Abstract:
:Vitamin B-6 has a strong antioxidative effect. It would be useful to determine whether vitamin B-6 supplementation had effects on antioxidant capacities in patients with hepatocellular carcinoma (HCC) who had recently undergone tumor resection. Thirty-three HCC patients were randomly assigned to either the placebo (n = 16) group or the vitamin B-6 50 mg/d (n = 17) group for 12 weeks. Plasma pyridoxal 5'-phosphate, homocysteine, indicators of oxidative stress, and antioxidant capacities were measured. Plasma homocysteine in the vitamin B-6 group was significantly decreased at week 12, while the level of trolox equivalent antioxidant capacity (TEAC) was significantly increased at the end of the intervention period. Vitamin B-6 supplementation had a significant reducing effect on the change of plasma homocysteine (β = -2.4, p = 0.02) but not on the change of TEAC level after adjusting for potential confounders. The change of plasma homocysteine was significantly associated with the change of TEAC after adjusting for potential confounders (β = -162.0, p = 0.03). Vitamin B-6 supplementation seemed to mediate antioxidant capacity via reducing plasma homocysteine rather than having a direct antioxidative effect in HCC patients who had recently undergone tumor resection. The clinical trial number is NCT01964001, ClinicalTrials.gov.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Cheng SB,Lin PT,Liu HT,Peng YS,Huang SC,Huang YCdoi
10.1155/2016/7658981subject
Has Abstractpub_date
2016-01-01 00:00:00pages
7658981eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
杂志文章,随机对照试验abstract::Seeking new biomarkers for epithelial ovarian cancer, the fifth most common cause of death from all cancers in women and the leading cause of death from gynaecological malignancies, we performed a meta-analysis of three independent studies and compared the results in regard to clinicopathological parameters. This anal...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2013/238284
更新日期:2013-01-01 00:00:00
abstract::Different opinions exist on the relationship between the C-reactive protein-to-albumin ratio (CAR) and the prognosis of colon cancer. This study is aimed at evaluating the relationship between CAR and prognosis of stage II-III colon cancer and establishing a clinical prognosis model. Patients were randomised to a trai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8812974
更新日期:2020-11-22 00:00:00
abstract::The rapid development of picture archiving and communication systems (PACSs) thoroughly changes the way of medical informatics communication and management. However, as the scale of a hospital's operations increases, the large amount of digital images transferred in the network inevitably decreases system efficiency. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/657417
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To evaluate HIV risk perception and its associated factors among Chinese MSM. METHODS:A cross-sectional study was conducted among MSM with an HIV negative or unknown status in Beijing, China, between 2011 and 2012. A questionnaire interview was conducted and a blood sample was collected for HIV and syphilis ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/232451
更新日期:2014-01-01 00:00:00
abstract::Oyster mushroom Pleurotus florida was cultivated on different combinations of wheat straw (WS) as basal substrate and oyster shell powder (OSP) supplement. The OSP supplementation considerably responded to different cultivation phases. The mycelium grew fast and showed rapid growth rate (8.91 mmd(-1)) in WS + OSP (97 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/386265
更新日期:2014-01-01 00:00:00
abstract:Purpose:Fractures are common among all types of paediatric injuries, with differences in incidence over time. Here, we present the epidemiologic features of traumatic fractures in a population of youth ≤ 18 years of age who were admitted to our university-affiliated hospitals from 2002 to 2010. Methods:We retrospectiv...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/8019063
更新日期:2019-02-20 00:00:00
abstract::This review examines studies of radiofrequency ablation (RFA) of nonsmall cell lung cancer (NSCLC) and discusses the role of RFA in treatment of early-stage NSCLC. RFA is usually performed under local anesthesia with computed tomography guidance. RFA-associated mortality, while being rare, can result from pulmonary ev...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/152087
更新日期:2014-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2014/479180.]. ...
