Gene profiling of bone around orthodontic mini-implants by RNA-sequencing analysis.

Abstract:

:This study aimed to evaluate the genes that were expressed in the healing bones around SLA-treated titanium orthodontic mini-implants in a beagle at early (1-week) and late (4-week) stages with RNA-sequencing (RNA-Seq). Samples from sites of surgical defects were used as controls. Total RNA was extracted from the tissue around the implants, and an RNA-Seq analysis was performed with Illumina TruSeq. In the 1-week group, genes in the gene ontology (GO) categories of cell growth and the extracellular matrix (ECM) were upregulated, while genes in the categories of the oxidation-reduction process, intermediate filaments, and structural molecule activity were downregulated. In the 4-week group, the genes upregulated included ECM binding, stem cell fate specification, and intramembranous ossification, while genes in the oxidation-reduction process category were downregulated. GO analysis revealed an upregulation of genes that were related to significant mechanisms, including those with roles in cell proliferation, the ECM, growth factors, and osteogenic-related pathways, which are associated with bone formation. From these results, implant-induced bone formation progressed considerably during the times examined in this study. The upregulation or downregulation of selected genes was confirmed with real-time reverse transcription polymerase chain reaction. The RNA-Seq strategy was useful for defining the biological responses to orthodontic mini-implants and identifying the specific genetic networks for targeted evaluations of successful peri-implant bone remodeling.

journal_name

Biomed Res Int

authors

Nahm KY,Heo JS,Lee JH,Lee DY,Chung KR,Ahn HW,Kim SH

doi

10.1155/2015/538080

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

538080

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • In Vitro Anthelmintic Activity of Crude Extracts of Aerial Parts of Cissus quadrangularis L. and Leaves of Schinus molle L. against Haemonchus contortus.

    abstract:Background:Haemonchus contortus, the causative agent of Haemonchosis, is the most economically important parasite in small ruminant production. Control with chemotherapy has not been successful due to rapid emergence of drug-resistant strains. There is a continuous search for alternative leads particularly from plants....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/1905987

    authors: Zenebe S,Feyera T,Assefa S

    更新日期:2017-01-01 00:00:00

  • Factors Influencing Administration, Recognition, and Compliance of Medicine among Community Residents from Jilin Province, China: A Questionnaire Study.

    abstract:Introduction:To identify and analyze factors that influence administration, recognition, and compliance of medicine among community residents in Jilin Province, China. Methods:A survey was carried out among 2417 community residents in Jilin Province, China, to study their administration (CRA), recognition (CRR), and c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8730212

    authors: Song YQ,Zhang WR,Zhang SX,Wang TH,Jiang Z,Meng CF,Zhang TZ,Xin QZ,Cao KJ,Zhang Y,Sun Y

    更新日期:2020-07-18 00:00:00

  • Antagonistic interactions of "Ya-Sa-Marn-Phlae" ethanol extract in combination with topical antiseptics against clinical isolates of Staphylococcus aureus.

    abstract::This investigation was aimed at assessing a possible interaction of a traditional Thai herbal recipe, "Ya-Sa-Marn-Phlae (YSMP)," used for wound treatments with topical antiseptics, povidone-iodine (PI) solution and hydrogen peroxide (H2O2), and effects of THR-SK010 alone and the combinations on Staphylococcus aureus. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/867603

    authors: Chusri S,Tongrod S,Chokpaisarn J,Limsuwan S,Voravuthikunchai SP

    更新日期:2014-01-01 00:00:00

  • Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The vasoconstrictor endothelin-1 (ET-1) has been implicated in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage (SAH). Previous results showed that CGS 26303, an endothelin converting enzyme (ECE) inhibitor, effectively prevented and reversed arterial narrowing in animal m...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/531508

    authors: Wang CJ,Lee PY,Wu BN,Wu SC,Loh JK,Tsai HP,Chung CL,Kassell NF,Kwan AL

    更新日期:2014-01-01 00:00:00

  • Variation Overtime among Patients of the Six Methadone Maintenance Treatment Clinics in Thai Nguyen from 2011 to 2015.

