Abstract:
:Stability and mobility in functional motor activities depend on a precise regulation of phasic and tonic muscular activity that is carried out automatically, without conscious awareness. The sensorimotor control of posture involves a complex integration of multisensory inputs that results in a final motor adjustment process. All or some of the components of this system may be dysfunctional in Parkinsonian patients, rendering postural instability one of the most disabling features of Parkinson's disease (PD). Balance control is critical for moving safely in and adapting to the environment. PD induces a multilevel impairment of this function, therefore worsening the patients' physical and psychosocial disability. In this review, we describe the complex ways in which PD impairs posture and balance, collecting and reviewing the available experimental evidence.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Rinalduzzi S,Trompetto C,Marinelli L,Alibardi A,Missori P,Fattapposta F,Pierelli F,Currà Adoi
10.1155/2015/434683subject
Has Abstractpub_date
2015-01-01 00:00:00pages
434683eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract:INTRODUCTION:Previous studies have demonstrated the safety and efficacy of using Paricalcitol for the treatment of secondary hyperparathyroidism (SHPT) in patients on dialysis. The aim of the current meta-analysis was to assess the safety and efficacy of Paricalcitol for the management of SHPT in patients with chronic ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2013/320560
更新日期:2013-01-01 00:00:00
abstract:Purpose:To explore the effect of VEGF (vascular endothelial growth factor) on the vasculogenic mimicry (VM) formation of Choroidal Melanoma (CM) through PI3k signal pathway, to find novel targets for CM therapy. Methods:This research investigated the molecular mechanism of VEGF promoting VM formation of CM. First, we ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3909102
更新日期:2019-07-11 00:00:00
abstract::The pathogenesis of intractable epilepsy is not fully clear. In recent years, both animal and clinical trials have shown that the expression of ATP-binding cassette (ABC) transporters is increased in patients with intractable epilepsy; additionally, epileptic seizures can lead to an increase in the number of sites tha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/194541
更新日期:2015-01-01 00:00:00
abstract::Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes of human papillomavirus (HPV). Vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma have different etiopathogenic pathways and a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/480573
更新日期:2014-01-01 00:00:00
abstract::Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1843142
更新日期:2018-02-06 00:00:00
abstract::According to the Ministry of Labor, Health and Social Affairs of Georgia a new health management system has to be introduced in the nearest future. In this context arises the problem of structuring and classifying documents containing all the history of medical services provided. The present work introduces the instru...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8313454
更新日期:2016-01-01 00:00:00
abstract:Introduction:Retinol Binding Protein 4 (RBP4) is mainly excreted by the kidney and plays a pivotal role in insulin resistance (IR). In our study, we evaluated the association between RBP4 and IR in hemodialysis subjects (HD). We also assessed how circulating RBP4 could be influenced by kidney transplant or different di...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7270595
更新日期:2017-01-01 00:00:00
abstract::Tomatoes and tomato based-foods contain beneficial microorganisms and various organic acids that have important nutritional values for human. The objective of this study was to access the physiochemical properties of fermented tomatoes juices and to evaluate the competitiveness of lactic acid bacteria (LAB) against Li...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6937837
更新日期:2019-02-26 00:00:00
abstract::The ability of Aspergillus niger strain to reduce organic and mineral pollution as well as the toxicity of two tannery wastewaters, the unhairing effluent (UE) and the final effluent (FE), taken from a local Tunisian tannery and under nonsterile conditions, was studied. Raw effluents show alkaline pH ≥11; thus experim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9020178
更新日期:2019-06-03 00:00:00
abstract:OBJECTIVE:Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with eccentric versus traditio...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/398960
更新日期:2014-01-01 00:00:00
abstract::Introduction. This study aimed to evaluate the effects of resorbable blasting media (RBM) treatment on early stability of orthodontic mini-implants by mechanical, histomorphometric, and histological analyses. Methods. Ninety-six (64 for mechanical study and 32 for histological study and histomorphometric analysis) tit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7520959
更新日期:2016-01-01 00:00:00
abstract::Studies pertaining to trans fatty acids (TFA), which have been implicated in development of chronic diseases, are more relevant in developing countries where nutrition transition is changing traditional habits and practices. Measuring TFA is an arduous task because of the need for fat biopsies. This study identifies a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276174
