Alteration of Angiopoietin-Like Protein 4 Levels in Serum or Urine Correlate with Different Biochemical Markers in Hyperlipidemia-Related Proteinuria.

Abstract:

:Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuria (HL-Pro group), 68 patients with HL without proteinuria (HL-NPro group), 46 patients with non-HL-related proteinuria (NHL-Pro group), and 50 healthy control (Con) subjects were selected. There were no significant differences in serum ANGPTL4 levels between the Con group (36.82 ± 17.03 ng/ml) and the HL-Pro group (27.94 (18.90, 53.72) ng/ml). Additionally, the serum ANGPTL4 levels in the HL-Pro group were significantly lower than those in the HL-NPro group (53.32 ± 24.01 ng/ml) (P < 0.001). The urine ANGPTL4/Cr levels in the HL-Pro group (52.01 (45.25, 79.79) μg/g) were significantly higher than those in the HL-NPro group (9.96 (8.35, 12.43) ng/ml) (P < 0.05). A significant alteration in urine ANGPTL4/Cr levels was observed in the NHL-Pro group (69.41 ± 55.36 μg/g) and the Con group (10.08 ± 2.38 μg/g) as well. There was no correlation between serum and urine ANGPTL4 levels of the four groups (P > 0.05). Serum ANGPTL4 levels (HL-Pro/HL-NPro group) were positively correlated with total cholesterol (TC) and triglyceride (TG) levels in hyperlipidemia patients. However, there was no correlation between urinary ANGPTL4 levels and TC or TG (P > 0.05). Urine ANGPTL4 levels were positively correlated with 24hUPro in patients with renal impairment (HL-Pro/NHL-Pro group). To summarize, ANGPTL4 may be considered an accurate predictor of proteinuria with HL. Notably, serum or urine ANGPTL4 levels indicated the degree of proteinuria or hyperlipidemia, respectively, in HL patients.

journal_name

Biomed Res Int

authors

Gao X,Zhang M,Feng W,Xu Z,Wang Y,Shi L,Zhang J

doi

10.1155/2020/5281251

subject

Has Abstract

pub_date

2020-03-23 00:00:00

pages

5281251

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

杂志文章
  • The mouse median nerve experimental model in regenerative research.

    abstract::Sciatic nerve crush injury in rat animal model is one of the most common experimental models used in regenerative research. However, the availability of transgenic mouse for nerve regeneration studies is constantly increasing and, therefore, the shift from rat model to mouse model is, in some cases, necessary. Moreove...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/701682

    authors: Jager SB,Ronchi G,Vaegter CB,Geuna S

    更新日期:2014-01-01 00:00:00

  • Multisensory integration and internal models for sensing gravity effects in primates.

    abstract::Gravity is crucial for spatial perception, postural equilibrium, and movement generation. The vestibular apparatus is the main sensory system involved in monitoring gravity. Hair cells in the vestibular maculae respond to gravitoinertial forces, but they cannot distinguish between linear accelerations and changes of h...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/615854

    authors: Lacquaniti F,Bosco G,Gravano S,Indovina I,La Scaleia B,Maffei V,Zago M

    更新日期:2014-01-01 00:00:00

  • Effects of 8-Week Hatha Yoga Training on Metabolic and Inflammatory Markers in Healthy, Female Chinese Subjects: A Randomized Clinical Trial.

    abstract::We aimed to determine the effects of an 8 wk Hatha yoga training on blood glucose, insulin, lipid profiles, endothelial microparticles (EMPs), and inflammatory status in healthy, lean, and female Chinese subjects. A total of 30 healthy, female Chinese subjects were recruited and randomized into control or yoga practic...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/5387258

    authors: Chen N,Xia X,Qin L,Luo L,Han S,Wang G,Zhang R,Wan Z

    更新日期:2016-01-01 00:00:00

  • Influencing Factors on the Overestimation of Self-Reported Physical Activity: A Cross-Sectional Analysis of Low Back Pain Patients and Healthy Controls.

    abstract::Introduction. The aim of the present study was to determine the closeness of agreement between a self-reported and an objective measure of physical activity in low back pain patients and healthy controls. Beyond, influencing factors on overestimation were identified. Methods. 27 low back pain patients and 53 healthy c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1497213

    authors: Schaller A,Rudolf K,Dejonghe L,Grieben C,Froboese I

    更新日期:2016-01-01 00:00:00

  • Biological Activities of Tetrodotoxin-Producing Enterococcus faecium AD1 Isolated from Puffer Fishes.

