Abstract:
:Toll-like receptors (TLRs) play a key role in the innate immune response to numerous pathogens, including Acanthamoeba spp. The aim of this study was to determine the expression of TLR2 and TLR4 in the eyes of mice following intranasal infection with Acanthamoeba spp. in relation to the host's immunological status. Amoebae used in this study were isolated from the bronchial aspirate of a patient with acute myeloid leukemia (AML) and atypical symptoms of pneumonia. We found statistically significant differences in the expression of TLR2 and TLR4 in the eye of immunocompetent mice at 8, 16, and 24 days after Acanthamoeba spp. infection (dpi) compared to control group. Immunosuppressed mice showed significant differences in the expression of TLR2 at 16 and 24 dpi compared to uninfected animals. Our results indicate that TLR2 and TLR4 are upregulated in the eyes of mice in response to Acanthamoeba spp. We suggest that it is possible for trophozoites to migrate through the optic nerve from the brain to the eyes. The course of disseminated acanthamoebiasis may be influenced by the host's immunological status, and the observed changes in expression of TLR2 and TLR4 in the host's organs may indicate the role of these receptors in the pathomechanism of acanthamoebiasis.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Kot K,Kosik-Bogacka D,Łanocha-Arendarczyk N,Wojtkowiak-Giera A,Kolasa-Wołosiuk Adoi
10.1155/2019/1401894subject
Has Abstractpub_date
2019-06-12 00:00:00pages
1401894eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章abstract::This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM). Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study. The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-14...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1575468
更新日期:2019-12-14 00:00:00
abstract::The objective of this study was to investigate the effects of selective inducible nitric oxide synthase and neuronal nitric oxide synthase inhibitors on cartilage regeneration. The study involved 27 Wistar rats that were divided into five groups. On Day 1, both knees of 3 rats were resected and placed in a formalin so...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7857345
更新日期:2016-01-01 00:00:00
abstract::Viral infections result in millions of deaths in the world today. A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies. In this study, we presented a landscape of virus-host interactomes based on protein domain interaction. Compared to the analysis at protei...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/867235
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abstract::Immunomodulatory agents have been proposed as therapeutic candidates to improve outcomes in sepsis. Transferon™, a dialyzable leukocyte extract (DLE), has been supported in Mexico as an immunomodulatory adjuvant in anti-infectious therapy. Here we present a retrospective study describing the experience of a referral p...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8980506
更新日期:2019-06-23 00:00:00
abstract::The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC si...
journal_title:BioMed research international
pub_type: 杂志文章
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abstract::This study introduced a combined computational fluid dynamics (CFD) and echocardiography methodology to simulate blood flow in the single right ventricle (SRV) and normal ventricles to study the intraventricular flow. Derived from echocardiographic image loops, CFD-based three-dimensional (3D) flow models of normal su...
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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更新日期:2019-02-12 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/850316
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9192575
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8582901
更新日期:2018-05-02 00:00:00
abstract::India is highly endemic to malaria with prevalence of all five species of human malaria parasites of Plasmodium genus. India is set for malaria elimination by 2030. Since cases of mixed Plasmodium species infections remain usually undetected but cause huge disease burden, in order to understand the distributional prev...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2847548
更新日期:2017-01-01 00:00:00
abstract:Background and Aims:The value of hepatocyte regeneration in predicting the outcomes of hepatitis B-related acute-on-chronic liver failure (HBV-ACLF) is not fully assessed. The present study was aimed at establishing a novel scoring system to predict patients' outcomes within 3 months by applying serological indicators ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5062873
更新日期:2020-08-06 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2350482
更新日期:2017-01-01 00:00:00
abstract::A prospective nonrandomized controlled study was conducted to explore the association between ocular dominance and degree of myopia in patients with anisometropia and to investigate the character of visual evoked potential (VEP) in high anisometropias. 1771 young myopia cases including 790 anisometropias were recruite...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5064892
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7617148
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Although expression of miR-200s is aberrant in liver fibrosis, its role in liver fibrogenesis still remains unknown. Here, we investigated the role of miR-200c in the activation of human hepatic stellate cells (HSCs) and induction of liver fibrosis. METHODS:We engineered human HSCs (LX2 cell line) to stably...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2670658
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to investigate the impact of polishing methods on the bonding effectiveness and durability of different resin cements to dentin. The dentin surfaces were either treated with a fine-grit diamond bur (polishing A) or further polished by polishing disks (polishing B), and then they were bond...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9189354
更新日期:2018-02-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/420380
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3860743
更新日期:2018-01-30 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/673018
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4345205
更新日期:2017-01-01 00:00:00
abstract::Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg bod...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8428304
更新日期:2019-12-03 00:00:00
abstract::Background. There has been a decline in emphasis of the value of physical examination in heart failure (HF) with increased reliance on cardiac imaging. We aim to study the clinical and prognostic significance of positive hepatojugular reflux (HJR) on discharge in patients hospitalized with HF. Methods. Using the ESCAP...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5734749
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1097149
更新日期:2019-11-06 00:00:00
abstract::Targeted drug delivery using folate receptors is one of the most interesting chemotherapeutic research areas over the past few years. A novel folate targeted copolymer was synthesized using dextran stearate coupled to folic acid. FT-IR and NMR spectroscopy were used to confirm successful conjugation. Micelles prepared...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/708593
更新日期:2014-01-01 00:00:00
abstract::High-dose melphalan (200 mg/m(2)) as conditioning regimen followed by autologous stem cell transplantation (ASCT) rescue has been established as a standard treatment for patients with multiple myeloma (MM) younger than 65 years of age. However, the role of ASCT in elderly patients older than 65 years remains controver...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/394792
更新日期:2014-01-01 00:00:00
abstract::Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, n = 9) and lo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/169841
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/508342
更新日期:2015-01-01 00:00:00