The prognostic significance of CD44V6, CDH11, and β-catenin expression in patients with osteosarcoma.

Abstract:

:This study aimed to examine the expression of and the relationship between CD44V6, CDH11, and β-catenin. The expression of these cell adhesion molecules was detected in 90 osteosarcoma and 20 osteochondroma specimens using immunohistochemistry. Associations between these parameters and clinicopathological data were also examined. The expression rates of CD44V6, CDH11, and β-catenin were 25.0% (5/20), 70.0% (14/20), and 20.0% (4/20) in osteochondroma specimens, respectively. Compared to osteochondromas, the proportions of expression of CD44V6 and β-catenin in osteosarcoma specimens increased to 65.6% (59/90) and 60.0% (54/90), respectively. However, the expression rate of CDH11 in osteosarcomas was reduced to 40.0% (36/90). The expression of these markers was significantly associated with metastasis and overall survival (P < 0.05). Survival analysis revealed that patients with increased expression of CD44V6 and β-catenin as well as decreased expression of CDH11 were correlated with a shorter survival time. Multivariate analysis indicated that clinical stage, metastasis status, and the expression of CD44V6, CDH11, and β-catenin were found to be associated with overall survival. Further, the expression of β -catenin and that of CD44V6 were positively correlated with each other. Thus, our results indicated abnormal expression of CD44V6, CDH11, and β-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research.

journal_name

Biomed Res Int

authors

Deng Z,Niu G,Cai L,Wei R,Zhao X

doi

10.1155/2013/496193

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

496193

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

杂志文章
  • Accuracy on Scanned Images of Full Arch Models with Orthodontic Brackets by Various Intraoral Scanners in the Presence of Artificial Saliva.

    abstract:Aim:This study aims to evaluate the accuracy of scanned images of 4 clinically used intraoral scanners (CS3600, i500, Trios3, Omnicam) when scanning the surface of full arch models with various kinds of orthodontic brackets in the presence of artificial saliva. Materials and Methods. Four study models were prepared; bo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2920804

    authors: Song J,Kim M

    更新日期:2020-02-27 00:00:00

  • Novel Model to Predict the Prognosis of Patients with Stage II-III Colon Cancer.

    abstract::Different opinions exist on the relationship between the C-reactive protein-to-albumin ratio (CAR) and the prognosis of colon cancer. This study is aimed at evaluating the relationship between CAR and prognosis of stage II-III colon cancer and establishing a clinical prognosis model. Patients were randomised to a trai...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8812974

    authors: Xu Y,Liang F,Chen Y,Wang Z,Zhong H,Tang W

    更新日期:2020-11-22 00:00:00

  • Clinical Features, Outcomes, and Risk Factors of Bloodstream Infections due to Stenotrophomonas maltophilia in a Tertiary-Care Hospital of China: A Retrospective Analysis.

    abstract::Background. Stenotrophomonas maltophilia bacteremia (SMB) is the most perilous situation as compared to other types of S. maltophilia infection. The present study aimed to investigate the clinical features, distribution, drug resistance, and predictors of survival of SMB in a tertiary-care hospital of China. Methods. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4931501

    authors: Chen Y,Suo J,Du M,Chen L,Liu Y,Wang L,Liang Z

    更新日期:2019-12-09 00:00:00

  • Effect of mesenchymal stem cells and a novel curcumin derivative on Notch1 signaling in hepatoma cell line.

    abstract::This study was conducted to evaluate the effect of mesenchymal stem cells (MSCs) and a novel curcumin derivative (NCD) on HepG2 cells (hepatoma cell line) and to investigate their effect on Notch1 signaling pathway target genes. HepG2 cells were divided into HepG2 control group, HepG2 cells treated with MSC conditione...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/129629

    authors: Abdel Aziz MT,Khaled HM,El Hindawi A,Roshdy NK,Rashed LA,Sabry D,Hassouna AA,Taha F,Ali WI

    更新日期:2013-01-01 00:00:00

  • Clinical Characteristics of Hospitalized Patients with Drug-Induced Acute Kidney Injury and Associated Risk Factors: A Case-Control Study.

