Abstract:
:Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long history of approaches to cancer therapy. In this review, we discuss the history of cancer treatment from generic natural extracts and radical surgical procedures to site-specific and combinatorial treatment regimens, which have incrementally improved patient outcomes. We discuss the related contributions of genetics and epigenetics to cancer progression and the response to targeted therapies and identify challenges and opportunities for the success of precision medicine. The identification of patients who will benefit from targeted therapies is more complex than simply identifying patients whose tumors harbour the targeted aberration, and intratumoral heterogeneity makes it difficult to determine if a precision therapy is successful during treatment. This heterogeneity enables tumors to develop resistance to targeted approaches; therefore, the rational combination of therapeutic agents will limit the threat of acquired resistance to therapeutic success. By incorporating the view of malignant transformation modulated by networks of genetic and epigenetic interactions, molecular strategies will enable precision medicine for effective treatment across cancer subtypes.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Coyle KM,Boudreau JE,Marcato Pdoi
10.1155/2017/9620870subject
Has Abstractpub_date
2017-01-01 00:00:00pages
9620870eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章,评审abstract:UNLABELLED:Isoniazid (INH), a key agent in the treatment of tuberculosis (TB), is metabolized primarily by the genetically polymorphic N-acetyltransferase 2 (NAT2) enzyme. Patients treated with INH can be classified as fast, intermediate, and slow acetylators. The objective of this study was to explore the relationship...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/853602
更新日期:2013-01-01 00:00:00
abstract::In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in prostate homeostasis. Most of the studies evaluated intraprostatic hormone metabolism using cell lines or preprocessed specimens. Using an ex vivo model of intact tissue cultures with preserved architecture, we characteriz...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/464869
更新日期:2014-01-01 00:00:00
abstract::Legumes have developed a unique way to interact with bacteria: in addition to preventing infection from pathogenic bacteria like any other plant, legumes also developed a mutualistic symbiotic relationship with one gender of soil bacteria: rhizobium. This interaction leads to the development of a new root organ, the n...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/507946
更新日期:2014-01-01 00:00:00
abstract::To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/419376
更新日期:2014-01-01 00:00:00
abstract:Background:Acute myocardial infarction (AMI) is regarded as an urgent clinical entity, and identification of differentially expressed genes, lncRNAs, and altered pathways shall provide new insight into the molecular mechanisms behind AMI. Materials and Methods:Microarray data was collected to identify key genes and ln...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1470867
更新日期:2020-10-06 00:00:00
abstract::Liver transplantation is the best treatment option for early-stage hepatocellular carcinoma, liver cirrhosis, fulminant liver failure, and end-stage liver diseases. Even though advances in surgical techniques and perioperative care have improved postoperative outcomes, perioperative cardiovascular complications are a ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/4081525
更新日期:2017-01-01 00:00:00
abstract::Rhabdoid tumor of the kidney (RTK) is a rare and severely malignant tumor occurring in infancy and early childhood, with the overall outcomes remain poor. Neither gene regulatory networks nor biomarkers to predict the prognostic outcomes have been elucidated in RTK. In this study, RNA sequencing data were obtained to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5843874
更新日期:2020-08-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/867235
更新日期:2014-01-01 00:00:00
abstract::The interaction of patulin with human serum albumin (HSA) was studied in vitro under normal physiological conditions. The study was performed using fluorescence, ultraviolet-visible spectroscopy (UV-Vis), circular dichroism (CD), atomic force microscopy (AFM), and molecular modeling techniques. The quenching mechanism...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/734850
更新日期:2014-01-01 00:00:00
abstract:Background:Ischemic heart disease (IHD) is the major cause of death in patients with cardiovascular disease. Cardiac remodeling is a common pathological change following myocardial infarction (MI), and cardiomyocyte apoptosis plays a key role in this change. Transcription factor recombination signal-binding protein-J (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5207031
更新日期:2018-07-03 00:00:00
abstract:Background:Neighborhood destinations play important roles in daily activity levels of older adults. However, little is known about how specific destinations are associated with these activities and/or sedentary behaviors, especially in Asia. This study investigated how neighborhood destinations were associated with phy...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8432934
更新日期:2020-07-30 00:00:00
abstract::In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The ex...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/317403
更新日期:2015-01-01 00:00:00
abstract::We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/419805
更新日期:2014-01-01 00:00:00
abstract::Schwannomas are the commonest tumours of peripheral nerves. Despite the classical description that schwannomas are well encapsulated and can be completely enucleated during excision, a portion of them have fascicular involvement and could not be completely shelled out. A retrospective review for 8 patients was carried...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/167196