    abstract::Puffer fishes were collected from the central sea in Vietnam from spring to summer season. The eggs were incubated in MRS broth that was used to test the toxicity in mice and isolate the lactic acid bacteria community that could produce tetrodotoxin (TTX). Thin layer chromatography (TLC) and high performance lipid chr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/973235

    authors: Nguyen TH,Nguyen HN,Nghe DV,Nguyen KH

    更新日期:2015-01-01 00:00:00

  • Analysis of Self-Adhesive Resin Cement Microshear Bond Strength on Leucite-Reinforced Glass-Ceramic with/without Pure Silane Primer or Universal Adhesive Surface Treatment.

    abstract:OBJECTIVE:To evaluate the microshear bond strength (μSBS) of self-adhesive resin (SA) cement on leucite-reinforced glass-ceramic using silane or universal adhesive. MATERIALS AND METHODS:Ceramic blocks were etched with 9.5% hydrofluoric acid and divided into three groups (n = 16): (1) negative control (NC) without tre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/361893

    authors: Lee Y,Kim JH,Woo JS,Yi YA,Hwang JY,Seo DG

    更新日期:2015-01-01 00:00:00

  • Vitreous tamponades in highly myopic eyes.

    abstract::The use of endotamponade agents has gained a major role in the management of macular complications of high myopia. Myopic foveoschisis and macular hole are the main macular complication of pathologic myopia, this growing condition that is a main cause of visual loss, especially in patients at a younger age. We discuss...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/420380

    authors: Valldeperas X,Lorenzo-Carrero J

    更新日期:2014-01-01 00:00:00

  • Microtubule Polymerization Functions in Hypersensitive Response and Accumulation of H2O2 in Wheat Induced by the Stripe Rust.

    abstract::The plant cytoskeleton, including microtubules and microfilaments, is one of the important factors in determining the polarity of cell division and growth, as well as the interaction of plants with invading pathogens. In defense responses of wheat against the stripe rust (Puccinia striiformis f. sp. tritici) infection...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7830768

    authors: Wang J,Wang Y,Liu X,Xu Y,Ma Q

    更新日期:2016-01-01 00:00:00

  • IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients.

    abstract::Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall surviva...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/654727

    authors: Stancheva G,Goranova T,Laleva M,Kamenova M,Mitkova A,Velinov N,Poptodorov G,Mitev V,Kaneva R,Gabrovsky N

    更新日期:2014-01-01 00:00:00

  • Expression of Toll-Like Receptors (TLR2 and TLR4) in the Eyes of Mice with Disseminated Acanthamoebiasis.

    abstract::Toll-like receptors (TLRs) play a key role in the innate immune response to numerous pathogens, including Acanthamoeba spp. The aim of this study was to determine the expression of TLR2 and TLR4 in the eyes of mice following intranasal infection with Acanthamoeba spp. in relation to the host's immunological status. Am...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/1401894

    authors: Kot K,Kosik-Bogacka D,Łanocha-Arendarczyk N,Wojtkowiak-Giera A,Kolasa-Wołosiuk A

    更新日期:2019-06-12 00:00:00

  • Development of bioadhesive chitosan superporous hydrogel composite particles based intestinal drug delivery system.

    abstract::Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full fact...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/563651

    authors: Chavda H,Modhia I,Mehta A,Patel R,Patel C

    更新日期:2013-01-01 00:00:00

  • Decision Support Systems in Prostate Cancer Treatment: An Overview.

    abstract:Background:A multifactorial decision support system (mDSS) is a tool designed to improve the clinical decision-making process, while using clinical inputs for an individual patient to generate case-specific advice. The study provides an overview of the literature to analyze current available mDSS focused on prostate ca...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/4961768

    authors: van Wijk Y,Halilaj I,van Limbergen E,Walsh S,Lutgens L,Lambin P,Vanneste BGL

    更新日期:2019-06-06 00:00:00

  • Varicocele Repair Improves Testicular Histology in Men with Nonobstructive Azoospermia.

    abstract:OBJECTIVE:To determine the histopathological differences after varicocele repair in testicular tissue in males with nonobstructive azoospermia. METHODS:Between 2009 and 2014, 45 men with complete azoospermia and palpable varicocele, presenting with primary infertility of at least 1 year, undergoing varicocele repair a...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2015/709452

    authors: Ustuner M,Yilmaz H,Yavuz U,Ciftci S,Saribacak A,Aynur BS,Yasar H,Culha MM

