The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis.

Abstract:

Introduction:We investigated the proportion of myeloid-derived suppressor cells (MDSCs) and their subsets in patients with rheumatic diseases and clarified the association between these cells and the patient clinical data. Methods:Patients with rheumatic diseases and healthy controls were recruited. The clinical characteristics were obtained. The MDSCs and their subsets were marked with fluorescently labelled antibodies and were then analyzed with flow cytometry. Results:The patients included 31 with RA, 21 with AS, 14 with OA, 11 with SLE with arthritis, 13 with SLE without arthritis, 9 with Gout, 10 with HUA, and 25 healthy controls. The proportions of MDSCs, M-MDSCs, and G-MDSCs were higher in patients with RA than in healthy controls (6.56±6.77% versus 1.46±0.96%, 2.52±3.81% versus 0.35±0.35%, and 1.13±1.64% versus 0.18±0.14%; p<0.001). The same increased cells were also found in other patients. The proportions of MDSCs and M-MDSCs were mostly correlated with the patient's joint inflammation indexes and the disease activity. When other cell subsets were adjusted, the increased risk of arthritis was also obtained for M-MDSCs (adjusted OR=5.772; p=0.031). Conclusions:The expansion of MDSCs and their subsets was correlated with the disease activity and joint inflammation in patient with different rheumatic diseases. The proportion of M-MDSCs was associated with the risk of arthritis in those populations.

journal_name

Biomed Res Int

authors

Zhu J,Chen S,Wu L,Wang R,Zheng S,Zhao D,Wang X,Li J

doi

10.1155/2018/5474828

subject

Has Abstract

pub_date

2018-06-26 00:00:00

pages

5474828

eissn

2314-6133

issn

2314-6141

journal_volume

2018

pub_type

杂志文章
  • Danggui Buxue Tang Attenuates Tubulointerstitial Fibrosis via Suppressing NLRP3 Inflammasome in a Rat Model of Unilateral Ureteral Obstruction.

    abstract::Inflammation significantly contributes to the progression of chronic kidney disease (CKD). This study aimed to characterize Danggui Buxue Tang (DBT) renoprotection and relationship with NOD-like receptors family pyrin domain-containing 3 (NLRP3) inflammasome expression in rats with unilateral ureteral obstruction (UUO...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/9368483

    authors: Wang L,Ma J,Guo C,Chen C,Yin Z,Zhang X,Chen X

    更新日期:2016-01-01 00:00:00

  • In Vitro Protective Effects of Lycium barbarum Berries Cultivated in Umbria (Italy) on Human Hepatocellular Carcinoma Cells.

    abstract::Lycium barbarum is a famous plant in the traditional Chinese medicine. The plant is known to have health-promoting bioactive components. The properties of Lycium barbarum berries cultivated in Umbria (Italy) and their effect on human hepatocellular carcinoma cells (HepG2) have been investigated in this work. The obtai...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7529521

    authors: Ceccarini MR,Vannini S,Cataldi S,Moretti M,Villarini M,Fioretti B,Albi E,Beccari T,Codini M

    更新日期:2016-01-01 00:00:00

  • The effectiveness of preemptive thoracic epidural analgesia in thoracic surgery.

    abstract:BACKGROUND:The aim of this study is to investigate the effectiveness of preemptive thoracic epidural analgesia (TEA) comparing conventional postoperative epidural analgesia on thoracotomy. MATERIAL AND METHODS:Forty-four patients were randomized in to two groups (preemptive: Group P, control: Group C). Epidural cathet...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/673682

    authors: Erturk E,Aydogdu Kaya F,Kutanis D,Besir A,Akdogan A,Geze S,Tugcugil E

    更新日期:2014-01-01 00:00:00

  • Epithelial-mesenchymal transition regulated by EphA2 contributes to vasculogenic mimicry formation of head and neck squamous cell carcinoma.

    abstract:PURPOSE:Vasculogenic mimicry (VM) was related to invasion and metastasis of head and neck squamous cell carcinoma (HNSCC) patients. This study was designed to investigate the role of EphA2 in VM formation of HNSCC. METHODS:The SiRNA technique was used to knock down the expression of EphA2 in vitro. The ability of cell...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/803914

    authors: Wang W,Lin P,Sun B,Zhang S,Cai W,Han C,Li L,Lu H,Zhao X

    更新日期:2014-01-01 00:00:00

  • In silico investigation of traditional Chinese medicine compounds to inhibit human histone deacetylase 2 for patients with Alzheimer's disease.