    abstract:Background:Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clinical characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. Methods:A retrospec...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9742754

    authors: Yu C,Guo D,Yao C,Yang H,Liu S,Zhu Y,Kong X

    更新日期:2020-09-14 00:00:00

  • Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study.

    abstract:OBJECTIVE:We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer's disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). METHODS:The baseline sample of 18...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1155/2015/828120

    authors: Laske C,Sohrabi HR,Jasielec MS,Müller S,Koehler NK,Gräber S,Förster S,Drzezga A,Mueller-Sarnowski F,Danek A,Jucker M,Bateman RJ,Buckles V,Saykin AJ,Martins RN,Morris JC,Dominantly Inherited Alzheimer Network Dian

    更新日期:2015-01-01 00:00:00

  • Detection of Folliculin Gene Mutations in Two Chinese Families with Birt-Hogg-Dube Syndrome.

    abstract::Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/8751384

    authors: Liu L,Yang K,Wang X,Shi Z,Yang Y,Yuan Y,Guo T,Xiao X,Luo H

    更新日期:2017-01-01 00:00:00

  • Selection of Lipases for the Synthesis of Biodiesel from Jatropha Oil and the Potential of Microwave Irradiation to Enhance the Reaction Rate.

    abstract::The present study deals with the enzymatic synthesis of biodiesel by transesterification of Jatropha oil (Jatropha curcas L.) with ethanol in a solvent-free system. Seven commercial lipase preparations immobilized by covalent attachment on epoxy-polysiloxane-polyvinyl alcohol composite (epoxy-SiO2-PVA) were tested as ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1404567

    authors: Souza LT,Mendes AA,de Castro HF

    更新日期:2016-01-01 00:00:00

  • Expression of pluripotency and oocyte-related genes in single putative stem cells from human adult ovarian surface epithelium cultured in vitro in the presence of follicular fluid.

    abstract::The aim of this study was to trigger the expression of genes related to oocytes in putative ovarian stem cells scraped from the ovarian surface epithelium of women with premature ovarian failure and cultured in vitro in the presence of follicular fluid, rich in substances for oocyte growth and maturation. Ovarian surf...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/861460

    authors: Virant-Klun I,Skutella T,Kubista M,Vogler A,Sinkovec J,Meden-Vrtovec H

    更新日期:2013-01-01 00:00:00

  • Elevated red blood cell distribution width as a simple prognostic factor in patients with symptomatic multiple myeloma.

    abstract::Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/145619

    authors: Lee H,Kong SY,Sohn JY,Shim H,Youn HS,Lee S,Kim HJ,Eom HS

    更新日期:2014-01-01 00:00:00

  • The Vulnerability of Vessels Involved in the Role of Embolism and Hypoperfusion in the Mechanisms of Ischemic Cerebrovascular Diseases.

    abstract::Accurate definition and better understanding of the mechanisms of stroke are crucial as this will guide the effective care and therapy. In this paper, we review the previous basic and clinical researches on the causes or mechanisms of ischemic cerebrovascular diseases (ICVD) and interpret the correlation between embol...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/8531958

    authors: Yu YP,Tan L

    更新日期:2016-01-01 00:00:00

  • CD57 expression in incidental, clinically manifest, and metastatic carcinoma of the prostate.

    abstract:OBJECTIVES:CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue. METHODS:We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared wit...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/356427

    authors: Wangerin H,Kristiansen G,Schlomm T,Stephan C,Gunia S,Zimpfer A,Weichert W,Sauter G,Erbersdobler A

    更新日期:2014-01-01 00:00:00

  • Evaluating the Use of Serum Inflammatory Markers for Preoperative Diagnosis of Infection in Patients with Nonunions.

    abstract:Purpose:The aim of this study is to evaluate the effectiveness of laboratory serum tests in the diagnosis of infected nonunion. Methods:Forty-two patients suspected of having infected nonunion were investigated in the study. The serum levels of white blood-cell count (WBC), C-reactive protein (CRP), erythrocyte sedime...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/9146317

    authors: Wang S,Yin P,Quan C,Khan K,Wang G,Wang L,Cui L,Zhang L,Zhang L,Tang P

    更新日期:2017-01-01 00:00:00

  • Inverse Kinematics for Upper Limb Compound Movement Estimation in Exoskeleton-Assisted Rehabilitation.

