Abstract:
:Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuria (HL-Pro group), 68 patients with HL without proteinuria (HL-NPro group), 46 patients with non-HL-related proteinuria (NHL-Pro group), and 50 healthy control (Con) subjects were selected. There were no significant differences in serum ANGPTL4 levels between the Con group (36.82 ± 17.03 ng/ml) and the HL-Pro group (27.94 (18.90, 53.72) ng/ml). Additionally, the serum ANGPTL4 levels in the HL-Pro group were significantly lower than those in the HL-NPro group (53.32 ± 24.01 ng/ml) (P < 0.001). The urine ANGPTL4/Cr levels in the HL-Pro group (52.01 (45.25, 79.79) μg/g) were significantly higher than those in the HL-NPro group (9.96 (8.35, 12.43) ng/ml) (P < 0.05). A significant alteration in urine ANGPTL4/Cr levels was observed in the NHL-Pro group (69.41 ± 55.36 μg/g) and the Con group (10.08 ± 2.38 μg/g) as well. There was no correlation between serum and urine ANGPTL4 levels of the four groups (P > 0.05). Serum ANGPTL4 levels (HL-Pro/HL-NPro group) were positively correlated with total cholesterol (TC) and triglyceride (TG) levels in hyperlipidemia patients. However, there was no correlation between urinary ANGPTL4 levels and TC or TG (P > 0.05). Urine ANGPTL4 levels were positively correlated with 24hUPro in patients with renal impairment (HL-Pro/NHL-Pro group). To summarize, ANGPTL4 may be considered an accurate predictor of proteinuria with HL. Notably, serum or urine ANGPTL4 levels indicated the degree of proteinuria or hyperlipidemia, respectively, in HL patients.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Gao X,Zhang M,Feng W,Xu Z,Wang Y,Shi L,Zhang Jdoi
10.1155/2020/5281251subject
Has Abstractpub_date
2020-03-23 00:00:00pages
5281251eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::Sciatic nerve crush injury in rat animal model is one of the most common experimental models used in regenerative research. However, the availability of transgenic mouse for nerve regeneration studies is constantly increasing and, therefore, the shift from rat model to mouse model is, in some cases, necessary. Moreove...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/701682
更新日期:2014-01-01 00:00:00
abstract::Gravity is crucial for spatial perception, postural equilibrium, and movement generation. The vestibular apparatus is the main sensory system involved in monitoring gravity. Hair cells in the vestibular maculae respond to gravitoinertial forces, but they cannot distinguish between linear accelerations and changes of h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/615854
更新日期:2014-01-01 00:00:00
abstract::We aimed to determine the effects of an 8 wk Hatha yoga training on blood glucose, insulin, lipid profiles, endothelial microparticles (EMPs), and inflammatory status in healthy, lean, and female Chinese subjects. A total of 30 healthy, female Chinese subjects were recruited and randomized into control or yoga practic...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5387258
更新日期:2016-01-01 00:00:00
abstract::Introduction. The aim of the present study was to determine the closeness of agreement between a self-reported and an objective measure of physical activity in low back pain patients and healthy controls. Beyond, influencing factors on overestimation were identified. Methods. 27 low back pain patients and 53 healthy c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1497213
更新日期:2016-01-01 00:00:00
abstract::Puffer fishes were collected from the central sea in Vietnam from spring to summer season. The eggs were incubated in MRS broth that was used to test the toxicity in mice and isolate the lactic acid bacteria community that could produce tetrodotoxin (TTX). Thin layer chromatography (TLC) and high performance lipid chr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/973235
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the microshear bond strength (μSBS) of self-adhesive resin (SA) cement on leucite-reinforced glass-ceramic using silane or universal adhesive. MATERIALS AND METHODS:Ceramic blocks were etched with 9.5% hydrofluoric acid and divided into three groups (n = 16): (1) negative control (NC) without tre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/361893
更新日期:2015-01-01 00:00:00
abstract::The use of endotamponade agents has gained a major role in the management of macular complications of high myopia. Myopic foveoschisis and macular hole are the main macular complication of pathologic myopia, this growing condition that is a main cause of visual loss, especially in patients at a younger age. We discuss...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/420380
更新日期:2014-01-01 00:00:00
abstract::The plant cytoskeleton, including microtubules and microfilaments, is one of the important factors in determining the polarity of cell division and growth, as well as the interaction of plants with invading pathogens. In defense responses of wheat against the stripe rust (Puccinia striiformis f. sp. tritici) infection...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7830768
更新日期:2016-01-01 00:00:00
abstract::Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall surviva...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/654727
更新日期:2014-01-01 00:00:00
abstract::Toll-like receptors (TLRs) play a key role in the innate immune response to numerous pathogens, including Acanthamoeba spp. The aim of this study was to determine the expression of TLR2 and TLR4 in the eyes of mice following intranasal infection with Acanthamoeba spp. in relation to the host's immunological status. Am...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1401894
更新日期:2019-06-12 00:00:00
abstract::Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full fact...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/563651
更新日期:2013-01-01 00:00:00
abstract:Background:A multifactorial decision support system (mDSS) is a tool designed to improve the clinical decision-making process, while using clinical inputs for an individual patient to generate case-specific advice. The study provides an overview of the literature to analyze current available mDSS focused on prostate ca...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/4961768
