Impact of pregnancy on zonisamide pharmacokinetics in rabbits.

abstract：:Background. The aim of this study was to assess the effects of low concentrations of H2O2 on angiogenesis of human umbilical vein endothelial cells (HUVECs) in vitro and explore the underlying mechanisms. Methods. HUVECs were cultured and stimulated with different concentrations of H2O2. Flow cytometric analysis was u...

journal_title：BioMed research international

authors： Jiang S,Zhang D,Huang H,Lei Y,Han Y,Han W

更新日期：2017-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to H...

journal_title：BioMed research international

authors： Chou YE,Hsieh MJ,Chiou HL,Lee HL,Yang SF,Chen TY

更新日期：2014-01-01 00:00:00

abstract：:Tissues in the anterior segment of the eye are particular vulnerable to oxidative stress. To minimise oxidative stress, ocular tissues utilise a range of antioxidant defence systems which include nonenzymatic and enzymatic antioxidants in combination with repair and chaperone systems. However, as we age our antioxidan...

journal_title：BioMed research international

authors： Umapathy A,Donaldson P,Lim J

更新日期：2013-01-01 00:00:00

abstract：:Progression of idiopathic dilated cardiomyopathy (IDCM) is marked with extensive left ventricular remodeling whose clinical manifestations and molecular basis are poorly understood. We aimed to evaluate the clinical potential of titin ligands in monitoring progression of cardiac remodeling associated with end-stage ID...

journal_title：BioMed research international

authors： Bogomolovas J,Brohm K,Čelutkienė J,Balčiūnaitė G,Bironaitė D,Bukelskienė V,Daunoravičus D,Witt CC,Fielitz J,Grabauskienė V,Labeit S

更新日期：2015-01-01 00:00:00

abstract：:Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to bet...

journal_title：BioMed research international

authors： Bimonte S,Barbieri A,Rea D,Palma G,Luciano A,Cuomo A,Arra C,Izzo F

更新日期：2015-01-01 00:00:00

abstract：Purpose:This study aims to compare the functional outcomes of nonunion humeral diaphyseal fractures following conservative treatment when managed surgically with either a plate or intramedullary (IM) nail fixation. Methods:This was a retrospective study of 56 patients with nonunion humeral fractures following conserva...

journal_title：BioMed research international

authors： Micic I,Kholinne E,Kwak JM,Sun Y,Nanda A,Kim H,Koh KH,Jeon IH

更新日期：2019-07-22 00:00:00

abstract：:The aim of the study is to investigate the relationship between physical activity as assessed by accelerometers and cognitive development across the human age ranges (from children and adolescents to adults). Additionally, this study seeks to explore whether physical activity contributes to cognitive development via m...

journal_title：BioMed research international

authors： Zhao G,Quan M,Su L,Zhang H,Zhang J,Zhang J,Fang H,Cao ZB,Zhu Z,Niu Z,Wang R,Chen P

更新日期：2017-01-01 00:00:00

abstract：:Large amounts of various biological networks exist for representing different types of interaction data, such as genetic, metabolic, gene regulatory, and protein-protein relationships. Recent approaches on biological network study are based on different mathematical concepts. It is necessary to construct a uniform fra...

journal_title：BioMed research international

authors： Cao Y,Xu W,Niu C,Bo X,Li F

更新日期：2017-01-01 00:00:00

abstract：Background:Left ventricular (LV) systolic dysfunction is common in septic shock. Global longitudinal strain (GLS) measured by speckle tracking echocardiography (STE) is a useful marker of intrinsic left ventricular systolic function. However, the association between left ventricular GLS and outcome in septic patients i...

journal_title：BioMed research international

authors： Hai PD,Binh NT,Hien NVQ,Hoang NH,Hoan VN,Son PN,Hoa LTV

更新日期：2020-10-21 00:00:00

abstract：PURPOSE:To evaluate tumor structure in children with diffuse intrinsic pontine glioma (DIPG) using histogram analyses of mean diffusivity (MD), determine potential treatment and corticosteroid-related effects on MD, and monitor changes in MD distributions over time. MATERIALS AND METHODS:DTI was performed on a 1.5T GE...

