Abstract:
:We test the hypothesis that ultrasound-targeted microbubble destruction (UTMD) technique increases the renoprotective effect of kidney-targeted transplantation of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in diabetic nephropathy (DN) rats. Diabetes was induced by streptozotocin injection (60 mg/Kg, intraperitoneally) in Sprague-Dawley rats. MSCs were administered alone or in combination with UTMD to DN rats at 4 weeks after diabetes onset. Random blood glucose concentrations were measured at 1, 2, 4, and 8 weeks, and plasma insulin levels, urinary albumin excretion rate (UAER) values, the structures of pancreas and kidney, the expressions of TGF- β 1, synaptopodin, and IL-10 were assessed at 8 weeks after MSCs transplantation. MSCs transplantation decreased blood glucose concentrations and attenuated pancreatic islets/ β cells damage. The permeability of renal interstitial capillaries and VCAM-1 expression increased after UTMD, which enhanced homing and retention of MSCs to kidneys. MSCs transplantation together with UTMD prevented renal damage and decreased UAER values by inhibiting TGF- β 1 expression and upregulating synaptopodin and IL-10 expression. We conclude that MSCs transplantation reverts hyperglycemia; UTMD technique noninvasively increases the homing of MSCs to kidneys and promotes renal repair in DN rats. This noninvasive cell delivery method may be feasible and efficient as a novel approach for personal MSCs therapy to diabetic nephropathy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zhang Y,Ye C,Wang G,Gao Y,Tan K,Zhuo Z,Liu Z,Xia H,Yang D,Li Pdoi
10.1155/2013/526367subject
Has Abstractpub_date
2013-01-01 00:00:00pages
526367eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, n = 9) and lo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/169841
更新日期:2015-01-01 00:00:00
abstract::Objective. Our objective is to develop a computerized scheme for liver tumor segmentation in MR images. Materials and Methods. Our proposed scheme consists of four main stages. Firstly, the region of interest (ROI) image which contains the liver tumor region in the T1-weighted MR image series was extracted by using se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3219068
更新日期:2016-01-01 00:00:00
abstract::Three-dimensional (3D) liver tumor segmentation from Computed Tomography (CT) images is a prerequisite for computer-aided diagnosis, treatment planning, and monitoring of liver cancer. Despite many years of research, 3D liver tumor segmentation remains a challenging task. In this paper, an efficient semiautomatic meth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5207685
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/714230.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2016/9325260
更新日期:2016-01-01 00:00:00
abstract::The objective of this study was the synthesis of folic acid- (FA-) targeted polymeric micelles of Synperonic PE/F 127-cholesteryl hemisuccinate (PF127-Chol) for specific delivery of docetaxel (DTX). Targeted or nontargeted micelles loaded with DTX were prepared via dialysis method. The effects of processing variables ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/746093
更新日期:2015-01-01 00:00:00
abstract::Here we wanted to investigate predictive value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in the diagnosis of brucellosis. Thirty-two brucellosis patients diagnosed with positive serum agglutination test and thirty-two randomized healthy subjects were enrolled in this study retrospectivel...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/210502
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:To study whether weaker self-esteem in adolescence is connected with smoking behavior in adulthood. METHODS:An age cohort born in 1979 responded to the Lawrence Self-Esteem Questionnaire (LAWSEQ) at the age of 16 (n = 1,072). Respondents' smoking behavior was monitored annually during adolescence and 75.3% ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/687541
更新日期:2015-01-01 00:00:00
abstract::Multiple sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system (CNS). Neurotropic demyelinating strain of MHV (MHV-A59 or its isogenic recombinant strain RSA59) induces MS-like disease in mice mediated by microglia, along with a small population of T cells. The mechanism of demyel...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/589048
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/6935123.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2017/1641589
更新日期:2017-01-01 00:00:00
abstract::Chlamydophila psittaci (C. psittaci) is a human zoonotic pathogen, which could result in severe respiratory disease. In the present study, we investigated the role and mechanism of the type III secretion system (T3SS) of C. psittaci in regulating the inflammatory response in host cells. C. psittaci-infected THP-1 cell...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/652416
更新日期:2015-01-01 00:00:00
abstract::The selection of the most relevant molecular descriptors to describe a target variable in the context of QSAR (Quantitative Structure-Activity Relationship) modelling is a challenging combinatorial optimization problem. In this paper, a novel software tool for addressing this task in the context of regression and clas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2905203
更新日期:2019-02-17 00:00:00
abstract:Purpose:To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods:A high-fat diet (HF) was given to 28 rats and 28 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3472190
更新日期:2018-08-16 00:00:00
abstract::The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5'-hydroxy auraptene (5'-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteobla...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9395146
更新日期:2019-12-28 00:00:00
abstract::Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation in periodontitis. In this study, we aimed to investigate the anti-inflammatory effects of quercetin on Porphyromonas gingivalis (P. gingivalis) ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6282635
更新日期:2019-08-20 00:00:00
abstract::Previous study showed that East Asian mtDNA haplogroups, especially those of Koreans, could be successfully assigned by the coupled use of analyses on coding region SNP markers and control region mutation motifs. In this study, we tried to see if the same triple multiplex analysis for coding regions SNPs could be also...
