Abstract:
:Cumulative evidence has indicated that there is an important role for adult hippocampal neurogenesis in cognitive function. With the increasing prevalence of cognitive decline associated with neurodegenerative diseases among the ageing population, physical exercise, a potent enhancer of adult hippocampal neurogenesis, has emerged as a potential preventative strategy/treatment to reduce cognitive decline. Here we review the functional role of adult hippocampal neurogenesis in learning and memory, and how this form of structural plasticity is altered in neurodegenerative diseases known to involve cognitive impairment. We further discuss how physical exercise may contribute to cognitive improvement in the ageing brain by preserving adult neurogenesis, and review the recent approaches for measuring changes in neurogenesis in the live human brain.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yau SY,Gil-Mohapel J,Christie BR,So KFdoi
10.1155/2014/403120subject
Has Abstractpub_date
2014-01-01 00:00:00pages
403120eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章,评审abstract::This paper represents data of long-term open prospective study. 312 male clean-up workers, who participated in elimination of the Chernobyl disaster consequences in 1986-87, were observed and examined in Moscow Research Institute of Psychiatry. The average age of patients was 57,0 ± 6,8 years. All patients were diagno...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/948473
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Primary malignant spine/spinal tumors (PMSTs) are rare and life-threatening diseases. In this study, we demonstrated the advantage of volume-based 18F-FDG PET/CT metabolic parameter, metabolic tumor volume (MTV), for assessing the aggressiveness of PMSTs. MATERIALS AND METHODS:We retrospectively...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8132676
更新日期:2017-01-01 00:00:00
abstract::There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma sam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9807918
更新日期:2020-09-02 00:00:00
abstract::Polymyxin E or colistin, produced by Paenibacillus polymyxa, is an important antibiotic against Gram-negative pathogens. The objective of this study is to evaluate the effect of starch in fermentation medium on colistin biosynthesis in P. polymyxa. The results indicated that replacement of glucose by starch stimulated...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1934309
更新日期:2018-10-14 00:00:00
abstract::Patients aged from 40 to 60 with displaced fractures of the femoral neck (Garden III or IV) who received fixation with three cannulated screws from January 2005 to December 2012 were evaluated retrospectively for the development of nonunion. Plasma HbA1C, a marker for long-term plasma glucose level, anti-T2DM medicati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5682541
更新日期:2016-01-01 00:00:00
abstract::Legumes have developed a unique way to interact with bacteria: in addition to preventing infection from pathogenic bacteria like any other plant, legumes also developed a mutualistic symbiotic relationship with one gender of soil bacteria: rhizobium. This interaction leads to the development of a new root organ, the n...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/507946
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To assess quality of care of women with severe maternal morbidity and to identify associated factors. METHOD:This is a national multicenter cross-sectional study performing surveillance for severe maternal morbidity, using the World Health Organization criteria. The expected number of maternal deaths was cal...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2014/989815
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/207250
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To evaluate the changes of keratocytes and dendritic cells in the central clear graft by laser scanning in vivo confocal microscopy after penetrating keratoplasty (PK). METHODS:Thirty adult subjects receiving PK at Shandong Eye Institute and with clear grafts and no sign of immune rejection after surgery were ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5159746
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4743974
更新日期:2020-10-21 00:00:00
abstract::RRM2B gene encodes ribonucleoside-diphosphate reductase subunit M2 B, the p53-inducible small subunit (p53R2) of ribonucleotide reductase (RNR), an enzyme catalyzing dNTP synthesis for mitochondrial DNA. Defects in this gene may cause severe mitochondrial disease affecting mainly the nervous system. This study is aime...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7614634
更新日期:2020-07-25 00:00:00
abstract::Light traps represent the most used attractive system to collect and monitor phlebotomine sand flies. Recent studies have suggested that light traps can be easily upgraded by the use of light-emitting diode (LED) with positive effects on trap design, weight, and battery life. However, scant data on the effect of diffe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6432637
更新日期:2018-06-27 00:00:00
abstract::Purslane, a fleshy herbaceous plant, plays a pivotal role in various preventive and therapeutic purposes. To date, no report has documented the consequence of salt stress on metabolite accumulation in purslane. Herein, we proposed an insight into the metabolic and physiological traits of purslane under saline stress e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4827045
更新日期:2020-06-17 00:00:00
abstract::Purpose. We examined the role of miR-20b in development of thymoma-associated myasthenia gravis, especially in T cell proliferation and activation. Materials and Methods. Using qRT-PCR, we assessed expression levels of miR-20b and its target genes in cultured cells and patient samples and examined the proliferation of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9595718
更新日期:2016-01-01 00:00:00
