Abstract:
:The aim of this study is to inform about the development of a new semispherical surgical instrument for the bipolar multielectrode radiofrequency liver ablation. Present tools are universal; however they have several disadvantages such as ablation of healthy tissue, numerous needle punctures, and, therefore, longer operating procedure. Our newly designed and tested semispherical surgical tool can solve some of these disadvantages. By conducting an in vivo study on a set of 12 pigs, randomly divided into two groups, we have compared efficiency of the newly developed instrument with the commonly used device. Statistical analysis showed that there were no significant differences between the groups. On average, the tested instrument RONJA had shorter ablation time in both liver lobes and reduced the total operating time. The depth of the thermal alteration was on average 4 mm larger using the newly tested instrument. The new radiofrequency method described in this study could be used in open liver surgery for the treatment of small liver malignancies (up to 2 cm) in a single application with the aim of saving healthy liver parenchyma. Further experimental studies are needed to confirm these results before clinical application of the method in the treatment of human liver malignancies.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Vavra P,Penhaker M,Grepl J,Jurcikova J,Palecek J,Crha M,Nowakova J,Hasal M,Skrobankova M,Ostruszka P,Ihnat P,Delongova P,Salounova D,Habib NA,Zonca Pdoi
10.1155/2014/532792subject
Has Abstractpub_date
2014-01-01 00:00:00pages
532792eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Spinal cord injury (SCI) is a highly debilitating disease and is increasingly being recognized as an important global health priority. However, the mechanisms underlying SCI have not yet been fully elucidated, and effective therapies for SCI are lacking. Long noncoding RNAs (lncRNAs), which form a major class of nonco...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/3467121
更新日期:2019-10-15 00:00:00
abstract::Bone marrow-derived mesenchymal stem cells (BM-MSCs) represent a modern approach for management of chronic skin injuries. In this work, we describe BM-MSCs application versus their conditioned media (CM) when delivered topically admixed with fibrin glue to enhance the healing of chronic excisional wounds in rats. Fift...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/846062
更新日期:2015-01-01 00:00:00
abstract::Regulation of hematopoietic stem cell release, migration, and homing from the bone marrow (BM) and of the mobilization pathway involves a complex interaction among adhesion molecules, cytokines, proteolytic enzymes, stromal cells, and hematopoietic cells. The identification of new mechanisms that regulate the traffick...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/312656
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Inflammation in dental pulp cells (DPCs) initiated by Lipopolysaccharide (LPS) results in dental pulp necrosis. So far, whether there is a common system regulating inflammation response and tissue regeneration remains unknown. miR-146a is closely related to inflammation. Basic fibroblast growth factor (bFG...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3892685
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse pregnancy complications and neurocognitive deficiencies in the developing fetus. Currently, some researchers demonstrated that body mass index (BMI) is associated with thyroid function in nonpregnant population. Hence, the Ameri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/351831
更新日期:2015-01-01 00:00:00
abstract:Objective:The aim of this study was to investigate the respective correlation between the height (H) of a posterior malleolar fracture (PMF) and the involved area (S) of an articular surface and the presence of "die-punch." Methods:Patients with closed posterior malleolar fractures admitted to our hospital from Januar...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2903537
更新日期:2020-07-29 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/157295
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Frail older people are often unable to undertake high-intensity exercise programmes. Chair-based exercises (CBEs) are used as an alternative, for which health benefits are uncertain. OBJECTIVE:To examine the effects of CBE programmes for frail older people through a systematic review of existing literatur...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/309506
更新日期:2013-01-01 00:00:00
abstract::28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/823829
更新日期:2015-01-01 00:00:00
abstract::The objective of the current research was to review and update evidence on the dietary effect of the consumption of tagatose in type 2 diabetes, as well as to elucidate the current approach that exists on its production and biotechnological utility in functional food for diabetics. Articles published before July 1, 20...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/8718053
更新日期:2018-01-09 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5870875
更新日期:2017-01-01 00:00:00
abstract::Schwannomas are the commonest tumours of peripheral nerves. Despite the classical description that schwannomas are well encapsulated and can be completely enucleated during excision, a portion of them have fascicular involvement and could not be completely shelled out. A retrospective review for 8 patients was carried...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/167196
更新日期:2013-01-01 00:00:00
abstract::A potent fibrinolytic enzyme-producing Bacillus cereus IND1 was isolated from the Indian food, rice. Solid-state fermentation was carried out using agroresidues for the production of fibrinolytic enzyme. Among the substrates, wheat bran supported more enzyme production and has been used for the optimized enzyme produc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/725064
