Abstract:
:Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems. We established an acute and chronic PD model in nonuremic and uremic rats. We observed that kinetics of PD in rats change as the animals are aging, and this effect is due not only to an increasing peritoneal surface area, but also to changes in the permeability of the peritoneum. Changes of the peritoneal permeability seen during chronic PD in rats are comparable to results obtained in humans treated with PD. Effluent dialysate can be drained repeatedly to measure concentration of various bioactive molecules and to correlate the results with the peritoneal permeability. Additionally we can study in in vitro conditions properties of the effluent dialysate on cultured peritoneal mesothelial cells or fibroblasts. We can evaluate acute and chronic effect of various additives to the dialysis fluid on function and permeability of the peritoneum. Results from such study are even more relevant to the clinical scenario when experiments are performed in uremic rats. Our experimental animal PD model not only helps to understand the pathophysiology of PD but also can be used for testing biocompatibility of new PD fluids.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Pawlaczyk K,Baum E,Schwermer K,Hoppe K,Lindholm B,Breborowicz Adoi
10.1155/2015/261813subject
Has Abstractpub_date
2015-01-01 00:00:00pages
261813eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8402035
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/179836
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/986436
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8576404
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9357203
更新日期:2019-01-23 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/934746
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3967427
更新日期:2020-12-04 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/8013575
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8421614
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5683026
更新日期:2016-01-01 00:00:00
abstract::Amylase is an industrially important enzyme and applied in many industrial processes such as saccharification of starchy materials, food, pharmaceutical, detergent, and textile industries. This research work deals with the optimization of fermentation conditions for α-amylase production from thermophilic bacterial str...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9173040
更新日期:2017-01-01 00:00:00
abstract::Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3019410
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2786598
更新日期:2016-01-01 00:00:00
abstract:Introduction:Rapid eye movement sleep behavior disorder (RBD) is characterized by dream-enacting behavior (shouting, punching, and falling out of bed) related to unpleasant dreams and loss of normal rapid eye movement (REM) sleep muscle atonia. Rapid eye movement sleep enhances learning and memory by regulating neurona...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1810836
更新日期:2020-05-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5958272
更新日期:2020-01-27 00:00:00
abstract:OBJECTIVE:To evaluate HIV risk perception and its associated factors among Chinese MSM. METHODS:A cross-sectional study was conducted among MSM with an HIV negative or unknown status in Beijing, China, between 2011 and 2012. A questionnaire interview was conducted and a blood sample was collected for HIV and syphilis ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/232451
更新日期:2014-01-01 00:00:00
abstract::Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effect...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/801214
更新日期:2013-01-01 00:00:00
abstract::The perceived risk of nonremunerated blood donation (NRBD) is one of the most important factors which hinder the Chinese public from donating blood. To understand deeply and measure scientifically the public's perceived risk of NRBD, in this paper the qualitative and quantitative methods were used to explore the const...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/302043
更新日期:2015-01-01 00:00:00
abstract:Background:In vitro fertilization and embryo transfer (IVF-ET) technology has been widely used in the therapy of refractory infertility. Previous studies showed that acupuncture can effectively increase the clinical pregnancy rate of IVF-ET. However, the molecular mechanism is unknown. Materials and Methods:In this st...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/4179617
更新日期:2019-05-28 00:00:00
abstract::Diabetic patients are at risk for spontaneous foot ulcers, chronic wounds, infections, and tissue necrosis. Current theories suggest that the development and progression of diabetic foot ulcers are mainly caused by arteriosclerosis and peripheral neuropathy. Tissue necrosis plays a primordial role in the progression o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/490964
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2425693
更新日期:2020-02-17 00:00:00
abstract::Energy dispersive X-ray spectroscopy microanalysis (EDX), scanning electron microscopy (SEM), and Archimedes' Principle were used to determine the characteristics of inorganic filler particles in five dental alginates, including Cavex ColorChange (C), Hydrogum 5 (H5), Hydrogum (H), Orthoprint (O), and Jeltrate Plus (J...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/178064
更新日期:2014-01-01 00:00:00
abstract::Sericin is a natural protein component of silks of silkworm and has potential utility in multiple areas such as pharmacological, cosmetics, and biotechnological industries. However, the understanding of its toxicological safety is still limited. This study evaluated the safety of water-extract sericin from silkworm (B...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9689386
更新日期:2020-11-05 00:00:00
abstract::Cellulase from Aspergillus niger was immobilized onto β-cyclodextrin-conjugated magnetic particles by silanization and reductive amidation. The immobilized cellulase gained supermagnetism due to the magnetic nanoparticles. Ninety percent of cellulase was immobilized, but the activity of immobilized cellulase decreased...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/409103
更新日期:2015-01-01 00:00:00
abstract::The zebrafish constitutes a powerful model organism with unique advantages for investigating the vertebrate circadian timing system and its regulation by light. In particular, the remarkably early and rapid development of the zebrafish circadian system has facilitated exploring the factors that control the onset of ci...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/235781
更新日期:2014-01-01 00:00:00
abstract::The aims of this study were to investigate the reasons of transfers from long-term care hospitals (LTCHs) to emergency departments (EDs) of university hospitals in geriatric patients and to categorize the avoidable causes of these transfers. This retrospective multicenter study involved patients aged 65 years and olde...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2019/7041607
更新日期:2019-06-19 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/402536
更新日期:2015-01-01 00:00:00
abstract::Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanism...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/926729
更新日期:2014-01-01 00:00:00
abstract::Background. Acute graft-versus-host disease (aGVHD) involving skin is one of the most frequent complications of allogeneic hematopoietic stem cell transplantation (alloHSCT), usually diagnosed based on clinical manifestations. So far, skin biopsy with histopathological evaluation is the only method to confirm the diag...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4535717
更新日期:2016-01-01 00:00:00