Abstract:
:Deep venous thrombosis (DVT) constitutes a great threat to health worldwide. Endothelial cell injury and dysfunction comprise the critical contributor for the development of DVT. However, the mechanism behind it remains poorly elucidated. The study is aimed at investigating the role of microRNA-122 (miR-122) and oxidative stress on DVT. The results showed that miR-122 overexpression dampened H2O2-evoked cytotoxic injury in human umbilical vein endothelial cells (HUVECs) by increasing cell viability, suppressing cell apoptosis and oxidative stress injury. Notably, miR-122 overexpression attenuated provasoconstriction factor endothelin-1 (ET-1) expression in HUVECs exposed to H2O2 but enhanced the productions of vasodilatation factor Prostaglandin F1α (PGF1α). Moreover, inhibition of miR-122 had the opposite results. miR-122 could inhibit the expression of p53. Low expression of p53 could enhance the protection of miR-122 on HUVEC injury. This study highlights that miR-122 overexpression may restore H2O2-induced HUVEC injury by regulating the expression of p53.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Li HQ,Pan ZY,Yang Z,Zhang DB,Chen Qdoi
10.1155/2020/9791608subject
Has Abstractpub_date
2020-10-27 00:00:00pages
9791608eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5'-hydroxy auraptene (5'-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteobla...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9395146
更新日期:2019-12-28 00:00:00
abstract::Background. Surgical correction of mitral regurgitation (MR) can lead to postoperative low cardiac output state. We aimed to assess the acute hemodynamic changes after percutaneous MitraClip therapy (a unique model without influence of factors linked to surgical procedure) in patients with functional MR without the in...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/6296972
更新日期:2016-01-01 00:00:00
abstract:Objective:Mounting evidence has elaborated the implication of long noncoding RNAs (lncRNAs) in tumorigenesis of several cancers, including glioma. However, little was known about the mechanism of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of glioma. This work is designed to explore the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4309161
更新日期:2020-01-11 00:00:00
abstract::It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/283429
更新日期:2013-01-01 00:00:00
abstract::Effective alteration of the recalcitrance properties like crystallization of cellulose, lignin shield, and interlinking of lignocellulosic biomass is an ideal way to utilize the full-scale potential for biofuel production. This study exhibited three different pretreatment effects to enhance the digestibility of corn s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2786598
更新日期:2016-01-01 00:00:00
abstract::Blocking glioma cell invasion has been challenging due to cancer cells that can swiftly switch their migration mode, and agents that can block more than one migration mode are sought after. We found that small molecule 2-(1H-indole-3-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE), an endogenous aryl hydrocarb...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2616930
更新日期:2020-10-03 00:00:00
abstract::Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of 99Tc-MDP is unclear. We systematically investigated the effects of 99Tc-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7902760
更新日期:2018-10-14 00:00:00
abstract::Toll-like receptors (TLRs) play a key role in the innate immune response to numerous pathogens, including Acanthamoeba spp. The aim of this study was to determine the expression of TLR2 and TLR4 in the eyes of mice following intranasal infection with Acanthamoeba spp. in relation to the host's immunological status. Am...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1401894
更新日期:2019-06-12 00:00:00
abstract::Patients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve reg...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/949624
更新日期:2015-01-01 00:00:00
abstract::Aging is the principal risk factor for the development of Alzheimer's disease (AD). The hallmarks of AD are accumulation of the amyloid-β peptide 1-42 (Aβ42) and abnormal hyperphosphorylation of Tau (p-Tau) protein in different areas of the brain and, more recently reported, in the visual cortex. Recently, Aβ42 peptid...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3706018
更新日期:2017-01-01 00:00:00
abstract::As a major tumor suppressor gene, the role of PinX1 in breast cancer and its molecular mechanism remain unclear. In this study, overexpression of PinX1 was generated in 3 breast cancer cell lines, and knockdown of PinX1 was performed in a nontumorigenic breast cell line. The regulation of PinX1 on cell proliferation a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/978984
更新日期:2014-01-01 00:00:00
abstract::The anaerobic batch test (45 days at 37°C) was performed to describe the effect of thermal pretreatment at moderate temperatures (60, 80, and 100°C) over durations of 10 and 20 minutes on the enhancement of biogas production using hotel food waste from city of Jaipur, India. The results showed that the total cumulativ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9416249
更新日期:2018-09-16 00:00:00
abstract:Purpose:To detect the responsiveness and predictive ability of the Chinese version Action Research Arm Test (C-ARAT) in participants within the first 3 months after cerebral infarction. Methods:Ninety-seven individuals (75 men, mean age 59.87 ± 10.94 years) with a first cerebral infarction were enrolled in this study....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8270187
更新日期:2019-10-07 00:00:00
