Postsurgical pathologies associated with intradural electrical stimulation in the central nervous system: design implications for a new clinical device.

Abstract:

:Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk of certain postsurgical complications, it became exclusively epidural eventually. Here we review the relevant clinical and experimental pathologic findings, including spinal cord compression, infection, hematoma formation, cerebrospinal fluid leakage, chronic fibrosis, and stimulation-induced neurotoxicity, associated with the early approaches to subdural electrical stimulation of the central nervous system, and the spinal cord in particular. These findings may help optimize the safety and efficacy of a new approach to subdural spinal cord stimulation now under development.

journal_name

Biomed Res Int

authors

Gibson-Corley KN,Flouty O,Oya H,Gillies GT,Howard MA

doi

10.1155/2014/989175

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

989175

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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