Abstract:
:Abnormal metabolism is another cancer hallmark. The two most characterized altered metabolic pathways are high rates of glycolysis and glutaminolysis, which are natural targets for cancer therapy. Currently, a number of newer compounds to block glycolysis and glutaminolysis are being developed; nevertheless, lonidamine and 6-diazo-5-oxo-L-norleucine (DON) are two old drugs well characterized as inhibitors of glycolysis and glutaminolysis, respectively, whose clinical development was abandoned years ago when the importance of cancer metabolism was not fully appreciated and clinical trial methodology was less developed. In this review, a PubMed search using the words lonidamine and 6-diazo-5-oxo-L-norleucine (DON) was undertaken to analyse existing information on the preclinical and clinical studies of these drugs for cancer treatment. Data show that they exhibit antitumor effects; besides there is also the suggestion that they are synergistic. We conclude that lonidamine and DON are safe and potentially effective drugs that need to be reevaluated in combination as metabolic therapy of cancer.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Cervantes-Madrid D,Romero Y,Dueñas-González Adoi
10.1155/2015/690492subject
Has Abstractpub_date
2015-01-01 00:00:00pages
690492eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::Prostate cancer is a life-threatening and highly heterogeneous malignancy. In the past decade, circulating tumor cells (CTCs) have been suggested to play a critical role in the occurrence and progression of prostate cancer. In particular, as the "seed" of the cancer metastasis cascade, CTCs determine numerous biologic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2021/6230826
更新日期:2021-01-08 00:00:00
abstract:Methods:The implantation sites, fetus resorption, and abnormal fetuses were studied in pregnant mice treated with different doses of BaP by oral gavage from day 1 to day 10 of gestation. Additionally, apoptosis and related signaling pathway, and the migration and invasion of trophoblasts, were assessed before and after...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8983494
更新日期:2020-10-16 00:00:00
abstract::To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/782490
更新日期:2014-01-01 00:00:00
abstract::The white-rot fungus Phanerochaete chrysosporium was investigated for its capacity to degrade the herbicide diuron in liquid stationary cultures. The presence of diuron increased the production of lignin peroxidase in relation to control cultures but only barely affected the production of manganese peroxidase. The her...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/251354
更新日期:2013-01-01 00:00:00
abstract:Background:Haemonchus contortus, the causative agent of Haemonchosis, is the most economically important parasite in small ruminant production. Control with chemotherapy has not been successful due to rapid emergence of drug-resistant strains. There is a continuous search for alternative leads particularly from plants....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1905987
更新日期:2017-01-01 00:00:00
abstract:Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7146028
更新日期:2020-03-07 00:00:00
abstract:Purpose:To analyze retrospectively the clinical efficacy and safety for patients treated with fractionated stereotactic radiation therapy (FSRT) using volumetric modulated arc therapy. Methods:Between 2016 and 2017, 46 patients with solitary brain metastasis who underwent FSRT consisting of 25-40 Gy/5 fractions were r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6342057
更新日期:2020-09-09 00:00:00
abstract::Although triacylglycerol, the major component for lipid storage, is essential for normal physiology, its excessive accumulation causes obesity in adipose tissue and is associated with organ dysfunction in nonadipose tissue. Here, we focused on the Drosophila model to develop therapeutics for preventing obesity. The br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6293163
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To identify an effective method to prevent myopia progression by characterizing the regulation of matrix metalloproteinase- (MMP-) 2 expression and its secretion from scleral fibroblasts and retinal pigment epithelium (RPE) cells by miR-29a. METHODS:The effects of miR-29a on the growth of scleral fibroblasts a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2647879
更新日期:2017-01-01 00:00:00
abstract::MicroRNAs are small noncoding RNAs, involved in the regulation of many cellular processes in plants. Hundreds of miRNAs have been identified in cassava by various techniques, yet these identifications were constrained by a lack of miRNA templates and the narrow range of conditions in transcriptome study. In this resea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2019846
更新日期:2019-06-19 00:00:00
abstract::Background. The aim of this study was to assess the effects of low concentrations of H2O2 on angiogenesis of human umbilical vein endothelial cells (HUVECs) in vitro and explore the underlying mechanisms. Methods. HUVECs were cultured and stimulated with different concentrations of H2O2. Flow cytometric analysis was u...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6895730
更新日期:2017-01-01 00:00:00
abstract::Diabetes-triggered apoptosis of Schwann cells (SC) contributes to the degradation of diabetic peripheral neuropathy (DNP). In recent years, mesenchymal stem cells (MSC) were applied to DPN repair and it was demonstrated that paracrine secretion played a key role in neuroprotection exerted by MSC. Erythropoietin (EPO) ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6352858
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/7865747.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/6348625
更新日期:2018-05-14 00:00:00
abstract:Background:Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectab...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6278403
更新日期:2018-08-27 00:00:00
