 panoramic radiographs of edentulous patients. Radiographs were interpreted for the visibility and charact...

journal_title：BioMed research international

authors： Yesilova E,Bayrakdar IS

更新日期：2018-07-08 00:00:00

abstract：BACKGROUND:Although binge drinking prevalence and correlates among young people have been extensively studied in the USA and Northern Europe, less is known for Southern Europe countries with relatively healthier drinking cultures. OBJECTIVE:We aimed at analyzing prevalence and correlates of binge drinking in a represe...

journal_title：BioMed research international

authors： Bartoli F,Carretta D,Crocamo C,Schivalocchi A,Brambilla G,Clerici M,Carrà G

更新日期：2014-01-01 00:00:00

abstract：:Insecticide resistance in malaria vectors threatens malaria prevention and control efforts. In Colombia the three primary vectors, Anopheles darlingi, An. nuneztovari s.l., and An. albimanus, have reported insecticide resistance to pyrethroids, organophosphates, carbamates, and DDT; however, the insecticide resistance...

journal_title：BioMed research international

authors： Orjuela LI,Morales JA,Ahumada ML,Rios JF,González JJ,Yañez J,Rosales A,Cabarcas DM,Venegas J,Yasnot MF,Quiñones ML

更新日期：2018-08-29 00:00:00

abstract：:Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide. In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with bai...

journal_title：BioMed research international

authors： Du H,Zhang S,He M,Ming K,Wang J,Yuan W,Qiao M,Wu Y,Wang D,Hu Y,Liu J

更新日期：2019-04-04 00:00:00

abstract：PURPOSE:To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. METHODS:89 patients (124 eyes) with established myopia ra...

journal_title：BioMed research international

authors： Zivkovic M,Jaksic V,Giarmoukakis A,Grentzelos M,Zlatanovic M,Zlatanovic G,Miljkovic A,Jovanovic S,Stamenkovic M,Kymionis G

更新日期：2017-01-01 00:00:00

abstract：:The aim of our study was to monitor serum levels of two miRNAs (miR-21 and miR-141) and three KLKs (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy, in order to characterize their fluctuations after surgery. 38 patients with prostate cancer were included. miR-21 and miR-141 were quant...

journal_title：BioMed research international

authors： Egidi MG,Cochetti G,Serva MR,Guelfi G,Zampini D,Mechelli L,Mearini E

更新日期：2013-01-01 00:00:00

abstract：Objective:To observe the effect of adenosine A1 receptor in the hippocampus of mice on GSK-3β phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Α1 receptor mediating cerebral ischemia-reperfusion injury. Method:The model of middle cerebral artery occlusion (...

journal_title：BioMed research international

authors： Geng W,Cai L,Han K,Li D,Mo Y,Dai Q,Tang H,Zhang M,Akuetteh PDP,Balelang MF,Wang J

更新日期：2020-02-20 00:00:00

abstract：:The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but the functional underlying mechanism has not been studied clearly. We detected the expression level of SNHG12 in PCa tissues and matched adjacent normal tissues that were collected ...

journal_title：BioMed research international

authors： Chen Z,Qi T,Qin XP,Wang J,Huang ZS,Hu XY,Chen G,Qu LJ,Zhuo YM

更新日期：2020-12-22 00:00:00

abstract：:Purpose. To evaluate correlation between tomographic gradation of keratoconus (KC) and its corresponding air-puff induced biomechanical response. Methods. Corneal tomography and biomechanics were measured with Scheimpflug imaging in 44 normal and 92 KC corneas. Deformation waveform was also analyzed with Fourier serie...

journal_title：BioMed research international

authors： Shetty R,Nuijts RM,Srivatsa P,Jayadev C,Pahuja N,Akkali MC,Sinha Roy A

更新日期：2015-01-01 00:00:00

abstract：:Slaughterhouse work involves a high degree of repetitive and forceful upper limb movements and thus implies an elevated risk of work-related musculoskeletal disorders. High intensity strength training effectively rehabilitates musculoskeletal disorders among sedentary employees, but less is known about the effect amon...

journal_title：BioMed research international

authors： Sundstrup E,Jakobsen MD,Jay K,Brandt M,Andersen LL

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Cost sharing between beneficiaries and government is critical to attain universal health coverage. The government of Ethiopia introduced social health insurance to improve access to quality health services. Hence, HCP are the ultimate frontline service provider; their WTP for health insurance could influence...