abstract::The 13 million nurses worldwide constitute most of the global healthcare workforce and are uniquely positioned to engage with others to address disparities in healthcare to achieve the goal of better health for all. A new vision for nurses involves active participation and collaboration with international colleagues a...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3127543
更新日期:2016-01-01 00:00:00
abstract::Microbial strain optimisation for the overproduction of a desired phenotype has been a popular topic in recent years. Gene knockout is a genetic engineering technique that can modify the metabolism of microbial cells to obtain desirable phenotypes. Optimisation algorithms have been developed to identify the effects of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/124537
更新日期:2015-01-01 00:00:00
abstract::This study examines the isoform-specific effects of short-term hindlimb suspension (HS) on the Na,K-ATPase in rat soleus muscle. Rats were exposed to 24-72 h of HS and we analyzed the consequences on soleus muscle mass and contractile parameters; excitability and the resting membrane potential (RMP) of muscle fibers; ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/720172
更新日期:2015-01-01 00:00:00
abstract::Bone marrow-derived mesenchymal stem cells (BM-MSCs) represent a modern approach for management of chronic skin injuries. In this work, we describe BM-MSCs application versus their conditioned media (CM) when delivered topically admixed with fibrin glue to enhance the healing of chronic excisional wounds in rats. Fift...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/846062
更新日期:2015-01-01 00:00:00
abstract::Tumourigenesis is a mutation accumulation process, which is likely to start with a mutated founder cell. The evolutionary nature of tumor development makes phylogenetic models suitable for inferring tumor evolution through genetic variation data. Copy number variation (CNV) is the major genetic marker of the genome wi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5482750
更新日期:2017-01-01 00:00:00
abstract::Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/615312
更新日期:2014-01-01 00:00:00
abstract:Objective:To explore multiscale integrated analysis methods in identifying key regulators of esophageal cancer (ESCA). Methods:We downloaded the ESCA dataset from The Cancer Genome Atlas (TCGA) database, which contained RNA-seq data, miRNA-seq data, methylation data, and clinical phenotype information. Then, we combin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5603958
更新日期:2020-08-12 00:00:00
abstract::Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb, i.e., the aetiological agent); the WHO has established this disease as high priority due to its ensuing mortality. Mtb uses a range of mechanisms for preventing its elimination by an infected host; new, viable alternatives for blocking th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8680935
更新日期:2019-04-14 00:00:00
abstract::Objective. Our objective is to develop a computerized scheme for liver tumor segmentation in MR images. Materials and Methods. Our proposed scheme consists of four main stages. Firstly, the region of interest (ROI) image which contains the liver tumor region in the T1-weighted MR image series was extracted by using se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3219068
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Macrosomia has become a worldwide problem with the rapid economic growth in the past few years. However, the detailed mechanism of how the macrosomia happened remains unknown. Growing evidence indicates that miRNAs are involved in maintaining metabolic homeostasis. We hypothesized that serum miRNAs are poten...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/394125
更新日期:2014-01-01 00:00:00
abstract::Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2957941
更新日期:2017-01-01 00:00:00
abstract::Energy dispersive X-ray spectroscopy microanalysis (EDX), scanning electron microscopy (SEM), and Archimedes' Principle were used to determine the characteristics of inorganic filler particles in five dental alginates, including Cavex ColorChange (C), Hydrogum 5 (H5), Hydrogum (H), Orthoprint (O), and Jeltrate Plus (J...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/178064
更新日期:2014-01-01 00:00:00
abstract::Little is known about the clinical value of the Hadlock and INTERGROWTH-21st EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and the risk of APOs and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7698038
更新日期:2019-01-09 00:00:00
abstract::Integrin αIIbβ3 plays a crucial role in the process of platelet aggregation. Three integrin αIIbβ3 antagonists (abciximab, eptifibatide, and tirofiban) have been approved by FDA for clinical use. Unfortunately, they all showed severe side effects such as thrombocytopenia and bleeding risk. Thus, researches on the deve...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8587164
更新日期:2016-01-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Salivary mic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9792730
更新日期:2018-11-21 00:00:00
abstract::Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, n = 9) and lo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/169841
更新日期:2015-01-01 00:00:00
abstract:Introduction:To investigate the clinical results of arthroscopic management for the unstable inferior leaf of the lateral meniscus anterior horn and associated cysts through an inframeniscal portal. Methods:From March 2005 to October 2014, 64 patients with an unstable inferior leaf of the lateral meniscus anterior hor...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9264907
更新日期:2017-01-01 00:00:00