journal_title：BioMed research international

authors： Steffen-Smith EA,Sarlls JE,Pierpaoli C,Shih JH,Bent RS,Walker L,Warren KE

更新日期：2014-01-01 00:00:00

abstract：:Eccentric exercise is characterized by initial unfavorable effects such as subcellular muscle damage, pain, reduced fiber excitability, and initial muscle weakness. However, stretch combined with overload, as in eccentric contractions, is an effective stimulus for inducing physiological and neural adaptations to train...

journal_title：BioMed research international

authors： Hedayatpour N,Falla D

更新日期：2015-01-01 00:00:00

abstract：:Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving su...

journal_title：BioMed research international

authors： Yang DS,Lee JA,Yoon WS,Lee NK,Park YJ,Lee S,Kim CY,Son GS

更新日期：2016-01-01 00:00:00

abstract：:Introduction. The lateral lumbar interbody fusion (LLIF) surgical approach has potential advantages over other approaches but is associated with some unique neurologic risks due to the proximity of the lumbosacral plexus. The present study analyzed complications following LLIF surgical approach using a novel single fl...

journal_title：BioMed research international

authors： Nunley P,Sandhu F,Frank K,Stone M

更新日期：2016-01-01 00:00:00

abstract：:Bone grafts are medical devices that are in high demand in clinical practice for substitution of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern groups of bone grafts, the particularities of their composition, the mechanisms of their biological effects, and their therapeutic ind...

journal_title：BioMed research international

authors： Deev RV,Drobyshev AY,Bozo IY,Isaev AA

更新日期：2015-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/3746232.]. ...

journal_title：BioMed research international

authors： Liu Q,Wang C,Li P,Liu J,Huang G,Song S

更新日期：2016-01-01 00:00:00

abstract：:The aim of the study was to comparatively evaluate the fracture strength and mode of root canal treated teeth restored with resin composites with and without posts. The lingual cusps of root canal treated first upper premolars (n = 10/group) were removed down to cervical enamel and restored with the following: group A...

journal_title：BioMed research international

authors： Gaintantzopoulou MD,Farmakis ET,Eliades GC

更新日期：2018-08-14 00:00:00

abstract：:For the induction of robust humoral and cellular immune responses, a strong rationale exists to use vaccine-adjuvant combinations possessing both immune modulatory and enhanced delivery capabilities. Herein, we evaluated the combination of 2 different adjuvants, a TLR9 agonist, composed of synthetic oligodeoxynucleoti...

journal_title：BioMed research international

authors： McCluskie MJ,Weeratna RD,Evans DM,Makinen S,Drane D,Davis HL

更新日期：2013-01-01 00:00:00

abstract：:Schistosomiasis is one of the world's major public health problems. Praziquantel is currently the only effective drug against schistosomiasis. As resistance of praziquantel has emerged in some endemic areas, development of new antischistosomal agents should be a high priority. In this study, a phage display peptide li...

journal_title：BioMed research international

authors： Song LJ,Li JH,Yin XR,Zhang W,Jin Y,Gao H,Wang J,Yu CX,Hua ZC

更新日期：2018-06-05 00:00:00

abstract：:Tripartite Motif Containing 11 (TRIM11), an E3 ubiquitin ligase, is identified as a carcinogen causing certain human cancers. However, the specific role of TRIM11 is still uncovered in human osteosarcoma (OS) cells. To explore the role of TRIM11 in OS cells, TRIM11 was induced by silencing and overexpression in OS cel...

journal_title：BioMed research international

authors： Wang Z,Xu X,Tang W,Zhu Y,Hu J,Zhang X

更新日期：2019-12-25 00:00:00

abstract：:Diabetic foot ulcers (DFUs) are characterized by an unsatisfactory inflammatory and migratory response. Skin inflammation involves the participation of many cells and particularly macrophages. Macrophage function can be modulated by neuropeptides; however, little is known regarding the role of neurotensin (NT) as a mo...

