Abstract:
:C-type lectins are multifunctional sugar-binding molecules expressed on dendritic cells (DCs) and macrophages that internalize antigens for processing and presentation. Macrophage galactose-type lectin 1 (MGL1) recognizes glycoconjugates expressing Lewis X structures which contain galactose residues, and it is selectively expressed on immature DCs and macrophages. Helminth parasites contain large amounts of glycosylated components, which play a role in the immune regulation induced by such infections. Macrophages from MGL1(-/-) mice showed less binding ability toward parasite antigens than their wild-type (WT) counterparts. Exposure of WT macrophages to T. crassiceps antigens triggered tyrosine phosphorylation signaling activity, which was diminished in MGL1(-/-) macrophages. Following T. crassiceps infection, MGL1(-/-) mice failed to produce significant levels of inflammatory cytokines early in the infection compared to WT mice. In contrast, MGL1(-/-) mice developed a Th2-dominant immune response that was associated with significantly higher parasite loads, whereas WT mice were resistant. Flow cytometry and RT-PCR analyses showed overexpression of the mannose receptors, IL-4Rα, PDL2, arginase-1, Ym1, and RELM-α on MGL1(-/-) macrophages. These studies indicate that MGL1 is involved in T. crassiceps recognition and subsequent innate immune activation and resistance.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Montero-Barrera D,Valderrama-Carvajal H,Terrazas CA,Rojas-Hernández S,Ledesma-Soto Y,Vera-Arias L,Carrasco-Yépez M,Gómez-García L,Martínez-Saucedo D,Becerra-Díaz M,Terrazas LIdoi
10.1155/2015/615865subject
Has Abstractpub_date
2015-01-01 00:00:00pages
615865eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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