Abstract:
:Hyaluronic acid (HA), a macropolysaccharidic component of the extracellular matrix, is common to most species and it is found in many sites of the human body, including skin and soft tissue. Not only does HA play a variety of roles in physiologic and in pathologic events, but it also has been extensively employed in cosmetic and skin-care products as drug delivery agent or for several biomedical applications. The most important limitations of HA are due to its short half-life and quick degradation in vivo and its consequently poor bioavailability. In the aim to overcome these difficulties, HA is generally subjected to several chemical changes. In this paper we obtained an acetylated form of HA with increased bioavailability with respect to the HA free form. Furthermore, an improved radical scavenging and anti-inflammatory activity has been evidenced, respectively, on ABTS radical cation and murine monocyte/macrophage cell lines (J774.A1).
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Saturnino C,Sinicropi MS,Parisi OI,Iacopetta D,Popolo A,Marzocco S,Autore G,Caruso A,Cappello AR,Longo P,Puoci Fdoi
10.1155/2014/921549subject
Has Abstractpub_date
2014-01-01 00:00:00pages
921549eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::This paper represents data of long-term open prospective study. 312 male clean-up workers, who participated in elimination of the Chernobyl disaster consequences in 1986-87, were observed and examined in Moscow Research Institute of Psychiatry. The average age of patients was 57,0 ± 6,8 years. All patients were diagno...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/948473
更新日期:2015-01-01 00:00:00
abstract::Embryology of normal web space creation and the genetics of syndactyly in humans and experimental animals are well described in the literature. In this review, the author offers a 3-step pathway of pathogenesis for syndactyly. The first step is initiated either by the overactivation of the WNT canonical pathway or the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9652649
更新日期:2019-09-15 00:00:00
abstract::Recent studies suggest that nucleotide-binding domain leucine-rich repeat protein 1 (NLRP1) is a pivotal factor in the inflammatory process. However, the role of NLRP1 in breast cancer pathogenesis remains unclear. The aim of this study was to examine the expression and function of NLRP1 in breast cancer. We found tha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4938473
更新日期:2017-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2019/5879089.]. ...
journal_title:BioMed research international
pub_type: 撤回出版物
doi:10.1155/2020/5014928
更新日期:2020-08-26 00:00:00
abstract::Background and Purposes. The 320-detector row CT scanner enables visualization of whole-brain hemodynamic information (dynamic CT angiography (CTA) derived from CT perfusion scans). However, arterial image quality in dynamic CTA (dCTA) is inferior to arterial image quality in standard CTA. This study evaluates whether...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/603173
更新日期:2014-01-01 00:00:00
abstract::Pediatric myelodysplastic syndrome (MDS) is an uncommon disease and little is known about the molecular alterations of its development and evolution to acute myeloid leukemia (AML). The Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PCR2). It is a histone methyltransferas...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/3176565
更新日期:2019-12-10 00:00:00
abstract::The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0.5% 4-nitroquinoline-1-oxide (4-NQO) in propylene glycol to tongue, thrice a week for 8 weeks. From 8th to 22nd week, cisplatin (0.23 mg/kg, i.v.) was administere...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/642848
更新日期:2013-01-01 00:00:00
abstract::Stem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the formation of new cardiomyocytes within the injured myocardium has not been co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/7874109
更新日期:2020-03-03 00:00:00
abstract:OBJECTIVE:Firstly, to, through instrumentation with the iPhone4 smartphone, measure and describe variability of tridimensional acceleration, angular velocity, and displacement of the trunk in the turn transition during the ten-meter Extended Timed-Get-up-and-Go test in two groups of frail and physically active elderly ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/279197
更新日期:2013-01-01 00:00:00
abstract::There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma sam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9807918
更新日期:2020-09-02 00:00:00
abstract::A series of halo-substituted mixed ester/amide-based analogues 4a-l have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8867407
更新日期:2020-12-24 00:00:00
abstract::The Toll-Like receptor 4 (TLR4) plays an important role in immunity, tissue repair, and regeneration. The objective of the present work was to evaluate the association of TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/318686
更新日期:2013-01-01 00:00:00
abstract::We evaluated single nucleotide polymorphism (SNP) detection via a target-capture, C-probe ligation, and RAM assay in a single-blind comparison to clinical samples that had been tested with FDA-cleared tests for up to 4 different vascular disease-related SNPs. In the RAM assay circulizable linear probes (C- or padlock ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/641090
更新日期:2014-01-01 00:00:00