journal_title：BioMed research international

authors： Mekonne A,Seifu B,Hailu C,Atomsa A

更新日期：2020-04-14 00:00:00

abstract：:cir-ITCH, a well-known tumor-suppressive circular RNA, plays a critical role in different cancers. However, its expression and functional role in prostate cancer (PCa) are unclear. Herein, we explored the potential mechanism and tumor-inhibiting role of cir-ITCH in PCa. Using reverse transcriptase polymerase chain rea...

journal_title：BioMed research international

authors： Li S,Yu C,Zhang Y,Liu J,Jia Y,Sun F,Zhang P,Li J,Guo L,Xiao H,Gao F,Deng X,Cai Z,Cai J

更新日期：2020-08-20 00:00:00

abstract：:The regulation of transcriptome expression level is a complex process involving multiple-level interactions among molecules such as protein coding RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA), which are essential for the transcriptome stability and maintenance and regulation of body homeostasis. The a...

journal_title：BioMed research international

authors： Liu C,Zhang YH,Deng Q,Li Y,Huang T,Zhou S,Cai YD

更新日期：2017-01-01 00:00:00

abstract：Introduction:The purpose of this study was to investigate the difference in surgical outcomes between symptomatic and asymptomatic patients with primary hyperparathyroidism (PHPT) and between patients with high serum calcium and those with normal blood calcium, as well as to explore the epidemiological trend of PHPT in...

journal_title：BioMed research international

authors： Yu Q,Liu K,Ma D,Xie C,Wu Y,Dai W,Jiang H

更新日期：2019-07-01 00:00:00

abstract：:A novel approach for selecting a rectangular template around periocular region optimally potential for human recognition is proposed. A comparatively larger template of periocular image than the optimal one can be slightly more potent for recognition, but the larger template heavily slows down the biometric system by ...

journal_title：BioMed research international

authors： Bakshi S,Sa PK,Majhi B

更新日期：2013-01-01 00:00:00

abstract：:Astragalus membranaceus polysaccharide (APS) components are main ingredients of TCM and have proven efficacy to activate T cells and B cells, enhancing immunity in humans. In this study, elevated cytokine and anti-PD-1 antibody titers were found in mice after immunization with APS. Therefore, phage-display technology ...

journal_title：BioMed research international

authors： Chang FL,Tsai KC,Lin TY,Yang TW,Lo YN,Chen WC,Chang JH,Lu MK,Chiou CT,Chen PH,Yen Y,Pan SL,Lee YC

更新日期：2020-03-03 00:00:00

abstract：Background:Several studies found that physicians develop a negative attitude toward biochemistry and genetics disciplines. Many medical schools adopt an integrated system-based curriculum supplemented with clinical correlations. Medical schools in Jordan switched to the integrated curriculum; however, studies that eval...

journal_title：BioMed research international

authors： Alfaqih MA,Khader YS,Bashir N,Nusair Z,Nuseir Q,Nusier M

更新日期：2019-11-13 00:00:00

abstract：:Angiogenesis and lymphangiogenesis are important in the proliferation and survival of the malignant hematopoietic neoplasms, including non-Hodgkin's lymphomas (NHLs). Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in the initiation of angiogenesis. Both VEGF ...

journal_title：BioMed research international

authors： Wróbel T,Mazur G,Dzietczenia J,Gębura K,Kuliczkowski K,Bogunia-Kubik K

更新日期：2013-01-01 00:00:00

abstract：:Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence o...

journal_title：BioMed research international

authors： Dakouane-Giudicelli M,Alfaidy N,de Mazancourt P

更新日期：2014-01-01 00:00:00

abstract：:Bone grafts are medical devices that are in high demand in clinical practice for substitution of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern groups of bone grafts, the particularities of their composition, the mechanisms of their biological effects, and their therapeutic ind...

journal_title：BioMed research international

authors： Deev RV,Drobyshev AY,Bozo IY,Isaev AA

更新日期：2015-01-01 00:00:00

abstract：Purpose:We evaluated the efficacies of the adaptive steepest descent projection onto convex sets (ASD-POCS), simultaneous algebraic reconstruction technique (SART), filtered back projection (FBP), and maximum likelihood expectation maximization (MLEM) total variation minimization iterative algorithms for reducing expos...

journal_title：BioMed research international

authors： Gomi T,Koibuchi Y

更新日期：2018-06-19 00:00:00

abstract：:Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing t...

journal_title：BioMed research international

authors： Farini A,Sitzia C,Erratico S,Meregalli M,Torrente Y

更新日期：2014-01-01 00:00:00