Prognostic Value of Cancer Stem Cells Markers in Triple-Negative Breast Cancer.

Abstract:

:Triple-negative breast cancer (TNBC) has a significant clinical relevance of being associated with a shorter median time to relapse and death and does not respond to endocrine therapy or other available targeted agents. Increased aggressiveness of this tumor, as well as resistance to standard drug therapies, may be associated with the presence of stem cell populations within the tumor. Several stemness markers have been described for the various histological subtypes of breast cancer, such as CD44, CD24, CD133, ALDH1, and ABCG2. The role of these markers in breast cancer is not clear yet and above all there are conflicting opinions about their real prognostic value. To investigate the role of CSCs markers in TNBC cancerogenesis and tumor progression, we selected 160 TNBCs samples on which we detected protein expression of CD44, CD24, CD133, ALDH1, and ABCG2 by immunohistochemistry. Our results highlighted a real prognostic role only for CD44 in TNBCs. All other CSCs markers do not appear to be related to the survival of TNBC patients. In conclusion, despite the fact that the presence of the cancer stem cells in the tumor provides important information on its potential aggressiveness, today their detection by immunohistochemistry is not sufficient to confirm their role in carcinogenesis, because specific markers probably are not yet identified.

journal_name

Biomed Res Int

authors

Collina F,Di Bonito M,Li Bergolis V,De Laurentiis M,Vitagliano C,Cerrone M,Nuzzo F,Cantile M,Botti G

doi

10.1155/2015/158682

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

158682

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • Assessment of tumor cells in a mouse model of diffuse infiltrative glioma by Raman spectroscopy.

    abstract::Glioma of infiltrative nature is challenging for surgeons to achieve tumor-specific and maximal resection. Raman spectroscopy provides structural information on the targeted materials as vibrational shifts. We utilized Raman spectroscopy to distinguish invasive tumors from normal tissues. Spectra obtained from replica...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/860241

    authors: Tanahashi K,Natsume A,Ohka F,Momota H,Kato A,Motomura K,Watabe N,Muraishi S,Nakahara H,Saito Y,Takeuchi I,Wakabayashi T

    更新日期:2014-01-01 00:00:00

  • Efficacy and safety of docetaxel plus oxaliplatin and capecitabine in the first line treatment of advanced gastric adenocarcinoma.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of docetaxel plus oxaliplatin and capecitabine (DOX) in the first line treatment of advanced gastric adenocarcinoma. METHODS:A total of 37 patients were enrolled into this study, and they received DOX regimen (docetaxel 75 mg/m² and oxaliplatin 130 mg/m² intravenous infusi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/971096

    authors: Liu Y,Ye Z,Xi W,Ma T,Shi M,Yang L,Zhu Z,Zhang J

    更新日期:2013-01-01 00:00:00

  • Amplification of the insulin-like growth factor 1 receptor gene is a rare event in adrenocortical adenocarcinomas: searching for potential mechanisms of overexpression.

    abstract:CONTEXT:IGF1R overexpression appears to be a prognostic biomarker of metastatic pediatric adrenocortical tumors. However, the molecular mechanisms that are implicated in its upregulation remain unknown. Aim. To investigate the potential mechanisms involved in IGF1R overexpression. PATIENTS AND METHODS:We studied 64 ad...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/936031

    authors: Ribeiro TC,Jorge AA,Almeida MQ,Mariani BM,Nishi MY,Mendonca BB,Fragoso MC,Latronico AC

    更新日期:2014-01-01 00:00:00

  • Evaluation of the presence of endocrine-disrupting compounds in dissolved and solid wastewater treatment plant samples of Gran Canaria Island (Spain).

    abstract::Liquid and solid samples from two wastewater treatment plants (WWTPs) on Gran Canaria Island (Spain) have been tested for the presence of compounds with endocrine-disrupting properties. The selected degradation stages were sampled bimonthly from each WWTP over the 12-month period from July 2010 to July 2011. The analy...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/790570

    authors: Vega-Morales T,Sosa-Ferrera Z,Santana-Rodríguez JJ

    更新日期:2013-01-01 00:00:00

  • Recent trends of polymer mediated liposomal gene delivery system.

    abstract::Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route ...

    journal_title:BioMed research international

    pub_type: 杂志文章,收录出版,评审

    doi:10.1155/2014/934605

    authors: Kundu SK,Sharma AR,Lee SS,Sharma G,Doss CG,Yagihara S,Kim DY,Nam JS,Chakraborty C

