Detection of genetic variations in coagulopathy-related genes using ramified rolling circle amplification.

abstract：:Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...

journal_title：BioMed research international

authors： Liu L,Yang K,Wang X,Shi Z,Yang Y,Yuan Y,Guo T,Xiao X,Luo H

更新日期：2017-01-01 00:00:00

abstract：:Energy dispersive X-ray spectroscopy microanalysis (EDX), scanning electron microscopy (SEM), and Archimedes' Principle were used to determine the characteristics of inorganic filler particles in five dental alginates, including Cavex ColorChange (C), Hydrogum 5 (H5), Hydrogum (H), Orthoprint (O), and Jeltrate Plus (J...

journal_title：BioMed research international

authors： Guiraldo RD,Berger SB,Consani RL,Consani S,de Carvalho RV,Lopes MB,Meneghel LL,da Silva FB,Sinhoreti MA

更新日期：2014-01-01 00:00:00

abstract：:The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5'-hydroxy auraptene (5'-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteobla...

journal_title：BioMed research international

authors： Abdallah BM,Ali EM,Elsawy H,Badr GM,Abdel-Moneim AM,Alzahrani AM

更新日期：2019-12-28 00:00:00

abstract：:Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autophagy in neurodegene...

journal_title：BioMed research international

authors： Ou Z,Luo M,Niu X,Chen Y,Xie Y,He W,Song B,Xian Y,Fan D,OuYang S,Sun X

更新日期：2016-01-01 00:00:00

abstract：Purpose:High tibial osteotomy (HTO) has been adopted as an effective surgery for medial degeneration of the osteoarthritis (OA) knee. However, satisfactory outcomes necessitate the precise creation and distraction of osteotomized wedges and the use of intraoperative X-ray images to continually monitor the wedge-related...

journal_title：BioMed research international

authors： Yang JC,Chen CF,Luo CA,Chang MC,Lee OK,Huang Y,Lin SC

更新日期：2018-05-08 00:00:00

abstract：:Severe stages of acute, colonic diverticulitis can progress into intestinal perforations with peritonitis. In such cases, urgent treatment is needed, and Hartmann's procedure is the standard treatment for cases with fecal peritonitis. Peritoneal lavage may be an alternative to resection for acute diverticulitis with p...

journal_title：BioMed research international

authors： Hupfeld L,Burcharth J,Pommergaard HC,Rosenberg J

更新日期：2014-01-01 00:00:00

abstract：:28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15...

journal_title：BioMed research international

authors： Johari SA,Mohtar M,Mohammad SA,Sahdan R,Shaameri Z,Hamzah AS,Mohammat MF

更新日期：2015-01-01 00:00:00

abstract：:Here we aimed to develop a capillary electrophoresis-based high-throughput multiplex polymerase chain reaction (PCR) system for the simultaneous detection of nine pathogens in swine. Nine pairs of specific primers and a set of universal primers were designed; the multiplex PCR was established. The specificity and cros...

journal_title：BioMed research international

authors： Wu XL,Xiao L,Lin H,Yang M,Chen SJ,An W,Wang Y,Yao XP,Yang ZX,Tang ZZ

更新日期：2017-01-01 00:00:00

abstract：:Sciatic nerve crush injury in rat animal model is one of the most common experimental models used in regenerative research. However, the availability of transgenic mouse for nerve regeneration studies is constantly increasing and, therefore, the shift from rat model to mouse model is, in some cases, necessary. Moreove...

journal_title：BioMed research international

authors： Jager SB,Ronchi G,Vaegter CB,Geuna S

更新日期：2014-01-01 00:00:00

abstract：:Microalgae are a promising source of omega-3. The purpose of this study was to extract lipid with a relatively high content of eicosapentaenoic acid (EPA) from Nannochloropsis gaditana using subcritical water extraction (SWE). The effects of different temperatures (156.1-273.9°C), extraction times (6.6-23.4 minutes), ...

journal_title：BioMed research international

authors： Ho BCH,Kamal SMM,Danquah MK,Harun R

更新日期：2018-12-27 00:00:00

abstract：Background:sCD30 and sCD26 are correlated with autoimmune diseases. However, little research has been done on the relationship between them and primary immune thrombocytopenia (ITP). Methods:This study enrolled 47 patients diagnosed with ITP in the Institute of Hematology and Blood Disease Hospital, Chinese Academy of...

