Immunomodulatory effect of continuous venovenous hemofiltration during sepsis: preliminary data.

Abstract:

INTRODUCTION:Severe sepsis and septic shock are the primary causes of multiple organ dysfunction syndrome (MODS), which is the most frequent cause of death in intensive care unit patients. Many pro- and anti-inflammatory mediators, such as interleukin-6 (IL-6), play a strategic role in septic syndrome. Continuous renal replacement therapy (CRRT) removes in a nonselective way pro- and anti-inflammatory mediators. OBJECTIVE:To investigate the effects of continuous venovenous hemofiltration (CVVH) as an immunomodulatory treatment of sepsis in a prospective clinical study. METHODS:High flux hemofiltration (Qf = 60 ml/Kg/hr) was performed for 72 hr in thirteen critically ill patients suffering from severe sepsis or septic shock with acute renal failure (ARF). IL-6 gene expression was measured by real-time PCR analysis on RNA extracted from peripheral blood mononuclear cell before beginning of treatment (T0) and after 12, 24, 48, and 72 hours (T1-4). RESULTS:Real-time PCR analysis demonstrated in twelve patients IL-6 mRNA reduction after 12 hours of treatment and a progressive increase after 24, 48, and 72 hours. CONCLUSIONS:We suggest that an immunomodulatory effect might exist during CVVH performed in critically ill patients with severe sepsis and septic shock. Our data show that the transcriptional activity of IL-6 increases during CVVH.

journal_name

Biomed Res Int

authors

Servillo G,Vargas M,Pastore A,Procino A,Iannuzzi M,Capuano A,Memoli A,Riccio E,Memoli B

doi

10.1155/2013/108951

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

108951

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

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