    更新日期:2015-01-01 00:00:00

  • Improving Physical Fitness of Children with Intellectual and Developmental Disabilities through an Adapted Rhythmic Gymnastics Program in China.

    abstract:Background:Health-related physical fitness is vital for children with intellectual and developmental disabilities (IDD) to gain healthier lives. The adapted rhythmic gymnastics (ARG) program was designed for children with IDD and is aimed at testing the effects of the exercise program on children's physical fitness. M...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2345607

    authors: Xu C,Yao M,Kang M,Duan G

    更新日期:2020-08-10 00:00:00

  • Hypoglycaemia, Abnormal Lipids, and Cardiovascular Disease among Chinese with Type 2 Diabetes.

    abstract::We recruited a group of 6713 consecutive Chinese patients with T2D but normal renal and liver function who were admitted to one of 81 top tertiary care hospitals in China. Mild hypoglycaemia was defined as having symptomatic hypoglycaemia in one month before hospitalization. Severe hypoglycaemia was defined as having ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/862896

    authors: Li Y,Mu Y,Ji Q,Huang Q,Kuang H,Ji L,Yang X

    更新日期:2015-01-01 00:00:00

  • Bacterial Extracellular DNA Production Is Associated with Outcome of Prosthetic Joint Infections.

    abstract::In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staph...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/1067413

    authors: Zatorska B,Arciola CR,Haffner N,Segagni Lusignani L,Presterl E,Diab-Elschahawi M

    更新日期:2018-10-22 00:00:00

  • Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy.

    abstract::It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2607928

    authors: Czarzasta K,Cudnoch-Jedrzejewska A,Niemczyk L,Wrzesien R,Tkaczyk M,Puchalska L,Saracyn M,Zmudzki W,Niemczyk S

    更新日期:2018-06-14 00:00:00

  • Electroacupuncture Improves Intestinal Dysfunction in Septic Patients: A Randomised Controlled Trial.

    abstract:Objective:To investigate the effects of electroacupuncture (EA) at "Zusanli" (ST36) and "Shangjuxu"(ST37) on reducing inflammatory reaction and improving intestinal dysfunction in patients with sepsis-induced intestinal dysfunction with syndrome of obstruction of the bowels Qi. Methods:A total of 71 patients with seps...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2018/8293594

    authors: Meng JB,Jiao YN,Zhang G,Xu XJ,Ji CL,Hu MH,Lai ZZ,Zhang M

    更新日期:2018-06-26 00:00:00

  • Overexpression of MicroRNA-122 Resists Oxidative Stress-Induced Human Umbilical Vascular Endothelial Cell Injury by Inhibition of p53.

    abstract::Deep venous thrombosis (DVT) constitutes a great threat to health worldwide. Endothelial cell injury and dysfunction comprise the critical contributor for the development of DVT. However, the mechanism behind it remains poorly elucidated. The study is aimed at investigating the role of microRNA-122 (miR-122) and oxida...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9791608

    authors: Li HQ,Pan ZY,Yang Z,Zhang DB,Chen Q

    更新日期:2020-10-27 00:00:00

  • The Diagnostic Accuracy of Ultrasound in Assessment of Myometrial Invasion in Endometrial Cancer: Subjective Assessment versus Objective Techniques.

    abstract::The aim of this study was to assess the diagnostic accuracy of subjective ultrasound evaluation of myometrial invasion of endometrial cancer and to compare its accuracy to objective methods. All consecutive patients with histologically proven endometrial cancer, who underwent ultrasound evaluation followed by surgical...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/1318203

    authors: Frühauf F,Zikan M,Semeradova I,Dundr P,Nemejcova K,Dusek L,Cibula D,Fischerova D

    更新日期:2017-01-01 00:00:00

  • CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis.

    abstract:Background:Pyroptosis, a novel form of inflammatory programmed cell death, was recently found to be a cause of mucosal barrier defect. In our pervious study, CD147 expression was documented to increase in intestinal tissue of inflammatory bowel disease (IBD). Objective:The aim of this study was to determine the functi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5341247

    authors: Xu Z,Liu R,Huang L,Xu Y,Su M,Chen J,Geng L,Xu W,Gong S

    更新日期:2020-06-30 00:00:00

  • Comparison of behaviour in different liquids and in cells of gold nanorods and spherical nanoparticles modified by linear polyethyleneimine and bovine serum albumin.