journal_title：BioMed research international

authors： Wang H,Gu X,Li H,Yin L,Tao W,Yu J,Zhou Q,Mu H,Shen Y,Yao J,Liu L,Bi H,Yang R,Zhou Z

更新日期：2020-03-31 00:00:00

abstract：:Objective. Duodenal atresia (DA) routinely has been corrected by laparotomy and duodenoduodenostomy with excellent long-term results. We revisited the patients with DA treated in the last 12 years (2004-2016) comparing the open and the minimally invasive surgical (MIS) approach. Methods. We divided our cohort of patie...

journal_title：BioMed research international

authors： Chiarenza SF,Bucci V,Conighi ML,Zolpi E,Costa L,Fasoli L,Bleve C

更新日期：2017-01-01 00:00:00

abstract：Purpose:To evaluate the diagnostic performance of deep learning with a multichannel fusion three-dimensional convolutional neural network (MCF-3DCNN) in the differentiation of the pathologic grades of hepatocellular carcinoma (HCC) based on dynamic contrast-enhanced magnetic resonance images (DCE-MR images). Methods a...

journal_title：BioMed research international

authors： Yang DW,Jia XB,Xiao YJ,Wang XP,Wang ZC,Yang ZH

更新日期：2019-04-28 00:00:00

abstract：INTRODUCTION:Thiopurine drugs are metabolized via S-methylation and catalyzed by thiopurine S-methyltransferase (TPMT). Patients with very low TPMT activity are at high risk of fatal bone marrow toxicity when standard doses of thiopurine drugs are administered. TPMT genotyping can predict TPMT activity and is not affec...

journal_title：BioMed research international

authors： Kim S,Lee HW,Lee W,Chun S,Min WK

更新日期：2013-01-01 00:00:00

abstract：:We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions. Male Wistar rats were divided into four groups: control (CON), diabetic (DM; streptozotocin (STZ), i.v. 55 mg/kg BW), control-treated with cu...

journal_title：BioMed research international

authors： Wongeakin N,Bhattarakosol P,Patumraj S

更新日期：2014-01-01 00:00:00

abstract：:During vertebrate development, the lung inaugurates as an endodermal bud from the primitive foregut. Dichotomous subdivision of the bud results in arborizing airways that form the prospective gas exchanging chambers, where a thin blood-gas barrier (BGB) is established. In the mammalian lung, this proceeds through conv...

journal_title：BioMed research international

authors： Makanya A,Anagnostopoulou A,Djonov V

更新日期：2013-01-01 00:00:00

abstract：:The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P. hysterophorus leaf. Dried leaf samples were sequentially extracted with nonpolar and polar solvents. Ethanol fraction showed noticeable cytotoxic activity (81-85%) in SRB assay against MCF-...

journal_title：BioMed research international

authors： Kumar S,Chashoo G,Saxena AK,Pandey AK

更新日期：2013-01-01 00:00:00

abstract：:Liver transplantation is the best treatment option for early-stage hepatocellular carcinoma, liver cirrhosis, fulminant liver failure, and end-stage liver diseases. Even though advances in surgical techniques and perioperative care have improved postoperative outcomes, perioperative cardiovascular complications are a ...

journal_title：BioMed research international

authors： Choi JM,Kong YG,Kang JW,Kim YK

更新日期：2017-01-01 00:00:00

abstract：:There is mounting evidence that burnout is a risk factor for cardiovascular disease (CVD). Stress-related dysregulation of the sympathetic and parasympathetic system and the hypothalamic pituitary adrenal (HPA) axis may explain the enhanced risk for CVD. To test this hypothesis, 55 patients (34 males and 21 females) w...

journal_title：BioMed research international

authors： de Vente W,van Amsterdam JG,Olff M,Kamphuis JH,Emmelkamp PM

更新日期：2015-01-01 00:00:00

abstract：:The use of supplemental oxygen in uncomplicated cesarean deliveries under spinal anesthesia has been thoroughly investigated during recent decades. The aim of this study was to determine the benefits for both mother and infant of administering supplemental, low-dose oxygen via a nasal cannula versus having no suppleme...

journal_title：BioMed research international

authors： Siriussawakul A,Triyasunant N,Nimmannit A,Ngerncham S,Hirunkanokpan P,Luang-Aram S,Pechpaisit N,Wangdee A,Ruangvutilert P

