Abstract:
:The aim of our study was to monitor serum levels of two miRNAs (miR-21 and miR-141) and three KLKs (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy, in order to characterize their fluctuations after surgery. 38 patients with prostate cancer were included. miR-21 and miR-141 were quantified through real-time PCR, while ELISA assays were used to quantify hK3 (PSA), hK11, and hK13. Both miR-21 and miR-141 showed a significant increase at the 5th postoperative day, after which a gradual return to the preoperative levels was recorded. These findings suggest that miR-21 and miR-141 could be involved in postsurgical inflammatory processes and that radical prostatectomy does not seem to alter their circulating levels. Postoperative serum kallikreins showed a significant decrease, highlighting the potential usefulness of kallikreins apart from PSA as potential prostate cancer markers.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Egidi MG,Cochetti G,Serva MR,Guelfi G,Zampini D,Mechelli L,Mearini Edoi
10.1155/2013/241780subject
Has Abstractpub_date
2013-01-01 00:00:00pages
241780eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::In esophageal squamous cell carcinoma, an elevated preoperative absolute monocyte count (Pre-AMC) is reported to be a predictor of survival, but the clinical application of postoperative absolute monocyte count change (AMCc) remains unknown. The present study was designed to investigate the prognostic value of AMCc in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2702719
更新日期:2019-08-14 00:00:00
abstract::Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase sub...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4935386
更新日期:2020-02-12 00:00:00
abstract::Nitric oxide (NO) has a wide variety of physiological functions in the kidney. Besides the regulatory effects in intrarenal haemodynamics and glomerular microcirculation, in vivo studies reported the diuretic and natriuretic effects of NO. However, opposite results showing the stimulatory effect of NO on Na+ reabsorpt...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/6871081
更新日期:2017-01-01 00:00:00
abstract::Background. Surgical correction of mitral regurgitation (MR) can lead to postoperative low cardiac output state. We aimed to assess the acute hemodynamic changes after percutaneous MitraClip therapy (a unique model without influence of factors linked to surgical procedure) in patients with functional MR without the in...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/6296972
更新日期:2016-01-01 00:00:00
abstract::This study aimed to evaluate the genes that were expressed in the healing bones around SLA-treated titanium orthodontic mini-implants in a beagle at early (1-week) and late (4-week) stages with RNA-sequencing (RNA-Seq). Samples from sites of surgical defects were used as controls. Total RNA was extracted from the tiss...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/538080
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:The aim of this study was to evaluate the relation between the sensory and anthropometric variables in the quiet standing. METHODS:One hundred individuals (50 men, 50 women; 20-40 years old) participated in this study. For all participants, the body composition (fat tissue, lean mass, bone mineral content, ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/985312
更新日期:2015-01-01 00:00:00
abstract::Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long h...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/9620870
更新日期:2017-01-01 00:00:00
abstract::Nickel-titanium (NiTi) rotary files have enabled efficient root canal preparations that maintain the canal center with fewer aberrations compared to hand files. However, NiTi rotary files are susceptible to fracture, which can thereby compromise root canal treatment. Therefore, NiTi files have been developed to enhanc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6368958
更新日期:2019-11-07 00:00:00
abstract:Background and Aims:Contrast-induced nephropathy (CIN) is a relatively infrequent complication after percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). However, little is known about the association between cytochrome c (cyt c) and increased risk of CIN. We conducted t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9357203
更新日期:2019-01-23 00:00:00
abstract::Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can b...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/6104738
更新日期:2019-01-29 00:00:00
abstract::The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P. hysterophorus leaf. Dried leaf samples were sequentially extracted with nonpolar and polar solvents. Ethanol fraction showed noticeable cytotoxic activity (81-85%) in SRB assay against MCF-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/810734
更新日期:2013-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal condition primarily characterized by the selective loss of upper and lower motor neurons. At present, the diagnosis and monitoring of ALS is based on clinical examination, electrophysiological findings, medical history, and exclusion of confounding disorders. There is the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/525097
更新日期:2014-01-01 00:00:00
abstract::The use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry criteria of probe dr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/857327
更新日期:2015-01-01 00:00:00
abstract::Early Infantile Epileptic Encephalopathy (known as Ohtahara Syndrome) is one of the most severe and earliest forms of epilepsy, characterized by early seizures onset. It affects newborns and children between two and six years old. Among the genes that have been associated with early infantile epileptic encephalopathy,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4872101
