Abstract:
:Adverse perinatal outcomes in singleton IVF pregnancies have been most often explained by parental underlying diseases and so far laboratory conditions during embryo culture are still not explored well. The following review discusses the current state of knowledge on the influence of IVF laboratory procedures on the possible perinatal outcome. The role of improved media for human embryo culture is unquestionable. Addition of certain components to culture media and their effect on embryo survival and implantation rates have been taken into consideration recently and studied on animal model. Impact of media on perinatal outcome in IVF offspring has also been studied. It has been discovered that epigenetic changes and neonatal birth weight are probably associated with the use of specific culture media, as is the relation between placental size and its influence on perinatal outcome. There are still questions in the discussion about duration of embryo culture (cleavage stage versus blastocyst transfer). Some of the IVF methods, such as in vitro maturation of oocytes and freezing/thawing procedures, also require well-powered randomized controlled trials in order to define their exact impact on perinatal outcome. Constant further research is needed to assess the impact of laboratory environment on fetal and postnatal development.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Marianowski P,Dąbrowski FA,Zyguła A,Wielgoś M,Szymusik Idoi
10.1155/2016/3285179subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3285179eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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