    abstract::Robot-Assisted Rehabilitation (RAR) is relevant for treating patients affected by nervous system injuries (e.g., stroke and spinal cord injury). The accurate estimation of the joint angles of the patient limbs in RAR is critical to assess the patient improvement. The economical prevalent method to estimate the patient...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/2581924

    authors: Cortés C,de Los Reyes-Guzmán A,Scorza D,Bertelsen Á,Carrasco E,Gil-Agudo Á,Ruiz-Salguero O,Flórez J

    更新日期:2016-01-01 00:00:00

  • Forecasting COVID-19 Cases Using Alpha-Sutte Indicator: A Comparison with Autoregressive Integrated Moving Average (ARIMA) Method.

    abstract::COVID-19 is a pandemic which has spread to more than 200 countries. Its high transmission rate makes it difficult to control. To date, no specific treatment has been found as a cure for the disease. Therefore, prediction of COVID-19 cases provides a useful insight to mitigate the disease. This study aims to model and ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8850199

    authors: Attanayake AMCH,Perera SSN

    更新日期:2020-12-03 00:00:00

  • Netrins and their roles in placental angiogenesis.

    abstract::Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence o...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/901941

    authors: Dakouane-Giudicelli M,Alfaidy N,de Mazancourt P

    更新日期:2014-01-01 00:00:00

  • Corrigendum to "Sodium Fluorescein-Guided Resection under the YELLOW 560 nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience".

    abstract::[This corrects the article DOI: 10.1155/2017/7865747.]. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,已发布勘误

    doi:10.1155/2018/6348625

    authors: Zhang N,Tian H,Huang D,Meng X,Guo W,Wang C,Yin X,Zhang H,Jiang B,He Z,Wang Z

    更新日期:2018-05-14 00:00:00

  • Antilisterial Effect of Rosa damascena and Nymphaea alba in Mus musculus.

    abstract::The present study was proposed to investigate the toxicological and prophylactic potential of ethanolic extracts of Rosa damascena and Nymphaea alba and their mixture in albino mice. For toxicity study, three different doses of plant extracts were orally administrated to three groups of mice for 14 successive days. Bl...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4543723

    authors: Batool R,Kalsoom A,Akbar I,Arshad N,Jamil N

    更新日期:2018-01-23 00:00:00

  • Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions.

    abstract::In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Se...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6452965

    authors: Wattanathorn J,Prabsattroo T,Somsapt P,Sritragool O,Thukham-Mee W,Muchimapura S

    更新日期:2018-10-25 00:00:00

  • A Fatty Acids Mixture Reduces Anxiety-Like Behaviors in Infant Rats Mediated by GABAA Receptors.

    abstract::Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/8798546

    authors: Bernal-Morales B,Cueto-Escobedo J,Guillén-Ruiz G,Rodríguez-Landa JF,Contreras CM

    更新日期:2017-01-01 00:00:00

  • Expression Atlas of FGF and FGFR Genes in Pancancer Uncovered Predictive Biomarkers for Clinical Trials of Selective FGFR Inhibitors.

    abstract:Background:Clinical trials based on FGFR mutation or amplification as a druggable target of FGFR inhibitors have produced disappointing clinical outcomes. Therefore, the identification of predictive biomarkers for FGFR-targeted agents has remained a crucial issue. Methods:Expression profiles of FGFs and FGFRs in 8,111...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5658904

    authors: Li Y,Wu L,Tao W,Wu D,Ma F,Li N

    更新日期:2020-06-03 00:00:00

  • ACE-I/ARB therapy prior to contrast exposure: what should the clinician do?

    abstract::Contrast-induced nephropathy (CIN) is now one of the three leading causes of acute kidney injury in the world. A lot is known about the risk factors of CIN, yet it remains a major cause of morbidity, end stage renal disease, prolonged hospital stay, and increased costs as well as a high mortality. Many patients underg...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/423848

    authors: Kalyesubula R,Bagasha P,Perazella MA

    更新日期:2014-01-01 00:00:00

  • Accelerating the Morphogenetic Cycle of the Viral Vector Aedes aegypti Larvae for Faster Larvicidal Bioassays.