    更新日期:2014-01-01 00:00:00

  • Tanshinone IIA induces apoptosis in human oral cancer KB cells through a mitochondria-dependent pathway.

    abstract::Tanshinone IIA (Tan IIA), an active phytochemical in the dried root of Salvia miltiorrhiza Bunge, has shown an antiproliferative activity on various human cancer cell lines including nasopharyngeal carcinoma cells. However, the effects of Tan IIA on human oral cancer cells are still unknown. This study aimed to invest...

    journal_title:BioMed research international

    pub_type: 杂志文章,收录出版

    doi:10.1155/2014/540516

    authors: Tseng PY,Lu WC,Hsieh MJ,Chien SY,Chen MK

    更新日期:2014-01-01 00:00:00

  • Platelet rich plasma and knee surgery.

    abstract::In orthopaedic surgery and sports medicine, the knee joint has traditionally been considered the workhorse. The reconstruction of every damaged element in this joint is crucial in achieving the surgeon's goal to restore the knee function and prevent degeneration towards osteoarthritis. In the last fifteen years, the f...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/890630

    authors: Sánchez M,Delgado D,Sánchez P,Fiz N,Azofra J,Orive G,Anitua E,Padilla S

    更新日期:2014-01-01 00:00:00

  • Effects of Arteriovenous Thrombolysis Combined with Mechanical Thrombectomy on Efficacy and Neurological Function of Acute Cerebral Infarct Patients.

    abstract:Objective:To investigate the effects of arteriovenous thrombolysis combined with mechanical thrombectomy on clinical efficacy, neurological function, and the changes of nerve injury markers of acute cerebral infarct (ACI) patients. Methods:A total of 143 cases with ACI admitted to our hospital from June 2017 to June 2...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9743075

    authors: Ding T,Tang L,Hu B,Yuan J,Li X,Wen J

    更新日期:2020-10-09 00:00:00

  • Bilateral single-port sympathectomy: long-term results and quality of life.

    abstract:OBJECT:Video-assisted thoracoscopic sympathectomy is a safe, effective, and minimally invasive procedure for primary hyperhidrosis. This study aims to evaluate long-term results and patients' quality of life and investigate potential variables responsible for compensatory sweating after one-stage bilateral single-port ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/348017

    authors: Ibrahim M,Menna C,Andreetti C,Ciccone AM,D'Andrilli A,Maurizi G,Pomes LM,Cassiano F,Venuta F,Rendina EA

    更新日期:2013-01-01 00:00:00

  • Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Salivary mic...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9792730

    authors: Salazar-Ruales C,Arguello JV,López-Cortés A,Cabrera-Andrade A,García-Cárdenas JM,Guevara-Ramírez P,Peralta P,Leone PE,Paz-Y-Miño C

    更新日期:2018-11-21 00:00:00

  • The Construct and Measurement of Perceived Risk of Nonremunerated Blood Donation: Evidence from the Chinese Public.

    abstract::The perceived risk of nonremunerated blood donation (NRBD) is one of the most important factors which hinder the Chinese public from donating blood. To understand deeply and measure scientifically the public's perceived risk of NRBD, in this paper the qualitative and quantitative methods were used to explore the const...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/302043

    authors: Chen L,Ma Z

    更新日期:2015-01-01 00:00:00

  • Antioxidant and cytotoxic effects of crude extract, fractions and 4-nerolidylcathecol from aerial parts of Pothomorphe umbellata L. (Piperaceae).

    abstract::The crude ethanolic extract from aerial parts of Pothomorphe umbellata L. (Piperaceae) and fractions obtained by partitions sequentially among water-methanol, methylene chloride, and ethyl acetate, as well as the major constituent, 4-nerolidylcatechol, were, respectively, evaluated and evidenced for antioxidant and cy...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/206581

    authors: Lopes AP,Bagatela BS,Rosa PC,Nanayakkara DN,Tavares Carvalho JC,Maistro EL,Bastos JK,Perazzo FF

    更新日期:2013-01-01 00:00:00

  • Scanning electron microscopy and X-ray microanalysis for chemical and morphological characterisation of the inorganic component of gunshot residue: selected problems.

    abstract::Chosen aspects of examinations of inorganic gunshot particles by means of scanning electron microscopy and energy dispersive X-ray spectrometry technique are presented. The research methodology of particles was worked out, which included a precise and repeatable procedure of the automatic detection and identification ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/428038

    authors: Brożek-Mucha Z

    更新日期:2014-01-01 00:00:00

  • A Prediction Model for Membrane Proteins Using Moments Based Features.

