Detecting Genetic Interactions for Quantitative Traits Using m-Spacing Entropy Measure.

Abstract:

:A number of statistical methods for detecting gene-gene interactions have been developed in genetic association studies with binary traits. However, many phenotype measures are intrinsically quantitative and categorizing continuous traits may not always be straightforward and meaningful. Association of gene-gene interactions with an observed distribution of such phenotypes needs to be investigated directly without categorization. Information gain based on entropy measure has previously been successful in identifying genetic associations with binary traits. We extend the usefulness of this information gain by proposing a nonparametric evaluation method of conditional entropy of a quantitative phenotype associated with a given genotype. Hence, the information gain can be obtained for any phenotype distribution. Because any functional form, such as Gaussian, is not assumed for the entire distribution of a trait or a given genotype, this method is expected to be robust enough to be applied to any phenotypic association data. Here, we show its use to successfully identify the main effect, as well as the genetic interactions, associated with a quantitative trait.

journal_name

Biomed Res Int

authors

Yee J,Kwon MS,Jin S,Park T,Park M

doi

10.1155/2015/523641

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

523641

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.

    abstract::In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The ex...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/317403

    authors: Yao S,Hu K,Tang G,Gao S,Tang C,Yao B,Nie D,Sun T,Jiang S

    更新日期:2015-01-01 00:00:00

  • High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial cells.

    abstract::Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-β (TGF-β) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-β signaling in DN is...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/782625

    authors: Zhou X,Gao C,Huang W,Yang M,Chen G,Jiang L,Gou F,Feng H,Ai N,Xu Y

    更新日期:2014-01-01 00:00:00

  • The usefulness of impedance cardiography for predicting beneficial effects of cardiac rehabilitation in patients with heart failure.

    abstract:AIM:Cardiac rehabilitation (CR) is an important part of heart failure (HF) treatment. The aim of this paper was to evaluate if thoracic fluid content (TFC) measured by impedance cardiography (ICG) is a useful parameter for predicting the outcome of CR. METHODS:Fifty HF patients underwent clinical and noninvasive haemo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/595369

    authors: Gielerak G,Krzesiński P,Piotrowicz E,Piotrowicz R

    更新日期:2013-01-01 00:00:00

  • Incidence and Risk Factors for Postoperative Delirium in Patients Undergoing Spine Surgery: A Systematic Review and Meta-Analysis.

    abstract:Background:The present study aims to investigate the incidence and risk factors associated with postoperative delirium in patients undergoing spine surgery. Methods:PubMed, EMBASE, Cochrane Library, and Science Citation Index were searched up to August 2019 for studies examining postoperative delirium following spine ...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2019/2139834

    authors: Wu X,Sun W,Tan M

    更新日期:2019-11-26 00:00:00

  • Methylamine-sensitive amperometric biosensor based on (His)6-tagged Hansenula polymorpha methylamine oxidase immobilized on the gold nanoparticles.

    abstract::A novel methylamine-selective amperometric bienzyme biosensor based on recombinant primary amine oxidase isolated from the recombinant yeast strain Saccharomyces cerevisiae and commercial horseradish peroxidase is described. Two amine oxidase preparations were used: free enzyme (AMO) and covalently immobilized on the ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/480498

    authors: Stasyuk NY,Smutok OV,Zakalskiy AE,Zakalska OM,Gonchar MV

    更新日期:2014-01-01 00:00:00

  • Differentiation of Human Amniotic Mesenchymal Stem Cells into Human Anterior Cruciate Ligament Fibroblast Cells by In Vitro Coculture.

    abstract::Anterior cruciate ligament injuries are common in humans, though cellular components of the knee have little regenerative or proliferation potential. This study investigated the differentiation of human amnion-derived mesenchymal stem cells (hAMSCs) into human anterior cruciate ligament fibroblasts (hACLFs) in vitro t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/7360354

    authors: Li Y,Liu Z,Jin Y,Zhu X,Wang S,Yang J,Ren Y,Fu Q,Xiong H,Zou G,Liu Y

    更新日期:2017-01-01 00:00:00

  • Customized Scaffold Design Based on Natural Peripheral Nerve Fascicle Characteristics for Biofabrication in Tissue Regeneration.