journal_title:BioMed research international
pub_type: 历史文章,杂志文章
doi:10.1155/2015/850648
更新日期:2015-01-01 00:00:00
abstract::A novel approach for selecting a rectangular template around periocular region optimally potential for human recognition is proposed. A comparatively larger template of periocular image than the optimal one can be slightly more potent for recognition, but the larger template heavily slows down the biometric system by ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/481431
更新日期:2013-01-01 00:00:00
abstract:Purpose:To evaluate the influence of systemic and ocular factors on the foveal avascular zone (FAZ) area in young Chinese subjects' healthy eyes. Methods:The current observational, cross-sectional study included 344 eyes from 172 healthy individuals (103 women, 69 men). Optical coherence tomography angiography realize...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7361492
更新日期:2020-03-24 00:00:00
abstract::RAW264.7 is a macrophage strain derived from mice tumour and shows a significant ability in antigen uptake. Real-time quantitative PCR (RT-qPCR) is one of the most commonly used methods in gene studies and requires suitable reference genes to normalize and quantitate the expression of gene of interest with sensitivity...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6131879
更新日期:2019-05-16 00:00:00
abstract::This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of struct...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/502093
更新日期:2014-01-01 00:00:00
abstract:UNLABELLED:The aims of this study were first to clearly define two different entities: locoregional recurrences and limited metastatic disease and secondly to evaluate the place of extensive surgery in these two types of recurrence. MATERIAL AND METHODS:Twenty-four patients were followed from June 2004 until May 2014....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/782654
更新日期:2015-01-01 00:00:00
abstract:Objective:To explore multiscale integrated analysis methods in identifying key regulators of esophageal cancer (ESCA). Methods:We downloaded the ESCA dataset from The Cancer Genome Atlas (TCGA) database, which contained RNA-seq data, miRNA-seq data, methylation data, and clinical phenotype information. Then, we combin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5603958
更新日期:2020-08-12 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease and its targeting of the joints indicates the presence of a candidate autoantigen(s) in synovial joints. Patients with RA show immune responses in their peripheral blood to proteoglycan (PG) aggrecan. One of the most relevant animal models of RA appears to be ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/942148
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:The aim of this study is to describe the robotic assisted transfer device (RATD) and an initial focus group evaluation by end users. The purpose of the device is to aid in the transfers of people with disabilities to and from their electric powered wheelchair (EPW) onto other surfaces. The device can be used fo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/198476
更新日期:2015-01-01 00:00:00
abstract::Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8751384
更新日期:2017-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a lethal malignancy with poor prognosis and limited treatment options. Transarterial chemoembolization (TACE) using chemotherapy agents-doxorubicin and cisplatin-is an accepted treatment option for locally advanced hepatocellular carcinoma. In the current study, we analyzed the expres...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/649750
更新日期:2015-01-01 00:00:00
abstract::Our previous studies have demonstrated that diabetes-induced oxidative stress alters homeostasis of retinal nerve growth factor (NGF) resulting in accumulation of its precursor, proNGF, at the expense of NGF which plays a critical role in preserving neuronal and retinal function. This imbalance coincided with retinal ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/571456
更新日期:2015-01-01 00:00:00
abstract::This study included 30 patients with diagnosed rheumatoid arthritis (RA) and 30 test subjects without RA (control group). The objective of the study was to examine both groups for the presence of temporomandibular disorders (TMD) and morphological changes of the temporomandibular joint (TMJ). All individuals were exam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/328560
更新日期:2014-01-01 00:00:00
abstract::The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4923640
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Histones play important roles in both host defenses and inflammation related to microbial infection. A peptide mimotope (SSV) was identified from a novel histone H1 monoclonal antibody (16G9 mAb) that was shown to inhibit the mixed lymphocyte reaction. In the present study, an anti-SSV producing hybridoma wa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/491649
更新日期:2015-01-01 00:00:00
abstract:Background:In patients with reduced systolic function, the natriuretic peptide system affects heart failure (HF) progression, but the expression of key activating (corin) and degrading enzymes (neprilysin) is not well understood. Methods and Results:This pilot study (n=48) compared plasma levels of corin, neprilysin, ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7279036
更新日期:2018-07-26 00:00:00