abstract::Influenza vaccination for health care personnel (HCP) is recommended particularly because it indirectly protects patients from contracting the disease. Vaccinating can therefore be interpreted as a prosocial act. However, HCP vaccination rates are often far too low to prevent nosocomial infections. Effective intervent...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6870984
更新日期:2016-01-01 00:00:00
abstract::Actin is one of the most highly conserved proteins and plays crucial roles in many vital cellular functions. In most eukaryotes, it is encoded by a multigene family. Although the actin gene family has been studied a lot, few investigators focus on the comparison of actin gene family in relative species. Here, the purp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/630803
更新日期:2013-01-01 00:00:00
abstract::Carotenoids produced by microbial sources are of industrial and medicinal importance due to their antioxidant and anticancer properties. In the current study, optimization of β-carotene production in M. circinelloides strain 277.49 was achieved using response surface methodology (RSM). Cerulenin and ketoconazole were ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8890269
更新日期:2020-12-29 00:00:00
abstract::The use of anaesthetic drugs in the treatment of oral aphthosis is one of the pharmaceutical possibilities that a doctor can use for the most painful forms. Normally, Lidocaine or Diclofenac is used to treat this disease, but they can be used for a very limited time and so they are of little practical use. In this stu...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1868254
更新日期:2018-03-11 00:00:00
abstract::Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a major cause of nonrelapse mortality after allo-HSCT. A conditioning regimen plays a pivotal role in the development of aGVHD. To provide a platform for studying aGVHD and evaluating t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3071214
更新日期:2016-01-01 00:00:00
abstract::In previous studies, we have demonstrated the function of uc.167 in the heart development. DNA methylation plays a crucial role in regulating the expression of developmental genes during embryonic development. In this study, the methylomic landscape was investigated in order to identify the DNA methylation alterations...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4658024
更新日期:2018-05-30 00:00:00
abstract::This review examines studies of radiofrequency ablation (RFA) of nonsmall cell lung cancer (NSCLC) and discusses the role of RFA in treatment of early-stage NSCLC. RFA is usually performed under local anesthesia with computed tomography guidance. RFA-associated mortality, while being rare, can result from pulmonary ev...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/152087
更新日期:2014-01-01 00:00:00
abstract::The aim of this population-based cohort study was to explore postoperative renal outcomes of patients receiving pyelolithotomy versus percutaneous nephrolithotomy (PCNL). Data were retrieved from the Taiwan National Health Insurance Research Database. During the period from Jan 1, 1998, to Dec 31, 2012, there were 254...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8582901
更新日期:2018-05-02 00:00:00
abstract::The aim of this study was to evaluate, at a laboratory scale, the ability of this microorganism to grow in seawater and bioaccumulate in mussels (Mytilus galloprovincialis) maintained in constantly aerated tanks, containing twenty litres of artificial seawater. Three concentrations of A. butzleri LMG 10828(T) were tes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/153419
更新日期:2013-01-01 00:00:00
abstract::The efficiency of oat bran and barley bran in lowering the induced hyperlipidemia and hypercholesterolemia in blood of male Albino rats (Rattus rattus) was studied. Twenty rats were divided into four groups each consisted of five rats and fed the specified test diets for eight weeks. The first group (G1) is the negati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/263594
更新日期:2013-01-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in TNFSF4 and ANKRD55 genes have been shown to be associated with several autoimmune diseases, although whether these genes are susceptibility genes for dermatomyositis/polymyositis (DM/PM) has, to date, not been reported. This study aimed to investigate the potential association...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2905987
更新日期:2017-01-01 00:00:00
abstract::Previously, a novel technique was proposed to quantify the relationship between the muscle stiffness and its nonfatigue contraction intensity. The method extended the measured range of isometric contraction to 100% maximum voluntary contraction (MVC) using an ultrasonic shear wave measurement setup. Yet, it has not be...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9469548
更新日期:2017-01-01 00:00:00
abstract::Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2021/4051504
更新日期:2021-01-05 00:00:00
abstract::Cholesterol is a waxy substance present in all types of the body cells. The presence of higher concentration of low density lipoprotein (LDL) is characterized by abnormal cholesterol level and is associated with cardiovascular diseases which lead to the development of atheroma in arteries known as atherosclerosis. The...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1359528
更新日期:2019-04-28 00:00:00
abstract::Lipases are water-soluble enzymes that act on insoluble substrates and catalyze the hydrolysis of long-chain triglycerides. Lipases play a vital role in the food, detergent, chemical, and pharmaceutical industries. In the past, fungal lipases gained significant attention in the industries due to their substrate specif...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/154549
更新日期:2013-01-01 00:00:00
abstract::Traumatic brain injury (TBI) represents a significant public health concern and has been associated with high rates of morbidity and mortality. Although several research groups have proposed the use of repetitive transcranial magnetic stimulation (rTMS) to enhance neuroprotection and recovery in patients with TBI, few...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4540291
更新日期:2017-01-01 00:00:00