abstract::The body's autoimmune process is involved in the development of Graves' disease (GD), which is manifested by an overactive thyroid gland. In some patients, autoreactive inflammatory reactions contribute to the development of symptoms such as thyroid ophthalmopathy, and the subsequent signs and symptoms are derived fro...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/7453260
更新日期:2019-11-12 00:00:00
abstract::Arrhythmia is a disease that is caused by abnormal electrical activity in the heart rate or rhythm. It is the major cause of cardiovascular morbidity and mortality. Although several antiarrhythmic drugs have been used in clinic for decades, their application is often limited by their adverse effects. As a result, natu...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/4615727
更新日期:2017-01-01 00:00:00
abstract::Renal inflammation can result in renal injury. Uric acid (UA) is the final product of purine metabolism in humans and because of the lack of urate oxidase, UA may accumulate in tissues, including kidney, causing inflammation. Galangin was isolated from a traditional Chinese medicine plant and possesses several benefic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3018357
更新日期:2019-05-26 00:00:00
abstract::The interaction of patulin with human serum albumin (HSA) was studied in vitro under normal physiological conditions. The study was performed using fluorescence, ultraviolet-visible spectroscopy (UV-Vis), circular dichroism (CD), atomic force microscopy (AFM), and molecular modeling techniques. The quenching mechanism...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/734850
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Frail older people are often unable to undertake high-intensity exercise programmes. Chair-based exercises (CBEs) are used as an alternative, for which health benefits are uncertain. OBJECTIVE:To examine the effects of CBE programmes for frail older people through a systematic review of existing literatur...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/309506
更新日期:2013-01-01 00:00:00
abstract::Brain injury such as traumatic brain injury (TBI) and stroke is the major cause of long-term disabilities in many countries. The increasing rate of brain damaged victims and the heterogeneity of impairments decrease rehabilitation effectiveness and competence resulting in higher cost of rehabilitation treatment. On th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/493562
更新日期:2015-01-01 00:00:00
abstract::Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/341308
更新日期:2015-01-01 00:00:00
abstract::Waldenström macroglobulinemia (WM) is a malignant lymphoplasma-proliferative disorder with IgM monoclonal gammopathy. A recent whole-genome study identified MYD88 L265P as the key mutation in WM. We investigated MYD88 mutations in conjunction with cytogenetic study in 22 consecutive Korean WM patients. Conventional G-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/363540
更新日期:2014-01-01 00:00:00
abstract::Objectives. Lung ultrasonography (LUS) is a useful examination to identify lung problems. Unfortunately, there are currently no LUS educational programs for medical students. We designed a brief LUS training course for medical students during the ED rotation. The purpose of training was improving cognitive and psychom...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8147075
更新日期:2017-01-01 00:00:00
abstract::Carotenoids produced by microbial sources are of industrial and medicinal importance due to their antioxidant and anticancer properties. In the current study, optimization of β-carotene production in M. circinelloides strain 277.49 was achieved using response surface methodology (RSM). Cerulenin and ketoconazole were ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8890269
更新日期:2020-12-29 00:00:00
abstract::This study aimed to estimate the distribution of hepatitis B virus (HBV) C/D recombinant in Han and Tibet patients with chronic hepatitis B (CHB) and then learn such strain's replication capacity in vivo. A total of 331 serum samples were collected from Han outpatients from Sichuan Province and Tibetan outpatients fro...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8415907
更新日期:2017-01-01 00:00:00
abstract::Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2123601
更新日期:2020-09-05 00:00:00
abstract::We have developed a new "drug" and approach that appear to be effective in reducing arterial age. This "drug" represents a low, subtherapeutic dose of statin and sartan and particularly their low-dose combination. The improvement of arterial wall characteristics, also reflecting in a decrease of arterial age, was achi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/235709
更新日期:2015-01-01 00:00:00
abstract:Objective:To observe the effect of adenosine A1 receptor in the hippocampus of mice on GSK-3β phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Α1 receptor mediating cerebral ischemia-reperfusion injury. Method:The model of middle cerebral artery occlusion (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6848450
更新日期:2020-02-20 00:00:00
abstract:Background:The distinction between right-sided and left-sided colon adenocarcinoma has recently received considerable. This study aims to identify key MicroRNA (miRNA) and mRNAs in right-sided colon adenocarcinoma (RSCOAD) and left-sided colon adenocarcinoma (LSCOAD) by TCGA integration analysis. Methods:The miRNA and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7149296
更新日期:2019-04-03 00:00:00
abstract::Cholesterol is a waxy substance present in all types of the body cells. The presence of higher concentration of low density lipoprotein (LDL) is characterized by abnormal cholesterol level and is associated with cardiovascular diseases which lead to the development of atheroma in arteries known as atherosclerosis. The...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1359528
更新日期:2019-04-28 00:00:00