Kölliker's organ and the development of spontaneous activity in the auditory system: implications for hearing dysfunction.

Abstract:

:Prior to the "onset of hearing," developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound. One of the major hypotheses regarding the origin of such activity involves a group of columnar epithelial supporting cells forming Kölliker's organ, which is only present during this critical period of auditory development. There is strong evidence for a purinergic signalling mechanism underlying such activity. ATP released through connexin hemichannels may activate P2 purinergic receptors in both Kölliker's organ and the adjacent IHCs, leading to generation of electrical activity throughout the auditory system. However, recent work has suggested an alternative origin, by demonstrating the ability of IHCs to generate this spontaneous activity without activation by ATP. Regardless, developmental abnormalities of Kölliker's organ may lead to congenital hearing loss, considering that mutations in ion channels (hemichannels, gap junctions, and calcium channels) involved in Kölliker's organ activity share strong links with such types of deafness.

journal_name

Biomed Res Int

authors

Dayaratne MW,Vlajkovic SM,Lipski J,Thorne PR

doi

10.1155/2014/367939

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

367939

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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