Abstract:
:In response to cytokine signalling and other factors, CD4-positive T lymphocytes differentiate into distinct populations that are characterized by the production of certain cytokines and are controlled by different master transcription factors. The spectrum of such populations, which was initially limited to Th1 and Th2 subsets, is currently broadened to include Th17 and Treg subsets, as well as a number of less studied subtypes, such as Tfh, Th9, and Th22. Although these subsets appear to be relatively stable, certain plasticity exists that allows for transition between the subsets and formation of hybrid transition forms. This provides the immune system flexibility needed for adequate response to pathogens but, at the same time, can play a role in the pathogenic processes in cases of deregulation. In this review, we will discuss the properties of T lymphocyte subsets and their plasticity, as well as its implications for cancer and autoimmune diseases.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Ivanova EA,Orekhov ANdoi
10.1155/2015/327470subject
Has Abstractpub_date
2015-01-01 00:00:00pages
327470eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::Purpose. Atherosclerosis is a diseased condition of blood vessel. It causes partial blockage in lumen of vessel and affects hemodynamic of localized flowing blood. Complex geometries like region of bifurcation also affects hemodynamic to a larger extent. Complexity further increases in presence of stenoses at region o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2935195
更新日期:2017-01-01 00:00:00
abstract:Purpose:To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods:A high-fat diet (HF) was given to 28 rats and 28 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3472190
更新日期:2018-08-16 00:00:00
abstract::Toxoplasma gondii (T. gondii) can be transmitted by blood transfusion. We determined the prevalence of T. gondii infection in healthy blood donors in Hermosillo city, Mexico, and the association of infection with T. gondii with the sociodemographic, clinical, and behavioral characteristics of blood donors. Four hundre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9597276
更新日期:2016-01-01 00:00:00
abstract::Professional phagocytic cells, such as dendritic cells, are mainly responsible for phagocytosis, antigen presentation, and cytokine secretion, which induce subsequent activation of T cell-mediated immunity. Thus, strategies that deliver antigens and stimulatory signals to the cells have significant implications for va...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/562924
更新日期:2013-01-01 00:00:00
abstract::Aims. To compare the clinical features of endometrial polyps (EPs) between patients with endometriosis (EM) (EM group) and without EM (non-EM group). Methods and Results. Seventy-six cases in the EM group and 133 cases in the non-EM group underwent laparotomy or hysteroscopy and laparoscopy; later, it was confirmed th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1460793
更新日期:2016-01-01 00:00:00
abstract::Bacterial infections are the most common cause of purulent soft tissue inflammations in the head and neck area. These bacteria are also responsible for the majority of inflammatory complications after third molar removal. The key to success of antibacterial treatment in both cases is the use of an appropriate antibact...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2010453
更新日期:2019-10-07 00:00:00
abstract::We identified a nitidine- (NTD-) accumulating organelle and evaluated the net cytotoxicity of accumulated NTD. To evaluate tumor cell selectivity of the drug, we evaluated its selective cytotoxicity against 39 human cancer cell lines (JFCR39 panel), and the profile was compared with those of known anticancer drugs. Or...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2130594
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/978984
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC). METHODS:Functional reannotation for the human lncRNA was carried out by ncFANs. Real-time quantitative PCR was used to v...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/405860
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4217076
更新日期:2019-03-10 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906356
更新日期:2015-01-01 00:00:00
abstract::Two fullerene derivatives (fullerenes 1 and 2), bearing a hydrophilic chain on the pyrrolidinic nitrogen, were developed with the aim to deliver anticancer agents to solid tumors. These two compounds showed a significantly different behaviour on human neoplastic cell lines in vitro in respect to healthy leukocytes. In...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/915130
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:To study whether weaker self-esteem in adolescence is connected with smoking behavior in adulthood. METHODS:An age cohort born in 1979 responded to the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the age of 16 (n = 1,072). Respondents' smoking behavior was monitored annually during adolescence and 75.3% ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/687541
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6968473
更新日期:2020-11-12 00:00:00
abstract::Peritoneal dialysis (PD) is associated with structural and functional alterations of the peritoneal membrane, consisting of fibrosis, angiogenesis, and loss of ultrafiltration capacity. Vitamin D receptor activation (VDRA) plays an important role in mineral metabolism and inflammation, but also antiangiogenic and anti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/468574
更新日期:2015-01-01 00:00:00
abstract::Diabetic foot ulcers (DFUs) are characterized by an unsatisfactory inflammatory and migratory response. Skin inflammation involves the participation of many cells and particularly macrophages. Macrophage function can be modulated by neuropeptides; however, little is known regarding the role of neurotensin (NT) as a mo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/941764
更新日期:2013-01-01 00:00:00
abstract::The uncertain position of lung tumor during radiotherapy compromises the treatment effect. To effectively control respiratory motion during radiotherapy of lung cancer without any side effects, a novel control scheme, hypnosis, has been introduced in lung cancer treatment. In order to verify the suggested method, six ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/574934
更新日期:2013-01-01 00:00:00
abstract::Angiogenesis and lymphangiogenesis are important in the proliferation and survival of the malignant hematopoietic neoplasms, including non-Hodgkin's lymphomas (NHLs). Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in the initiation of angiogenesis. Both VEGF ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/159813
更新日期:2013-01-01 00:00:00
abstract::Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C; n = 14)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2494067
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/891390
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1386158
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Vasculogenic mimicry (VM) was related to invasion and metastasis of head and neck squamous cell carcinoma (HNSCC) patients. This study was designed to investigate the role of EphA2 in VM formation of HNSCC. METHODS:The SiRNA technique was used to knock down the expression of EphA2 in vitro. The ability of cell...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/803914
更新日期:2014-01-01 00:00:00
abstract::Small renal masses have been diagnosed increasingly in recent decades, allowing surgical treatment by partial nephrectomy. This treatment option is associated with better renal function preservation, in comparison with radical nephrectomy. However, for obtaining a bloodless field during surgery, occlusion of renal art...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/8575398
更新日期:2019-02-07 00:00:00
abstract::The purpose of this study was to investigate the impact of polishing methods on the bonding effectiveness and durability of different resin cements to dentin. The dentin surfaces were either treated with a fine-grit diamond bur (polishing A) or further polished by polishing disks (polishing B), and then they were bond...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9189354
更新日期:2018-02-28 00:00:00
abstract:Objective:The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF). Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/8498603
更新日期:2019-03-21 00:00:00
abstract:Background:Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ALCF) is a complicated syndrome with extremely high short-term mortality. The artificial liver support system (ALSS) may improve the liver function for patients with HBV-ACLF, but the data on its short-term outcomes are insufficient in China. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3757149
更新日期:2019-11-29 00:00:00
abstract::The prediction of RNA-binding proteins is one of the most challenging problems in computation biology. Although some studies have investigated this problem, the accuracy of prediction is still not sufficient. In this study, a highly accurate method was developed to predict RNA-binding proteins from amino acid sequence...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/425810
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to trigger the expression of genes related to oocytes in putative ovarian stem cells scraped from the ovarian surface epithelium of women with premature ovarian failure and cultured in vitro in the presence of follicular fluid, rich in substances for oocyte growth and maturation. Ovarian surf...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/861460
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/387673
更新日期:2013-01-01 00:00:00
abstract::Diethylnitrosamine (DEN) induces hepatocarcinogenesis, increasing mitotic hepatocytes and leading to chronic inflammation. In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment. Given the association of diabetes, insulin treatment, an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9472939
更新日期:2018-04-23 00:00:00