    abstract::Any bioassay to test new chemically synthesized larvicides or phytolarvicides against Culicidae and more harmful mosquito species, such as Aedes aegypti and Aedes albopictus, which specifically transmit dengue, yellow fever, chikungunya viral fevers as well as Zika virus, or Anopheles gambiae, a vector for malaria and...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7405421

    authors: Fontana JD,Ferreira RL,Zuccolotto T,de Borba Dallagassa C,Wielewski LP,Chalcoski BMS,da Silva MAN,Richardi VS,Golart J,de Melo Rodovalho C

    更新日期:2020-08-29 00:00:00

  • Autologous and Nonautologous Blood Transfusion in Patients with Ruptured Ectopic Pregnancy and Severe Blood Loss.

    abstract:BACKGROUND:There are some theoretical concerns for the use of intraoperative cell salvage (ICS) in patients with ectopic pregnancy. This study aimed to observe the impact of ICS on the coagulation function and clinical outcomes of patients with ruptured ectopic pregnancy and severe blood loss. METHODS:This was a retro...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/7501807

    authors: Huang J,Qin D,Gu C,Huang Y,Ma H,Huang H,Huang F,Ruan J,Ling M

    更新日期:2017-01-01 00:00:00

  • A Review of Ginseng Clinical Trials Registered in the WHO International Clinical Trials Registry Platform.

    abstract::Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/1843142

    authors: He Y,Yang J,Lv Y,Chen J,Yin F,Huang J,Zheng Q

    更新日期:2018-02-06 00:00:00

  • Drinking Water Quality Status and Contamination in Pakistan.

    abstract::Due to alarming increase in population and rapid industrialization, drinking water quality is being deteriorated day by day in Pakistan. This review sums up the outcomes of various research studies conducted for drinking water quality status of different areas of Pakistan by taking into account the physicochemical pro...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/7908183

    authors: Daud MK,Nafees M,Ali S,Rizwan M,Bajwa RA,Shakoor MB,Arshad MU,Chatha SAS,Deeba F,Murad W,Malook I,Zhu SJ

    更新日期:2017-01-01 00:00:00

  • P-selectin: an unpredicted factor for deep vein thrombosis after total hip arthroplasty.

    abstract:INTRODUCTION:Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. MATERIAL...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/783967

    authors: Shi D,Xu X,Xu Z,Nakamura T,Pang Y,Yao C,Wang F,Chen D,Dai J,Jiang Q

    更新日期:2014-01-01 00:00:00

  • Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats.

    abstract::This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as normal control, hepatic control, and ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/356729

    authors: Akhter S,Rahman MA,Aklima J,Hasan MR,Chowdhury JM

    更新日期:2015-01-01 00:00:00

  • Urinary IgG and α2-macroglobulin are powerful predictors of outcome and responsiveness to steroids and cyclophosphamide in idiopathic focal segmental glomerulosclerosis with nephrotic syndrome.

    abstract:OBJECTIVE:To assess whether high-molecular-weight proteins excretion predicts outcome and therapy-responsiveness in patients with FSGS and nephrotic syndrome. RESEARCH DESIGN AND METHODS:Thirty-eight patients measured at biopsy fractional excretion of IgG (FEIgG) and urinary α2-macroglobulin/creatinine ratio ( α m/C)....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/941831

    authors: Bazzi C,Rizza V,Casellato D,Stivali G,Rachele G,Napodano P,Gallieni M,D'Amico G

    更新日期:2013-01-01 00:00:00

  • Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl⁻ secretion: useful tools as regulators of Cl⁻ secretion.

    abstract::Epithelial Cl(-) secretion plays important roles in water secretion preventing bacterial/viral infection and regulation of body fluid. We previously suggested that quercetin would be a useful compound for maintaining epithelial Cl(-) secretion at a moderate level irrespective of cAMP-induced stimulation. However, we n...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/902735

    authors: Sun H,Niisato N,Nishio K,Hamilton KL,Marunaka Y

    更新日期:2014-01-01 00:00:00