Abstract:
Background:The distinction between right-sided and left-sided colon adenocarcinoma has recently received considerable. This study aims to identify key MicroRNA (miRNA) and mRNAs in right-sided colon adenocarcinoma (RSCOAD) and left-sided colon adenocarcinoma (LSCOAD) by TCGA integration analysis. Methods:The miRNA and mRNA expression profiles of a large group of patients with RSCOAD and LSCOAD were obtained from TCGA. The differentially expressed miRNAs (DEmiRNAs) and mRNAs (DEmRNAs) were identified by TCGA integration analysis. The optimal diagnostic miRNA biomarkers for RSCOAD and LSCOAD were identified by Boruta algorithm. We established classification models to distinguish RSCOAD and LSCOAD. Protein-protein interaction (PPI) network analysis, DEmiRNA-DEmRNA interaction analysis, and functional annotation were performed. The expression of selected DEmiRNAs and DEmRNAs was validated by qRT-PCR. Results:A total of 2534 DEmRNAs (940 downregulated and 1594 upregulated mRNAs) and 54 DEmiRNAs (22 downregulated and 32 upregulated miRNAs) between RSCOAD and LSCOAD were identified. The feature selection procedure was to obtain 22 optimal diagnostic miRNAs biomarkers in RSCOAD compared to LSCOAD. The AUC of the random forests model was 0.869 and the specificity and sensitivity of this model were 79% and 84.6%, respectively. Three DEmiRNAs (hsa-miR-224-5p, hsa-miR-155-5p, and hsa-miR-31-5p) and five DEmRNAs (CXCR4, SMAD4, KRAS, FITM2, and PLAGL2) were identified key DEmiRNAs and DEmRNAs in RSCOAD compared to LSCOAD. The qRT-PCR results of CXCR4, FITM2, TFAP2A, ULBP2, hsa-miR-224-5p, and hsa-miR-155-5p were consistent with our integrated analysis. Conclusion:A total of three DEmiRNAs (hsa-miR-224-5p, hsa-miR-155-5p, and hsa-miR-31-5p) and five DEmRNAs (CXCR4, SMAD4, KRAS, FITM2, and PLAGL2) may be involved in the pathogenesis of RSCOAD and LSCOAD which may make a contribution for understanding mechanisms and developing therapeutic strategies for RSCOAD and LSCOAD.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yang L,Li L,Ma J,Yang S,Zou C,Yu Xdoi
10.1155/2019/7149296subject
Has Abstractpub_date
2019-04-03 00:00:00pages
7149296eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章abstract::Since 2009 pandemic, international health authorities recommended monitoring severe and complicated cases of respiratory disease, that is, severe acute respiratory infection (SARI) and acute respiratory distress syndrome (ARDS). We evaluated the proportion of SARI/ARDS cases and deaths due to influenza A(H1N1)pdm09 in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/241298
更新日期:2014-01-01 00:00:00
abstract::The craniofacial complex is the billboard of sorts containing information about sex, health, ancestry, kinship, genes, and environment. A thorough knowledge of the genes underlying craniofacial morphology is fundamental to understanding craniofacial biology and evolution. These genes can also provide an important foun...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3054578
更新日期:2016-01-01 00:00:00
abstract::Toll-like receptors (TLRs) play a key role in the innate immune response to numerous pathogens, including Acanthamoeba spp. The aim of this study was to determine the expression of TLR2 and TLR4 in the eyes of mice following intranasal infection with Acanthamoeba spp. in relation to the host's immunological status. Am...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1401894
更新日期:2019-06-12 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/682857
更新日期:2015-01-01 00:00:00
abstract::Neem (Azadirachta indica A. Juss) oil (NO) was assayed against forty-eight isolates of Escherichia coli by standardised disc diffusion test and microdilution test. By molecular biology characterization, fourteen isolates resulted in diarrheagenic E. coli with sixteen primer pairs that specifically amplify unique seque...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/343610
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1434538
更新日期:2019-03-12 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4376598
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/129048
更新日期:2014-01-01 00:00:00
abstract::Severe acute pancreatitis (SAP) results in high mortality. This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS). Many studies have reported the beneficial effects of emodin against SAP with SIRS. However, the exact mechanism unde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1736024
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/437328
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/264971
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/761264
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2014/468959
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/460106
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3909102
更新日期:2019-07-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/637853
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/496193
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3687416
更新日期:2019-01-14 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3462363
更新日期:2020-06-27 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4250329
更新日期:2020-07-22 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/580460
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/9647156
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4193538
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3162649
更新日期:2016-01-01 00:00:00
abstract::This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subs...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1758071
更新日期:2020-11-24 00:00:00
abstract::Secretory leukoprotease inhibitor (SLPI) is an anti-inflammatory protein present in respiratory secretions. Whilst epithelial cell SLPI is extensively studied, neutrophil associated SLPI is poorly characterised. Neutrophil function including chemotaxis and degranulation of proteolytic enzymes involves changes in cytos...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/560141
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/6021394
更新日期:2016-01-01 00:00:00
abstract::The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats. In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw. Doxorubicin was adminis...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/934239
更新日期:2013-01-01 00:00:00
abstract:Objectives:(1) To determine whether manual (MTB), or electric, tooth brushing (ETB) modulates whole salivary flow rate in older adults who are free of systemic disease. (2) To determine the duration of the brushing-related modulation of salivary flow rate. (3) To compare salivary flow rate modulation associated with MT...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3904139
更新日期:2018-02-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3656574
更新日期:2016-01-01 00:00:00