Abstract:
:This study tested the hypothesis that sensitivity of Escherichia coli to lactic acid at concentrations relevant for fermented sausages (pH 4.6, 150 mM lactic acid, aw = 0.92, temperature = 20 or 27°C) increases with increasing growth rate. For E. coli strain 683 cultured in TSB in chemostat or batch, subsequent inactivation rates when exposed to lactic acid stress increased with increasing growth rate at harvest. A linear relationship between growth rate at harvest and inactivation rate was found to describe both batch and chemostat cultures. The maximum difference in T90, the estimated times for a one-log reduction, was 10 hours between bacteria harvested during the first 3 hours of batch culture, that is, at different growth rates. A 10-hour difference in T90 would correspond to measuring inactivation at 33°C or 45°C instead of 37°C based on relationships between temperature and inactivation. At similar harvest growth rates, inactivation rates were lower for bacteria cultured at 37°C than at 15-20°C. As demonstrated for E. coli 683, culture conditions leading to variable growth rates may contribute to variable lactic acid inactivation rates. Findings emphasize the use and reporting of standardised culture conditions and can have implications for the interpretation of data when developing inactivation models.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Lindqvist R,Barmark Gdoi
10.1155/2014/471317subject
Has Abstractpub_date
2014-01-01 00:00:00pages
471317eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The ex...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/317403
更新日期:2015-01-01 00:00:00
abstract::This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6758017
更新日期:2019-12-07 00:00:00
abstract::The aim of this study was to analyze periprocedural and mid-term effect of clopidogrel on platelet function using the VerifyNow P2Y12 point-of-care assay in patients undergoing TAVI. Platelet reactivity was measured at the beginning of the procedure after 300 mg clopidogrel bolus administration and during the follow-u...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/386074
更新日期:2013-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-related death worldwide, and the most common histologic subtype is lung adenocarcinoma (LUAD). Due to the significant mortality and morbidity rates among patients with LUAD, the identification of novel biomarkers to guide diagnosis, prognosis, and therapy is urgent. Guanosine...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5171242
更新日期:2020-10-19 00:00:00
abstract:Purpose:Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/4756313
更新日期:2018-02-06 00:00:00
abstract:Background:Existing literature suggests that an association exists between coronary artery disease (CAD) and carpal tunnel syndrome (CTS), but few researchers have explored whether CTS is a risk for CAD. Materials and Methods:This large case-control study explored the association between CTS and CAD, using health insu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3171925
更新日期:2019-03-03 00:00:00
abstract::Arrhythmia is a disease that is caused by abnormal electrical activity in the heart rate or rhythm. It is the major cause of cardiovascular morbidity and mortality. Although several antiarrhythmic drugs have been used in clinic for decades, their application is often limited by their adverse effects. As a result, natu...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/4615727
更新日期:2017-01-01 00:00:00
abstract::Contrast enhanced magnetic resonance imaging (CE-MRI) has acquired a central role in the field of diagnosis and evaluation of breast cancer due to its high sensitivity; on the other hand, MRI has shown a variable specificity because of the wide overlap between the imaging features of benign and malignant lesions. Ther...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/3896946
更新日期:2018-10-21 00:00:00
abstract::Exposure to microgravity conditions causes cardiovascular deconditioning in astronauts during spaceflight. Until now, no specific drugs are available for countermeasure, since the underlying mechanism is largely unknown. Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in various vascular function...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/413708
更新日期:2014-01-01 00:00:00
abstract::Carotenoids produced by microbial sources are of industrial and medicinal importance due to their antioxidant and anticancer properties. In the current study, optimization of β-carotene production in M. circinelloides strain 277.49 was achieved using response surface methodology (RSM). Cerulenin and ketoconazole were ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8890269
更新日期:2020-12-29 00:00:00
abstract::Infective endocarditis (IE) is a life-threatening disease that is associated with high morbidity and mortality. Its long-term prognosis strongly depends on a timely and optimized antibiotic treatment. Therefore, identification of the causative pathogen is crucial and currently based on blood cultures followed by chara...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7923874
更新日期:2016-01-01 00:00:00
abstract::Autophagic elements typically appear as spherical bodies. During their life they undergo a series of changes (e.g., fusion, degradation of content, and swelling) which influence their size in a way that may be characteristic for cell type, stage of maturation, or various experimentally manipulated parameters. A simple...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/578698
更新日期:2014-01-01 00:00:00
abstract::Diabetes mellitus is a disease which has affected 415 million patients in 2015. In an effort to replace the significant demands on transplantation and morbidity associated with transplantation, the production of β-like cells differentiated from induced pluripotent stem cells (iPSCs) was evaluated. This approach is ass...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4276928