    abstract::Human histone deacetylase 2 (HDAC2) has been identified as being associated with Alzheimer's disease (AD), a neuropathic degenerative disease. In this study, we screen the world's largest Traditional Chinese Medicine (TCM) database for natural compounds that may be useful as lead compounds in the search for inhibitors...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/769867

    authors: Hung TC,Lee WY,Chen KB,Chan YC,Lee CC,Chen CY

    更新日期:2014-01-01 00:00:00

  • Preoperative Chemotherapy for Gastric Cancer: Personal Interventions and Precision Medicine.

    abstract::In spite of the declining incidence of gastric cancer (GC) in recent years, the mortality rate is still high. The asymptomatic nature and nonspecific clinical manifestations combined with the lack of efficient screening programs delay the diagnosis of GC. Therefore, the prevalence of advanced gastric cancer (AGC) has ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3923585

    authors: Xu W,Beeharry MK,Liu W,Yan M,Zhu Z

    更新日期:2016-01-01 00:00:00

  • Coronary CT angiography in the quantitative assessment of coronary plaques.

    abstract::Coronary computed tomography angiography (CCTA) has been recently evaluated for its ability to assess coronary plaque characteristics, including plaque composition. Identification of the relationship between plaque composition by CCTA and patient clinical presentations may provide insight into the pathophysiology of c...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/346380

    authors: Sun Z,Xu L

    更新日期:2014-01-01 00:00:00

  • Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease.

    abstract::Objectives. To investigate the potential association of a set of serum cytokines with the severity of coronary artery disease (CAD). Methods. A total of 201 patients who underwent coronary angiography for chest discomfort were enrolled. The concentrations of serum IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-9, and IL-17...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/4013685

    authors: Min X,Lu M,Tu S,Wang X,Zhou C,Wang S,Pang S,Qian J,Ge Y,Guo Y,Xu D,Cao K

    更新日期:2017-01-01 00:00:00

  • Aerobic sludge granulation in a full-scale sequencing batch reactor.

    abstract::Aerobic granulation of activated sludge was successfully achieved in a full-scale sequencing batch reactor (SBR) with 50,000 m(3) d(-1) for treating a town's wastewater. After operation for 337 days, in this full-scale SBR, aerobic granules with an average SVI30 of 47.1 mL g(-1), diameter of 0.5 mm, and settling veloc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/268789

    authors: Li J,Ding LB,Cai A,Huang GX,Horn H

    更新日期:2014-01-01 00:00:00

  • Modification of Mechanical Properties, Polymerization Temperature, and Handling Time of Polymethylmethacrylate Cement for Enhancing Applicability in Vertebroplasty.

    abstract::Polymethylmethacrylate (PMMA) bone cement is a popular bone void filler for vertebroplasty. However, the use of PMMA has some drawbacks, including the material's excessive stiffness, exothermic polymerization, and short handling time. This study aimed to create an ideal modified bone cement to solve the above-mentione...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7901562

    authors: Tai CL,Lai PL,Lin WD,Tsai TT,Lee YC,Liu MY,Chen LH

    更新日期:2016-01-01 00:00:00

  • Treatment of Hemorrhagic Vocal Polyps by Pulsed Dye Laser-Assisted Laryngomicrosurgery.

    abstract:OBJECTIVE:Conventional surgical techniques of laryngomicrosurgery (LMS) on hemorrhagic vocal polyps are often difficult due to obscuration of the surgical field by inadvertent bleeding from the lesion, and there are often significant amounts of mucosal epithelium loss. Here, we introduce our surgical technique using pu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/820654

    authors: Byeon HK,Han JH,Choi BI,Hwang HJ,Kim JH,Choi HS

    更新日期:2015-01-01 00:00:00

  • Dosimetric Comparison of Three Radiotherapy Techniques in Irradiation of Left-Sided Breast Cancer Patients after Radical Mastectomy.

    abstract:Results:The VMAT plans showed superior to PTV dose conformity index (CI), homogeneity index (HI), protection of the ipsilateral lung, monitor units (MUs), and maximum dose (Dmax) to the contralateral breast compared with TSP and 9FIMRT plans. The TSP provided better protection for Dmean of the heart and left ventricle ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2020/7131590

    authors: Hu J,Han G,Lei Y,Xu X,Ge W,Ruan C,Chang S,Zhang A,Li X

    更新日期:2020-03-26 00:00:00

  • A Novel Seventeen-Gene Metabolic Signature for Predicting Prognosis in Colon Cancer.

    abstract::A metabolic disorder is considered one of the hallmarks of cancer. Multiple differentially expressed metabolic genes have been identified in colon cancer (CC), and their biological functions and prognostic values have been well explored. The purpose of the present study was to establish a metabolic signature to optimi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4845360

    authors: Luo D,Shan Z,Liu Q,Cai S,Li Q,Li X

    更新日期:2020-11-17 00:00:00

  • The Effects of Tooth Brushing on Whole Salivary Flow Rate in Older Adults.

