Abstract:
:Alzheimer's disease (AD) and multiple sclerosis are major neurodegenerative diseases, which are characterized by the accumulation of abnormal pathogenic proteins due to oxidative stress, mitochondrial dysfunction, impaired autophagy, and pathogens, leading to neurodegeneration and behavioral deficits. Herein, we reviewed the utility of plant polyphenols in regulating proliferation and differentiation of stem cells for inducing brain self-repair in AD and multiple sclerosis. Firstly, we discussed the genetic, physiological, and environmental factors involved in the pathophysiology of both the disorders. Next, we reviewed various stem cell therapies available and how they have proved useful in animal models of AD and multiple sclerosis. Lastly, we discussed how polyphenols utilize the potential of stem cells, either complementing their therapeutic effects or stimulating endogenous and exogenous neurogenesis, against these diseases. We suggest that polyphenols could be a potential candidate for stem cell therapy against neurodegenerative disorders.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Tandon A,Singh SJ,Chaturvedi RKdoi
10.1155/2018/1483791subject
Has Abstractpub_date
2018-07-12 00:00:00pages
1483791eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章,评审abstract::Schistosomiasis is the most prevalent tropical disease in the world after malaria. According to the World Health Organization, the disease afflicts more than 240 million people in about 80 countries. Recently, an epidemiological surveillance study performed between 1997 and 2010 by the European Network for Tropical Me...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/8257310
更新日期:2017-01-01 00:00:00
abstract::J-proteins are molecular chaperones and present in a wide variety of organisms from prokaryote to eukaryote. Based on their domain organizations, J-proteins can be classified into 4 types, that is, Type I, Type II, Type III, and Type IV. Different types of J-proteins play distinct roles in influencing cancer propertie...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/935719
更新日期:2014-01-01 00:00:00
abstract::Bacterial nanocellulose (BNC) has demonstrated a tempting prospect for applications in substitute of small blood vessels. However, present technology is inefficient in production and BNC tubes have a layered structure that may bring danger after implanting. Double oxygen-permeable silicone tubes in different diameters...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/560365
更新日期:2015-01-01 00:00:00
abstract::It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium deriva...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/182846
更新日期:2014-01-01 00:00:00
abstract::Calcium phosphate cement (CPC) has good release efficiency and has therefore been used as a drug delivery system for postoperative infection. The release profile of CPC has mainly been evaluated by in vitro studies, which are carried out by immersing test specimens in a relatively large amount of solvent. However, it ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4560647
更新日期:2018-05-15 00:00:00
abstract::Plant-associated bacteria provide important services to host plants. Environmental factors such as cultivar type and pedoclimatic conditions contribute to shape their diversity. However, whether these environmental factors may influence the plant growth promoting (PGP) potential of the root-associated bacteria is not ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/491091
更新日期:2013-01-01 00:00:00
abstract::Gold nanoparticles (AuNPs) have several potential biological applications as well as excellent biocompatibility. AuNPs with surface modification using polyethylene glycol (PEG-AuNPs) can facilitate easy conjugation with various biological molecules of interest. To examine the anticancer bioactivity of PEG-AuNPs, we in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/182353
更新日期:2014-01-01 00:00:00
abstract::Osteocalcin (Ocn) and testosterone play important roles in male skeleton. However, the concentrations of serum osteocalcin and testosterone have never been systematically compared between populations with and without primary male osteoporosis, a common skeletal disorder in adult males. We searched the PubMed, Embase, ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2017/9892048
更新日期:2017-01-01 00:00:00
abstract::To understand the progression of recovery in postural stability and physical functioning after patients received the minimally invasive total hip arthroplasty (MTHA), we monitor the pain level, functional capacity, and postural stability before and after operation within one year. In total of 23 subjects in our study,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/463792
更新日期:2015-01-01 00:00:00
abstract::The neural dysfunction is triggered by cellular and molecular events that provoke neurotoxicity and neural death. Currently, neurodegenerative diseases are increasingly common, and available treatments are focused on relieving symptoms. Based on the above, in this review we describe the participation of vitexin in the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4785089
更新日期:2018-12-05 00:00:00
abstract:Objective:The exact shape of the dose-response relationship between maternal body mass index (BMI) and the risk of congenital heart defects (CHDs) in infants has not been clearly defined yet. This study aims to further clarify the relationship between maternal obesity and the risk of CHDs in infants by an overall and d...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/1315796
更新日期:2019-07-07 00:00:00
abstract:Background:Identification of potential molecular targets of acute myocardial infarction is crucial to our comprehensive understanding of the disease mechanism. However, studies of gene coexpression analysis via jointing multiple microarray data of acute myocardial infarction still remain restricted. Methods:Microarray...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5742608
更新日期:2019-02-11 00:00:00
