Abstract:
:Heart failure commonly results from an irreparable damage due to cardiovascular diseases (CVDs), the leading cause of morbidity and mortality in the United States. In recent years, the rapid advancements in stem cell research have garnered much praise for paving the way to novel therapies in reversing myocardial injuries. Cell types currently investigated for cellular delivery include embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and adult stem cell lineages such as skeletal myoblasts, bone-marrow-derived stem cells (BMSCs), mesenchymal stem cells (MSCs), and cardiac stem cells (CSCs). To engraft these cells into patients' damaged myocardium, a variety of approaches (intramyocardial, transendocardial, transcoronary, venous, intravenous, intracoronary artery and retrograde venous administrations and bioengineered tissue transplantation) have been developed and explored. In this paper, we will discuss the pros and cons of these delivery modalities, the current state of their therapeutic potentials, and a multifaceted evaluation of their reported clinical feasibility, safety, and efficacy. While the issues of optimal delivery approach, the best progenitor stem cell type, the most effective dose, and timing of administration remain to be addressed, we are highly optimistic that stem cell therapy will provide a clinically viable option for myocardial regeneration.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Sheng CC,Zhou L,Hao Jdoi
10.1155/2013/547902subject
Has Abstractpub_date
2013-01-01 00:00:00pages
547902eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章,评审abstract::There is minimal research of upper extremity joint dynamics during pediatric wheelchair mobility despite the large number of children using manual wheelchairs. Special concern arises with the pediatric population, particularly in regard to the longer duration of wheelchair use, joint integrity, participation and commu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/634768
更新日期:2015-01-01 00:00:00
abstract::Probiotic Lactobacillus casei Shirota (LcS) is a potential decontaminating agent of aflatoxin B1 (AFB1). However, few studies have investigated the influence of diet, especially a high protein (HP) diet, on the binding of AFB1 by probiotics. This research was conducted to determine the effect of HP diet on the ability...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9568351
更新日期:2018-05-23 00:00:00
abstract::Subtle perturbations in intraglomerular VEGF/VEGFR-2 signaling or in the influencing microenvironment can profoundly affect renal function, resulting in the apparently paradoxical observation that VEGF blockade attenuates proteinuria development in experimental diabetes despite exerting the opposite effect under other...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/201475
更新日期:2013-01-01 00:00:00
abstract::Oil palm (Elaeis guineensis Jacq) is one of the major sources of edible oil. Reducing the effect of Ganoderma, main cause of basal stem rot (BSR) on oil palm, is the main propose of this study. Understanding the oil palm defense mechanism against Ganoderma infection through monitoring changes in the secondary metaboli...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1494157
更新日期:2018-03-12 00:00:00
abstract::To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/782490
更新日期:2014-01-01 00:00:00
abstract::Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to bet...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/161508
更新日期:2015-01-01 00:00:00
abstract::Information and communications technology (ICT) could support ambient assisted living (AAL) based interventions to provide support to informal caregivers of people with dementia, especially when they need to cope with their feelings of overburden or isolation. An e-learning platform (understAID application) was tested...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2016/5726465
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/5953036
更新日期:2019-12-04 00:00:00
abstract::The relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) has attracted wide attention. Studies have reported that ginsenoside Rb1 can improve human cognitive ability and glucose tolerance during the development of diabetes. The mechanism behind the improvement in cognitive ability and glucose toler...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3905719
更新日期:2020-05-20 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5292090
更新日期:2020-06-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2926419
更新日期:2020-08-14 00:00:00
abstract::Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2957941
更新日期:2017-01-01 00:00:00
abstract::Several factors, including compressive load and knee kinematics, have been shown to influence wear. External knee moments (a surrogate for load) have recently been correlated with the medial and lateral wear scar areas of an unconstrained, PCL retaining knee design. Therefore, the purpose of this study was to determin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/284513
更新日期:2015-01-01 00:00:00
abstract::Diesel exhaust and its particles (DEP) have been under scrutiny for health effects in humans. In the development of these effects inflammation is regarded as a key process. Overall, in vitro studies report similar DEP-induced changes in markers of inflammation, including cytokines and chemokines, as studies in vivo. I...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/685142