更新日期:2017-01-01 00:00:00
abstract::Purpose. Atherosclerosis is a diseased condition of blood vessel. It causes partial blockage in lumen of vessel and affects hemodynamic of localized flowing blood. Complex geometries like region of bifurcation also affects hemodynamic to a larger extent. Complexity further increases in presence of stenoses at region o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2935195
更新日期:2017-01-01 00:00:00
abstract::The influence of biomimetic calcium phosphate coating on osteoblasts behavior in vitro is not well established yet. In this study, we investigated the behavior of osteoblastic rat osteosarcoma 17/2.8 cells (ROS17/2.8) on two groups of biomaterial surfaces: alkaline-treated titanium surface (ATT) and biomimetic calcium...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/832790
更新日期:2013-01-01 00:00:00
abstract::Moringa grows in the tropical and subtropical regions of the world. The genus Moringa belongs to family Moringaceae. It is found to possess various medicinal uses including hypoglycemic, analgesic, anti-inflammatory, hypolipidemic, and antioxidant activities. In this study, we investigated the antimicrobial and the an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2698570
更新日期:2019-01-01 00:00:00
abstract::This study investigated the role of gender as a potential predictor of health behaviour and potential moderator of the relationship between emotional intelligence and health behaviour. This cross-sectional study included 1214 students (597 males and 617 females). Data were collected using the Schutte Self-Report Inven...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7058105
更新日期:2018-06-04 00:00:00
abstract::Transcatheter treatment of children with congenital heart disease such as coarctation of the aorta and pulmonary artery stenosis currently involves the use of metal stents. While these provide good short term results, there are long term complications with their use. Children outgrow metal stents, obligating them to f...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/137985
更新日期:2013-01-01 00:00:00
abstract:Purpose:To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods:Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3684971
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:This study investigates the safety and efficacy of a multimodality approach combining staged endovascular embolizations with subsequent SRS for the management of larger AVMs. METHODS:Ninety-five patients with larger AVMs were treated with staged endovascular embolization followed by SRS between 1996 and 2011...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/306518
更新日期:2014-01-01 00:00:00
abstract:Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6182464
更新日期:2020-06-07 00:00:00
abstract::Seed inoculation with bacterial consortium was found to increase legume yield, providing a higher growth than the standard nitrogen treatment methods. Alfalfa plants were inoculated by mono- and binary compositions of nitrogen-fixing microorganisms. Their physiological and biochemical properties were estimated. Inocul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/202597
更新日期:2015-01-01 00:00:00
abstract::We aimed to assess the prevalence of hospitalization for endometriosis in the general population in France and in each French region and to describe temporal trends, rehospitalization rates, and prevalence of the different types of endometriosis. The analyses were carried out on French hospital discharge data and cove...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3260952
更新日期:2016-01-01 00:00:00
abstract:Background:Many studies, comparing the health associated risks of electronic cigarettes with conventional cigarettes focus mainly on the common chemical compounds found between them. Aim:Review chemical compounds found exclusively in electronic cigarettes and describe their toxic effects, focusing on electronic-cigare...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/1386710
更新日期:2019-12-19 00:00:00
abstract:Background:The present study aims to investigate the incidence and risk factors associated with postoperative delirium in patients undergoing spine surgery. Methods:PubMed, EMBASE, Cochrane Library, and Science Citation Index were searched up to August 2019 for studies examining postoperative delirium following spine ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/2139834
更新日期:2019-11-26 00:00:00
abstract::Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is a mitochondrial inner membrane protein and plays an important role in mitochondrial ATP production and biogenesis. High expression levels of LETM1 have been correlated with numerous human malignancies. This study explored the clinicopathological sign...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/850316
更新日期:2014-01-01 00:00:00
abstract::Dietary polyphenols present in a broad range of plant foods have been related to beneficial health effects. This review aims to update the current information about the modulation of the gut microbiota by dietary phenolic compounds, from a perspective based on the experimental approaches used. After referring to gener...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/850902
更新日期:2015-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/796869
更新日期:2014-01-01 00:00:00
abstract::It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress. Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a tar...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/736104
更新日期:2015-01-01 00:00:00
abstract::Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long h...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/9620870
更新日期:2017-01-01 00:00:00