Abstract:
:This study aimed to examine the expression of and the relationship between CD44V6, CDH11, and β-catenin. The expression of these cell adhesion molecules was detected in 90 osteosarcoma and 20 osteochondroma specimens using immunohistochemistry. Associations between these parameters and clinicopathological data were also examined. The expression rates of CD44V6, CDH11, and β-catenin were 25.0% (5/20), 70.0% (14/20), and 20.0% (4/20) in osteochondroma specimens, respectively. Compared to osteochondromas, the proportions of expression of CD44V6 and β-catenin in osteosarcoma specimens increased to 65.6% (59/90) and 60.0% (54/90), respectively. However, the expression rate of CDH11 in osteosarcomas was reduced to 40.0% (36/90). The expression of these markers was significantly associated with metastasis and overall survival (P < 0.05). Survival analysis revealed that patients with increased expression of CD44V6 and β-catenin as well as decreased expression of CDH11 were correlated with a shorter survival time. Multivariate analysis indicated that clinical stage, metastasis status, and the expression of CD44V6, CDH11, and β-catenin were found to be associated with overall survival. Further, the expression of β -catenin and that of CD44V6 were positively correlated with each other. Thus, our results indicated abnormal expression of CD44V6, CDH11, and β-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Deng Z,Niu G,Cai L,Wei R,Zhao Xdoi
10.1155/2013/496193subject
Has Abstractpub_date
2013-01-01 00:00:00pages
496193eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::Previously, a novel technique was proposed to quantify the relationship between the muscle stiffness and its nonfatigue contraction intensity. The method extended the measured range of isometric contraction to 100% maximum voluntary contraction (MVC) using an ultrasonic shear wave measurement setup. Yet, it has not be...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9469548
更新日期:2017-01-01 00:00:00
abstract::Several intestinal parasites of baboons are of zoonotic importance, especially where there is considerable interaction between the baboons and humans. The identification of gastrointestinal parasite infections of baboons (Papio anubis) was undertaken at the Shai Hills Reserve Resort, Ghana. A total of 51 faecal sample...
journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2020-03-11 00:00:00
abstract:Background:Diagnosis using reliable tools and treatment following in vitro antimicrobial susceptibility tests are critical to proper addressing of antibiotic-resistant Salmonella infection. Methodology:A cross-sectional study was conducted to assess the practice of diagnosis and treatment of salmonellosis in Addis Aba...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6406405
更新日期:2018-05-23 00:00:00
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pub_type: 杂志文章,评审
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abstract::Sentinel lymph node biopsy (SLNB) emerged in the 1990s as a new technique in the surgical management of the axilla for patients with early breast cancer, resulting in lower complication rates and better quality of life than axillary lymph node dissection (ALND). Today SLNB is firmly established in the armamentarium of...
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1155/2015/240240
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/931028
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3941242
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/965853
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2013/206525
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/957547
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5171242
更新日期:2020-10-19 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3071214
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/872701
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2015/635745
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/6982897
更新日期:2018-03-12 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8037273
更新日期:2020-09-29 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/1907906.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2019/6897187
更新日期:2019-11-20 00:00:00
abstract::In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues. The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/814984
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3909102
更新日期:2019-07-11 00:00:00
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doi:10.1155/2019/6274545
更新日期:2019-04-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/318364
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7485409
更新日期:2019-07-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1854269
更新日期:2018-01-08 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6937837
更新日期:2019-02-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/513906
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/923742
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/153437
更新日期:2015-01-01 00:00:00