Abstract:
:Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged organelles or protein aggregation, which participates in many pathological processes including liver diseases. Autophagy participates in hepatic fibrosis by activating hepatic stellate cells and may participate as well through influencing other fibrogenic cells. Besides that, autophagy can induce some liver diseases to develop while it may play a protective role in hepatocellular abnormal aggregates related liver diseases and reduces fibrosis. With a better understanding of the potential effects of autophagy on hepatic fibrosis, targeting autophagy might be a novel therapeutic strategy for hepatic fibrosis in the near future.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Song Y,Zhao Y,Wang F,Tao L,Xiao J,Yang Cdoi
10.1155/2014/436242subject
Has Abstractpub_date
2014-01-01 00:00:00pages
436242eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章,评审abstract::Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版
doi:10.1155/2014/483501
更新日期:2014-01-01 00:00:00
abstract::IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bowel disease (IBD), t...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/5140691
更新日期:2018-12-10 00:00:00
abstract::Objective. To confirm that physical activity program improves the symptoms of dementia and the most effective physical activity was selected to help establish exercise programs. Methods. Three databases, PubMed, Science Direct, and Willey online, were used to collect articles. The databases were published between Janu...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2016/2920146
更新日期:2016-01-01 00:00:00
abstract::Recombinant adeno-associated virus (AAV) vectors are powerful tools for both basic neuroscience experiments and clinical gene therapies for neurological diseases. Intravascularly administered self-complementary AAV9 vectors can cross the blood-brain barrier. However, AAV9 vectors are of limited usefulness because they...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/974819
更新日期:2013-01-01 00:00:00
abstract::Vitamin B-6 has a strong antioxidative effect. It would be useful to determine whether vitamin B-6 supplementation had effects on antioxidant capacities in patients with hepatocellular carcinoma (HCC) who had recently undergone tumor resection. Thirty-three HCC patients were randomly assigned to either the placebo (n ...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/7658981
更新日期:2016-01-01 00:00:00
abstract::Spasticity is the velocity-dependent increase in muscle tone due to the exaggeration of stretch reflex. It is only one of the several components of the upper motor neuron syndrome (UMNS). The central lesion causing the UMNS disrupts the balance of supraspinal inhibitory and excitatory inputs directed to the spinal cor...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/354906
更新日期:2014-01-01 00:00:00
abstract::Effective alteration of the recalcitrance properties like crystallization of cellulose, lignin shield, and interlinking of lignocellulosic biomass is an ideal way to utilize the full-scale potential for biofuel production. This study exhibited three different pretreatment effects to enhance the digestibility of corn s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2786598
更新日期:2016-01-01 00:00:00
abstract:Background:To improve the efficacy of regenerative treatment for gingival recessions, the autologous platelet concentrates (APCs) combined with coronally advanced flap (CAF) have been investigated. However, few studies systematically assess the complementary effect of APCs in periodontal regeneration. The present study...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/2587245
更新日期:2019-07-25 00:00:00
abstract::Human epididymis protein 4 (HE4) is an available tumor biomarker mainly for detecting ovarian cancer. However, it is unknown whether it can be a novel indicator for diagnosis of diabetic kidney disease (DKD). The aim of this study was to investigate the possibility of serum HE4 as a novel biomarker for DKD in patients...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4831459
更新日期:2019-11-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/909860
更新日期:2013-01-01 00:00:00
abstract::Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. A large number of studies demonstrated the association of low vitamin D levels and variations in five common single nucl...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7562958
更新日期:2020-06-15 00:00:00
abstract::Chronic hypoxia (CH) is characterized by long-term hypoxia that is associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described in a variety of human cancers and plays an essential role in microvessel proliferation and BM degradation. Th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9204708
更新日期:2020-01-23 00:00:00
abstract::Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/145619
更新日期:2014-01-01 00:00:00
abstract:Background:A deficiency in steroid 5α-reductase type 2 is an autosomal recessive disorder. Affected individuals manifested ambiguous genitalia, which is caused by decreased dihydrotestosterone (DHT) synthesis in the fetus. Methods:We analyzed 25 patients with 5α-reductase deficiency in China. Seventeen of the 25 patie...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1789514
更新日期:2020-06-09 00:00:00
abstract::Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control studies to assess the association between PON1 (Q192R and L55M) ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2019/5897505
