Netrins and their roles in placental angiogenesis.

Abstract:

:Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence of netrins has also been reported. Recent studies demonstrated the involvement of netrins in the regulation of placental angiogenesis. In this review we focused on the role of netrins in human placental angiogenesis. Among all netrins examined, netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors. These opposite effects appear to be related to the endothelial cell phenotype studied and seem also to depend on the receptor type to which netrin binds, that is, the canonical receptor member of the DCC family, the members of the UNC5 family, or the noncanonical receptor members of the integrin family or DSCAM.

journal_name

Biomed Res Int

authors

Dakouane-Giudicelli M,Alfaidy N,de Mazancourt P

doi

10.1155/2014/901941

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

901941

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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