Abstract:
:Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expression throughout the different subtypes of mucosal melanoma and tumor development. We detected a frequent expression of CT7 in primaries and corresponding metastases (55%) as well as for CT10 (30%). This expression resulted to be heterogeneous in the same tumor specimen and moreover influenced by the tissue of origin. Our results support the role of these antigens in immunotherapy for mucosal melanoma.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Curioni-Fontecedro A,Pitocco R,Schoenewolf NL,Holzmann D,Soldini D,Dummer R,Calvieri S,Moch H,Mihic-Probst D,Fitsche Adoi
10.1155/2015/432479subject
Has Abstractpub_date
2015-01-01 00:00:00pages
432479eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, po...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/790842
更新日期:2013-01-01 00:00:00
abstract::Influenza virus contains two highly variable envelope glycoproteins, hemagglutinin (HA) and neuraminidase (NA). Here we show that, while HA evolution is much more complex than NA evolution, it still shows abrupt punctuation changes linked to punctuation changes of NA. HA exhibits proteinquakes, which resemble earthqua...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243162
更新日期:2015-01-01 00:00:00
abstract:Objective:Epidemiological studies have shown a correlation between periodontal disease (PD) and age-related macular degeneration (AMD). However, the results have been inconsistent, and no relevant meta-analysis has been performed on this topic. Hence, we performed a meta-analysis to evaluate whether the two diseases ar...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4753645
更新日期:2020-09-28 00:00:00
abstract::Vocal tract morphology is an important factor in voice production. Its analysis has potential implications for educational matters as well as medical issues like voice therapy. The knowledge of the complex adjustments in the spatial geometry of the vocal tract during phonation is still limited. For a major part, this ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906356
更新日期:2015-01-01 00:00:00
abstract::The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/604385
更新日期:2015-01-01 00:00:00
abstract::Cancer is a significant global health concern affecting men and women worldwide. Although current chemopreventive drugs could inhibit the growth of cancer cells, they exert many adverse side effects. Dietary factor plays a crucial role in the management of cancers and has drawn the attention of researchers to be used ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/9017902
更新日期:2017-01-01 00:00:00
abstract::We test the hypothesis that ultrasound-targeted microbubble destruction (UTMD) technique increases the renoprotective effect of kidney-targeted transplantation of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in diabetic nephropathy (DN) rats. Diabetes was induced by streptozotocin injection (60 mg/Kg, intraper...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/526367
更新日期:2013-01-01 00:00:00
abstract::New and innovative treatment strategies for cancer patients in the fields of immunotherapy and radiotherapy are rapidly developing in parallel. Among the most promising preclinical treatment approaches is combining immunotherapy with radiotherapy where early data suggest synergistic effects in several tumor model syst...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/658126
更新日期:2013-01-01 00:00:00
abstract::Patients aged from 40 to 60 with displaced fractures of the femoral neck (Garden III or IV) who received fixation with three cannulated screws from January 2005 to December 2012 were evaluated retrospectively for the development of nonunion. Plasma HbA1C, a marker for long-term plasma glucose level, anti-T2DM medicati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5682541
更新日期:2016-01-01 00:00:00
abstract:Objectives:Despite the fact that it is widely acknowledged that immune checkpoint inhibitors (ICIs) rely on the presence of immune response to take their antitumor effect, little is known whether there is an influence exerted on the efficacy of ICIs based on patients' age. We performed a systematic review and meta-anal...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/9853701
更新日期:2019-05-13 00:00:00
abstract::Background. Whether additional benefit can be achieved with the use of L-carnitine (L-C) in patients with chronic heart failure (CHF) remains controversial. We therefore performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of L-C treatment in CHF patients. Methods. Pubmed, Ovid Emba...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2017/6274854
更新日期:2017-01-01 00:00:00
abstract::Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease. However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive. Here, we showed that the anti-AβO antibody (monoclonal 72D9)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/984041
更新日期:2013-01-01 00:00:00
abstract:Objectives:To evaluate the effects of pentobarbital dosages on lower urinary tract function and to define an appropriate dosage of sodium pentobarbital that would be suitable for urodynamic studies in which recovery from anesthesia and long term survive were needed for subsequent experiment. Methods:Twenty-four 8-week...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6109497
更新日期:2020-06-11 00:00:00