abstract::Remote organ impairments are frequent and increase patient morbidity and mortality after lower limb ischemia-reperfusion (IR). We challenged the hypothesis that lower limb IR might also impair lung, renal, and liver mitochondrial respiration. Two-hour tourniquet-induced ischemia was performed on both hindlimbs, follow...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/392390
更新日期:2014-01-01 00:00:00
abstract::Alzheimer's disease (AD) and multiple sclerosis are major neurodegenerative diseases, which are characterized by the accumulation of abnormal pathogenic proteins due to oxidative stress, mitochondrial dysfunction, impaired autophagy, and pathogens, leading to neurodegeneration and behavioral deficits. Herein, we revie...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1483791
更新日期:2018-07-12 00:00:00
abstract:Objective:Mounting evidence has elaborated the implication of long noncoding RNAs (lncRNAs) in tumorigenesis of several cancers, including glioma. However, little was known about the mechanism of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of glioma. This work is designed to explore the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4309161
更新日期:2020-01-11 00:00:00
abstract::[This corrects the article DOI: 10.1155/2013/783690.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2016/8693826
更新日期:2016-01-01 00:00:00
abstract::This study was aimed to evaluate the in vitro lethal activity of the nematophagous fungi Clonostachys rosea against 5 nematodes species belonging to different taxa. Two groups of 35 Petri dishes (PD) each were divided into 5 series of 7 (PD). Group 1 (series 1, 2, 3, 4, and 5) contained only water agar; meanwhile grou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3501827
更新日期:2018-03-20 00:00:00
abstract::Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8798546
更新日期:2017-01-01 00:00:00
abstract::(124)Iodine ((124)I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of (124)I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecul...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/672094
更新日期:2014-01-01 00:00:00
abstract::Cellulase from Aspergillus niger was immobilized onto β-cyclodextrin-conjugated magnetic particles by silanization and reductive amidation. The immobilized cellulase gained supermagnetism due to the magnetic nanoparticles. Ninety percent of cellulase was immobilized, but the activity of immobilized cellulase decreased...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/409103
更新日期:2015-01-01 00:00:00
abstract::A series of amides derived from vanillic acid were obtained by coupling reactions using PyBOP ((Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate) and DCC (Dicyclohexylcarbodiimide) coupling reagents. These were submitted to biological evaluation for species of Candida, Staphylococcus, and Pseudomonas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9209676
更新日期:2019-04-15 00:00:00
abstract::Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing t...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/818107
更新日期:2014-01-01 00:00:00
abstract::To evaluate the role of Cystatin C (Cys-C) in tumorigenesis and progression of prostate cancer (PCa), we retrospectively collected the clinical information from the records of 492 benign prostatic hyperplasia (BPH), 48 prostatic intraepithelial neoplasia (PIN), and 173 PCa patients, whose disease was newly diagnosed a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7450459
更新日期:2017-01-01 00:00:00
abstract::Inflammatory bowel disease (IBD), one kind of intestinal chronic inflammatory disease, is characterized by colonic epithelial barrier injury, overproduction of proinflammatory cytokines, and fewer short-chain fatty acids (SCFAs). The present study is aimed at testing the hypothesis that resistant maltodextrin (RM), a ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7694734
更新日期:2020-09-16 00:00:00
abstract:PURPOSE:Suppressor of cytokine signaling 7 (SOCS7) is a member of the SOCS family and is known to interact with phospholipase Cγ-1 (PLCγ-1), a key downstream mediator of the hepatocyte growth factor (HGF)/C-MET axis. Here, we report our observations of the effect of knocking down SOCS7 gene on the behaviour of breast c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/648040
更新日期:2014-01-01 00:00:00
abstract::Background. With the introduction of three-dimensional (3D) ultrasound it has become possible to measure volumes. The relative increase in embryonic volume (EV) is much larger than that of the crown-rump length (CRL) over the same time period. We examined whether EV is a better parameter to determine growth restrictio...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/1953076
更新日期:2017-01-01 00:00:00
abstract::Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltrati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1267038
更新日期:2018-10-08 00:00:00
abstract::Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions and molecular mechanisms in ovarian cancer remain unclear. In this study, we found that TNKS was aberrantly overexpressed in human ovarian cancer ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2686340
更新日期:2019-02-20 00:00:00
abstract::To compare the clinical efficacy and radiological outcome of treating 4-level cervical spondylotic myelopathy (CSM) with either anterior cervical discectomy and fusion (ACDF) or "skip" corpectomy and fusion, 48 patients with 4-level CSM who had undergone ACDF or SCF at our hospital were analyzed retrospectively betwee...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/513906
更新日期:2015-01-01 00:00:00