Abstract:
:Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk of certain postsurgical complications, it became exclusively epidural eventually. Here we review the relevant clinical and experimental pathologic findings, including spinal cord compression, infection, hematoma formation, cerebrospinal fluid leakage, chronic fibrosis, and stimulation-induced neurotoxicity, associated with the early approaches to subdural electrical stimulation of the central nervous system, and the spinal cord in particular. These findings may help optimize the safety and efficacy of a new approach to subdural spinal cord stimulation now under development.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Gibson-Corley KN,Flouty O,Oya H,Gillies GT,Howard MAdoi
10.1155/2014/989175subject
Has Abstractpub_date
2014-01-01 00:00:00pages
989175eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章,评审abstract::An excessive pulmonary inflammatory response could explain the poor prognosis of chronic obstructive pulmonary disease (COPD) patients submitted to invasive mechanical ventilation. The aim of this study was to evaluate the response to normal tidal volume mechanical ventilation in an elastase-induced murine model of pu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5721293
更新日期:2018-12-19 00:00:00
abstract:Background:Hypertrophic pachymeningitis (HP) is generally regarded as a rare inflammatory disease, which results in a diffuse thickening of the dura mater. We retrospectively collected data from patients with HP. Methods:A total of 16 patients with HP were included in our study. The clinical features, laboratory evalu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2926419
更新日期:2020-08-14 00:00:00
abstract::Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults. Despite continuous improvements in diagnosis and therapeutic method, the prognosis is still far away from expectations. The invasive phenotype of GBM is the main reason for the poor prognosis. Epithelial-mesenchymal transition (EMT) is r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1321973
更新日期:2019-04-17 00:00:00
abstract::Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μ g%; C14:0, myristic acid, 6.9 μ g%; C16:0, palmitic acid, 35.3 μ g%; C16:1, palmitoleic acid, 16.4 μ g%; C18:0, stearic acid, 8.5 μ g%; C18:1 cis, oleic acid, 18.4 μ g%; C18:1 trans, elaidic aci...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/121794
更新日期:2013-01-01 00:00:00
abstract::Hyaluronic acid (HA), a macropolysaccharidic component of the extracellular matrix, is common to most species and it is found in many sites of the human body, including skin and soft tissue. Not only does HA play a variety of roles in physiologic and in pathologic events, but it also has been extensively employed in c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/921549
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). MATERIALS AND METHODS:Institutional review board approval...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/835385
更新日期:2013-01-01 00:00:00
abstract::One of the biggest obstetric challenges is the diagnosis and management of a short cervix as cervical length has an inverse relationship with risk of preterm birth. A cervical cerclage is a surgical procedure to reduce the risk of preterm birth and can be placed in an elective or emergency setting. This is a retrospec...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2018/2065232
更新日期:2018-09-30 00:00:00
abstract::Due to anthropogenic activities the relative concentrations of cadmium and manganese have increased in the marine environment. Cephalopods are able to accumulate such metals and, as inhabitant of coastal waters, Octopus vulgaris is continuously exposed to anthropogenic activities. Since no study is available on the ef...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/437328
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Aortic diameters, aortic distensibility, microalbuminuria, coronary artery disease which are all together related to vascular aging are investigated in this paper. METHODS:Eighty consecutive nondiabetic patients undergoing elective coronary angiography were enrolled into the study. Systolic and diastolic ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/857628
更新日期:2015-01-01 00:00:00
abstract::Ablative therapies have been utilized with increasing frequency for the treatment of Barrett's esophagus with and without dysplasia. Multiple modalities are available for topical ablation of the esophagus, but radiofrequency ablation (RFA) remains the most commonly used. There have been significant advances in techniq...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/642063
更新日期:2014-01-01 00:00:00
abstract:Background:Neonatal jaundice is common a clinical problem worldwide. Globally, every year, about 1.1 million babies develop severe hyperbilirubinemia with or without bilirubin encephalopathy and the vast majority reside in sub-Saharan Africa and South Asia. Strategies and information on determinants of neonatal jaundic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4743974
更新日期:2020-10-21 00:00:00
abstract::Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-β (TGF-β). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis. In tubular epithelial cells we have recently described that Gremlin induces EMT and acts...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/802841
更新日期:2014-01-01 00:00:00
abstract::A potent fibrinolytic enzyme-producing Bacillus cereus IND1 was isolated from the Indian food, rice. Solid-state fermentation was carried out using agroresidues for the production of fibrinolytic enzyme. Among the substrates, wheat bran supported more enzyme production and has been used for the optimized enzyme produc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/725064