    abstract:Objectives:(1) To determine whether manual (MTB), or electric, tooth brushing (ETB) modulates whole salivary flow rate in older adults who are free of systemic disease. (2) To determine the duration of the brushing-related modulation of salivary flow rate. (3) To compare salivary flow rate modulation associated with MT...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3904139

    authors: Affoo RH,Trottier K,Garrick R,Mascarenhas T,Jang Y,Martin RE

    更新日期:2018-02-26 00:00:00

  • Production and enhancement of omega-3 fatty acid from Mortierella alpina CFR-GV15: its food and therapeutic application.

    abstract::Mortierella sp. has been known to produce polyunsaturated fatty acids (PUFAs) such as GLA and AA under normal growth medium conditions. Similarly, under the stress condition, this fungus produces EPA and DHA in their mycelial biomass. Among the 67 soil samples screened from the Western Ghats of India, 11 Mortierella i...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/657414

    authors: Vadivelan G,Venkateswaran G

    更新日期:2014-01-01 00:00:00

  • Association analysis between g.18873C>T and g.27522G>A genetic polymorphisms of OPG and bone mineral density in Chinese postmenopausal women.

    abstract::Several studies report that the OPG is an important candidate gene in the pathogenesis of osteoporosis. This study aimed to detect the potential association of OPG gene polymorphisms with osteoporosis in postmenopausal women. We recruited 928 subjects containing 463 with primary postmenopausal osteoporosis and 465 hea...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/320828

    authors: Wang F,Cao Y,Li F,Shan J,Wen T

    更新日期:2014-01-01 00:00:00

  • Blood Pressure Measurements with Different Currently Available Methods in Elderly Hypertensive Hospitalized Patients: A Real World Cross-Sectional Study.

    abstract:Background:The reliability of blood pressure (BP) measurement in hospitalized patients is a topic of debate and the therapeutic implication of the routinely collected BP profiles is probably overestimated. When measurements are performed in elderly patients, further potential sources of misinterpretation occur. Method...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6274545

    authors: Del Giorno R,Heiniger PS,Balestra L,Gabutti L

    更新日期:2019-04-01 00:00:00

  • Phytoremediation potential of Maná-Cubiu (Solanum sessiliflorum Dunal) for the deleterious effects of methylmercury on the reproductive system of rats.

    abstract::Methylmercury, organic form of mercury, can increase the number of abnormal sperm and decrease sperm concentration and testosterone levels possibly due to the damage caused by reactive species to germ and Leydig cells. Maná-cubiu (Solanum sessiliflorum Dunal) is a native fruit from Amazon rich in iron, zinc, niacin, p...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/309631

    authors: Frenedoso da Silva R,Missassi G,dos Santos Borges C,Silva de Paula E,Hornos Carneiro MF,Grotto D,Barbosa Junior F,De Grava Kempinas W

    更新日期:2014-01-01 00:00:00

  • Corrigendum to "Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly".

    abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2020/9175369

    authors: Arosio B,D'Addario C,Gussago C,Casati M,Tedone E,Ferri E,Nicolini P,Rossi PD,Maccarrone M,Mari D

    更新日期:2020-09-07 00:00:00

  • Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism.

    abstract::Patients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve reg...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/949624

    authors: Roussel E,Drolet MC,Walsh-Wilkinson E,Dhahri W,Lachance D,Gascon S,Sarrhini O,Rousseau JA,Lecomte R,Couet J,Arsenault M

    更新日期:2015-01-01 00:00:00

  • Advances in Exosomes Derived from Different Cell Sources and Cardiovascular Diseases.

    abstract::Exosomes can reach distant tissues through blood circulation to communicate directly with target cells and rapidly regulate intracellular signals. Exosomes play an important role in cardiovascular pathophysiology. Different exosomes derived from different sources, and their cargos have different mechanisms of action. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/7298687

    authors: Liang B,He X,Zhao YX,Zhang XX,Gu N

    更新日期:2020-07-07 00:00:00

  • Prevalence of gene rearrangements in Mexican children with acute lymphoblastic leukemia: a population study-report from the Mexican Interinstitutional Group for the identification of the causes of childhood leukemia.

