Abstract:
:The rising global incidence of obesity cannot be fully explained within the context of traditional risk factors such as an unhealthy diet, physical inactivity, aging, or genetics. Adipose tissue is an endocrine as well as a metabolic organ that may be susceptible to disruption by environmental estrogenic chemicals. Since some of the endocrine disruptors are lipophilic chemicals with long half-lives, they tend to bioaccumulate in the adipose tissue of exposed populations. Elevated exposure to these chemicals may predispose susceptible individuals to weight gain by increasing the number and size of fat cells. Genetic studies have demonstrated that the transcriptional regulator inhibitor of differentiation-3 (ID3) promotes high fat diet-induced obesity in vivo. We have shown previously that PCB153 and natural estrogen 17β-estradiol increase ID3 expression. Based on our findings, we postulate that ID3 is a molecular target of estrogenic endocrine disruptors (EEDs) in the adipose tissue and a better understanding of this relationship may help to explain how EEDs can lead to the transcriptional programming of deviant fat cells. This review will discuss the current understanding of ID3 in excess fat accumulation and the potential for EEDs to influence susceptibility to obesity or metabolic disorders via ID3 signaling.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Doke M,Avecilla V,Felty Qdoi
10.1155/2018/6821601subject
Has Abstractpub_date
2018-01-08 00:00:00pages
6821601eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章,评审abstract::Heart failure commonly results from an irreparable damage due to cardiovascular diseases (CVDs), the leading cause of morbidity and mortality in the United States. In recent years, the rapid advancements in stem cell research have garnered much praise for paving the way to novel therapies in reversing myocardial injur...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/547902
更新日期:2013-01-01 00:00:00
abstract::This study documented the population dynamics of Biomphalaria and associated natural infections with digenetic trematodes, along the shores of Lake Albert and Lake Victoria, recording local physicochemical factors. Over a two-and-a-half-year study period with monthly sampling, physicochemical factors were measured at ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/717261
更新日期:2015-01-01 00:00:00
abstract::Restriction enzymes are the main defence system against foreign DNA, in charge of preserving genome integrity. Lactococcus raffinolactis BGTRK10-1 expresses LraI Type II restriction-modification enzyme, whose activity is similar to that shown for EcoRI; LraI methyltransferase protects DNA from EcoRI cleavage. The gene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5657085
更新日期:2018-01-29 00:00:00
abstract:OBJECTIVE:To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI). METHODS:Forty patients with SAP and 20 with UAP/n-ST...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/401357
更新日期:2015-01-01 00:00:00
abstract::Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults. Despite continuous improvements in diagnosis and therapeutic method, the prognosis is still far away from expectations. The invasive phenotype of GBM is the main reason for the poor prognosis. Epithelial-mesenchymal transition (EMT) is r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1321973
更新日期:2019-04-17 00:00:00
abstract::Alzheimer's disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/796869
更新日期:2014-01-01 00:00:00
abstract::Pregnancy is associated with various physiological changes which may lead to significant alterations in the pharmacokinetics of many drugs. The present study was aimed to investigate the potential effects of pregnancy on the pharmacokinetic profile of zonisamide (ZNM) in the rabbit. Seven female rabbits were used in t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/140327
更新日期:2013-01-01 00:00:00
abstract::The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have be...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/261745
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Fusarium, Aspergillus, and Dematiaceous are the most common fungal species causing keratitis in tropical countries. Herein we report a prospective study on fungal keratitis caused by these three fungal species. METHODOLOGY:A prospective investigation was undertaken to evaluate eyes with presumed fungal keratit...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/605308
更新日期:2013-01-01 00:00:00
abstract::Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by an impairment of corneal sensory innervation, characterized by decreased or absent corneal sensitivity resulting in epithelial keratopathy, ulceration, and perforation. The aetiopathogenesis of corneal sensory innervation impairment in ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/805876
更新日期:2015-01-01 00:00:00
abstract::Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/905215
更新日期:2015-01-01 00:00:00
abstract::Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/121254
更新日期:2014-01-01 00:00:00
abstract::Catalases are widely used in many scientific areas. A catalase gene (Kat) from Geobacillus sp. CHB1 encoding a monofunctional catalase was cloned and recombinant expressed in Escherichia coli (E. coli), which was the first time to clone and express this type of catalase of genus Geobacillus strains as far as we know. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7535604
更新日期:2016-01-01 00:00:00
abstract::Although the application of patient-specific instruments (PSI) for total knee arthroplasty (TKA) increases the cost of the surgical procedure, PSI may reduce operative time and improve implant alignment, which could reduce the number of revision surgeries. We report our experience with TKA using PSI techniques in 120 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/978686
更新日期:2015-01-01 00:00:00