    abstract:Objective:The use of a biofabrication nerve scaffold, which mimics the nerve microstructure, as an alternative for autologous nerve transplantation is a promising strategy for treating peripheral nerve defects. This study aimed to design a customized biofabrication scaffold model with the characteristics of human perip...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/3845780

    authors: Yao Z,Yan LW,Qiu S,He FL,Gu FB,Liu XL,Qi J,Zhu QT

    更新日期:2019-12-14 00:00:00

  • Socioeconomic Factors in Patients with Ulnar Nerve Compression at the Elbow: A National Registry-Based Study.

    abstract:Aims:To investigate demographics and socioeconomic status in patients with ulnar nerve compression and the influence of socioeconomic factors on patient-reported outcome measurements (PROM) as evaluated by QuickDASH (short version of Disabilities of Arm, Shoulder and Hand) after surgery for ulnar nerve compression at t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5928649

    authors: Zimmerman M,Nyman E,Steen Carlsson K,Dahlin LB

    更新日期:2020-12-18 00:00:00

  • Alterations of Hair and Nail Content of Selected Trace Elements in Nonoccupationally Exposed Patients with Chronic Depression from Different Geographical Regions.

    abstract::The aim of this study was to determine if altered levels of selected trace elements manifest themselves during chronic depression. To identify elements strongly associated with chronic depression, relationships between the elemental contents of hair and nails and the interelement correlations were checked. Inductively...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/3178784

    authors: Błażewicz A,Liao KY,Liao HH,Niziński P,Komsta Ł,Momčilović B,Jabłońska-Czapla M,Michalski R,Prystupa A,Sak JJ,Kocjan R

    更新日期:2017-01-01 00:00:00

  • Extraction and Characterization of Organ Components of the Malaysian Sea Cucumber Holothuria leucospilota Yielded Bioactives Exhibiting Diverse Properties.

    abstract::The aim of the present study was to extract and characterize bioactive components from separate body organs of Holothuria leucospilota. Preliminary qualitative assessment of the crude extracts was positive for phenols, terpenoids, carbohydrates, flavonoids, saponins, glycosides, cardiac glycosides, steroids, phlobatan...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2640684

    authors: Ceesay A,Nor Shamsudin M,Aliyu-Paiko M,Ismail IS,Nazarudin MF,Mohamed Alipiah N

    更新日期:2019-04-15 00:00:00

  • Impact of the 2009 (7th edition) AJCC melanoma staging system in the classification of thin cutaneous melanomas.

    abstract:CONTEXT:The 7th (2009) edition of the AJCC melanoma staging system incorporates tumor (Breslow) thickness, MR, and ulceration in stratifying T1 primary melanomas. Compared to the prior 6th (2001) edition, MR has replaced CL for thin melanomas. OBJECTIVE:We sought to identify and report differences of the classificatio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/898719

    authors: Chu VH,Tetzlaff MT,Torres-Cabala CA,Prieto VG,Bassett R Jr,Gershenwald JE,McLemore MS,Ivan D,Wang WL,Ross MI,Curry JL

    更新日期:2013-01-01 00:00:00

  • In vitro inhibitory and cytotoxic activity of MFM 501, a novel codonopsinine derivative, against Methicillin-Resistant Staphylococcus aureus clinical isolates.

    abstract::28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/823829

    authors: Johari SA,Mohtar M,Mohammad SA,Sahdan R,Shaameri Z,Hamzah AS,Mohammat MF

    更新日期:2015-01-01 00:00:00

  • Performance of glutamate dehydrogenase and triose phosphate isomerase genes in the analysis of genotypic variability of isolates of Giardia duodenalis from livestocks.

    abstract::Giardia duodenalis is a small intestinal protozoan parasite of several terrestrial vertebrates. This work aims to assess the genotypic variability of Giardia duodenalis isolates from cattle, sheep and pigs in the Southeast of Brazil, by comparing the standard characterization between glutamate dehydrogenase (gdh) and ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/875048

    authors: Fava NM,Soares RM,Scalia LA,Kalapothakis E,Pena IF,Vieira CU,Faria ES,Cunha MJ,Couto TR,Cury MC

    更新日期:2013-01-01 00:00:00

  • Cigarette Smoke Induced Lung Barrier Dysfunction, EMT, and Tissue Remodeling: A Possible Link between COPD and Lung Cancer.

