Abstract：
:Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system, characterized by an extremely aggressive clinical phenotype. Patients with GBM have a poor prognosis and only 3-5% of them survive for more than 5 years. The current GBM treatment standards include maximal resection followed by radiotherapy with concomitant and adjuvant therapies. Despite these aggressive therapeutic regimens, the majority of patients suffer recurrence due to molecular heterogeneity of GBM. Consequently, a number of potential diagnostic, prognostic, and predictive biomarkers have been investigated. Some of them, such as IDH mutations, 1p19q deletion, MGMT promoter methylation, and EGFRvIII amplification are frequently tested in routine clinical practice. With the development of sequencing technology, detailed characterization of GBM molecular signatures has facilitated a more personalized therapeutic approach and contributed to the development of a new generation of anti-GBM therapies such as molecular inhibitors targeting growth factor receptors, vaccines, antibody-based drug conjugates, and more recently inhibitors blocking the immune checkpoints. In this article, we review the exciting progress towards elucidating the potential of current and novel GBM biomarkers and discuss their implications for clinical practice.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Szopa W,Burley TA,Kramer-Marek G,Kaspera Wdoi
10.1155/2017/8013575subject
Has Abstractpub_date
2017-01-01 00:00:00pages
8013575eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章,评审abstract：:The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited by its side effects like high toxicity and insolubility. Nanomedicine offers new hope for overcoming the shortcomings. But how to increase in vivo stability and to control intracellular drug release is a key issue for nano-based for...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2015/987404
更新日期：2015-01-01 00:00:00
abstract：:Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of this study was to introduce a computational simulation approach to screen aptamers with high binding ability for Ang2. We carried out...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2015/658712
更新日期：2015-01-01 00:00:00
abstract：Purpose:High tibial osteotomy (HTO) has been adopted as an effective surgery for medial degeneration of the osteoarthritis (OA) knee. However, satisfactory outcomes necessitate the precise creation and distraction of osteotomized wedges and the use of intraoperative X-ray images to continually monitor the wedge-related...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2018/9246529
更新日期：2018-05-08 00:00:00
abstract：:Febrile seizures (FS) are the most common neurological disorder in childhood and are a great stress for parents due to their dramatic clinical appearance. Using test for determination of homozygously recessive characteristics in humans (HRC test) we analyzed presence, distribution, and individual combination of 20 sel...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2018/7845904
更新日期：2018-07-05 00:00:00
abstract：:Among uterine structural abnormalities, myomas and adenomyosis represent two distinct, though frequently coexistent entities, with a remarkable prevalence in women of reproductive age. Various mechanisms have been proposed to explain the impact of each of them on reproductive outcome. In respect to myomas, current evi...
journal_title：BioMed research international
pub_type： 杂志文章,评审
doi：10.1155/2017/5926470
更新日期：2017-01-01 00:00:00
abstract：:To evaluate the effects of curcumin (CUR) on tumor progression and angiogenesis in cervical cancer- (CaSki-) implanted nude mice and on the angiogenic biomarkers: vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and epidermal growth factor receptor (EGFR). CaSki cells were subcutaneously injected i...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2014/817972
更新日期：2014-01-01 00:00:00
abstract：:The regiospecific characteristics of n-3 polyunsaturated fatty acids (PUFAs) in triacylglycerol (TAG) significantly affect the physicochemical and physiological properties of marine fish oils. In this study, the TAG molecular species composition and positional distributions of fatty acids were investigated in three ma...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2018/3529682
更新日期：2018-07-10 00:00:00
abstract：:Pregnancy is associated with various physiological changes which may lead to significant alterations in the pharmacokinetics of many drugs. The present study was aimed to investigate the potential effects of pregnancy on the pharmacokinetic profile of zonisamide (ZNM) in the rabbit. Seven female rabbits were used in t...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2013/140327
更新日期：2013-01-01 00:00:00
abstract：:Professional phagocytic cells, such as dendritic cells, are mainly responsible for phagocytosis, antigen presentation, and cytokine secretion, which induce subsequent activation of T cell-mediated immunity. Thus, strategies that deliver antigens and stimulatory signals to the cells have significant implications for va...
journal_title：BioMed research international
pub_type： 杂志文章,评审
doi：10.1155/2013/562924
更新日期：2013-01-01 00:00:00
abstract：:Cognitive dysfunction is an important complicated disease in obesity. Exercise ameliorates obesity and the related cognitive dysfunction. However, the underlying mechanism is still unclear. In this study, we investigated whether aerobic interval training (AIT) could attenuate high-fat-diet- (HFD-) associated cognitive...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2018/2708491
更新日期：2018-03-22 00:00:00
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journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2014/814984
更新日期：2014-01-01 00:00:00
abstract：:Cardiac computed tomography angiography (CCTA) is widely used as a diagnostic tool for evaluation of coronary artery disease (CAD). Despite the excellent capability to rule-out CAD, CCTA may overestimate the degree of stenosis; furthermore, CCTA analysis can be time consuming, often requiring advanced postprocessing t...
