Abstract:
:The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum. In addition, IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were substantially following oral mushroom polysaccharides treatments. The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wang WJ,Wu YS,Chen S,Liu CF,Chen SNdoi
10.1155/2015/604385subject
Has Abstractpub_date
2015-01-01 00:00:00pages
604385eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::During vertebrate development, the lung inaugurates as an endodermal bud from the primitive foregut. Dichotomous subdivision of the bud results in arborizing airways that form the prospective gas exchanging chambers, where a thin blood-gas barrier (BGB) is established. In the mammalian lung, this proceeds through conv...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/101597
更新日期:2013-01-01 00:00:00
abstract::Antiepileptics used for treating neuropathic pain have various actions including voltage-gated Na(+) and Ca(2+) channels, glutamate-receptor inhibition, and GABA(A)-receptor activation, while local anesthetics are also used to alleviate the pain. It has not been fully examined yet how nerve conduction inhibitions by l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/540238
更新日期:2014-01-01 00:00:00
abstract::To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/419376
更新日期:2014-01-01 00:00:00
abstract::Moringa grows in the tropical and subtropical regions of the world. The genus Moringa belongs to family Moringaceae. It is found to possess various medicinal uses including hypoglycemic, analgesic, anti-inflammatory, hypolipidemic, and antioxidant activities. In this study, we investigated the antimicrobial and the an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2698570
更新日期:2019-01-01 00:00:00
abstract::Tripartite Motif Containing 11 (TRIM11), an E3 ubiquitin ligase, is identified as a carcinogen causing certain human cancers. However, the specific role of TRIM11 is still uncovered in human osteosarcoma (OS) cells. To explore the role of TRIM11 in OS cells, TRIM11 was induced by silencing and overexpression in OS cel...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9612125
更新日期:2019-12-25 00:00:00
abstract::Introduction. Pelvic organ prolapse (POP) and urinary incontinence (UI) have increasing prevalence in the elderly population. The aim of this study was to compare the comorbidities of these procedures between <70 y/o and ≥70 y/o patients. Materials and Methods. In our retrospective study over a period of 2.5 years, 40...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5184595
更新日期:2016-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a lethal malignancy with poor prognosis and limited treatment options. Transarterial chemoembolization (TACE) using chemotherapy agents-doxorubicin and cisplatin-is an accepted treatment option for locally advanced hepatocellular carcinoma. In the current study, we analyzed the expres...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/649750
更新日期:2015-01-01 00:00:00
abstract::Spontaneous bacterial peritonitis (SBP) is a common cirrhotic ascites complication which exacerbates the patient's condition. SBP is caused by gram-negative bacilli and, to a lesser extent, gram-positive cocci. Hospital-acquired infections show higher levels of drug-resistant bacteria. Geographical location influences...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/3743962
更新日期:2020-07-06 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/693613
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4935386
更新日期:2020-02-12 00:00:00
abstract:Methods:circRNA expression was analysed in six cerebrospinal fluid (CSF) samples from three patients of the infectious and noninfectious phases using an Arraystar Human circRNA Array. Differentially altered circRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR) in the 66 CSF samples of 33...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2536272
更新日期:2020-05-02 00:00:00
abstract::Parkinson's disease (PD) is a major neurodegenerative disorder for which the etiology and pathogenesis remain as elusive as for Alzheimer's disease. PD appears to be caused by genetic and environmental factors, and pedigree and cohort studies have identified numerous susceptibility genes and loci related to PD. Autoso...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/371256
更新日期:2014-01-01 00:00:00
abstract::Cumulative evidence has indicated that there is an important role for adult hippocampal neurogenesis in cognitive function. With the increasing prevalence of cognitive decline associated with neurodegenerative diseases among the ageing population, physical exercise, a potent enhancer of adult hippocampal neurogenesis,...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/403120
更新日期:2014-01-01 00:00:00
abstract::Trypanosoma cruzi causes a cardiac infection characterized by an inflammatory imbalance that could become the inciting factor of the illness. To this end, we evaluated the role of carvedilol, a beta-blocker with potential immunomodulatory properties, on the immune response in C57BL/6 mice infected with VL-10 strain of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9205062
更新日期:2017-01-01 00:00:00
abstract::Trichoderma spp. are important biocontrol filamentous fungi, which are widely used for their adaptability, broad antimicrobial spectrum, and various antagonistic mechanisms. In our previous studies, we cloned thga1 gene encoding GαI protein from Trichoderma harzianum Th-33. Its knockout mutant showed that the growth r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8329513