    abstract::The most expedient unit of the human body is its cell. Encapsulated within the cell are many infinitesimal entities and molecules which are protected by a cell membrane. The proteins that are associated with this lipid based bilayer cell membrane are known as membrane proteins and are considered to play a significant ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8370132

    authors: Butt AH,Khan SA,Jamil H,Rasool N,Khan YD

    更新日期:2016-01-01 00:00:00

  • Oral Streptococci Biofilm Formation on Different Implant Surface Topographies.

    abstract::The establishment of the subgingival microbiota is dependent on successive colonization of the implant surface by bacterial species. Different implant surface topographies could influence the bacterial adsorption and therefore jeopardize the implant survival. This study evaluated the biofilm formation capacity of five...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/159625

    authors: Pita PP,Rodrigues JA,Ota-Tsuzuki C,Miato TF,Zenobio EG,Giro G,Figueiredo LC,Gonçalves C,Gehrke SA,Cassoni A,Shibli JA

    更新日期:2015-01-01 00:00:00

  • Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers.

    abstract::The occurrence of head and neck cancer (HNC) is associated with smoking and alcohol drinking. Tobacco smoking exposes smokers to a series of carcinogenic chemicals. Cytochrome P450 enzymes (CYP450s), such as CYP1A1, CYP1B1, and CYP2D6, usually metabolize carcinogens to their inactive derivatives, but they occasionally...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/582768

    authors: Khlifi R,Messaoud O,Rebai A,Hamza-Chaffai A

    更新日期:2013-01-01 00:00:00

  • The Prognosis of Cardiac Origin and Noncardiac Origin in-Hospital Cardiac Arrest Occurring during Night Shifts.

    abstract::Background. The survival rates of in-hospital cardiac arrests (IHCAs) are reportedly low at night, but the difference between the survival rates of cardiac origin and noncardiac origin IHCAs occurring at night remains unclear. Methods. Outcomes of IHCAs during different shifts (night, day, and evening) were compared a...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/4626027

    authors: Syue YJ,Huang JB,Cheng FJ,Kung CT,Li CJ

    更新日期:2016-01-01 00:00:00

  • Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1/PD-L1 Blockade.

    abstract:Introduction:Baseline neutrophil-to-lymphocyte ratio (NLR) has been repeatedly reported as a significant prognostic factor in advanced cancer patients. We explored whether changes in NLR may predict outcome of advanced cancer patients enrolled into phase 1 trials and treated with PD-1/PD-L1 inhibitors. Patients and Me...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/1506824

    authors: Moschetta M,Uccello M,Kasenda B,Mak G,McClelland A,Boussios S,Forster M,Arkenau HT

    更新日期:2017-01-01 00:00:00

  • Inflammation-related effects of diesel engine exhaust particles: studies on lung cells in vitro.

    abstract::Diesel exhaust and its particles (DEP) have been under scrutiny for health effects in humans. In the development of these effects inflammation is regarded as a key process. Overall, in vitro studies report similar DEP-induced changes in markers of inflammation, including cytokines and chemokines, as studies in vivo. I...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/685142

    authors: Schwarze PE,Totlandsdal AI,Låg M,Refsnes M,Holme JA,Øvrevik J

    更新日期:2013-01-01 00:00:00

  • Antiadherent and antibiofilm activity of Humulus lupulus L. derived products: new pharmacological properties.

    abstract::New antimicrobial properties of products derived from Humulus lupulus L. such as antiadherent and antibiofilm activities were evaluated. The growth of gram-positive but not gram-negative bacteria was inhibited to different extents by these compounds. An extract of hop cones containing 51% xanthohumol was slightly less...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/101089

    authors: Rozalski M,Micota B,Sadowska B,Stochmal A,Jedrejek D,Wieckowska-Szakiel M,Rozalska B

    更新日期:2013-01-01 00:00:00

  • Genotype-specific changes in vitamin B6 content and the PDX family in potato.

    abstract::Vitamin B6 is one of the most versatile cofactors in plants and an essential phytonutrient in the human diet that benefits a variety of human health aspects. Although biosynthesis of the vitamin has been well resolved in recent years, the main research is currently based on Arabidopsis thaliana with very little work d...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/389723

    authors: Mooney S,Chen L,Kühn C,Navarre R,Knowles NR,Hellmann H

    更新日期:2013-01-01 00:00:00

  • Nonlinear EEG decoding based on a particle filter model.