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To distinguish between normal (SV-HUC-1) and cancerous (TCCSUP) human urothelial cell lines using microelectrical impedance spectroscopy (μEIS). MATERIALS AND METHODS:Two types of μEIS devices were designed and used in combination to measure the impedance of SV-HUC-1 and TCCSUP cells flowing through the channe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8748023
更新日期:2016-01-01 00:00:00
abstract::The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of AKNA in gastric cancer (GC). By using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, AKNA was found deregulat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6726759
更新日期:2020-05-13 00:00:00
abstract::GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/648108
更新日期:2015-01-01 00:00:00
abstract::The differential effects of a selective kappa- (κ-) opioid receptor agonist, U50488, were elucidated by monitoring the contraction of isolated guinea pig atrial and ventricular muscles. In electrically driven left atria, U50488 in nanomolar concentration range decreased the contractile force. Norbinaltorphimine (norBN...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906039
更新日期:2015-01-01 00:00:00
abstract::Prior to the "onset of hearing," developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound. One of the major hypotheses regarding the origin of such activity inv...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/367939
更新日期:2014-01-01 00:00:00
abstract::Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, inclu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/916136
更新日期:2013-01-01 00:00:00
abstract::In vivo confocal microscopy (IVCM) of the living human cornea offers the ability to perform repeated imaging without tissue damage. Studies using corneal IVCM have led to significant contributions to scientific and clinical knowledge of the living cornea in health and pathological states. Recently the application of c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/951081
更新日期:2015-01-01 00:00:00
abstract::In response to cytokine signalling and other factors, CD4-positive T lymphocytes differentiate into distinct populations that are characterized by the production of certain cytokines and are controlled by different master transcription factors. The spectrum of such populations, which was initially limited to Th1 and T...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/327470
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/493019
更新日期:2013-01-01 00:00:00
abstract::Background. Neuroinflammation which presents as a possible mechanism of delirium is associated with MCP-1, an important proinflammatory factor which is expressed on astrocytes. It is known that dexmedetomidine (DEX) possesses potent anti-inflammatory properties. This study aimed to investigate the potential effects of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6352159
更新日期:2017-01-01 00:00:00
abstract:Background:Circular RNA (circRNA) is a noncoding RNA that forms a closed-loop structure, and its abnormal expression may cause disease. We aimed to find potential network for circRNA-related competitive endogenous RNA (ceRNA) in atrial fibrillation (AF). Methods:The circRNA, miRNA, and mRNA expression profiles in the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8037273
更新日期:2020-09-29 00:00:00
abstract::cir-ITCH, a well-known tumor-suppressive circular RNA, plays a critical role in different cancers. However, its expression and functional role in prostate cancer (PCa) are unclear. Herein, we explored the potential mechanism and tumor-inhibiting role of cir-ITCH in PCa. Using reverse transcriptase polymerase chain rea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7586521
更新日期:2020-08-20 00:00:00
abstract::Mammalian protection against leishmanial infection depends on the development of an effective immune response. Zoonotic visceral leishmaniasis (ZVL) patients are usually unable to mount an effective immune response against the parasite and indeed appear to be severely immunosuppressed. This suppression has strong nons...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5861453
更新日期:2017-01-01 00:00:00
abstract::Antipsychotic drugs (APDs) used to treat clinical psychotic syndromes cause a variety of blood dyscrasias. APDs suppress the aggregation of platelets; however, the underlying mechanism remains unknown. We first analyzed platelet aggregation and clot formation in platelets treated with APDs, risperidone, clozapine, or ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2532371
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS:A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2351037
更新日期:2017-01-01 00:00:00
abstract::Natural enzyme mimics have attracted considerable attention due to leakage of enzymes and their easy denaturation during their storage and immobilization procedure. Here in this study, for the first time, a new iron oxide hydroxide, ferrihydrite - Fe1.44O0.32 (OH) 3.68 magnetic nanoparticles were synthesized by bacter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7127869
更新日期:2019-03-28 00:00:00