更新日期:2016-01-01 00:00:00
abstract:AIM:To investigate the role and mechanism of miR-15b in the proliferation and apoptosis of glioma. METHODS:The miR-15b mimics were transfected into human glioma cells to upregulate the miR-15b expression. Cyclin D1 was determined by both western blotting analysis and luciferase reporter assay. Methylthiazol tetrazoliu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/687826
更新日期:2014-01-01 00:00:00
abstract::Recombinant adeno-associated virus (AAV) vectors are powerful tools for both basic neuroscience experiments and clinical gene therapies for neurological diseases. Intravascularly administered self-complementary AAV9 vectors can cross the blood-brain barrier. However, AAV9 vectors are of limited usefulness because they...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/974819
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Using a swine model of acute myocardial ischemia, we sought to validate N-(11)C-methyl-dopamine ((11)C-MDA) as an agent capable of imaging cardiac sympathetic nerve injury. METHODS:Acute myocardial ischemia was surgically generated in Chinese minipigs. ECG and serum enzyme levels were used to detect the pres...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8430637
更新日期:2016-01-01 00:00:00
abstract::Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO's association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to la...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1064029
更新日期:2016-01-01 00:00:00
abstract:Objective:Study the effect of quality control circle (QCC) in promoting the usage of rubber dams (RD) in root canal treatment of chronic pulpitis in primary teeth. Methods:Set up a quality control group to increase the amount of rubber dams used in the treatment of chronic pulpitis in primary teeth. Monthly monitoring...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5397838
更新日期:2020-02-24 00:00:00
abstract::cir-ITCH, a well-known tumor-suppressive circular RNA, plays a critical role in different cancers. However, its expression and functional role in prostate cancer (PCa) are unclear. Herein, we explored the potential mechanism and tumor-inhibiting role of cir-ITCH in PCa. Using reverse transcriptase polymerase chain rea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7586521
更新日期:2020-08-20 00:00:00
abstract::Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the key...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/827635
更新日期:2014-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic properties. Engineering m...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/9652817
更新日期:2018-12-26 00:00:00
abstract::The purpose of this study was to describe the first metabolic profile of human sperm cells through the application of an untargeted platform based on gas chromatography-mass spectrometry (GC-MS). Sperm cell samples from patients diagnosed with idiopathic asthenozoospermia (n = 30) and healthy subjects (n = 30) were an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8327506
更新日期:2018-02-28 00:00:00
abstract::The study quantified the relative absolute PSCA level in relation to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) level in the peripheral blood of 478 hormone-naive prostate cancer (PC) patients who underwent radical prostatectomy from 2005 to 2012 and evaluated its prognostic significance as a risk factor for...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/292454
更新日期:2015-01-01 00:00:00
abstract::The ultrasound imaging is one of the most common schemes to detect diseases in the clinical practice. There are many advantages of ultrasound imaging such as safety, convenience, and low cost. However, reading ultrasound imaging is not easy. To support the diagnosis of clinicians and reduce the load of doctors, many u...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/5137904
更新日期:2018-03-04 00:00:00
abstract:PURPOSE:The primary aim of this study was to explore if classification, whether using the BI-RADS categories based on CEUS or conventional ultrasound, was conducive to the identification of benign and malignant category 3 or 4 small breast lesions. MATERIAL AND METHODS:We evaluated 30 malignant and 77 benign small bre...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/572532
更新日期:2014-01-01 00:00:00
abstract::Osteoarthritis (OA) is one of the most common debilitating disorders among the elderly population. At present, there is no definite cure for the underlying causes of OA. However, adipose tissue-derived stem cells (ADSCs) in the form of stromal vascular fraction (SVF) may offer an alternative at this time. ADSCs are on...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/4702674
更新日期:2016-01-01 00:00:00
abstract::Pathological studies have shown an association between psoriasis and renal injury (RI), but the mechanism between RI and psoriasis was still unclear. This paper was designed to investigate the relationship and mechanism between psoriasis-like inflammation and renal injury in BALB/C mice. Mice were topically smeared im...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3535264
更新日期:2020-01-21 00:00:00
abstract::This study was designed to explore the effect of basic fibroblast growth factor (bFGF) on radiation-induced endothelial dysfunction and histological changes in the urinary bladder. bFGF was administrated to human umbilical vein cells (HUVEC) or urinary bladder immediately after radiation. Reduced expression of thrombo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/967680
更新日期:2015-01-01 00:00:00