更新日期:2019-07-28 00:00:00
abstract:Objective:We compared the prostate cancer (PCa) detection rates of targeted biopsy (TB) and saturation biopsy (SB) in patients with previous negative biopsy and the accuracy of TB and SB stratified by different serum prostate-specific antigen (PSA) levels. Materials and Methods:Overall 185 patients were enrolled. In t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7617148
更新日期:2017-01-01 00:00:00
abstract::Influences of environmental variables and emulsifiers on lipase production of a Candida viswanathii strain were investigated. The highest lipase activity (101.1 U) was observed at 210 rpm, pH 6.0, and 27.5°C. Other fermentation parameters analyzed showed considerable rates of biomass yield (Y L/S = 1.381 g/g), lipase ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/435818
更新日期:2013-01-01 00:00:00
abstract::Excessive ethanol consumption is one of the main causes of liver fibrosis. However, direct effects of ethanol exposure on endothelial cells and their contribution to fibrogenesis and metastasis were not investigated. Therefore we analysed whether ethanol directly affects endothelial cells and if this plays a role duri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/712893
更新日期:2014-01-01 00:00:00
abstract::The mycotoxin zearalenone (ZEN) is a frequent contaminant of animal feeds, but its effects on fish have not yet been investigated extensively. In order to fill this gap a feeding trial with juvenile carp was conducted. Three groups of fish were fed feeds contaminated with ZEN at three concentrations (low: 332 μg kg(-1...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/420702
更新日期:2015-01-01 00:00:00
abstract::CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4093435
更新日期:2018-03-29 00:00:00
abstract:Background:Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of Y...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/4039173
更新日期:2018-11-14 00:00:00
abstract::Mutations in the kinase domain of epidermal growth factor receptor (EGFR) have high levels of basal receptor phosphorylation and are associated with clinical responsiveness to Iressa in patients with nonsmall cell lung cancer (NSCLC). This study aimed to assess the feasibility of morpholino-[(124)I]IPQA derivative as ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/549359
更新日期:2013-01-01 00:00:00
abstract::Bloodstream infections are a major concern because of high levels of antibiotic consumption and of the increasing prevalence of antimicrobial resistance. Bacteraemia is identified in a small percentage of patients with signs and symptoms of sepsis. Biomarkers are widely used in clinical practice and they are useful fo...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/547818
更新日期:2014-01-01 00:00:00
abstract::Smoldering multiple myeloma (SMM) is an asymptomatic precursor stage of multiple myeloma (MM) characterized by clonal bone marrow plasma cells (BMPC) ≥ 10% and/or M protein level ≥ 30 g/L in the absence of end organ damage. It represents an intermediate stage between monoclonal gammopathy of undetermined significance ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/623254
更新日期:2015-01-01 00:00:00
abstract::High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biol...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/215135
更新日期:2015-01-01 00:00:00
abstract::The different techniques and methods employed as well as the different quantitative and qualitative variables measured in order to objectify postural control are often chosen without taking into account the population studied, the objective of the postural test, and the environmental conditions. For these reasons, the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/891390
更新日期:2015-01-01 00:00:00
abstract::Heart rate variability is a physiological feature indicating the influence of the autonomic nervous system on the heart rate. Association of the reduced heart rate variability due to myocardial infarction and the increased postinfarction mortality was first described more than thirty years ago. Many studies have unequ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/680515
更新日期:2015-01-01 00:00:00
abstract::The simultaneous effect of flexible wall and multiple stenoses on the flow and mass transfer of blood is investigated through numerical computation and simulations. The solution is obtained using the Marker and Cell technique on an axisymmetric model of Newtonian blood flow. The results compare favorably with physical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7609562
更新日期:2020-01-31 00:00:00
abstract::Chronic kidney disease (CKD) is considered a public health problem, assuming epidemic proportions worldwide. In this context, the preponderance of CKD prevalence in male over age-matched female patients is of note. In the present study, we investigated the impact of the gender on the development of experimental CKD in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2159739
更新日期:2017-01-01 00:00:00
abstract::Myofascial pain syndrome is characterized by pain and a limited range of joint motion caused by muscle contracture related to motor-end-plate dysfunction and the presence of myofascial trigger points (MTrPs). It is the most frequent cause of musculoskeletal pain, with a worldwide prevalence varying between 13.7% and 4...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9240581
更新日期:2020-01-22 00:00:00