更新日期:2019-12-17 00:00:00
abstract:Background and Aim:ROHHADNET (rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, neuroendocrine tumor) syndrome is a rare disease with grave outcome. Although early recognition is essential, prompt diagnosis may be challenging due to its extreme rarity. This study aimed to systematically r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1250721
更新日期:2018-11-21 00:00:00
abstract::The hepatoprotective and antioxidant activity of Bauhinia hookeri ethanol extract (BHE) against CCl4-induced liver injury was investigated in mice. BHE was administered (500 and 1000 mg/kg/day) along with CCl4 for 6 weeks. The hepatic marker enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/245171
更新日期:2014-01-01 00:00:00
abstract::Hyaluronic acid (HA), a macropolysaccharidic component of the extracellular matrix, is common to most species and it is found in many sites of the human body, including skin and soft tissue. Not only does HA play a variety of roles in physiologic and in pathologic events, but it also has been extensively employed in c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/921549
更新日期:2014-01-01 00:00:00
abstract::Numerous studies have shown that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of human cardiovascular diseases. However, whether lncRNA ezrin antisense RNA 1 (EZR-AS1) is associated with the progression of coronary heart disease (CHD) remains unclear. Accordingly, the aim of th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6840234
更新日期:2020-05-22 00:00:00
abstract::Feed efficiency (FE) is an important trait affecting costs in swine industry. Investigation on FE-related genes in different tissues is valuable for molecular breeding. Hypothalamus is a convergent and integrated centre for multiple nutrient-related signals. The present study identified 363 differentially expressed (D...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5862571
更新日期:2018-12-26 00:00:00
abstract:Background:Left ventricular (LV) systolic dysfunction is common in septic shock. Global longitudinal strain (GLS) measured by speckle tracking echocardiography (STE) is a useful marker of intrinsic left ventricular systolic function. However, the association between left ventricular GLS and outcome in septic patients i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7927353
更新日期:2020-10-21 00:00:00
abstract::Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2957941
更新日期:2017-01-01 00:00:00
abstract::Myostatin, a TGF-β family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Mu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/129048
更新日期:2014-01-01 00:00:00
abstract:Introduction:We investigated the proportion of myeloid-derived suppressor cells (MDSCs) and their subsets in patients with rheumatic diseases and clarified the association between these cells and the patient clinical data. Methods:Patients with rheumatic diseases and healthy controls were recruited. The clinical chara...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5474828
更新日期:2018-06-26 00:00:00
abstract::Alzheimer's disease (AD) and multiple sclerosis are major neurodegenerative diseases, which are characterized by the accumulation of abnormal pathogenic proteins due to oxidative stress, mitochondrial dysfunction, impaired autophagy, and pathogens, leading to neurodegeneration and behavioral deficits. Herein, we revie...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1483791
更新日期:2018-07-12 00:00:00
abstract::Microbial strain optimisation for the overproduction of a desired phenotype has been a popular topic in recent years. Gene knockout is a genetic engineering technique that can modify the metabolism of microbial cells to obtain desirable phenotypes. Optimisation algorithms have been developed to identify the effects of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/124537
更新日期:2015-01-01 00:00:00
abstract:Background:Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectab...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6278403
更新日期:2018-08-27 00:00:00
abstract:Objective:We identified differentially expressed microRNAs (DEMs) between esophageal carcinoma (ESCA) tissues and normal esophageal tissues. We then constructed a novel three-miRNA signature to predict the prognosis of ESCA patients using bioinformatics analysis. Materials and Methods. We combined two microarray profil...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5973082
更新日期:2020-02-10 00:00:00
abstract::Type 1 diabetes (T1D), a chronic autoimmune disease, is often preceded by a preclinical phase of islet autoimmunity (IA) where the insulin-producing beta cells of the pancreas are destroyed and circulating autoantibodies can be detected. The goal of this study was to demonstrate methods for identifying exposures that ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2015/708289
更新日期:2015-01-01 00:00:00
abstract::Antibiotics are among the most counterfeited anti-infectious medicines in developing countries. Amoxicillin is one of the commonly prescribed, affordable, and easily accessible antibiotic in Kenya. It is a broad-spectrum antibiotic hence commonly used in chemotherapy. This study sought to determine the quality and ide...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7091278
更新日期:2020-06-12 00:00:00
abstract:Background:Reduced baroreflex sensitivity (BRS) has been reported in patients with acute cardiovascular events. We tested the hypothesis that BRS varies in different subtypes of acute ischemic stroke (AIS) and that BRS is a predictor of clinical outcomes. Methods:We examined autonomic parameters in 34 patients with AI...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7614828
更新日期:2019-04-18 00:00:00