Abstract:
:Single nucleotide polymorphisms (SNPs) in TNFSF4 and ANKRD55 genes have been shown to be associated with several autoimmune diseases, although whether these genes are susceptibility genes for dermatomyositis/polymyositis (DM/PM) has, to date, not been reported. This study aimed to investigate the potential associations of these SNPs with DM/PM in a Chinese Han population. Five SNPs in TNFSF4 (rs2205960, rs844644, and rs844648) and ANKRD55 (rs6859219, rs7731626) genes were genotyped using the SequenomMassArray system in 2297 Chinese individuals. In total, 1017 DM/PM patients and 1280 gender-matched healthy controls were genotyped. No significant associations were observed in DM/PM patients for the five SNPs analyzed. The association between SNPs and interstitial lung disease (ILD) was also investigated. Both DM-ILD (P c = 0.030, OR = 0.65, 95% CI: 0.47-0.88) and DM/PM-ILD (P c = 0.015, OR = 0.67, 95% CI: 0.51-0.87) exhibited a significant association with the rs7731626-A allele. Rs7731626-A was less frequently found in DM-ILD and DM/PM-ILD patients compared with healthy controls. This is the first study to demonstrate a positive association between ANKRD55 polymorphism and DM-ILD and DM/PM-ILD. A decreased frequency of rs7731626-A in DM-ILD and DM/PM-ILD patients suggests that the A variant may be protective against DM/PM-ILD.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Li L,Chen S,Wen X,Wang Q,Lv G,Li J,Yang F,Zhang F,Li Ydoi
10.1155/2017/2905987subject
Has Abstractpub_date
2017-01-01 00:00:00pages
2905987eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::Stimuli responsive pH- and temperature-sensitive hydrogel drug delivery systems, as those based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA), have been attracting much of the attention of the scientific community nowadays, especially in the field of drug release. By adjusting comonomer composition, the mat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/364930
更新日期:2014-01-01 00:00:00
abstract::The purpose of this study was to describe the first metabolic profile of human sperm cells through the application of an untargeted platform based on gas chromatography-mass spectrometry (GC-MS). Sperm cell samples from patients diagnosed with idiopathic asthenozoospermia (n = 30) and healthy subjects (n = 30) were an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8327506
更新日期:2018-02-28 00:00:00
abstract::Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall surviva...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/654727
更新日期:2014-01-01 00:00:00
abstract::We evaluated single nucleotide polymorphism (SNP) detection via a target-capture, C-probe ligation, and RAM assay in a single-blind comparison to clinical samples that had been tested with FDA-cleared tests for up to 4 different vascular disease-related SNPs. In the RAM assay circulizable linear probes (C- or padlock ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/641090
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:DHA supplementation was compared to nutrition education to increase DHA consumption from fish and DHA fortified foods. DESIGN:This two-part intervention included a randomized double-blind placebo controlled DHA supplementation arm and a nutrition education arm designed to increase intake of DHA from dietary ...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/123078
更新日期:2015-01-01 00:00:00
abstract::Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/236745
更新日期:2015-01-01 00:00:00
abstract::Although a history of first-trimester recurrent spontaneous abortion (FRSA) is regarded as a risk factor in antenatal care, the characteristic of subsequent pregnancy outcome is not clearly elucidated. Here, a retrospective analysis was performed on the clinical data of 492 singleton pregnant women. 164 of them with t...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4359424
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Cost sharing between beneficiaries and government is critical to attain universal health coverage. The government of Ethiopia introduced social health insurance to improve access to quality health services. Hence, HCP are the ultimate frontline service provider; their WTP for health insurance could influence...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8412957
更新日期:2020-04-14 00:00:00
abstract::ELABELA (ELA) is considered to be implicated in the pathophysiology of preeclampsia (PE), since ELA-deficient mice exhibited PE-like symptoms and infusion of exogenous ELA normalized the gestational hypertension (GH) and proteinuria. However, no evidence show that circulating ELA is deficient in early placental develo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2051701
更新日期:2020-09-28 00:00:00
abstract::Macrophages, especially their activation state, are closely related to the progression of diabetic nephropathy. Classically activated macrophages (M1) are proinflammatory effectors, while alternatively activated macrophages (M2) exhibit anti-inflammatory properties. 1,25-Dihydroxyvitamin D3 has renoprotective roles th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/157834
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:There is an unmet need for a specific cardiovascular risk (CV) algorithm for rheumatoid arthritis (RA) patients. Lipoprotein data are often not available in RA cohorts but could be obtained from frozen blood samples. The objective of this study was to estimate the storage effect on lipoproteins in long-term (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/930925
更新日期:2014-01-01 00:00:00
abstract::Positive results of MitraClip in terms of improvement in clinical and left ventricular parameters have been described in detail. However, long-term effects on secondary pulmonary hypertension were not investigated in a larger patient cohort to date. 70 patients with severe mitral regurgitation, additional pulmonary hy...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6817832
更新日期:2018-03-14 00:00:00