更新日期：2014-01-01 00:00:00

abstract：:An FDA-regulated, prescription medical food (Fosteum; 27 mg natural genistein, 200 IU cholecalciferol, 20 mg citrated zinc bisglycinate (4 mg elemental zinc) per capsule) and an over-the-counter (OTC) supplement (Citracal Plus Bone Density Builder; 27 mg synthetic genistein, 600 mg elemental calcium (calcium citrate),...

journal_title：BioMed research international

authors： Bitto A,Burnett BP,Polito F,Russo S,D'Anna R,Pillai L,Squadrito F,Altavilla D,Levy RM

更新日期：2013-01-01 00:00:00

abstract：:Psoriasis is one of the most prevalent immune mediated skin diseases worldwide. Despite the large prevalence in both men and women, the pathogenesis of this disease has not yet been fully clarified. Nowadays, it is believed that psoriasis is most likely a T helper Th1/Th17 induced inflammatory disease. Stressful life ...

journal_title：BioMed research international

authors： Ceovic R,Mance M,Bukvic Mokos Z,Svetec M,Kostovic K,Stulhofer Buzina D

更新日期：2013-01-01 00:00:00

abstract：:Cumulative evidence has indicated that there is an important role for adult hippocampal neurogenesis in cognitive function. With the increasing prevalence of cognitive decline associated with neurodegenerative diseases among the ageing population, physical exercise, a potent enhancer of adult hippocampal neurogenesis,...

journal_title：BioMed research international

authors： Yau SY,Gil-Mohapel J,Christie BR,So KF

更新日期：2014-01-01 00:00:00

abstract：:Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of muscle mass and strength. The more rationale approach to delay the progression of sarcopenia is based on the combination of proper nutrition, possibly associated with the use of dietary supplements and a regular exercise program. ...

journal_title：BioMed research international

authors： Rondanelli M,Faliva M,Monteferrario F,Peroni G,Repaci E,Allieri F,Perna S

更新日期：2015-01-01 00:00:00

abstract：:We test the hypothesis that ultrasound-targeted microbubble destruction (UTMD) technique increases the renoprotective effect of kidney-targeted transplantation of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in diabetic nephropathy (DN) rats. Diabetes was induced by streptozotocin injection (60 mg/Kg, intraper...

journal_title：BioMed research international

authors： Zhang Y,Ye C,Wang G,Gao Y,Tan K,Zhuo Z,Liu Z,Xia H,Yang D,Li P

更新日期：2013-01-01 00:00:00

abstract：:Objectives. To investigate the potential association of a set of serum cytokines with the severity of coronary artery disease (CAD). Methods. A total of 201 patients who underwent coronary angiography for chest discomfort were enrolled. The concentrations of serum IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-9, and IL-17...

journal_title：BioMed research international

authors： Min X,Lu M,Tu S,Wang X,Zhou C,Wang S,Pang S,Qian J,Ge Y,Guo Y,Xu D,Cao K

更新日期：2017-01-01 00:00:00

abstract：:The perceived risk of nonremunerated blood donation (NRBD) is one of the most important factors which hinder the Chinese public from donating blood. To understand deeply and measure scientifically the public's perceived risk of NRBD, in this paper the qualitative and quantitative methods were used to explore the const...

journal_title：BioMed research international

authors： Chen L,Ma Z

更新日期：2015-01-01 00:00:00

abstract：Background:The present study aims to investigate the incidence and risk factors associated with postoperative delirium in patients undergoing spine surgery. Methods:PubMed, EMBASE, Cochrane Library, and Science Citation Index were searched up to August 2019 for studies examining postoperative delirium following spine ...

journal_title：BioMed research international

authors： Wu X,Sun W,Tan M

更新日期：2019-11-26 00:00:00

abstract：:New genomes are being sequenced at an increasingly rapid rate, far outpacing the rate at which manual gene annotation can be performed. Automated genome annotation is thus necessitated by this growth in genome projects; however, full-fledged annotation systems are usually home-grown and customized to a particular geno...

journal_title：BioMed research international

authors： Alioto T,Picardi E,Guigó R,Pesole G

更新日期：2013-01-01 00:00:00

abstract：:Microcystins (MCs) are hepatotoxins harmful for animal and human health. The most toxic type between them is MC-LR whose presence has been investigated in different reservoirs all around the world. In this work microcystins were monitored in spring and summer in water and mussels (Mytilus galloprovincialis) of two Sar...

journal_title：BioMed research international

authors： Baralla E,Varoni MV,Sedda T,Pasciu V,Floris A,Demontis MP

更新日期：2017-01-01 00:00:00