    abstract:Background:Methadone Maintenance Treatment (MMT) program's success depends on the likelihood of reducing drop-out rate and keeping patients remaining in the program. There have been neither comprehensive studies about variation among patients who have been experiencing MMT for long period nor prediction of MMT period i...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9081968

    authors: Dao ATM,Nguyen HTT,Nguyen LH

    更新日期:2018-08-07 00:00:00

  • Platelet rich plasma and knee surgery.

    abstract::In orthopaedic surgery and sports medicine, the knee joint has traditionally been considered the workhorse. The reconstruction of every damaged element in this joint is crucial in achieving the surgeon's goal to restore the knee function and prevent degeneration towards osteoarthritis. In the last fifteen years, the f...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/890630

    authors: Sánchez M,Delgado D,Sánchez P,Fiz N,Azofra J,Orive G,Anitua E,Padilla S

    更新日期:2014-01-01 00:00:00

  • Tubulointerstitial Infiltration of M2 Macrophages in Henoch-Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters.

    abstract::Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/8579619

    authors: Kim J,Choi SE,Lee KH,Jeong HJ,Shin JI,Lim BJ

    更新日期:2019-01-20 00:00:00

  • Health Effects of 12 Weeks of Team-Sport Training and Fitness Training in a Community Health Centre for Sedentary Men with Lifestyle Diseases.

    abstract::This study compares the effects of team-sport training, for sedentary men with lifestyle diseases, with fitness training in a pragmatic set-up in a community health centre (CHC). Thirty-two men in the fitness group (FiG) and 36 men in the team-sport group (TsG) completed the training and trained for 60-90 min, two tim...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/1571807

    authors: Møller TK,Nielsen TT,Andersen R,Lundager I,Hansen HF,Ottesen L,Krustrup P,Randers MB

    更新日期:2018-05-15 00:00:00

  • Neck Circumference as a Predictive Indicator of CKD for High Cardiovascular Risk Patients.

    abstract:BACKGROUND:Neck circumference (NC) is an anthropometric measure of obesity for upper subcutaneous adipose tissue distribution which is associated with cardiometabolic risk. This study investigated whether NC is associated with indicators of chronic kidney disease (CKD) for high cardiometabolic risk patients. METHODS:A...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/745410

    authors: Liu YF,Chang ST,Lin WS,Hsu JT,Chung CM,Chang JJ,Hung KC,Chen KH,Chang CW,Chen FC,Shih YW,Chu CM

    更新日期:2015-01-01 00:00:00

  • Humeral Diaphyseal Fracture Nonunion: An Audit of the Outcome from Intramedullary Nailing and DCP Plating.

    abstract:Purpose:This study aims to compare the functional outcomes of nonunion humeral diaphyseal fractures following conservative treatment when managed surgically with either a plate or intramedullary (IM) nail fixation. Methods:This was a retrospective study of 56 patients with nonunion humeral fractures following conserva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9107898

    authors: Micic I,Kholinne E,Kwak JM,Sun Y,Nanda A,Kim H,Koh KH,Jeon IH

    更新日期:2019-07-22 00:00:00

  • Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment.

    abstract::High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biol...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/215135

    authors: Rizzo D,Ruggiero A,Martini M,Rizzo V,Maurizi P,Riccardi R

    更新日期:2015-01-01 00:00:00

  • LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population.

    abstract::The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/867321

    authors: Gopalai AA,Lim SY,Chua JY,Tey S,Lim TT,Mohamed Ibrahim N,Tan AH,Eow GB,Abdul Aziz Z,Puvanarajah SD,Viswanathan S,Looi I,Lim SK,Tan LP,Chong YB,Tan CT,Zhao Y,Tan EK,Ahmad-Annuar A

    更新日期:2014-01-01 00:00:00

  • In Vitro Anticancer Potential of Berberis lycium Royle Extracts against Human Hepatocarcinoma (HepG2) Cells.

    abstract::Human liver cancer has emerged as a serious health concern in the world, associated with poorly available therapies. The Berberis genus contains vital medicinal plants with miraculous healing properties and a wide range of bioactivities. In this study, different crude extracts of B. lycium Royle were prepared and scre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8256809

    authors: Mustafa K,Mohamed H,Shah AM,Yu S,Akhlaq M,Xiao H,Li S,Naz T,Nosheen S,Bai X,Song Y