    abstract::Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comp...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/908175

    authors: Pyshnaya IA,Razum KV,Poletaeva JE,Pyshnyi DV,Zenkova MA,Ryabchikova EI

    更新日期:2014-01-01 00:00:00

  • miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/β-Catenin Signaling.

    abstract::Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2021/4051504

    authors: Zhang YH,Chen AL,Yu RQ,Jia BB,Ye DN,Wang M,Mei YZ,Fang GD,Jiang SY,Zhou Q,Zhang B

    更新日期:2021-01-05 00:00:00

  • Enhancing Ecoefficiency in Shrimp Farming through Interconnected Ponds.

    abstract::The future development of shrimp farming needs to improve its ecoefficiency. The purpose of this study was to evaluate water quality, flows, and nitrogen balance and production parameters on a farm with interconnected pond design to improve the efficiency of the semi-intensive culture of Litopenaeus vannamei ponds. Th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/873748

    authors: Barraza-Guardado RH,Arreola-Lizárraga JA,Miranda-Baeza A,Juárez-García M,Juvera-Hoyos A,Casillas-Hernández R

    更新日期:2015-01-01 00:00:00

  • Impact of MRSA Transmission and Infection in a Neonatal Intensive Care Unit in China: A Bundle Intervention Study during 2014-2017.

    abstract::Objective. To evaluate the efficacy of bundle intervention on healthcare-associated (HA) methicillin-resistant Staphylococcus Aureus (MRSA) infection in the neonatal intensive care unit (NICU). Methods. In this study, 11,277 infants having undergone treatment at the NICU in Xiamen, China, from January 2014 to February...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5490413

    authors: Huang H,Ran J,Yang J,Li P,Zhuang G

    更新日期:2019-07-10 00:00:00

  • Detoxification Assays of Tunisian Tannery Wastewater under Nonsterile Conditions Using the Filamentous Fungus Aspergillus niger.

    abstract::The ability of Aspergillus niger strain to reduce organic and mineral pollution as well as the toxicity of two tannery wastewaters, the unhairing effluent (UE) and the final effluent (FE), taken from a local Tunisian tannery and under nonsterile conditions, was studied. Raw effluents show alkaline pH ≥11; thus experim...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9020178

    authors: Boujelben R,Ellouze M,Sayadi S

    更新日期:2019-06-03 00:00:00

  • Multiparametric MRI for localized prostate cancer: lesion detection and staging.

    abstract::Multiparametric MRI of the prostate combines high-resolution anatomic imaging with functional imaging of alterations in normal tissue caused by neoplastic transformation for the identification and characterization of in situ prostate cancer. Lesion detection relies on a systematic approach to the analysis of both anat...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/684127

    authors: Margolis DJ

    更新日期:2014-01-01 00:00:00

  • Multidrug-resistant Staphylococcus aureus Colonization in Healthy Adults Is more Common in Bhutanese Refugees in Nepal than Those Resettled in Ohio.

    abstract::Although studies have shown that human migration is one of the risk factors for the spread of drug-resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA), surveillance studies examining MRSA among refugee populations in the US are lacking. This study aimed to assess the prevalence and molecular...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5739247

    authors: Kadariya J,Thapaliya D,Bhatta S,Mahatara RL,Bempah S,Dhakal N,Smith TC

    更新日期:2019-07-01 00:00:00

  • Pulsed Electromagnetic Field Inhibits Synovitis via Enhancing the Efferocytosis of Macrophages.

    abstract::Synovitis plays an important role in the pathogenesis of arthritis, which is closely related to the joint swell and pain of patients. The purpose of this study was to investigate the anti-inflammatory effects of pulsed electromagnetic fields (PEMF) on synovitis and its underlying mechanisms. Destabilization of the med...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4307385

    authors: Ouyang J,Zhang B,Kuang L,Yang P,Du X,Qi H,Su N,Jin M,Yang J,Xie Y,Tan Q,Chen H,Chen S,Jiang W,Liu M,Luo X,He M,Ni Z,Chen L

    更新日期:2020-05-26 00:00:00

  • Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents.

    abstract:Objective:Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods:In this retrospe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8052143

    authors: Zhao Q,Zhang M,Chu Y,Ji B,Pan H,Sun H,Ban B

    更新日期:2020-08-13 00:00:00