abstract::Internally symmetric proteins are proteins that have a symmetrical structure in their monomeric single-chain form. Around 10-15% of the protein domains can be regarded as having some sort of internal symmetry. In this regard, we previously published SymD (symmetry detection), an algorithm that determines whether a giv...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4628592
更新日期:2016-01-01 00:00:00
abstract::Previous studies indicated that intracerebroventricular administration of nerve growth factor (NGF) leads to massive Schwann cell hyperplasia surrounding the medulla oblongata and spinal cord. This study was designed to characterize the proliferation of peripheral glial cells, that is, Schwann and satellite cells, in ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/704259
更新日期:2014-01-01 00:00:00
abstract::With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compar...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/408683
更新日期:2014-01-01 00:00:00
abstract:Purpose:Triple-negative breast cancer refers to breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (Her2). This study aimed to identify the key pathways and genes and find the potential initiation and progression mechanism of triple-negati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2760918
更新日期:2018-08-02 00:00:00
abstract::Toll-like receptors (TLRs) play a key role in the innate immune response to numerous pathogens, including Acanthamoeba spp. The aim of this study was to determine the expression of TLR2 and TLR4 in the eyes of mice following intranasal infection with Acanthamoeba spp. in relation to the host's immunological status. Am...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1401894
更新日期:2019-06-12 00:00:00
abstract::Vitamin D is important for normal development and maintenance of the skeleton. Hypovitaminosis D adversely affects calcium metabolism, osteoblastic activity, matrix ossification, bone remodeling and bone density. It is well known that Vit. D deficiency in the developing skeleton is related to rickets, while in adults ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/396541
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Radiopharmaceutical production process must adhere to current good manufacturing process (CGMP) compliance to ensure the quality of precursor, prodrug (active pharmaceutical ingredient, API), and the final drug product that meet acceptance criteria. We aimed to develop an automated system for production of CG...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/680195
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. MATERIAL...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/783967
更新日期:2014-01-01 00:00:00
abstract::Primary ciliary dyskinesia (PCD) is a clinical rare peculiar disorder, mainly featured by respiratory infection, tympanitis, nasosinusitis, and male infertility. Previous study demonstrated it is an autosomal recessive disease and by 2017 almost 40 pathologic genes have been identified. Among them are the leucine-rich...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1854269
更新日期:2018-01-08 00:00:00
abstract::To overcome the issues connected to the use of autologous vascular grafts and artificial materials for reconstruction of small diameter (<6 mm) blood vessels, this study aimed to develop acellular matrix- (AM-) based vascular grafts. Rat iliac arteries were decellularized by a detergent-enzymatic treatment, whereas en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/685426
更新日期:2014-01-01 00:00:00
abstract::Whole body vibration (WBV) has a marked impact on lipid metabolism and the endocrine system, which is related to the progression of atherosclerosis (AS). To investigate the effects of WBV, we measured the atherosclerotic plaque area of apolipoprotein E-knockout (ApoE-/-) AS mice, which were trained by WBV (15 Hz, 30 m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4934861
更新日期:2018-03-07 00:00:00
abstract::The endoscopic and histopathological findings detected in Sparus aurata experimentally infected with third-stage Anisakis larvae without intermediate host are evaluated and discussed. In six fish, live nematode larvae were introduced by gastroscopy into the stomach. The first observation by endoscope, 15 days after ch...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/701828
更新日期:2013-01-01 00:00:00
abstract::Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/236745
更新日期:2015-01-01 00:00:00
abstract::Different animal models for peritoneal dialysis (PD) have been used in the past decades to develop PD fluids compatible with patient life and to identify markers of peritoneal fibrosis and inflammation. Only few of those studies have taken into account the importance of uraemia-induced alterations at both systemic and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/106902
更新日期:2015-01-01 00:00:00
abstract::The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P. hysterophorus leaf. Dried leaf samples were sequentially extracted with nonpolar and polar solvents. Ethanol fraction showed noticeable cytotoxic activity (81-85%) in SRB assay against MCF-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/810734
更新日期:2013-01-01 00:00:00
abstract::Seeking new biomarkers for epithelial ovarian cancer, the fifth most common cause of death from all cancers in women and the leading cause of death from gynaecological malignancies, we performed a meta-analysis of three independent studies and compared the results in regard to clinicopathological parameters. This anal...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2013/238284
更新日期:2013-01-01 00:00:00
abstract::Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentratio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3726029
更新日期:2017-01-01 00:00:00
abstract::GABAergic inhibition and particularly perisomatic inhibition play a crucial role in controlling the firing properties of large principal cell populations. Furthermore, GABAergic network is a key element in the therapy attempting to reduce epileptic activity. Here, we present a review showing the synaptic changes of pe...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7154295
更新日期:2017-01-01 00:00:00