    更新日期:2020-10-14 00:00:00

  • Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement.

    abstract::Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6416941

    authors: Liu T,Liu T,Liu H,Fan H,Chen B,Wang D,Zhang Y,Sun F

    更新日期:2019-06-11 00:00:00

  • Comparative Phytochemical Constituents and Antioxidant Activity of Wild and Cultivated Alepidea amatymbica Eckl & Zeyh.

    abstract::There is a need to scientifically validate the claim that wild species of medicinal plants are more potent than the cultivated plants. Thus, this study evaluated the phytochemical and antioxidant properties of wild and cultivated Alepidea amatymbica. Acetone, methanol, and water extracts of the rhizome of wild and cul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5808624

    authors: Mangoale RM,Afolayan AJ

    更新日期:2020-04-13 00:00:00

  • hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers.

    abstract::Because of their high incidence and mortality solid cancers are a major health problem worldwide. Although several new biomarkers and potential targets for therapy have been identified through biomolecular research in the last years, the effects on patients' outcome are still unsatisfactory. Increasing evidence indica...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/896432

    authors: Lastraioli E,Lottini T,Bencini L,Bernini M,Arcangeli A

    更新日期:2015-01-01 00:00:00

  • Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy.

    abstract::Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can b...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/6104738

    authors: Kang J,Fan W,Deng Q,He H,Huang F

    更新日期:2019-01-29 00:00:00

  • Reduced β2GPI Inhibiting Glomerular Mesangial Cells VEGF-NO Axis Uncoupling Induced by High Glucose.

    abstract::VEGF-NO axis uncoupling is an important pathogenesis for DN. Reduced β2GPI could play a part in VEGF signaling pathway and has a protective effect on diabetic vascular disease. This study investigates the effect of reduced β2GPI on glomerular mesangial cells VEGF-NO axis uncoupling induced by high glucose. Compared to...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5484731

    authors: Saijun Z,Xin L,Jie W,Shumin X,Shuaihui L,Pei Y

    更新日期:2018-07-18 00:00:00

  • Development of a TaqMan Based Real-Time Fluorescent Quantitative PCR Assay for Detection of Porcine Cytomegalovirus in Semen.

    abstract::This study described a TaqMan based real-time fluorescent quantitative PCR (qPCR) method to detect porcine cytomegalovirus (PCMV) infection, targeting the conserved region of the DNA polymerase (DPOL) gene. The standard curve showed a linear regression relationship with a coefficient of 0.999 and a slope of y = -3.249...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5673145

    authors: Chen R,Chen Q,Wu X,Che Y,Wang C,Wang L,Yan S,Zhou L

    更新日期:2020-01-10 00:00:00

  • New acquisition protocol of 18F-choline PET/CT in prostate cancer patients: review of the literature about methodology and proposal of standardization.

    abstract:PURPOSE:(1) To evaluate a new acquisition protocol of (18)F-choline (FCH) PET/CT for prostate cancer patients (PC), (2) to review acquisition (18)F-choline PET/CT methodology, and (3) to propose a standardized acquisition protocol on FCH PET/CT in PC patients. MATERIALS:100 consecutive PC patients (mean age 70.5 years...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/215650

    authors: Chondrogiannis S,Marzola MC,Grassetto G,Maffione AM,Rampin L,Veronese E,Massaro A,Rubello D

    更新日期:2014-01-01 00:00:00

  • Evaluation of Risk Factors Affecting Substance Use among Tenth-Grade Students.

    abstract:Aim:The aim of this study is to detect the prevalence of substance use among tenth-grade students; their thoughts, attitudes, behaviors, and tendencies towards substance use; and risk factors of substance use in tenth-grade students in general. Methods:This study is descriptive and cross-sectional conducted between Ap...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1407649

    authors: Öztaş D,Kalyon A,Ertuğrul A,Gündoğdu Ç,Balcıoğlu H,Sağlan Y,Bilge U,Karahan S

    更新日期:2018-03-15 00:00:00

  • Deep Response in Multiple Myeloma: A Critical Review.

    abstract::Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/832049

    authors: Fulciniti M,Munshi NC,Martinez-Lopez J

    更新日期:2015-01-01 00:00:00

  • Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery in the Sugammadex Era: A Retrospective Study.