journal_title:BioMed research international
pub_type: 撤回出版物
doi:10.1155/2016/4938464
更新日期:2016-01-01 00:00:00
abstract:Background:Acute heart failure (AHF) is associated with disturbances of the peripheral perfusion leading to the dysfunction of many organs. Consequently, an episode of AHF constitutes a "multiple organ failure" which may also affect the skeletal muscles. However, the abnormalities within skeletal muscles during AHF hav...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/6982897
更新日期:2018-03-12 00:00:00
abstract::The aim of this study was to determine if altered levels of selected trace elements manifest themselves during chronic depression. To identify elements strongly associated with chronic depression, relationships between the elemental contents of hair and nails and the interelement correlations were checked. Inductively...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3178784
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy. METHODS:In this cross-sectional study UC patients were interviewed, ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/359130
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant impact on the differentiation behaviour of hMSCs. Here, we investigate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/714230
更新日期:2015-01-01 00:00:00
abstract::Escherichia coli O157:H7 is the main causative agent of haemolytic uremic syndrome. Cattle are the main reservoir of these bacteria, and have been shown to develop immune response to colonization. Our aim was to investigate the faecal shedding pattern of E. coli O157:H7 in calves challenged intragastrically with eithe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/290679
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/537941
更新日期:2014-01-01 00:00:00
abstract::Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of a chronic intestinal inflammation in ruminants named Johne's disease or paratuberculosis and a possible etiopathological agent of human Crohn's disease (CD). Analysis of macrophage transcriptomes in response to Map infection is expected to pro...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/908348
更新日期:2013-01-01 00:00:00
abstract::This work evaluated the physicochemical properties and antioxidant activity of spray dried extracts (SDE) from Psidium guajava L. leaves. Different drying carriers, namely, maltodextrin, colloidal silicon dioxide, Arabic gum, and β -cyclodextrin at concentrations of 40 and 80% relative to solids content, were added to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/382891
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/1907906.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2019/6897187
更新日期:2019-11-20 00:00:00
abstract::Heavy metals have the potential to interact and induce several stress responses in the plants; thus, effects of heavy metal stress on DNA damages and total antioxidants level in Urtica dioica leaves and stems were investigated. The samples are sampled from areas with different metal exposition. Metal content was analy...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276417
更新日期:2013-01-01 00:00:00
abstract::Neutrophils comprise the first line of innate immune defense during a host-pathogen interaction. They attack microorganisms directly through three different methods, of which, phagocytosis and degranulation have been known and well-studied for decades. The formation of neutrophil extracellular traps (NETs) is the thir...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4192745
更新日期:2020-02-01 00:00:00
abstract::The aim of this study is to inform about the development of a new semispherical surgical instrument for the bipolar multielectrode radiofrequency liver ablation. Present tools are universal; however they have several disadvantages such as ablation of healthy tissue, numerous needle punctures, and, therefore, longer op...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/532792
更新日期:2014-01-01 00:00:00
abstract::Diabetic foot ulcers (DFUs) are characterized by an unsatisfactory inflammatory and migratory response. Skin inflammation involves the participation of many cells and particularly macrophages. Macrophage function can be modulated by neuropeptides; however, little is known regarding the role of neurotensin (NT) as a mo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/941764
更新日期:2013-01-01 00:00:00
abstract::Herein the extraction method of fucoidan from Laminaria japonica is reported. Firstly, chitosan, chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (HACC), and hexadecyltrimethylammonium bromide (CPAB) were used to extract the fucoidan. The results showed that chitosan was the optimal extractant compared with the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/193689
更新日期:2013-01-01 00:00:00
abstract:Background:The Oxford Happiness Inventory (OHI) is a self-report tool to measure happiness. A brief review of previous studies on OHI showed the lack of evaluation of OHI fairness/equivalence in measuring happiness among identified groups. Methods:To examine the psychometric properties and measurement invariance of th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8906209
更新日期:2020-06-21 00:00:00
abstract::We compared the efficacy of intravitreal aflibercept (IVA) to intravitreal ranibizumab (IVR) injections in eyes with diabetic macular edema (DME). The medical records of 49 eyes of 36 patients who were diagnosed with DME and had received IVR and 46 eyes of 40 patients who had received IVA treatment were reviewed. The ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/1747108
更新日期:2017-01-01 00:00:00
abstract::C-type lectins are multifunctional sugar-binding molecules expressed on dendritic cells (DCs) and macrophages that internalize antigens for processing and presentation. Macrophage galactose-type lectin 1 (MGL1) recognizes glycoconjugates expressing Lewis X structures which contain galactose residues, and it is selecti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/615865
更新日期:2015-01-01 00:00:00
abstract::Human histone deacetylase 2 (HDAC2) has been identified as being associated with Alzheimer's disease (AD), a neuropathic degenerative disease. In this study, we screen the world's largest Traditional Chinese Medicine (TCM) database for natural compounds that may be useful as lead compounds in the search for inhibitors...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/769867
更新日期:2014-01-01 00:00:00
abstract:Objective:The presence of radiological signs of femoroacetabular impingement (FAI) is not necessarily associated with symptoms. Hence, the prevalence of cam and pincer deformities in the overall population may be underestimated. The purpose of this study was to screen an unselected cohort of people without hip symptoms...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8562329
更新日期:2017-01-01 00:00:00
abstract::Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of this study was to introduce a computational simulation approach to screen aptamers with high binding ability for Ang2. We carried out...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/658712
更新日期:2015-01-01 00:00:00
abstract::The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 groups, which were treated with AC (300 mg/kg/day), metformin (180 mg/kg/day), or saline by gavage for 10 weeks. Ten db/m mice treated w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5280514
更新日期:2019-03-28 00:00:00
abstract::The aim of this study was to assess the diagnostic accuracy of subjective ultrasound evaluation of myometrial invasion of endometrial cancer and to compare its accuracy to objective methods. All consecutive patients with histologically proven endometrial cancer, who underwent ultrasound evaluation followed by surgical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1318203
更新日期:2017-01-01 00:00:00