    abstract::While the world is stepping into the aging society, rehabilitation robots play a more and more important role in terms of both rehabilitation treatment and nursing of the patients with neurological diseases. Benefiting from the abundant contents of movement information, electroencephalography (EEG) has become a promis...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/159486

    authors: Zhang J,Wei J,Wang B,Hong J,Wang J

    更新日期:2014-01-01 00:00:00

  • Enzyme Inhibitory Kinetics and Molecular Docking Studies of Halo-Substituted Mixed Ester/Amide-Based Derivatives as Jack Bean Urease Inhibitors.

    abstract::A series of halo-substituted mixed ester/amide-based analogues 4a-l have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8867407

    authors: Rashid M,Rafique H,Roshan S,Shamas S,Iqbal Z,Ashraf Z,Abbas Q,Hassan M,Qureshi ZUR,Asad MHHB

    更新日期:2020-12-24 00:00:00

  • The Challenge of Cross-Cultural Care Encounters: Perspective of Imported Nurses in Lhasa, Tibet.

    abstract:Aims:The purpose of this study was to describe the challenge of cross-cultural care encounters from perspective of imported nurses in Lhasa, Tibet, as well as investigate the relationship of cross-cultural care encounters and its influencing factors. Methods:A cross-sectional survey was designed among 300 imported nur...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3159178

    authors: Bai M,Sui X,Zhou C,Li Y,Li J,Gao R,Du Z,Xu L,Li F

    更新日期:2020-04-08 00:00:00

  • Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer.

    abstract::Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic properties. Engineering m...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/9652817

    authors: Kang J,Zhang L,Luo X,Ma X,Wang G,Yang Y,Yan Y,Qian H,Zhang X,Xu W,Mao F

    更新日期:2018-12-26 00:00:00

  • Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study.

    abstract::Single-sided deafness (SSD) induces cortical neural plastic changes according to duration of deafness. However, it is still unclear how the auditory cortical changes accompany the subcortical neural changes. The present study aimed to find the neural plastic changes in the cortical and subcortical auditory system foll...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8624745

    authors: Kim SY,Heo H,Kim DH,Kim HJ,Oh SH

    更新日期:2018-11-26 00:00:00

  • Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways.

    abstract::Objectives. To investigate the protective effects of tropisetron on acetaminophen- (APAP-) induced liver injury in a mice model. Methods. C57BL/6 male mice were given tropisetron (0.3 to 10 mg/kg) 30 minutes before a hepatotoxic dose of acetaminophen (300 mg/kg) intraperitoneally. Twenty hours after APAP intoxication,...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1952947

    authors: Liu FC,Lee HC,Liao CC,Li AH,Yu HP

    更新日期:2016-01-01 00:00:00

  • Reconstruction of cochlea based on micro-CT and histological images of the human inner ear.

    abstract::The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is therefore particularly at...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/485783

    authors: Bellos C,Rigas G,Spiridon IF,Bibas A,Iliopoulou D,Böhnke F,Koutsouris D,Fotiadis DI

    更新日期:2014-01-01 00:00:00

  • Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors in cT2R7/pDisplay-Gα16/gust44/pcDNA3.1 (+) Cells.

    abstract::Bitterness is an important taste sensation for chickens, which provides useful sensory information for acquisition and selection of diet, and warns them against ingestion of potentially harmful and noxious substances in nature. Bitter taste receptors (T2Rs) mediate the recognition of bitter compounds belonging to a fa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6301915

    authors: Su Y,Jie H,Zhu Q,Zhao X,Wang Y,Yin H,Kumar Mishra S,Li D

    更新日期:2019-10-31 00:00:00

  • The Effect of Longer versus Shorter Duration of Supervised Physiotherapy after ACL Reconstruction on the Vertical Jump Landing Limb Symmetry.

    abstract::The study investigated the vertical jump landing limb symmetry after ACLR between a group of patients receiving a longer supervised physiotherapeutic procedure and following a shorter supervised physiotherapy. Group I (n = 20) and Group II (n = 15) were males averagely 30 weeks after ACLR. The time since ACLR in both ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7519467

    authors: Królikowska A,Czamara A,Szuba Ł,Reichert P

    更新日期:2018-04-23 00:00:00