更新日期:2013-01-01 00:00:00
abstract::Alterations in pancreatic milieu to adapt to physiological shifts occurring in conditions of obesity and metabolic syndrome (MS) have been documented, though mechanisms leading to such a state have remained elusive so far. The data presented here tries to look at the gravity of metabolic insult during the early and pr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/617569
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/8193821.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2017/6418529
更新日期:2017-01-01 00:00:00
abstract::N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy num...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8826456
更新日期:2020-12-19 00:00:00
abstract::This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/617143
更新日期:2015-01-01 00:00:00
abstract:Background:The well-known rubber hand paradigm induces an illusion by having participants feel the touch applied to a fake hand. In parallel, the kinesthetic mirror illusion elicits illusions of movement by moving the reflection of a participant's arm. Experimental manipulation of sensory inputs leads to emergence of t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6937328
更新日期:2017-01-01 00:00:00
abstract::Traumatic brain injury (TBI) leads to important and deleterious neuroinflammation, as evidenced by indicators such as edema, cytokine production, induction of nitric oxide synthase, and leukocyte infiltration. After TBI, cerebral vascular endothelial cells play a crucial role in the pathogenesis of inflammation. In ou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/910260
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:The aim of this report is to study the graft and patient survival in a large cohort of recipients with an analysis of factors that may affect the final outcomes. METHODS:Between March 1976 and March 2008, 1967 consecutive live-donor renal transplants were carried out. Various variables that may have an im...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/912413
更新日期:2013-01-01 00:00:00
abstract::Glioma of infiltrative nature is challenging for surgeons to achieve tumor-specific and maximal resection. Raman spectroscopy provides structural information on the targeted materials as vibrational shifts. We utilized Raman spectroscopy to distinguish invasive tumors from normal tissues. Spectra obtained from replica...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/860241
更新日期:2014-01-01 00:00:00
abstract::Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/720514
更新日期:2013-01-01 00:00:00
abstract::Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/901941
更新日期:2014-01-01 00:00:00
abstract:Background:sCD30 and sCD26 are correlated with autoimmune diseases. However, little research has been done on the relationship between them and primary immune thrombocytopenia (ITP). Methods:This study enrolled 47 patients diagnosed with ITP in the Institute of Hematology and Blood Disease Hospital, Chinese Academy of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1279371
更新日期:2020-03-31 00:00:00
abstract::Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expressi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/432479
更新日期:2015-01-01 00:00:00
abstract:Objective:This paper included a retrospective review of the effect of tranexamic acid (TXA) combined with pressure bandaging on hemostasis of patients who received a unilateral total knee arthroplasty (TKA) from 2017 to 2019. Methods:A total of 197 patients undergoing TKA were chosen to be classified into 2 groups, th...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/2739560
更新日期:2020-11-02 00:00:00
abstract::The rising global incidence of obesity cannot be fully explained within the context of traditional risk factors such as an unhealthy diet, physical inactivity, aging, or genetics. Adipose tissue is an endocrine as well as a metabolic organ that may be susceptible to disruption by environmental estrogenic chemicals. Si...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6821601
更新日期:2018-01-08 00:00:00
abstract::Human dental pulp stem cells (DPSCs) hold great promise in bone regeneration. However, the exact mechanism of osteogenic differentiation of DPSCs remains unknown, especially the role of exosomes played in. The DPSCs were cultured and received osteogenic induction; then, exosomes from osteogenic-induced DPSCs (OI-DPSC-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6319395
更新日期:2020-09-28 00:00:00
abstract:PURPOSE:To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). MATERIALS AND METHODS:Institutional review board approval...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/835385
更新日期:2013-01-01 00:00:00
abstract::A diffusion theory-based, all-physical ab initio protein folding simulation is described and applied. The model is based upon the drift and diffusion of protein substructures relative to one another in the multiple energy fields present. Without templates or statistical inputs, the simulations were run at physiologic ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/583045
更新日期:2013-01-01 00:00:00
abstract::Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/981841
更新日期:2015-01-01 00:00:00