abstract::Adverse perinatal outcomes in singleton IVF pregnancies have been most often explained by parental underlying diseases and so far laboratory conditions during embryo culture are still not explored well. The following review discusses the current state of knowledge on the influence of IVF laboratory procedures on the p...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3285179
更新日期:2016-01-01 00:00:00
abstract::Destruction of extracellular matrix (ECM) is one of the basic steps of tumor invasion and metastasis. Matrix metalloproteinase (MMP) 9, a kind of zinc-ion-dependent endopeptidase, can degrade almost all protein components in the ECM, destroy the histological barrier of tumor cell invasion, and play a key role in tumor...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4350783
更新日期:2020-04-15 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to H...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/231474
更新日期:2014-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are defined as pluripotent cells found in numerous human tissues, including bone marrow and adipose tissue. Such MSCs, isolated from bone marrow and adipose tissue, have been shown to differentiate into bone and cartilage, along with other types of tissues. Therefore, MSCs represent a pro...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/436029
更新日期:2014-01-01 00:00:00
abstract::Acute nonspecific, or primary, mesenteric lymphadenitis is a self-limiting inflammatory condition affecting the mesenteric lymph nodes, whose presentation mimics appendicitis or intussusception. It typically occurs in children, adolescents, and young adults. White blood count and C-reactive protein are of limited usef...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/9784565
更新日期:2017-01-01 00:00:00
abstract::The aim of the present paper was to review the most important mechanisms explaining the possible association of vitamin D deficiency and cardiovascular diseases, focusing on recent experimental and clinical data. Low vitamin D levels favor atherosclerosis enabling vascular inflammation, endothelial dysfunction, format...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/109275
更新日期:2015-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor developm...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/430943
更新日期:2015-01-01 00:00:00
abstract:Purpose:Accumulated evidence suggests that reproductive factors are related to different breast cancer subtypes, but most studies on these relationships are mainly focused on middle-aged and older patients, and it remains unclear how reproductive factors impact different subtypes of breast cancer in young women. Metho...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5931529
更新日期:2020-04-06 00:00:00
abstract::Cancer and diabetes are among the most common diseases in western societies. Epidemiological studies have shown that diabetic patients have a significantly higher risk of developing a number of different types of cancers and that individuals with comorbidity (cancer and diabetes/prediabetes) have a poorer prognosis re...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/165105
更新日期:2015-01-01 00:00:00
abstract::Host jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin-the major capsid protein in influenza A viruses-is subjected to high rate mutations, of which several occur at its "head": the receptor-bindin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3870508
更新日期:2018-05-17 00:00:00
abstract::This study aims to evaluate whether diets containing mixture of formic and propionic acid alone or supplemented with either capric acid or Bacillus Licheniformis can alleviate immune inflammatory response of piglets challenged with enterotoxigenic Escherichia coli (ETEC). A total of 30 weaning pigs were assigned to 5 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6416187
更新日期:2019-03-25 00:00:00
abstract::India is highly endemic to malaria with prevalence of all five species of human malaria parasites of Plasmodium genus. India is set for malaria elimination by 2030. Since cases of mixed Plasmodium species infections remain usually undetected but cause huge disease burden, in order to understand the distributional prev...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2847548
更新日期:2017-01-01 00:00:00
abstract::Vocal tract morphology is an important factor in voice production. Its analysis has potential implications for educational matters as well as medical issues like voice therapy. The knowledge of the complex adjustments in the spatial geometry of the vocal tract during phonation is still limited. For a major part, this ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906356
更新日期:2015-01-01 00:00:00
abstract::It is challenging and inspiring for us to achieve high spatiotemporal resolutions in dynamic cardiac magnetic resonance imaging (MRI). In this paper, we introduce two novel models and algorithms to reconstruct dynamic cardiac MRI data from under-sampled k - t space data. In contrast to classical low-rank and sparse mo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/169317
更新日期:2015-01-01 00:00:00
abstract::The laser speckle contrast imaging (LSCI) is proved to be a reliable tool in flap monitoring in general surgery; however, it has not been evaluated in oral surgery yet. We applied the LSCI to compare the effect of a xenogeneic collagen matrix (Geistlich Mucograft®) to connective tissue grafts (CTG) on the microcircula...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4042902
更新日期:2017-01-01 00:00:00
abstract::A number of statistical methods for detecting gene-gene interactions have been developed in genetic association studies with binary traits. However, many phenotype measures are intrinsically quantitative and categorizing continuous traits may not always be straightforward and meaningful. Association of gene-gene inter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/523641
更新日期:2015-01-01 00:00:00