更新日期:2019-06-06 00:00:00
abstract:OBJECTIVE:To determine the histopathological differences after varicocele repair in testicular tissue in males with nonobstructive azoospermia. METHODS:Between 2009 and 2014, 45 men with complete azoospermia and palpable varicocele, presenting with primary infertility of at least 1 year, undergoing varicocele repair a...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/709452
更新日期:2015-01-01 00:00:00
abstract:Background:Health-related physical fitness is vital for children with intellectual and developmental disabilities (IDD) to gain healthier lives. The adapted rhythmic gymnastics (ARG) program was designed for children with IDD and is aimed at testing the effects of the exercise program on children's physical fitness. M...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2345607
更新日期:2020-08-10 00:00:00
abstract::We recruited a group of 6713 consecutive Chinese patients with T2D but normal renal and liver function who were admitted to one of 81 top tertiary care hospitals in China. Mild hypoglycaemia was defined as having symptomatic hypoglycaemia in one month before hospitalization. Severe hypoglycaemia was defined as having ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/862896
更新日期:2015-01-01 00:00:00
abstract::In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staph...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1067413
更新日期:2018-10-22 00:00:00
abstract::It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2607928
更新日期:2018-06-14 00:00:00
abstract:Objective:To investigate the effects of electroacupuncture (EA) at "Zusanli" (ST36) and "Shangjuxu"(ST37) on reducing inflammatory reaction and improving intestinal dysfunction in patients with sepsis-induced intestinal dysfunction with syndrome of obstruction of the bowels Qi. Methods:A total of 71 patients with seps...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/8293594
更新日期:2018-06-26 00:00:00
abstract::Deep venous thrombosis (DVT) constitutes a great threat to health worldwide. Endothelial cell injury and dysfunction comprise the critical contributor for the development of DVT. However, the mechanism behind it remains poorly elucidated. The study is aimed at investigating the role of microRNA-122 (miR-122) and oxida...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9791608
更新日期:2020-10-27 00:00:00
abstract::The aim of this study was to assess the diagnostic accuracy of subjective ultrasound evaluation of myometrial invasion of endometrial cancer and to compare its accuracy to objective methods. All consecutive patients with histologically proven endometrial cancer, who underwent ultrasound evaluation followed by surgical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1318203
更新日期:2017-01-01 00:00:00
abstract:Background:Pyroptosis, a novel form of inflammatory programmed cell death, was recently found to be a cause of mucosal barrier defect. In our pervious study, CD147 expression was documented to increase in intestinal tissue of inflammatory bowel disease (IBD). Objective:The aim of this study was to determine the functi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5341247
更新日期:2020-06-30 00:00:00
abstract::Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/908175
更新日期:2014-01-01 00:00:00
abstract::Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/4051504
更新日期:2021-01-05 00:00:00
abstract::The future development of shrimp farming needs to improve its ecoefficiency. The purpose of this study was to evaluate water quality, flows, and nitrogen balance and production parameters on a farm with interconnected pond design to improve the efficiency of the semi-intensive culture of Litopenaeus vannamei ponds. Th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/873748
更新日期:2015-01-01 00:00:00
abstract::Objective. To evaluate the efficacy of bundle intervention on healthcare-associated (HA) methicillin-resistant Staphylococcus Aureus (MRSA) infection in the neonatal intensive care unit (NICU). Methods. In this study, 11,277 infants having undergone treatment at the NICU in Xiamen, China, from January 2014 to February...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5490413
更新日期:2019-07-10 00:00:00
abstract::The ability of Aspergillus niger strain to reduce organic and mineral pollution as well as the toxicity of two tannery wastewaters, the unhairing effluent (UE) and the final effluent (FE), taken from a local Tunisian tannery and under nonsterile conditions, was studied. Raw effluents show alkaline pH ≥11; thus experim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9020178
更新日期:2019-06-03 00:00:00
abstract::Multiparametric MRI of the prostate combines high-resolution anatomic imaging with functional imaging of alterations in normal tissue caused by neoplastic transformation for the identification and characterization of in situ prostate cancer. Lesion detection relies on a systematic approach to the analysis of both anat...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/684127
更新日期:2014-01-01 00:00:00
abstract::Although studies have shown that human migration is one of the risk factors for the spread of drug-resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA), surveillance studies examining MRSA among refugee populations in the US are lacking. This study aimed to assess the prevalence and molecular...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5739247
更新日期:2019-07-01 00:00:00
abstract::Synovitis plays an important role in the pathogenesis of arthritis, which is closely related to the joint swell and pain of patients. The purpose of this study was to investigate the anti-inflammatory effects of pulsed electromagnetic fields (PEMF) on synovitis and its underlying mechanisms. Destabilization of the med...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4307385
更新日期:2020-05-26 00:00:00
abstract:Objective:Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods:In this retrospe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052143
更新日期:2020-08-13 00:00:00