Abstract:
:The craniofacial complex is the billboard of sorts containing information about sex, health, ancestry, kinship, genes, and environment. A thorough knowledge of the genes underlying craniofacial morphology is fundamental to understanding craniofacial biology and evolution. These genes can also provide an important foundation for practical efforts like predicting faces from DNA and phenotype-based facial diagnostics. In this work, we focus on the various sources of knowledge regarding the genes that affect patterns of craniofacial development. Although tremendous successes recently have been made using these sources in both methodology and biology, many challenges remain. Primary among these are precise phenotyping techniques and efficient modeling methods.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Roosenboom J,Hens G,Mattern BC,Shriver MD,Claes Pdoi
10.1155/2016/3054578subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3054578eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
杂志文章,评审abstract::Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems. We established an acute and chronic PD model in nonuremic and uremic rats. We observed that kinetics of PD in rats change as the animals are aging, and...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/261813
更新日期:2015-01-01 00:00:00
abstract::Vocal tract morphology is an important factor in voice production. Its analysis has potential implications for educational matters as well as medical issues like voice therapy. The knowledge of the complex adjustments in the spatial geometry of the vocal tract during phonation is still limited. For a major part, this ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906356
更新日期:2015-01-01 00:00:00
abstract::Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes of human papillomavirus (HPV). Vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma have different etiopathogenic pathways and a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/480573
更新日期:2014-01-01 00:00:00
abstract::We previously reported that Runx2/miR-3960/miR-2861 regulatory feedback loop stimulates osteoblast differentiation. However, the effect of this feedback loop on the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) remains unclear. Our recent study showed that miR-2861 and miR-3960 expression inc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/624037
更新日期:2015-01-01 00:00:00
abstract:Background:Salivary alpha-amylase (sAA) and salivary immunoglobulin A (sIgA) have been proposed as biomarkers for research on the mucosal immune system and on stress. Expression of both sAA and sIgA has been described to follow opposing diurnal patterns. This knowledge is crucial for the interpretation of studies using...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3687416
更新日期:2019-01-14 00:00:00
abstract::The aim of the present paper was to review the most important mechanisms explaining the possible association of vitamin D deficiency and cardiovascular diseases, focusing on recent experimental and clinical data. Low vitamin D levels favor atherosclerosis enabling vascular inflammation, endothelial dysfunction, format...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/109275
更新日期:2015-01-01 00:00:00
abstract::Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/436242
更新日期:2014-01-01 00:00:00
abstract::This 12-week clinical study evaluated the impact of 10% CPP-ACP and 5% sodium fluoride varnish regimes on the regression of nonorthodontic white spot lesions (WSLs). The study included 21 children with 101 WSLs who were randomised into four treatment regimes: weekly clinical applications of fluoride varnish for the fi...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/8357621
更新日期:2016-01-01 00:00:00
abstract::The perceived risk of nonremunerated blood donation (NRBD) is one of the most important factors which hinder the Chinese public from donating blood. To understand deeply and measure scientifically the public's perceived risk of NRBD, in this paper the qualitative and quantitative methods were used to explore the const...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/302043
更新日期:2015-01-01 00:00:00
abstract:Objective:To explore the ability of asiatic acid to interfere with the invasion and proliferation of breast cancer cells by inhibiting WAVE3 expression and activation through the PI3K/AKT signaling pathway. Methods:The MDA-MB-231 cells with strong invasiveness were screened by transwell assay, and plasmids with high e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1874387
更新日期:2020-02-10 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/5760612.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/7108272
更新日期:2018-01-08 00:00:00
abstract::Cancer related fatigue (CRF) is a common and debilitating symptom that can influence quality of life (QoL) in cancer patients. The increase in survival times stresses for a better understanding of how CRF affects patients' QoL. This was a cross-sectional descriptive study with 148 randomly recruited prostate cancer pa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3989286
更新日期:2016-01-01 00:00:00