abstract::Oil palm (Elaeis guineensis Jacq) is one of the major sources of edible oil. Reducing the effect of Ganoderma, main cause of basal stem rot (BSR) on oil palm, is the main propose of this study. Understanding the oil palm defense mechanism against Ganoderma infection through monitoring changes in the secondary metaboli...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1494157
更新日期:2018-03-12 00:00:00
abstract::The cytosolic isozyme of phosphoenolpyruvate carboxykinase (PCK1) was the first rate-limiting enzyme in the gluconeogenesis pathway, which exerted a critical role in maintaining the blood glucose levels. PCK1 has been established to be involved in various physiological and pathological processes, including glucose met...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3858465
更新日期:2020-02-12 00:00:00
abstract:INTRODUCTION:Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant impact on the differentiation behaviour of hMSCs. Here, we investigate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/714230
更新日期:2015-01-01 00:00:00
abstract::Accurately annotating biological functions of proteins is one of the key tasks in the postgenome era. Many machine learning based methods have been applied to predict functional annotations of proteins, but this task is rarely solved by deep learning techniques. Deep learning techniques recently have been successfully...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1729301
更新日期:2017-01-01 00:00:00
abstract::This study evaluated the presence of Acanthamoeba species in the Puzih River watershed, which features typical subtropical monsoon climate and is located just above the Tropic of Cancer in Taiwan. The relationship between the seasonal and geographical distributions of Acanthamoeba species in this rivershed was also in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/405794
更新日期:2013-01-01 00:00:00
abstract:Background:Diagnosis using reliable tools and treatment following in vitro antimicrobial susceptibility tests are critical to proper addressing of antibiotic-resistant Salmonella infection. Methodology:A cross-sectional study was conducted to assess the practice of diagnosis and treatment of salmonellosis in Addis Aba...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6406405
更新日期:2018-05-23 00:00:00
abstract::Objective. This study aims to extract motor ingredients through data mining from wearable sensors in a virtual reality goal-directed shoulder rehabilitation (GDSR) system and to examine their effects toward clinical assessment. Design. A single-group before/after comparison. Setting. Outpatient research hospital. Subj...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7075464
更新日期:2016-01-01 00:00:00
abstract::The receptor activator of NF-κB (RANK) pathway is involved in bone health as well as breast cancer (BC) pathogenesis and progression. Whereas the therapeutic implication of this pathway is established for the treatment of osteoporosis and bone metastases, the application in adjuvant BC is currently investigated. As ge...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2014/842452
更新日期:2014-01-01 00:00:00
abstract::Since the discovery of JAK2V617F tyrosine kinase-activating mutation, several genes have been found mutated in myeloproliferative neoplasms (MPNs). FLT3-ITD, NPM1, and DNMT3A mutations frequently occurred in AML patients and have been found conferred with myeloproliferative neoplasms in mouse model. Therefore, we soug...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/485645
更新日期:2014-01-01 00:00:00
abstract::DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4590609
更新日期:2017-01-01 00:00:00
abstract::Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2174657
更新日期:2016-01-01 00:00:00
abstract:Background:Preeclampsia (PE) is a pregnancy-specific hypertension syndrome and is one of the leading causes of maternal and perinatal morbidity and mortality. Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in many diseases, including preeclampsia. The present study is aimed at identifying t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1673486
更新日期:2020-06-05 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/4671349.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2020/7638969
更新日期:2020-06-30 00:00:00
abstract::The increased use of imaging modalities in the last years has led to a greater incidence in depicting abdominal incidental lesions. In particular, "incidentalomas" of the kidney are discovered in asymptomatic patients or patients who suffer from diseases not directly related to the kidneys. The aim of this paper is to...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/1854027
更新日期:2017-01-01 00:00:00
abstract::Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2123601
更新日期:2020-09-05 00:00:00
abstract:BACKGROUND:End-stage renal disease (ESRD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). OBJECTIVES:To analyze the outcome and prognostic factors of renal transplantation in patients with ESRD due to SLE from January 1986 to December 2013 in a single center. RESU...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/746192
更新日期:2014-01-01 00:00:00
abstract::Exosomal miRNAs are currently being explored as a novel class of biomarkers in cardiovascular diseases. However, few reports have focused on the value of circulating exosomal miRNAs as biomarkers for stable coronary artery disease (SCAD). Here, we aimed to investigate whether miRNAs involved in cardiovascular diseases...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3593962
更新日期:2020-12-11 00:00:00