Abstract:
:Large amounts of various biological networks exist for representing different types of interaction data, such as genetic, metabolic, gene regulatory, and protein-protein relationships. Recent approaches on biological network study are based on different mathematical concepts. It is necessary to construct a uniform framework to judge the functionality of biological networks. We recently introduced a knowledge-based computational framework that reliably characterized biological networks in system level. The method worked by making systematic comparisons to a set of well-studied "basic networks," measuring both the functional and topological similarities. A biological network could be characterized as a spectrum-like vector consisting of similarities to basic networks. Here, to facilitate the application, development, and adoption of this framework, we present an R package called NFP. This package extends our previous pipeline, offering a powerful set of functions for Network Fingerprint analysis. The software shows great potential in biological network study. The open source NFP R package is freely available under the GNU General Public License v2.0 at CRAN along with the vignette.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Cao Y,Xu W,Niu C,Bo X,Li Fdoi
10.1155/2017/7457131subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7457131eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::Although cases of Mediterranean spotted fever (MSF) have been reported for decades in southeastern Romania, there are few published data. We retrospectively studied 339 patients, diagnosed with MSF at the National Institute of Infectious Diseases "Prof. Dr. Matei Bals" between 2000 and 2011, in order to raise awarenes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/395806
更新日期:2013-01-01 00:00:00
abstract::This study evaluated the efficacy and safety of pulmonary rehabilitation (PR) for pneumoconiosis. We systematically searched PubMed, Embase, The Cochrane Library, Web of Science, SinoMed, CNKI, VIP databases and Wanfang Data from their inception to June 1, 2019. A systematic review and meta-analysis of randomized cont...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6174936
更新日期:2020-07-28 00:00:00
abstract::Blood pressure is the most important, modifiable risk factor for cardiovascular diseases. Lifestyle factors and also workload are the main, potential risk factors for the development of hypertension. This study focused on the early detection of unknown hypertension by screening employees in the hotel and restaurant in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6820160
更新日期:2018-04-08 00:00:00
abstract::Adverse drug reactions (ADRs) are responsible for drug candidate failure during clinical trials. It is crucial to investigate biological pathways contributing to ADRs. Here, we applied a large-scale analysis to identify overrepresented ADR-pathway combinations through merging clinical phenotypic data, biological pathw...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/670949
更新日期:2015-01-01 00:00:00
abstract::Stability and mobility in functional motor activities depend on a precise regulation of phasic and tonic muscular activity that is carried out automatically, without conscious awareness. The sensorimotor control of posture involves a complex integration of multisensory inputs that results in a final motor adjustment p...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/434683
更新日期:2015-01-01 00:00:00
abstract::It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2607928
更新日期:2018-06-14 00:00:00
abstract::Tantalum rod implantation with vascularized iliac grafting has been reported to be an effective method for the treatment of young patients with osteonecrosis of the femoral head (ONFH) to avert the need for total hip arthroplasty (THA). However, there have been unsatisfactory success rates for end-stage ONFH. The auth...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/240506
更新日期:2015-01-01 00:00:00
abstract::TAL effectors (TALEs) contain a modular DNA-binding domain that is composed of tandem repeats. In all naturally occurring TALEs, the end of tandem repeats is invariantly a truncated half repeat. To investigate the potential role of the last half repeat in TALEs, we performed comparative molecular dynamics simulations ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8036450
更新日期:2016-01-01 00:00:00
abstract::For the induction of robust humoral and cellular immune responses, a strong rationale exists to use vaccine-adjuvant combinations possessing both immune modulatory and enhanced delivery capabilities. Herein, we evaluated the combination of 2 different adjuvants, a TLR9 agonist, composed of synthetic oligodeoxynucleoti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/636847
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Suppressor of cytokine signaling 7 (SOCS7) is a member of the SOCS family and is known to interact with phospholipase Cγ-1 (PLCγ-1), a key downstream mediator of the hepatocyte growth factor (HGF)/C-MET axis. Here, we report our observations of the effect of knocking down SOCS7 gene on the behaviour of breast c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/648040
更新日期:2014-01-01 00:00:00
abstract:Objective:Cognitive impairment is considered to be an important complication of spinal cord injury (SCI), but its underlying mechanism remains unclear. The purpose of this study is to explore whether serum CCL21 can be used as a potential biomarker of cognitive impairment in SCI. Methods:In Neck-Shoulder and Lumbocrur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6692802
更新日期:2020-12-09 00:00:00
abstract:OBJECTIVES:To investigate the effect of two foot placements (normal or posterior placement) and three arm positions (hands on the thighs, arms crossed over chest, and augmented arm position with elbow extended) on the five times sit-to-stand (FTSTS) test times of individuals with chronic stroke. DESIGN:Cross-sectional...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/636530
更新日期:2014-01-01 00:00:00
abstract::Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, inclu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/916136