abstract::The study aimed to determine the suitability of testing the saliva of kickboxing athletes to show changes in biochemical parameters in dynamic of training. 8 elite male athletes (mean age 17.29± 0.31 years, body mass 66.82± 3.46kg, with 5.62±0.96 years of training experience) participated in the study. Indicators of l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2014347
更新日期:2019-01-10 00:00:00
abstract:Objective:Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in pati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8676343
更新日期:2020-05-21 00:00:00
abstract::In this study, the authors have developed endoscopic fibre-optic pressure sensor to detect variceal pressure and presented the validation of in vivo and in vitro studies, because the HVPG requires catheterization of hepatic veins, which is invasive and inconvenient. Compared with HVPG, it is better to measure directly...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1893474
更新日期:2016-01-01 00:00:00
abstract::Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expressi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/432479
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose. AIMS:To develop a metabolic syndrome rat model by induction of fructose drinking water (FDW) in male Wistar rats. METHODS:Eighteen male Wistar rats were fed with FDW 20%...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/263897
更新日期:2014-01-01 00:00:00
abstract::Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiolog...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/367359
更新日期:2014-01-01 00:00:00
abstract::Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8751384
更新日期:2017-01-01 00:00:00
abstract::While the world is stepping into the aging society, rehabilitation robots play a more and more important role in terms of both rehabilitation treatment and nursing of the patients with neurological diseases. Benefiting from the abundant contents of movement information, electroencephalography (EEG) has become a promis...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/159486
更新日期:2014-01-01 00:00:00
abstract::The effects of obstruction on renal function are the consequence of many factors that profoundly alter all components of glomerular function. Besides the acute effects on glomerular filtration rate and tubule function, a chronic obstruction induces tubular and interstitial injury that results from the activation of di...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/303298
更新日期:2014-01-01 00:00:00
abstract:Background:Cardiogenic shock is associated with high mortality, despite new strategies for reperfusion therapy. Short-term circulatory support devices may provide adequate support for appropriate myocardial and organ perfusion. Objectives:This review is aimed at evaluating the impact on survival when using venoarteria...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6126534
更新日期:2020-04-19 00:00:00
abstract::Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving su...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3656574
更新日期:2016-01-01 00:00:00
abstract::Study of the probiotic potential of microorganisms isolated from fermented foods has been increasing, especially studies related to lactobacilli. In intestinal models, lactobacilli have demonstrated beneficial properties, such as anti-inflammatory activity and increased antibody production, but the molecular mechanism...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3264194
更新日期:2017-01-01 00:00:00
abstract::Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8798546
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with eccentric versus traditio...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/398960
更新日期:2014-01-01 00:00:00
abstract::Medicinal plants have played an important role in the treatment of many diseases. Medicinal plants are believed to be well appropriate with the human body and to produce less side influences than the pharmaceuticals. Kingdom of Saudi Arabia has abundant and wide variety of medicinal plants whose therapeutic effects ha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3596287
更新日期:2019-02-27 00:00:00
abstract::Coronary artery diseases (CAD) and heart failure have high mortality rate in the world, although much progress has been made in this field in last two decades. There is still a clinical need for a novel diagnostic approach and a therapeutic strategy to decrease the incidence of CAD. MicroRNAs (miRNAs) are highly conse...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/682857
更新日期:2015-01-01 00:00:00
abstract::The relationship between socioeconomic position (SEP) and population health is contextual. This study identifies the determinants of SEP producing health inequalities in the Latvian population. We also estimate the proportional contribution of different socioeconomic strata- (SES-) related determinants in Latvian heal...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7541416
更新日期:2017-01-01 00:00:00
abstract::Effects of ketamine and lidocaine on electroencephalographic (EEG) changes were evaluated in minimally anaesthetized dogs, subjected to electric stimulus. Six dogs were subjected to six treatments in a crossover design with a washout period of one week. Dogs were subjected to intravenous boluses of lidocaine 2 mg/kg, ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/305367
更新日期:2015-01-01 00:00:00