    abstract::Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldeh...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/2025636

    authors: Hou W,Hu S,Li C,Ma H,Wang Q,Meng G,Guo T,Zhang J

    更新日期:2019-06-24 00:00:00

  • Evaluation of Antibiotic Resistance Pattern in Dental Bacteremia Detected by Multiplex PCR Technique.

    abstract::The aim of this study was to detect oral bacteremia and offer the antibiotic resistance patterns. Bacterial resistance pattern was evaluated in 50 patients. A spectrophotometer device equipped with UV and electrophoresis of the extracted samples on agarose gel for antibiogram test were used. PCR test 15 minutes after ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9502959

    authors: Rezazadeh F,Azad A,Khorami A,Modaresi F,Rezaie Z

    更新日期:2020-10-01 00:00:00

  • The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels.

    abstract::Sepsis is a severe and progressive disease characterized by systemic inflammatory response syndrome (SIRS). CD40 serves as a vital link between immune response and inflammation. This study was designed to investigate the potential association between a functional single-nucleotide polymorphism (SNP) of CD40 (rs1883832...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/7497314

    authors: Liu ZL,Hu J,Xiao XF,Peng Y,Zhao SP,Xiao XZ,Yang MS

    更新日期:2018-03-26 00:00:00

  • Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.

    abstract::Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred mo...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1155/2019/9721781

    authors: Shahidi M,Phillips RA,Chik CL

    更新日期:2019-03-13 00:00:00

  • Complications of trauma patients admitted to the ICU in level I academic trauma centers in the United States.

    abstract:BACKGROUND:The aims of this study were to evaluate the complications that occur after trauma and the characteristics of individuals who develop complications, to identify potential risk factors that increase their incidence, and finally to investigate the relationship between complications and mortality. METHODS:We di...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/473419

    authors: Mondello S,Cantrell A,Italiano D,Fodale V,Mondello P,Ang D

    更新日期:2014-01-01 00:00:00

  • Effect of Gamma Rays on Sophora davidii and Detection of DNA Polymorphism through ISSR Marker.

    abstract::Sophora davidii (Franch.) Kom. ex Pavol is an important medicinal plant and a feeding scrub with ecological value. The effects of different gamma irradiation doses (20-140 Kr) on seed germination and seedling morphology were investigated in S. davidii, and intersimple sequence repeat (ISSR) markers were used to identi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/8576404

    authors: Wang P,Zhang Y,Zhao L,Mo B,Luo T

    更新日期:2017-01-01 00:00:00

  • Lung cancer stem cell lose their stemness default state after exposure to microgravity.

    abstract::Microgravity influences cell differentiation by modifying the morphogenetic field in which stem cells are embedded. Preliminary data showed indeed that stem cells are committed to selective differentiation when exposed to real or simulated microgravity. Our study provides evidence that a similar event occurs when canc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/470253

    authors: Pisanu ME,Noto A,De Vitis C,Masiello MG,Coluccia P,Proietti S,Giovagnoli MR,Ricci A,Giarnieri E,Cucina A,Ciliberto G,Bizzarri M,Mancini R

    更新日期:2014-01-01 00:00:00

  • Hereditary Syndromes Manifesting as Endometrial Carcinoma: How Can Pathological Features Aid Risk Assessment?

    abstract::Endometrial carcinoma is the most common gynecological tumor worldwide. It can be the presenting malignancy, acting as the harbinger, of an undiagnosed hereditary syndrome. Up to 50% of females with Lynch syndrome present in this manner. Differentiation between Lynch, Muir-Torre, and Cowden syndromes can at times be c...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/219012

    authors: Wong A,Ngeow J

    更新日期:2015-01-01 00:00:00

  • Cloning and expression of synthetic genes encoding the broad antimicrobial spectrum bacteriocins SRCAM 602, OR-7, E-760, and L-1077, by recombinant Pichia pastoris.

    abstract::We have evaluated the cloning and functional expression of previously described broad antimicrobial spectrum bacteriocins SRCAM 602, OR-7, E-760, and L-1077, by recombinant Pichia pastoris. Synthetic genes, matching the codon usage of P. pastoris, were designed from the known mature amino acid sequence of these bacter...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/767183

    authors: Arbulu S,Jiménez JJ,Gútiez L,Cintas LM,Herranz C,Hernández PE

    更新日期:2015-01-01 00:00:00

  • Bone-Healing Capacity of PCL/PLGA/Duck Beak Scaffold in Critical Bone Defects in a Rabbit Model.

