Abstract:
:Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral cancer. Inducible nitric oxide synthase (iNOS) and p53 are associated with a variety of human cancers, but their expression and interaction in OSCC have not been fully explored. In this study, we investigated the expression of iNOS and p53 in OSCC and their correlation with tumor development and prognosis. In addition, we explored the interaction of iNOS and p53 in OSCC. The expression of iNOS and p53 in OSCC was investigated using immunohistochemical method and their interaction was studied using RNAi technique. Our results showed that the expression of both iNOS and p53 was significantly correlated with tumor stages and pathological grade of OSCC (P < 0.05). In contrast, there was no correlation between iNOS and p53 expression and lymph node metastasis (P < 0.05). The OSCC survival rate was negatively associated with iNOS expression, but not with p53. A significant increase in the expression of the p53 was observed when iNOS expression was knocked down. The immunoexpression of iNOS is correlated with tumorigenesis and prognosis of OSCC and may serve as a prognostic marker.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yang L,Wang Y,Guo L,Wang L,Chen W,Shi Bdoi
10.1155/2015/637853subject
Has Abstractpub_date
2015-01-01 00:00:00pages
637853eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,评审
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