journal_title：BioMed research international

authors： Moura LI,Silva L,Leal EC,Tellechea A,Cruz MT,Carvalho E

更新日期：2013-01-01 00:00:00

abstract：:Osteocalcin (Ocn) and testosterone play important roles in male skeleton. However, the concentrations of serum osteocalcin and testosterone have never been systematically compared between populations with and without primary male osteoporosis, a common skeletal disorder in adult males. We searched the PubMed, Embase, ...

journal_title：BioMed research international

authors： Liu ZY,Yang Y,Wen CY,Rong LM

更新日期：2017-01-01 00:00:00

abstract：Background:Spinal cord injury (SCI) is often associated with long-term impairments related to functional limitations in the sensorimotor system. The use of virtual reality (VR) technology may lead to increased motivation and engagement, besides allowing a wide range of possible tasks/exercises to be implemented in reha...

journal_title：BioMed research international

authors： de Araújo AVL,Neiva JFO,Monteiro CBM,Magalhães FH

更新日期：2019-11-13 00:00:00

abstract：Objective:Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods:In this retrospe...

journal_title：BioMed research international

authors： Zhao Q,Zhang M,Chu Y,Ji B,Pan H,Sun H,Ban B

更新日期：2020-08-13 00:00:00

abstract：:With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compar...

journal_title：BioMed research international

authors： Čapková M,Šáchová J,Strnad H,Kolář M,Hroudová M,Chovanec M,Čada Z,Šteffl M,Valach J,Kastner J,Vlček Č,Smetana K Jr,Plzák J

更新日期：2014-01-01 00:00:00

abstract：:To understand the progression of recovery in postural stability and physical functioning after patients received the minimally invasive total hip arthroplasty (MTHA), we monitor the pain level, functional capacity, and postural stability before and after operation within one year. In total of 23 subjects in our study,...

journal_title：BioMed research international

authors： Chang CJ,Lin NL,Lee MS,Chern JS

更新日期：2015-01-01 00:00:00

abstract：:Background. It has been suggested that, during pregnancy, endometriosis can cause a variety of disease-related complications. Objectives. The purpose of the study was to find out if women with histologically confirmed endometriosis do have a higher risk of adverse pregnancy outcome and if they suffer from a higher rat...

journal_title：BioMed research international

authors： Allerstorfer C,Oppelt P,Enzelsberger SH,Shamiyeh A,Schimetta W,Shebl OJ,Mayer RB

更新日期：2016-01-01 00:00:00

abstract：:Craniofacial development consists of a highly complex sequence of the orchestrated growth and fusion of facial processes. It is also known that craniofacial abnormalities can be detected in 1/3 of all patients with congenital diseases. Within the various craniofacial abnormalities, orofacial clefting is one of the mos...

journal_title：BioMed research international

authors： Kurosaka H

更新日期：2015-01-01 00:00:00

abstract：:Trypanosoma cruzi causes a cardiac infection characterized by an inflammatory imbalance that could become the inciting factor of the illness. To this end, we evaluated the role of carvedilol, a beta-blocker with potential immunomodulatory properties, on the immune response in C57BL/6 mice infected with VL-10 strain of...

journal_title：BioMed research international

authors： Horta AL,Leite AL,Paula Costa G,Figueiredo VP,Talvani A

更新日期：2017-01-01 00:00:00

abstract：:Guanosine is an important building block for supramolecular gels owing to the unique self-assembly property that results from the unique hydrogen bond acceptors and donor groups. Guanosine-derived supramolecular hydrogels have promise in the fields of drug delivery, targeted release, tissue engineering applications, e...

journal_title：BioMed research international

authors： Chen M,Lin W,Hong L,Ji N,Zhao H

更新日期：2019-06-13 00:00:00

abstract：:Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system, characterized by an extremely aggressive clinical phenotype. Patients with GBM have a poor prognosis and only 3-5% of them survive for more than 5 years. The current GBM treatment standards include maximal resection followed by radiot...

journal_title：BioMed research international

authors： Szopa W,Burley TA,Kramer-Marek G,Kaspera W

更新日期：2017-01-01 00:00:00