journal_title：BioMed research international
pub_type： 杂志文章,评审
doi：10.1155/2020/6649410
更新日期：2020-12-16 00:00:00
abstract：:Enzymes play important roles in most of the biological processes. Although only a small fraction of residues are directly involved in catalytic reactions, these catalytic residues are the most crucial parts in enzymes. The study of the fundamental and unique features of catalytic residues benefits the understanding of...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2013/802945
更新日期：2013-01-01 00:00:00
abstract：:The establishment of the subgingival microbiota is dependent on successive colonization of the implant surface by bacterial species. Different implant surface topographies could influence the bacterial adsorption and therefore jeopardize the implant survival. This study evaluated the biofilm formation capacity of five...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2015/159625
更新日期：2015-01-01 00:00:00
abstract：:In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in prostate homeostasis. Most of the studies evaluated intraprostatic hormone metabolism using cell lines or preprocessed specimens. Using an ex vivo model of intact tissue cultures with preserved architecture, we characteriz...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2014/464869
更新日期：2014-01-01 00:00:00
abstract：:Bayesian analysis was used to estimate the pig's and herd's true prevalence of enteropathogenic Yersinia in serum samples collected from Finnish pig farms. The sensitivity and specificity of the diagnostic test were also estimated for the commercially available ELISA which is used for antibody detection against entero...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2015/931542
更新日期：2015-01-01 00:00:00
abstract：:The recombinant catalase-peroxidase HPI from E. coli was used as an alternative enzyme in polymerization reactions for the production of (-) epicatechin oligomers and their biological activity was characterized. The enzyme was prepared in two forms: a purified and an immobilized form. Both were tested for their activi...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2018/3828627
更新日期：2018-04-23 00:00:00
abstract：:Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-β (TGF-β) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-β signaling in DN is...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2014/782625
更新日期：2014-01-01 00:00:00
abstract：:Malaria is one of the life-threatening diseases in the world. The spread of resistance to antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in the Southeast Asian region. In the previous study, the active compound of Streptomyces hygroscopicus subsp. Hygroscopicus (S. hygroscopic...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2020/6135696
更新日期：2020-01-09 00:00:00
abstract：INTRODUCTION:Cerebral emboli may occur in subarachnoid hemorrhage (SAH) and intracranial aneurysm surgery. Although embolic signs (ES) have been reported in SAH, their origin remains unclear. The aim of this study was to report the detection of ES during routine TCD monitoring in patients with aneurysmal SAH. METHODS:...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2015/153714
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS:A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2017/2351037
更新日期：2017-01-01 00:00:00
abstract：:Abnormal metabolism is another cancer hallmark. The two most characterized altered metabolic pathways are high rates of glycolysis and glutaminolysis, which are natural targets for cancer therapy. Currently, a number of newer compounds to block glycolysis and glutaminolysis are being developed; nevertheless, lonidamin...
journal_title：BioMed research international
pub_type： 杂志文章,评审
doi：10.1155/2015/690492
更新日期：2015-01-01 00:00:00
abstract：Background:Pakistan is a country with one of the highest burden of tuberculosis (TB) in the world, and therefore, it is imperative to revisit the design of behaviour change interventions in the program. This study was designed to understand and assess the knowledge, awareness, perceptions, and health-seeking behaviour ...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2020/1850541
更新日期：2020-04-21 00:00:00
abstract：:According to the Ministry of Labor, Health and Social Affairs of Georgia a new health management system has to be introduced in the nearest future. In this context arises the problem of structuring and classifying documents containing all the history of medical services provided. The present work introduces the instru...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2016/8313454
更新日期：2016-01-01 00:00:00
abstract：:Angiogenesis is essential for tumor growth and metastasis. Over the last decades, a substantial progress has been achieved in defining different patterns of tumor microcirculation. Sprouting angiogenesis, the oldest model of microcirculation, is the de novo vessel formation from preexisting blood vessels. Vessel split...
journal_title：BioMed research international
pub_type： 杂志文章,评审
doi：10.1155/2014/986768
更新日期：2014-01-01 00:00:00
abstract：:Liver transplantation is the best treatment option for early-stage hepatocellular carcinoma, liver cirrhosis, fulminant liver failure, and end-stage liver diseases. Even though advances in surgical techniques and perioperative care have improved postoperative outcomes, perioperative cardiovascular complications are a ...
journal_title：BioMed research international
pub_type： 杂志文章,评审
doi：10.1155/2017/4081525
更新日期：2017-01-01 00:00:00
abstract：:Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced ...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2013/919374
更新日期：2013-01-01 00:00:00
abstract：:Recent research had shown a correlation between aging and decreasing Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. However, how GABA level varies with age in the medial portion of the brain has not yet been studied. The purpose of this study was to investigate the GABA level var...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2016/6523909
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Given its propensity to metastasize, and lack of effective therapies for most patients with advanced disease, early detection of melanoma is a clinical imperative. Different computer-aided diagnosis (CAD) systems have been proposed to increase the specificity and sensitivity of melanoma detection. Although s...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2016/8934242
更新日期：2016-01-01 00:00:00
abstract：:The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 groups, which were treated with AC (300 mg/kg/day), metformin (180 mg/kg/day), or saline by gavage for 10 weeks. Ten db/m mice treated w...
journal_title：BioMed research international
pub_type： 杂志文章
doi：10.1155/2019/5280514
更新日期：2019-03-28 00:00:00