更新日期:2014-01-01 00:00:00
abstract::The most expedient unit of the human body is its cell. Encapsulated within the cell are many infinitesimal entities and molecules which are protected by a cell membrane. The proteins that are associated with this lipid based bilayer cell membrane are known as membrane proteins and are considered to play a significant ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8370132
更新日期:2016-01-01 00:00:00
abstract::Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autophagy in neurodegene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6701793
更新日期:2016-01-01 00:00:00
abstract::Perinatal infections have a negative impact on brain development. However, the underlying mechanisms leading to neurological impairment are not completely understood and reliable models of inflammation are urgently needed. Using phorbol-myristate-acetate as an activator of inflammation, we investigated the effect on t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/318306
更新日期:2015-01-01 00:00:00
abstract::Organic pollutants, like phenol, along with heavy metals, like chromium, are present in various industrial effluents that pose serious health hazard to humans. The present study looked at removal of chromium (VI) in presence of phenol in a counter-current continuous packed bed reactor packed with E. coli cells immobil...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/373412
更新日期:2013-01-01 00:00:00
abstract::Adverse drug reactions (ADRs) are responsible for drug candidate failure during clinical trials. It is crucial to investigate biological pathways contributing to ADRs. Here, we applied a large-scale analysis to identify overrepresented ADR-pathway combinations through merging clinical phenotypic data, biological pathw...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/670949
更新日期:2015-01-01 00:00:00
abstract::High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biol...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/215135
更新日期:2015-01-01 00:00:00
abstract:Background:Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods:Profile dat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7147824
更新日期:2020-07-31 00:00:00
abstract:Background:Adenosine, derived from the degradation of ATP via ectonucleotidases CD39 and CD73, is a critical immunosuppressive metabolite in the hypoxic microenvironment of tumor tissue. Adenosine signaling via A2aR can inhibit the antitumor immune response of CD8+ T cells. CD39 and CD73 high-expressing Tregs play a cr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4093214
更新日期:2019-12-14 00:00:00
abstract::DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4590609
更新日期:2017-01-01 00:00:00
abstract::Removal of MTA from dentin by applying 37% hydrochloric acid (HCl) to reduce microhardness and push-out bond strength. Forty dentin slices were filled with WMTA and divided into two groups (n = 20). Ten slices remained untreated while others were exposed to either HCl or phosphate buffer saline (PBS) and all samples w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/469164
更新日期:2013-01-01 00:00:00
abstract::Patients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve reg...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/949624
更新日期:2015-01-01 00:00:00
abstract::During hundreds of years of medication, it is believed that the steamed Panax notoginseng (SPN) can enrich and regulate the blood, replenish the body, and improve the health. The aim of this study was to optimize the steaming conditions of SPN which are related to the hematopoietic effect. In the study, network pharma...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9371426
更新日期:2020-07-26 00:00:00
abstract::Enterotoxigenic Escherichia coli (ETEC) K88 is a zoonotic pathogen. Previous studies have shown that lactic acid bacteria (LAB) have great potential in promoting health and resisting pathogenic infections; however, relatively little research has been done on the Pediococcus genus of LAB. This study is aimed at explori...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7340312
更新日期:2020-03-30 00:00:00
abstract::Targeting nanoparticles by conjugating various specific ligands has shown potential therapeutic efficacy in nanomedicine. However, poor penetration of antitumor drugs into solid tumors remains a major obstacle. Here, we describe a targeting strategy for antitumor drug delivery by conjugating a crosslinked multilamella...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/378380
更新日期:2013-01-01 00:00:00
abstract::A bioenergetical analysis of swimming at intensities near competitive distances is inexistent. It was aimed to compare the transient VO2 kinetics responses and metabolic contributions whilst swimming at different velocities around VO2max. 12 trained male swimmers performed (i) an incremental protocol to determine the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/675363
更新日期:2014-01-01 00:00:00
abstract::Breast cancer is the leading cause of death in women worldwide. The search for novel compounds with antitumor activity, with less adverse effects and higher efficacy, and the development of methods to evaluate their toxicity is an area of intense research. In this study we implemented the preparation and culture of br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/618021
更新日期:2015-01-01 00:00:00
abstract::Studies have found that biotin favors glucose and lipid metabolism, and medications containing biotin have been developed. Despite the use of biotin as a pharmacological agent, few studies have addressed toxicity aspects including the possible interaction with cytochrome P450 enzyme family. This study analyzed the eff...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/627907
更新日期:2013-01-01 00:00:00