更新日期:2013-01-01 00:00:00
abstract::Schistosomiasis, caused by infection with Schistosoma species, remains an important parasitic zoonosis. Thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR) plays an important role in the development of the parasite and for its survival. Here we present a recombinant plasmid DNA vaccine, pVAX1/SjTGR, to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/952416
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/673018
更新日期:2015-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-related death worldwide, and the most common histologic subtype is lung adenocarcinoma (LUAD). Due to the significant mortality and morbidity rates among patients with LUAD, the identification of novel biomarkers to guide diagnosis, prognosis, and therapy is urgent. Guanosine...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5171242
更新日期:2020-10-19 00:00:00
abstract:Aim:To investigate the effect of fecal microbiota transplantation on visceral hypersensitivity compared with Bifidobacterium longum. Methods:Mice visceral hypersensitivity was induced by Trichinella spiralis. After 8 weeks, they were divided into three groups (controls, Bifidobacterium longum, and fecal microbiota tra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3860743
更新日期:2018-01-30 00:00:00
abstract:Background:The aim of this article is to present a short review of noninvasive, nonpharmacological treatment methods used in somatic illnesses that fall under the umbrella of approach called behavioral medicine. Methods:The narrative review method was applied in the study. Science paper databases, including PubMed, ha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/5076516
更新日期:2020-11-03 00:00:00
abstract::The white-rot fungus Phanerochaete chrysosporium was investigated for its capacity to degrade the herbicide diuron in liquid stationary cultures. The presence of diuron increased the production of lignin peroxidase in relation to control cultures but only barely affected the production of manganese peroxidase. The her...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/251354
更新日期:2013-01-01 00:00:00
abstract::Saponins are a group of naturally occurring plant glycosides with the features of their strong foam-forming properties and multibiological effects such as antitumor activity. Though Misaponin B, one of the triterpenoid saponins from Madhuca longifolia, is known to have spermicidal and antioxidant activity, the other b...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5925094
更新日期:2020-02-07 00:00:00
abstract::Background. Prior studies have demonstrated that conventional and emerging CV risk factors are associated with worsening arterial stiffness among end-stage renal disease (ESRD) patients on hemodialysis. The present cross-sectional study evaluates the association between the etiology of ESRD and arterial stiffness amon...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2543262
更新日期:2017-01-01 00:00:00
abstract::Polymethylmethacrylate (PMMA) bone cement is a popular bone void filler for vertebroplasty. However, the use of PMMA has some drawbacks, including the material's excessive stiffness, exothermic polymerization, and short handling time. This study aimed to create an ideal modified bone cement to solve the above-mentione...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7901562
更新日期:2016-01-01 00:00:00
abstract::The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as well as other kinds o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/175721
更新日期:2014-01-01 00:00:00
abstract::Alzheimer's disease (AD) and multiple sclerosis are major neurodegenerative diseases, which are characterized by the accumulation of abnormal pathogenic proteins due to oxidative stress, mitochondrial dysfunction, impaired autophagy, and pathogens, leading to neurodegeneration and behavioral deficits. Herein, we revie...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1483791
更新日期:2018-07-12 00:00:00
abstract::This study compares the effects of team-sport training, for sedentary men with lifestyle diseases, with fitness training in a pragmatic set-up in a community health centre (CHC). Thirty-two men in the fitness group (FiG) and 36 men in the team-sport group (TsG) completed the training and trained for 60-90 min, two tim...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1571807
更新日期:2018-05-15 00:00:00
abstract::Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune syste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/143504
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To investigate the availability of correction of mandibular plane using software for vertical measurements in cone beam computed tomography (CBCT) according to the sites of the mandible. METHODS:CBCT scans of six dry mandibles were performed at 0-, 5-, 10-, 15-, and 20-degree angles relative to CBCT scannin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/808625
更新日期:2015-01-01 00:00:00
abstract::Somatostatin (SST) receptors (SSTRs) belong to the typical 7-transmembrane domain family of G-protein-coupled receptors. Five distinct subtypes (termed SSTR1-5) have been identified, with SSTR2 showing the highest affinity for natural SST and synthetic SST analogs. Most neuroendocrine tumors (NETs) have high expressio...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/917968
更新日期:2015-01-01 00:00:00
abstract::Herein the extraction method of fucoidan from Laminaria japonica is reported. Firstly, chitosan, chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (HACC), and hexadecyltrimethylammonium bromide (CPAB) were used to extract the fucoidan. The results showed that chitosan was the optimal extractant compared with the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/193689
更新日期:2013-01-01 00:00:00
abstract::Aim. The aim of the study was to compare the incidence of "de novo" overactive bladder (OAB) after sling surgeries and Burch procedure and to analyze the effect of the preoperative bladder volume on the incidence of this condition. Methods. This prospective trial included 290 female patients with stress urinary incont...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9515242
更新日期:2019-02-12 00:00:00