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To distinguish between normal (SV-HUC-1) and cancerous (TCCSUP) human urothelial cell lines using microelectrical impedance spectroscopy (μEIS). MATERIALS AND METHODS:Two types of μEIS devices were designed and used in combination to measure the impedance of SV-HUC-1 and TCCSUP cells flowing through the channe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8748023
更新日期:2016-01-01 00:00:00
abstract::Purpose. We aimed to study long-term outcome after pulmonary vein isolation (PVI) guided by remote magnetic navigation (RMN) and provided comparative data to outcome after manual navigation (MAN). Methods. Three hundred thirty-six patients with symptomatic paroxysmal AF underwent PVI by irrigated point-by-point radiof...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6323729
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2016/5726465
更新日期:2016-01-01 00:00:00
abstract::WNT proteins are involved in embryonic development, sex determination, stem cell recruitment, angiogenesis, and cancer. They take part in morphological changes in the endometrium during development, regulate processes of endometrial proliferation and differentiation. This review presents current knowledge about implic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/854056
更新日期:2015-01-01 00:00:00
abstract::Recent work in preservation of female fertility as well as new information on the nature of spermatogonial stem cells has prompted an investigation into the possibility of an effective clinical-grade procedure for the cryopreservation of testicular cells and/or tissue. Clinical-grade reagents, validated equipment, and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/930962
更新日期:2013-01-01 00:00:00
abstract::Objective. To evaluate the gut mucosa and blood-brain barrier (BBB) pharmacokinetic permeability properties of the plant N-alkylamide pellitorine. Methods. Pure pellitorine and an Anacyclus pyrethrum extract were used to investigate the permeation of pellitorine through (1) a Caco-2 cell monolayer, (2) the rat gut aft...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5497402
更新日期:2016-01-01 00:00:00
abstract:Purpose:High tibial osteotomy (HTO) has been adopted as an effective surgery for medial degeneration of the osteoarthritis (OA) knee. However, satisfactory outcomes necessitate the precise creation and distraction of osteotomized wedges and the use of intraoperative X-ray images to continually monitor the wedge-related...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9246529
更新日期:2018-05-08 00:00:00
abstract::Functional connectivity has been correlated with a patient's level of consciousness and has been found to be altered in several neuropsychiatric disorders. Absence epilepsy patients, who experience a loss of consciousness, are assumed to suffer from alterations in thalamocortical networks; however, previous studies ha...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/734893
更新日期:2013-01-01 00:00:00
abstract:Background:Mycoplasma pneumoniae is a common cause of community-acquired pneumonia (CAP). This cross-sectional study aimed to determine the prevalence of macrolide-resistant M. pneumoniae strains in a convenience series of 234 adult hospitalised and nonhospitalised subjects with a diagnosis of CAP in January 2013 to Ap...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7168949
更新日期:2019-03-17 00:00:00
abstract::A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimula...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7636290
更新日期:2020-01-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6930297
更新日期:2018-05-08 00:00:00
abstract::Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/179568
更新日期:2014-01-01 00:00:00
abstract::The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different conce...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/941318
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Cost sharing between beneficiaries and government is critical to attain universal health coverage. The government of Ethiopia introduced social health insurance to improve access to quality health services. Hence, HCP are the ultimate frontline service provider; their WTP for health insurance could influence...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8412957
更新日期:2020-04-14 00:00:00
abstract::Ambient assisted living (AAL) aims to help older persons "age-in-place" and manage everyday activities using intelligent and pervasive computing technology. AAL research, however, has yet to explore how AAL might support or collaborate with informal care partners (ICPs), such as relatives and friends, who play importa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/720483
更新日期:2015-01-01 00:00:00
abstract::Increasing consumption of tobacco and alcohol has led to a steady increase in the incidence of head and neck cancers in Asia. The drawbacks associated with the existing chemotherapeutic and surgical interventions have necessitated the development of a safer alternative for therapy of head and neck cancers. In this stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/424239
更新日期:2014-01-01 00:00:00
abstract::This study aimed to examine the expression of and the relationship between CD44V6, CDH11, and β-catenin. The expression of these cell adhesion molecules was detected in 90 osteosarcoma and 20 osteochondroma specimens using immunohistochemistry. Associations between these parameters and clinicopathological data were al...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/496193
更新日期:2013-01-01 00:00:00