更新日期:2013-01-01 00:00:00
abstract::Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today's experience of several gastrointestinal acute conditions such as abdominal hernia,...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/5716835
更新日期:2017-01-01 00:00:00
abstract::Cardiac computed tomography angiography (CCTA) is widely used as a diagnostic tool for evaluation of coronary artery disease (CAD). Despite the excellent capability to rule-out CAD, CCTA may overestimate the degree of stenosis; furthermore, CCTA analysis can be time consuming, often requiring advanced postprocessing t...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6649410
更新日期:2020-12-16 00:00:00
abstract::The aim of the present study was to extract and characterize bioactive components from separate body organs of Holothuria leucospilota. Preliminary qualitative assessment of the crude extracts was positive for phenols, terpenoids, carbohydrates, flavonoids, saponins, glycosides, cardiac glycosides, steroids, phlobatan...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2640684
更新日期:2019-04-15 00:00:00
abstract::Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune syste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/143504
更新日期:2015-01-01 00:00:00
abstract::Organic pollutants, like phenol, along with heavy metals, like chromium, are present in various industrial effluents that pose serious health hazard to humans. The present study looked at removal of chromium (VI) in presence of phenol in a counter-current continuous packed bed reactor packed with E. coli cells immobil...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/373412
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslink...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8301624
更新日期:2016-01-01 00:00:00
abstract::Salinity is a major environmental stress that limits crop production worldwide. In this study, we characterized plant growth-promoting rhizobacteria (PGPR) containing 1-aminocyclopropane-1-carboxylate (ACC) deaminase and examined their effect on salinity stress tolerance in okra through the induction of ROS-scavenging...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6284547
更新日期:2016-01-01 00:00:00
abstract::This investigation was aimed at assessing a possible interaction of a traditional Thai herbal recipe, "Ya-Sa-Marn-Phlae (YSMP)," used for wound treatments with topical antiseptics, povidone-iodine (PI) solution and hydrogen peroxide (H2O2), and effects of THR-SK010 alone and the combinations on Staphylococcus aureus. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/867603
更新日期:2014-01-01 00:00:00
abstract:Background:Currently, effective genetic markers are limited to predict the clinical outcome of melanoma. High-throughput multiomics sequencing data have provided a valuable approach for the identification of genes associated with cancer prognosis. Method:The multidimensional data of melanoma patients, including clinic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5323614
更新日期:2020-05-08 00:00:00
abstract::1-Deoxynojirimycin (DNJ), the main hypoglycemic constituent in mulberry (Morus alba) latex, has been extensively researched. Although there is considerable interest in the biological effects of DNJ, the roles of 1-deoxynojirimycin (DNJ) in glycometabolism and energy metabolism in insects have received little attention...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4676505
更新日期:2016-01-01 00:00:00
abstract::Sun Island Bund Wetland (SIBW) is a river floodplain wetland located at the south part of Heilongjiang Province in Northeast China. An investigation of the influence of habitat type on macroinvertebrates assemblages structure was conducted in July 2016. Nine (9) sampling sites were selected based on sediment type, wat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2650678
更新日期:2019-02-13 00:00:00
abstract:Objective:To observe the effect of adenosine A1 receptor in the hippocampus of mice on GSK-3β phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Α1 receptor mediating cerebral ischemia-reperfusion injury. Method:The model of middle cerebral artery occlusion (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6848450
更新日期:2020-02-20 00:00:00
abstract::Several studies have compared molecular components between red and white skeletal muscles in mammals. However, mammalian skeletal muscles are composed of mixed types of muscle fibers. In the current study, we analyzed and compared the distributions of titin, lipid, phosphate ions, and fatty acid levels in red and whit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5816875
更新日期:2018-11-18 00:00:00
abstract::Primary cilia are organelles protruding from cell surface into environment that function in regulating cell cycle and modulating cilia-related signal. Primary ciliogenesis and autophagy play important roles in tumorigenesis. However, the functions and interactions between primary cilia and autophagy in hepatocellular ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5202750
更新日期:2019-10-02 00:00:00
abstract::In the present study, we explored SA's activity against DOX-induced cardiotoxicity and revealed its underlying mechanisms. Male Wistar rats (weight, 190-210g; n = 6) were randomly divided into four groups: group I, normal control; group II, DOX 15 mg/kg via intraperitoneal (ip) route; group III, administered DOX+SA 20...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3921796
更新日期:2020-03-10 00:00:00
abstract::Anterior cruciate ligament injuries are common in humans, though cellular components of the knee have little regenerative or proliferation potential. This study investigated the differentiation of human amnion-derived mesenchymal stem cells (hAMSCs) into human anterior cruciate ligament fibroblasts (hACLFs) in vitro t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7360354
更新日期:2017-01-01 00:00:00