Abstract:
:Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence of netrins has also been reported. Recent studies demonstrated the involvement of netrins in the regulation of placental angiogenesis. In this review we focused on the role of netrins in human placental angiogenesis. Among all netrins examined, netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors. These opposite effects appear to be related to the endothelial cell phenotype studied and seem also to depend on the receptor type to which netrin binds, that is, the canonical receptor member of the DCC family, the members of the UNC5 family, or the noncanonical receptor members of the integrin family or DSCAM.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Dakouane-Giudicelli M,Alfaidy N,de Mazancourt Pdoi
10.1155/2014/901941subject
Has Abstractpub_date
2014-01-01 00:00:00pages
901941eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章,评审abstract:Purpose:To evaluate the relationships between objectively measured physical activity and physical fitness among preschool children. Methods:A total of 346 participants (201 boys and 145 girls) aged 3.5-5.5 years (M = 4.5 yr, SD = 0.47) from Shanghai, China, completed physical fitness assessments, including triceps ski...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9314026
更新日期:2017-01-01 00:00:00
abstract::Scaffolds play an important role in tissue engineering and their structure and biocompatibility have great influence on cell behaviors. In this study, poly(l-lactide-co-ε-caprolactone) (PLCL) scaffolds were printed by a 3D printing technology, low-temperature deposition manufacturing (LDM), and then PLCL scaffolds wer...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5147156
更新日期:2018-02-28 00:00:00
abstract::The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/867321
更新日期:2014-01-01 00:00:00
abstract:Purpose:To detect the responsiveness and predictive ability of the Chinese version Action Research Arm Test (C-ARAT) in participants within the first 3 months after cerebral infarction. Methods:Ninety-seven individuals (75 men, mean age 59.87 ± 10.94 years) with a first cerebral infarction were enrolled in this study....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8270187
更新日期:2019-10-07 00:00:00
abstract::Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Chinese Medicine (TCM...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/871576
更新日期:2014-01-01 00:00:00
abstract::Accurate definition and better understanding of the mechanisms of stroke are crucial as this will guide the effective care and therapy. In this paper, we review the previous basic and clinical researches on the causes or mechanisms of ischemic cerebrovascular diseases (ICVD) and interpret the correlation between embol...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/8531958
更新日期:2016-01-01 00:00:00
abstract::Triple-negative breast cancer (TNBC) has a significant clinical relevance of being associated with a shorter median time to relapse and death and does not respond to endocrine therapy or other available targeted agents. Increased aggressiveness of this tumor, as well as resistance to standard drug therapies, may be as...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/158682
更新日期:2015-01-01 00:00:00
abstract::Influences of environmental variables and emulsifiers on lipase production of a Candida viswanathii strain were investigated. The highest lipase activity (101.1 U) was observed at 210 rpm, pH 6.0, and 27.5°C. Other fermentation parameters analyzed showed considerable rates of biomass yield (Y L/S = 1.381 g/g), lipase ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/435818
更新日期:2013-01-01 00:00:00
abstract:AIMS:Nausea and vomiting of pregnancy is the most common medical condition in pregnancy. There is an increasing trend to prescribe ondansetron although its safety for use in pregnancy has not been established. METHODS:Exposed pregnancies were all births in Western Australia, 2002-2005, where the mother was dispensed o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/909860
更新日期:2013-01-01 00:00:00
abstract:Objective:The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at p...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6383906
更新日期:2020-06-21 00:00:00
abstract::Dental modeling resins have been developed for use in areas where highly precise resin structures are needed. The manufacturers claim that these polymethyl methacrylate/methyl methacrylate (PMMA/MMA) resins show little or no shrinkage after polymerization. This study examined the polymerization shrinkage of five denta...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/914739
更新日期:2014-01-01 00:00:00
abstract:Background:Musculoskeletal disorders (MSDs) are considered one of the most common health issues in working population and have a high social and economic impact. This study is aimed at determining the MSD patterns and associated risk factors among higher education academicians in Saudi Arabia. Methods:A cross-sectiona...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8930968
更新日期:2020-08-15 00:00:00
abstract:Aims:We aimed to summarize available lines of evidence about intraoperative and postoperative donor outcomes following robotic-assisted laparoscopic donor nephrectomy (RALDN) as well as outcomes of graft and recipients. Methods:A systematic review of PubMed/Medline, ISI Web of Knowledge, and Scopus databases was perfo...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/1729138
更新日期:2019-04-22 00:00:00
abstract::Toxoplasma gondii (T. gondii) can be transmitted by blood transfusion. We determined the prevalence of T. gondii infection in healthy blood donors in Hermosillo city, Mexico, and the association of infection with T. gondii with the sociodemographic, clinical, and behavioral characteristics of blood donors. Four hundre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9597276