abstract:OBJECTIVE:There is a paucity of a biological large animal model of myocardial infarction (MI). We hypothesized that, using autologous-aggregated platelets, we could create an ovine model that was reproducible and more closely mimicked the pathophysiology of MI. METHODS:Mepacrine stained autologous platelets from male ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/938047
更新日期:2013-01-01 00:00:00
abstract::Traumatic brain injury (TBI) leads to important and deleterious neuroinflammation, as evidenced by indicators such as edema, cytokine production, induction of nitric oxide synthase, and leukocyte infiltration. After TBI, cerebral vascular endothelial cells play a crucial role in the pathogenesis of inflammation. In ou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/910260
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Osteomyelitis is a severe orthopaedic complication which is difficult to diagnose and treat. Previous experimental studies mainly focussed on evaluating osteomyelitis in the presence of an implant or used a sclerosing agent to promote infection onset. In contrast, we focused on the longitudinal assessment ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/424652
更新日期:2014-01-01 00:00:00
abstract::The study investigated the vertical jump landing limb symmetry after ACLR between a group of patients receiving a longer supervised physiotherapeutic procedure and following a shorter supervised physiotherapy. Group I (n = 20) and Group II (n = 15) were males averagely 30 weeks after ACLR. The time since ACLR in both ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7519467
更新日期:2018-04-23 00:00:00
abstract::The role of nitric oxide and its reactive derivatives (NO x ) is well known in the pathogenesis of multiple sclerosis, which is an inflammatory disease while NO x seems to be important in coordinating inflammatory response. The...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4570351
更新日期:2016-01-01 00:00:00
abstract::Chronic kidney disease (CKD) is considered a public health problem, assuming epidemic proportions worldwide. In this context, the preponderance of CKD prevalence in male over age-matched female patients is of note. In the present study, we investigated the impact of the gender on the development of experimental CKD in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2159739
更新日期:2017-01-01 00:00:00
abstract:Objective:This study is aimed at evaluating the effects of platelet-rich plasma (PRP) on proliferation, viability, and odontogenic differentiation of neural crest stem-like cells (NCSCs) derived from human dental apical papilla. Materials and Methods:Cells from apical papillae were obtained and then induced to form ne...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4671989
更新日期:2020-05-09 00:00:00
abstract:Background:Oxycodone is a widely used opioid analgesic, which is involved in cancer pain and non-cancer pain. This study is intended to understand the publication characteristics of oxycodone research field and assess the quality of pertinent articles from 1998 to 2017. Methods:Oxycodone-related publications from 1998...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9096201
更新日期:2019-10-31 00:00:00
abstract:Background:Clinical trials based on FGFR mutation or amplification as a druggable target of FGFR inhibitors have produced disappointing clinical outcomes. Therefore, the identification of predictive biomarkers for FGFR-targeted agents has remained a crucial issue. Methods:Expression profiles of FGFs and FGFRs in 8,111...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5658904
更新日期:2020-06-03 00:00:00
abstract:Background:The Oxford Happiness Inventory (OHI) is a self-report tool to measure happiness. A brief review of previous studies on OHI showed the lack of evaluation of OHI fairness/equivalence in measuring happiness among identified groups. Methods:To examine the psychometric properties and measurement invariance of th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8906209
更新日期:2020-06-21 00:00:00
abstract:Objectives:To evaluate the role of short-term low-dose glucocorticoids in mild COVID-19 patients. Methods:We conducted a retrospective, cross-sectional, single-center study in Kunming, China. A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2854186
更新日期:2020-09-23 00:00:00
abstract::Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/739010
更新日期:2013-01-01 00:00:00
abstract::Contrast-induced acute kidney injury (CI-AKI) is commonly defined as a decline in kidney function occurring in a narrow time window after administration of iodinated contrast material. The incidence of AKI after contrast material administration greatly depends on the specific definition and cutoff values used. Althoug...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/859328
更新日期:2014-01-01 00:00:00
abstract::Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/989175
更新日期:2014-01-01 00:00:00
abstract::Sulfated polysaccharides (GSP) were isolated from the cloned Grateloupia filicina which was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral sugar analysis showed...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/612352
更新日期:2015-01-01 00:00:00
abstract::Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is a mitochondrial inner membrane protein and plays an important role in mitochondrial ATP production and biogenesis. High expression levels of LETM1 have been correlated with numerous human malignancies. This study explored the clinicopathological sign...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/850316
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:This study evaluated the frequencies of allergic symptoms and rate of upper respiratory infections during the past year in the general population, kitchen workers (KW) and health care workers (HCW). METHODS:The European Community Respiratory Health Survey (ECRHS) was used to inquire retrospectively about ast...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/285420
更新日期:2013-01-01 00:00:00
abstract::Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/839019
更新日期:2014-01-01 00:00:00