    abstract::Bone defects are repaired using either natural or synthetic bone grafts. Poly(ϵ-caprolactone) (PCL), β-tricalcium phosphate (TCP), and poly(lactic-co-glycolic acid) (PLGA) are widely used as synthetic materials for tissue engineering. This study aimed to investigate the bone-healing capacity of PCL/PLGA/duck beak scaf...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2136215

    authors: Lee JY,Son SJ,Son JS,Kang SS,Choi SH

    更新日期:2016-01-01 00:00:00

  • Role of Wnt/β-Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer.

    abstract::Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality worldwide. To date, chemotherapy plays an important role in the treatment of CRC patients. Multidrug resistance (MDR) is one of the major hurdles in chemotherapy for CRC, and the underlying mechanisms need to be explored. Studies have dem...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/9390878

    authors: Yuan S,Tao F,Zhang X,Zhang Y,Sun X,Wu D

    更新日期:2020-03-18 00:00:00

  • Strain diversity of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Afar pastoral region of Ethiopia.

    abstract::Data on genotypic diversity of Mycobacterium tuberculosis complex (MTBC) is important to understand its epidemiology, human adaptation, clinical phenotypes, and drug resistance. This study aimed to characterize MTBC clinical isolates circulating in a predominantly pastoralist area in Ethiopia, a country where tubercul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/238532

    authors: Belay M,Ameni G,Bjune G,Couvin D,Rastogi N,Abebe F

    更新日期:2014-01-01 00:00:00

  • Extra-Intestinal Fluoroquinolone-Resistant Escherichia coli Strains Isolated from Meat.

    abstract::Extra-intestinal E. coli are emerging as a global threat due to their diffusion as opportunistic pathogens and, above all, to their wide set of antibiotic resistance determinants. There are still many gaps in our knowledge of their origin and spread pathways, although food animals have been adjudicated vehicles for pa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8714975

    authors: Caruso G,Giammanco A,Cardamone C,Oliveri G,Mascarella C,Capra G,Fasciana T

    更新日期:2018-11-18 00:00:00

  • Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy.

    abstract:Design:From July 2016 to June 2018, 36 women with symptomatic early pregnancy around 4-8 weeks of gestation were recruited into the study. Among them, there were 16 women with viable intrauterine pregnancy (VIP), 9 women with spontaneous abortion (SA), and 11 women of EP. Serum exosomal miRNAs were extracted and measur...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3521859

    authors: Sun J,Deng G,Ruan X,Chen S,Liao H,Liu X,Li J,Zhao G,Gao J

    更新日期:2020-06-11 00:00:00

  • Tripartite Motif Containing 11 Interacts with DUSP6 to Promote the Growth of Human Osteosarcoma Cells through Regulating ERK1/2 Pathway.

    abstract::Tripartite Motif Containing 11 (TRIM11), an E3 ubiquitin ligase, is identified as a carcinogen causing certain human cancers. However, the specific role of TRIM11 is still uncovered in human osteosarcoma (OS) cells. To explore the role of TRIM11 in OS cells, TRIM11 was induced by silencing and overexpression in OS cel...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9612125

    authors: Wang Z,Xu X,Tang W,Zhu Y,Hu J,Zhang X

    更新日期:2019-12-25 00:00:00

  • Systemic and Ocular Hemodynamic Risk Factors in Glaucoma.

    abstract::Primary open angle glaucoma (POAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss. It is known that alterations in intraocular pressure (IOP), blood pressure (BP), and ocular perfusion pressure (OPP) can play a significant role in the pathogenesis of the dise...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/141905

    authors: Choi J,Kook MS

    更新日期:2015-01-01 00:00:00

  • Self-Reported Rapid Eye Movement Sleep Behavior Disturbance and Its Associated Factors among Medicine and Health Science Students at the University of Gondar.

    abstract:Introduction:Rapid eye movement sleep behavior disorder (RBD) is characterized by dream-enacting behavior (shouting, punching, and falling out of bed) related to unpleasant dreams and loss of normal rapid eye movement (REM) sleep muscle atonia. Rapid eye movement sleep enhances learning and memory by regulating neurona...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1810836

    authors: Dagnew B,Dagne H,Andualem Z

    更新日期:2020-05-15 00:00:00