更新日期:2016-01-01 00:00:00
abstract::Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5281251
更新日期:2020-03-23 00:00:00
abstract::The plant cytoskeleton, including microtubules and microfilaments, is one of the important factors in determining the polarity of cell division and growth, as well as the interaction of plants with invading pathogens. In defense responses of wheat against the stripe rust (Puccinia striiformis f. sp. tritici) infection...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7830768
更新日期:2016-01-01 00:00:00
abstract::Endometrial carcinoma is the most common gynecological tumor worldwide. It can be the presenting malignancy, acting as the harbinger, of an undiagnosed hereditary syndrome. Up to 50% of females with Lynch syndrome present in this manner. Differentiation between Lynch, Muir-Torre, and Cowden syndromes can at times be c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/219012
更新日期:2015-01-01 00:00:00
abstract::Actin is one of the most highly conserved proteins and plays crucial roles in many vital cellular functions. In most eukaryotes, it is encoded by a multigene family. Although the actin gene family has been studied a lot, few investigators focus on the comparison of actin gene family in relative species. Here, the purp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/630803
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Severe sepsis and septic shock are the primary causes of multiple organ dysfunction syndrome (MODS), which is the most frequent cause of death in intensive care unit patients. Many pro- and anti-inflammatory mediators, such as interleukin-6 (IL-6), play a strategic role in septic syndrome. Continuous renal...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/108951
更新日期:2013-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) accounts for a significant proportion of liver cancer, which has become the second most common cause of cancer-related mortality worldwide. To investigate the potential mechanisms of invasion and progression of HCC, bioinformatics analysis and validation by qRT-PCR were performed. We fou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1431396
更新日期:2018-08-29 00:00:00
abstract::The administration of probiotic bacteria for health benefit has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. The oral administration of most of the probiotics results in the lack of ability to survive in a high proportion of the harsh conditions of acidity and bile conc...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/620719
更新日期:2013-01-01 00:00:00
abstract::Human epididymis protein 4 (HE4) is an available tumor biomarker mainly for detecting ovarian cancer. However, it is unknown whether it can be a novel indicator for diagnosis of diabetic kidney disease (DKD). The aim of this study was to investigate the possibility of serum HE4 as a novel biomarker for DKD in patients...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4831459
更新日期:2019-11-11 00:00:00
abstract::A novel methylamine-selective amperometric bienzyme biosensor based on recombinant primary amine oxidase isolated from the recombinant yeast strain Saccharomyces cerevisiae and commercial horseradish peroxidase is described. Two amine oxidase preparations were used: free enzyme (AMO) and covalently immobilized on the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/480498
更新日期:2014-01-01 00:00:00
abstract:Background:Gegen Qinlian (GGQL) decoction is a common Chinese herbal compound for the treatment of ulcerative colitis (UC). In this study, we aimed to identify its molecular target and the mechanism involved in UC treatment by network pharmacology and molecular docking. Material and Methods. The active ingredients of P...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5217405
更新日期:2020-11-24 00:00:00
abstract::To identify novel susceptibility genes and gene sets for obesity, we conducted a genomewide expression association analysis of obesity via integrating genomewide association study (GWAS) and expression quantitative trait loci (eQTLs) data. GWAS summary data of body mass index (BMI) and waist-to-hip ratio (WHR) was dri...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/3848560
更新日期:2018-05-08 00:00:00
abstract::Cardiogenic shock (CS) is uncommon in patients suffering from acute myocardial infarction (AMI). Long-term outcome and adverse predictors for outcomes in AMI patients with CS receiving percutaneous coronary interventions (PCI) are unclear. A total of 482 AMI patients who received PCI were collected, including 53 CS an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8530539
更新日期:2017-01-01 00:00:00
abstract::Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/145619
更新日期:2014-01-01 00:00:00
abstract:Background:Large scalp defects, especially those complicated by calvarial defects, titanium mesh exposure, or cerebrospinal fluid (CSF) leak, pose a challenge for the neurosurgeon and plastic surgeon. Here, we describe our experience of reconstructing the complex scalp defect with free flap transfer. Methods:From Octo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2748219
更新日期:2020-01-10 00:00:00
abstract::Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts. This study sought to assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of human alveolar cleft defects. Ten patients with unilater...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6560234
更新日期:2017-01-01 00:00:00
abstract::This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6915789
更新日期:2016-01-01 00:00:00