    abstract:BACKGROUND:Residual neuromuscular block (NMB) after general anesthesia has been associated with pulmonary dysfunction and hypoxia, which are both associated with postoperative delirium (POD). We evaluated the effects of sugammadex on POD in elderly patients who underwent hip fracture surgery. METHODS:Medical records o...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2016/1054597

    authors: Oh CS,Rhee KY,Yoon TG,Woo NS,Hong SW,Kim SH

    更新日期:2016-01-01 00:00:00

  • Virulence factors associated with pediatric shigellosis in Brazilian Amazon.

    abstract::Shigellosis is a global human health problem and the incidence is highest among children. In the present work, main Shigella virulence genes was examined by PCR and compared to symptoms of pediatric shigellosis. Thirty Shigella isolates were identified from an etiologic study at which 1,339 children ranging 0-10 years...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/539697

    authors: da Cruz CB,de Souza MC,Serra PT,Santos I,Balieiro A,Pieri FA,Nogueira PA,Orlandi PP

    更新日期:2014-01-01 00:00:00

  • Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.

    abstract::It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium deriva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/182846

    authors: Chen MF,Tsai JT,Chen LJ,Wu TP,Yang JJ,Yin LT,Yang YL,Chiang TA,Lu HL,Wu MC

    更新日期:2014-01-01 00:00:00

  • Effects of various antiepileptics used to alleviate neuropathic pain on compound action potential in frog sciatic nerves: comparison with those of local anesthetics.

    abstract::Antiepileptics used for treating neuropathic pain have various actions including voltage-gated Na(+) and Ca(2+) channels, glutamate-receptor inhibition, and GABA(A)-receptor activation, while local anesthetics are also used to alleviate the pain. It has not been fully examined yet how nerve conduction inhibitions by l...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/540238

    authors: Uemura Y,Fujita T,Ohtsubo S,Hirakawa N,Sakaguchi Y,Kumamoto E

    更新日期:2014-01-01 00:00:00

  • Functions of the C2H2 Transcription Factor Gene thmea1 in Trichoderma harzianum under Copper Stress Based on Transcriptome Analysis.

    abstract::Trichoderma spp. are important biocontrol filamentous fungi and have tremendous potential in soil bioremediation. In our previous studies, a C2H2 type transcription factor coding gene (thmea1) was cloned from a biocontrol agent T. harzianum Th-33; the encoded sequence of thmea1 contained 3 conserved C2H2 domains with ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8149682

    authors: Mei J,Wang L,Jiang X,Wu B,Li M

    更新日期:2018-07-18 00:00:00

  • Transcriptional Regulation of lncRNA Genes by Histone Modification in Alzheimer's Disease.

    abstract::Increasing studies have revealed that long noncoding RNAs (lncRNAs) are not transcriptional noise but play important roles in the regulation of a wide range of biological processes, and the dysregulation of lncRNA genes is associated with disease development. Alzheimer's disease (AD) is a chronic neurodegenerative dis...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3164238

    authors: Wan G,Zhou W,Hu Y,Ma R,Jin S,Liu G,Jiang Q

    更新日期:2016-01-01 00:00:00

  • Efficacy and Safety of L-Carnitine Treatment for Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials.

    abstract::Background. Whether additional benefit can be achieved with the use of L-carnitine (L-C) in patients with chronic heart failure (CHF) remains controversial. We therefore performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of L-C treatment in CHF patients. Methods. Pubmed, Ovid Emba...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2017/6274854

    authors: Song X,Qu H,Yang Z,Rong J,Cai W,Zhou H

    更新日期:2017-01-01 00:00:00

  • The Association between Cerebral White Matter Lesions and Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acids Ratio to Cognitive Impairment Development.

    abstract:OBJECTIVE:Cerebral white matter hyperintensity (WMH) with magnetic resonance imaging (MRI) has a potential for predicting cognitive impairment. Serum polyunsaturated fatty acid (PUFA) levels are important for evaluating the extent of atherosclerosis. We investigated whether abnormal PUFA levels affected WMH grading and...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/153437

    authors: Suwa M,Yamaguchi S,Komori T,Kajimoto S,Kino M

    更新日期:2015-01-01 00:00:00