    abstract::Mexico has one of the highest incidences of childhood leukemia worldwide and significantly higher mortality rates for this disease compared with other countries. One possible cause is the high prevalence of gene rearrangements associated with the etiology or with a poor prognosis of childhood acute lymphoblastic leuke...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1155/2014/210560

    authors: Bekker-Méndez VC,Miranda-Peralta E,Núñez-Enríquez JC,Olarte-Carrillo I,Guerra-Castillo FX,Pompa-Mera EN,Ocaña-Mondragón A,Rangel-López A,Bernáldez-Ríos R,Medina-Sanson A,Jiménez-Hernández E,Amador-Sánchez R,Peñaloza-González JG,

    更新日期:2014-01-01 00:00:00

  • CT and MRI Findings of Soft Tissue Adult Fibrosarcoma in Extremities.

    abstract:Objective:To characterize and evaluate CT and MRI features of extremity soft tissue adult fibrosarcoma. Methods:CT and MRI images from 10 adult patients with pathologically proven fibrosarcomas were retrospectively analyzed with regard to tumor location, size, number, shape, margins, attenuation, signal intensity, and...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6075705

    authors: Wang H,Nie P,Dong C,Li J,Huang Y,Hao D,Xu W

    更新日期:2018-03-06 00:00:00

  • Breast cancer prognosis risk estimation using integrated gene expression and clinical data.

    abstract:BACKGROUND:Novel prognostic markers are needed so newly diagnosed breast cancer patients do not undergo any unnecessary therapy. Various microarray gene expression datasets based studies have generated gene signatures to predict the prognosis outcomes, while ignoring the large amount of information contained in establi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/459203

    authors: Saini A,Hou J,Zhou W

    更新日期:2014-01-01 00:00:00

  • The Alcohol Extract of Coreopsis tinctoria Nutt Ameliorates Diabetes and Diabetic Nephropathy in db/db Mice through miR-192/miR-200b and PTEN/AKT and ZEB2/ECM Pathways.

    abstract::The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 groups, which were treated with AC (300 mg/kg/day), metformin (180 mg/kg/day), or saline by gavage for 10 weeks. Ten db/m mice treated w...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5280514

    authors: Yu S,Zhao H,Yang W,Amat R,Peng J,Li Y,Deng K,Mao X,Jiao Y

    更新日期:2019-03-28 00:00:00

  • Assessment of antioxidant activity of spray dried extracts of Psidium guajava leaves by DPPH and chemiluminescence inhibition in human neutrophils.

    abstract::This work evaluated the physicochemical properties and antioxidant activity of spray dried extracts (SDE) from Psidium guajava L. leaves. Different drying carriers, namely, maltodextrin, colloidal silicon dioxide, Arabic gum, and β -cyclodextrin at concentrations of 40 and 80% relative to solids content, were added to...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/382891

    authors: Fernandes MR,Azzolini AE,Martinez ML,Souza CR,Lucisano-Valim YM,Oliveira WP

    更新日期:2014-01-01 00:00:00

  • Efficacy of rhBMP-2 Loaded PCL/β-TCP/bdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration.

    abstract::This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic protein-2 (rhBMP-2) on bone regeneration. Scaffolds were divided into PCL/...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2876135

    authors: Bae EB,Park KH,Shim JH,Chung HY,Choi JW,Lee JJ,Kim CH,Jeon HJ,Kang SS,Huh JB

    更新日期:2018-02-27 00:00:00

  • Natural Language Processing Based Instrument for Classification of Free Text Medical Records.

    abstract::According to the Ministry of Labor, Health and Social Affairs of Georgia a new health management system has to be introduced in the nearest future. In this context arises the problem of structuring and classifying documents containing all the history of medical services provided. The present work introduces the instru...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8313454

    authors: Khachidze M,Tsintsadze M,Archuadze M

    更新日期:2016-01-01 00:00:00

  • Numerical Solution of Blood Flow and Mass Transport in an Elastic Tube with Multiple Stenoses.

    abstract::The simultaneous effect of flexible wall and multiple stenoses on the flow and mass transfer of blood is investigated through numerical computation and simulations. The solution is obtained using the Marker and Cell technique on an axisymmetric model of Newtonian blood flow. The results compare favorably with physical...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7609562

    authors: Alsemiry RD,Sarifuddin,Mandal PK,Sayed HM,Amin N

    更新日期:2020-01-31 00:00:00

  • Evaluation of cardiac function index as measured by transpulmonary thermodilution as an indicator of left ventricular ejection fraction in cardiogenic shock.

    abstract:INTRODUCTION:The PiCCO transpulmonary thermodilution technique provides two indices of cardiac systolic function, the cardiac function index (CFI) and the global ejection fraction (GEF). Both appear to be correlated with left ventricular ejection fraction (LVEF) measured by echocardiography in patients with circulatory...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/598029

    authors: Perny J,Kimmoun A,Perez P,Levy B

    更新日期:2014-01-01 00:00:00